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Hana Kwon(Hana Kwon),Hyemin Oh(Hyemin Oh),Hyunjee Chae(Hyunjee Chae),Pattaraporn Thiangthae(Pattaraporn Thiangthae ),Kyoung-Jin Kang(Kyoung-Jin Kang) 대한미용의학회 2022 대한미용의학회지 Vol.6 No.2
Background: Filler injections are commonly used to soften deep nasolabial folds (NLF) by restoring volume in the depressed parts of fold. Recently, a combination technique using hyaluronic acid filler and polydioxanone (PDO) thread significantly improves deep NLF and induced changes in smile. Objective: This study retrospectively confirmed the effects of this combination therapy, focusing on smile changes. Methods: The NLF was divided into 3 parts: the lateral folded part (LFP), medial depressed part (MDP), and central creased part (CCP). Between November and December 2021, 14 patients underwent the combination treatment; of these, 11 were enrolled, excluding 3 who were not properly followed up. On average, 5.82±0.87 (right) and 5.73±0.47 (left) PDO mesh threads (6.0 cm length) were sequentially inserted into the LFP, MDP, and under the CCP of each NLF. Following this, an average of 1.82±0.71 ml (right) and 1.92±0.75 ml (left) of the filler was also sequentially injected into each NLF in a similar manner. They were mainly placed in the superficial and deep fat layers in the entire NLF and sub-malar areas. Smile index was measured during the fully expanded smile stage. The follow-up period was 3 months. The results were estimated using pre- and post-operative photographs. Results: Three months after the combination treatment, patients were pleased with the softening of their NLF. As indicated by the increased smile index (inter-commissural width/inter-labial gap), the old and expanded smile changed to younger and less expanded smile. The original smile type (eight and three patients with the commissure and cuspid types, respectively) remained unchanged. The contour changes in each smile varied according to the smile type. This could be explained by combination treatment’s NLF correction, which restricts facial expression muscle movement. Conclusion: These results demonstrate definite evidence of softening of the NLF, a youthful smile, and an increased smile index.
Kwon, Hyemin,Hong, Dajung,Ryu, Ilhwan,Yim, Sanggyu American Chemical Society 2017 ACS APPLIED MATERIALS & INTERFACES Vol.9 No.8
<P>A major limitation of polyaniline (PANi) electrodes for supercapacitors is the slow rate of ion transport during redox reactions and the resultant easy saturation of areal capacitance with film thickness. In this study, three dimensionally (3D)-arrayed PANi nanospheres with highly roughened surface nanomorphology were fabricated to overcome this limitation. A hierarchical nanostructure was obtained by polymerizing aniline monomers on a template of 3D-arrayed polystyrene (PS) nanospheres and appropriate oxidative acid doping. The structure provided dramatically increased surface area and porosity that led to the efficient diffusion of ions. Thus, the specific capacitance (C-sp) reached 1570 F g(-1), thereby approaching a theoretical capacitance of PANi. In addition, the retention at a high scan rate of 100 mV s(-1) was 77.6% of the Csp at a scan rate of 10 mV s(-1). Furthermore, 3D-arrayed hollow PANi (H-PANi) nanospheres could be obtained by dissolving the inner PS part of the PS/PANi core/shell nanospheres with tetrahydrofuran. The ruthenium oxide (RuO2) nanopartides (NPs) were also encaged in the H-PANi nanospheres by embedding RuO2 NPs on the PS nanospheres prior to polymerization of PANi. The combination of the two active electrode materials indicated synergetic effects. The areal capacitance of the RuO2-encaged PANi electrode was significantly larger than that of the RuO2-free PANi electrode and could be controlled by varying the amount of encaged RuO2 nanoparticles. The encagement could also solve the problem of detachment of RuO2 electrodes from the current collector. The effects of the nanostructuring and RuO2 encagement were also quantitatively analyzed by deconvoluting the total capacitance into the surface capacitive and insertion elements.</P>
Kwon Yeonju,Lee Hyein,Park Hyemin,Lee Boyoung,Kwon Tae-Uk,Kwon Yeo-Jung,Chun Young-Jin 한국독성학회 2023 Toxicological Research Vol.39 No.4
The Hippo pathway is a signaling pathway that controls organ size in animals by regulating cell proliferation and apoptosis. Yes-associated protein 1 (YAP1), an oncogene associated with the development and progression of breast cancer, is downregulated by the Hippo pathway and is associated with the development and progression of breast cancer. Yippee-like 3 (YPEL3) is a target gene of the tumor suppressor protein p53, and its activation has been shown to inhibit cell growth, induce cellular senescence, and suppress tumor cell metastasis. In this study, we found that YAP1 inhibits the expression of YPEL3 expression in breast cancer cells. Furthermore, a decrease in lamin B1, a marker protein of cellular senescence, coupled with the activation of senescence-associated β-galactosidase indicated that upregulating YPEL3 levels through YAP1 downregulation can induce cellular senescence. Additionally, elevated YPEL3 levels resulted in higher levels of oxygen consumption rate in mitochondria, thus promoting apoptosis. This suggests that YPEL3 plays a crucial role in regulating oxidative stress and cell apoptosis in breast cancer cells. Therefore, the interaction between YAP1 and YPEL3 represents a novel mechanism of cellular senescence mediated by the Hippo signaling pathway. Collectively, our findings suggest that the Hippo signaling pathway plays an important role in regulating cellular senescence, which could have implications for the development of new therapeutic strategies for diseases such as cancer.
Hyemin Lim,조만호,전종성,Seong Hee Bhoo,Yong-Kook Kwon,Tae-Ryong Hahn 한국분자세포생물학회 2009 Molecules and cells Vol.27 No.6
Pyrophosphate:fructose-6-phosphate 1-phosphotransferase (PFP) catalyzes the reversible interconversion of fructose-6-phosphate and fructose-1,6-bisphosphate, a key step in the regulation of the metabolic flux toward glycolysis or gluconeogenesis. To examine the role of PFP in plant growth, we have generated transgenic Arabidopsis plants that either overexpress or repress Arabidopsis PFP subunit genes. The overexpressing lines displayed increased PFP activity and slightly faster growth relative to wild type plants, although their photosynthetic activities and the levels of metabolites appeared not to have significantly changed. In contrast, the RNAi lines showed significantly retarded growth in parallel with the reduced PFP activity. Analysis of photosynthetic activity revealed that the growth retardation phenotype of the RNAi lines was accompanied by the reduced rates of CO2 assimilation. Microarray analysis of our transgenic plants further revealed that the altered expression of AtPFPβ affects the expression of several genes involved in diverse physiological processes. Our current data thus suggest that PFP is important in carbohydrate metabolism and other cellular processes.
Hyemin Na,Heon-Woong Kim,Ju Hyung Kim,Suji Lee,Ryeong Ha Kwon,So-Jeong Lee,Chi-Do Wee,Seon Mi Yoo,Sang Hoon Lee 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10
Until now, 3 acetylated saponin glycosides (kizuta saponin K11, kalopanaxsaponins JLa and JLb) have been only reported from the leaves of Kalopanax pictus based on NMR and MS techniques. However, in this study, A total of 15 acetylated glycosides including K-niasaponins B (m/z 1247 [M+H]+), C1 (m/z 1263 [M+H]+), H1 (m/z 1395 [M+H]+), H2 (m/z 1379 [M+H]+) and E1 (m/z 1263 [M+H]+) as new compounds were identified from young shoots of Kalopanax pictus using UPLC-DAD-QToF/MS, and they were composed of mono or di-acetylated glycosides based on aglycones of hederagenin, echinocystic acid, kalonagenin C and oleanolic acid. In particular, kizuta saponin K11 and K-niasaponins H1 were presented as major compounds in young shoots, and their detailed acetyl moieties (Da) such as 189 (Ac+Rham+H), 205 (Ac+Glu+H), 367 (Ac+2Glu+H), 393 (2Ac+Rham+Glu+H), 513 (Ac+Rham+2Glu+H), and 555 (2Ac+Rham+2Glu+H) were fragmented clearly to confirm the exact whole structure in positive ESI mode. Thus, it is considered that the acetylated saponin glycosides characterized in this study are closely related to the corresponding glycosides by specific changes during blanching and fermentation.
Hyemin Oh,Dohyun Kwon,Jaemyung Ahn,Jun-Young Paeng 대한악안면성형재건외과학회 2022 Maxillofacial Plastic Reconstructive Surgery Vol.44 No.-
Background: Complications from osteoradionecrosis (ORN) and medication-related osteonecrosis of the jaw (MRONJ) include oro-cutaneous fistulas, necrotic bone exposure, soft-tissue defects, and pathologic fractures. The fibula free flap (FFF) is a common free flap method used to reconstruct the mandible in severe cases. Recently, we have used the FFF successfully for the reconstruction of ORN and MRONJ mandibular defects. We report this method as a recommended technique for the treatment of ORN and MRONJ and the management method of postoperative infections. Methods: Four patients who were diagnosed with ORN of the mandible and 3 patients who were diagnosed with MRONJ of the mandible were included in the study. Among the 7 patients, 3 patients also had pathologic fractures. Partial mandibulectomy and FFF reconstruction were performed at the Department of Oral and Maxillofacial Surgery, Samsung Medical Center from April 2019 to March 2021. Results: All 7 patients recovered following the reconstruction of the defect by FFF. Four patients experienced infections after surgery and pus cultures were performed. All were well healed without flap damage after changing the antibiotics by consultation with infectious medicine experts. Conclusion: FFF is a widely used method and can provide an extensive flap to reconstruct the mandible, especially those affected by ORN or MRONJ. If an infection occurs after surgery, appropriate antibiotic changes should be made through cooperation with the infectious medicine department. Therefore, FFF is a well-established and recommended method even in cases of challenging reconstruction.