B형 간염 감염의 가족집적성에 관한 혈청역학적 연구

장석균,고응린,최보율,박항배 한양대학교 의과대학 1989 한양의대 학술지 Vol.9 No.2

B hepatitis is considered as one of the most serious health issues in Korea because of its high prevalence and incidence rates and its close relationships with liver cirrhosis and primary hepatic carcinoma. It was once believed that parenteral transmission was only possible mode of hepatitis B virus infection until its serologic markers could have been identified. However, non-parenteral route was also recognized as important as parenteral one and its mode was classified into vertical and horizontal types. The familial clustering of B hepatitis was well documented by many authors, and some portion of non-parenteral transmission in family unit was discovered by many clinical and epidemiological studies. This study were carried out in a rural community of Korea to discover the degree of familial clustering and possible non-parenteral transmission route. Susceptibles, infected before 1985, the incidence cases between June, 1985 and April, 1986, and chronic carriers had been identified as index cases by the twice axaminations of serologic markers (HBsAg; RPHA, Anti-HBs;PHA). The examination of serologic markers to index cases and their family members was done in June, 1987. The major results are summarized as followings. 1. HBsAg positive rate in family members with susceptible was 3.12%, and the ratio of HBsAg positive rate in family members with infected before 1985, incidence case and chronic carrier upon susceptible was 4.27, 3.51 and 11.65 respectively. This result imply a strong familial clustering of hepatitis B virus infection and it was strongest in families with chronic carriers. 2. The degree of clustering in familial relationship was observed to increase in order of with siblings, mother and father. This result suggests the horizontal transmission between siblings is strong, but the vertical transmission from mother to hter offspings should also be considered as related to clustering in siblings. From the results of this study, it is recommended that all family members with HBsAg carriers should be examined on the serologic markers of hepatitis B virus infection and to take the appropriate measures.

ISOLATION , STRUCTURE AND BIOCHEMICAL PROPERTIES OF CK -4416 , A NOVEL α - AMYLASE INHIBITOR PRODUCED BY STREPTOMYCES SP . CKD -4416

Hung Bae Chang,Jong Seo Lee,Sun Ho Kim,Jong Kwan Kim,Hyoung Sik Chun,Koo Hun Chung 생화학분자생물학회 1995 생화학분자생물학회 춘계학술발표논문집 Vol.- No.-

항공 응용 분야 : 기밀문서 유통체계 설계에 관한 탐색적 연구

장항배 ( Hang Bae Chang ),김흥국 ( Heung Gook Kim ) 한국항행학회 2011 韓國航行學會論文誌 Vol.15 No.3

1991년 Davis 가 ``정보기술수용모형(TAM, Technology Acceptance Model)``을 제시하여 조직의 정보통신기술 도입이 이것을 사용하는 사용자의 편이성과 기술 도입에 따른 업무의 효용성 및 효과의 정도에 따라 결정되어 진다는 정보화 추진의 이론적 배경을 제공한 이래로, 최근에는 인터넷, 전자우편, 전자문서교환, 그룹웨어 등의 급격한 기술 발전이 진행되면서 공공기관 및 일반 기업의 업무 조직에 많은 변화를 가져오고 있다. 하지만 정보기술의 순기능과 함께 정보기술의 발전은 업무 조직에게 다양한 혜택을 가져다주었으나, 치명적인 역기능도 부가적으로 발생하게 되었다. 통합적인 업무환경에 따라 비 권한자가 정보를 조회하거나 중요 정보의 전산화로 인해 정보관리가 한층 어려워졌으며, 통신 기술의 발달로 인하여 외부로부터의 해킹이나, 내부자에 의한 정보유출이 용이해졌다. 본 연구에서는 조직에서 취급하는 기밀문서의 전자적 처리를 위한 보안 규정과 지침개선안을 마련하여 기밀문서의 세부적 절차 및 구현 방법을 개발하고자 한다. Since, Davis(1991) has proposed the TAM(Technology Acceptance Model) through a literature review of informatization promotion, which insists that a user conveniency is judged by the degree of effectiveness caused by IT, the advancement of IT such as the Internet, e-mail, electronic data exchange, and groupware have brought into various changes in ordinary corporations and public institutions. However, with the right function, the advancement of IT has provided various benefits including additional reverse functions. Based on an integrated environment of business process, unauthorized user could access to information and a management of information becomes more difficult than before due to informatization of critical information. Furthermore, external hacking or information leakage by insider becomes easier owing to advancement in communication technology. This study has tried to develop a specified management procedure and implementation method for confidential documents.

Streptomyces sp. L77-140 이 생산하는 항생물질의 분리정제 및 동정

장흥배(Hung-Bae Chang) 산업기술교육훈련학회 2011 산업기술연구논문지 (JITR) Vol.16 No.4

In the course of the screening for microorganism producing antibiotics, Streptomyces sp. L77-140 was discovered which produced a water-soluble basic antibiotic L77-140. By using paper disk anti-microbial assay, the productivity of antibiotic from Streptomyces sp. L77-140 was tested by several carbon and nitrogen sources such as soluble starch and soybean flour, respectively. L77-140 showed anti-microbial activities against Gram-positive and Gram-negative bacteria. From the culture supernatant, L77-140 was purified by cation exchange chromatography and silicagel column chromatography. In the pH stability test, L77-140 was stable under acidic and alkali conditions. Based on the spectroscopic measurement including Ultra Violet(UV), In Frared(IR), Nuclear Magnetic Resonance (NMR) and mass spectrum(Mass) analyses, L77-140 was identified as spenolimycin.

Streptomyces sp. ᄂ79-290 배양액 유래의 산성지 용성 항균활성 물질의 분리정 제

장흥배(Hung Bae Chang) 산업기술교육훈련학회 2014 산업기술연구논문지 (JITR) Vol.19 No.3

In the course of the screening for microorganism producing antibiotics, Streptomyces sp. L79-290 was discovered which produced a water-nonsoluble acidic antibiotic L79-290. By using paper disk anti-microbial assay, the productivity of antibiotic from Streptomyces sp. L79-290 was tested by several carbon and nitrogen sources such as maltose and peptone, respectively. L79-290 showed anti-microbial activities against several Gram-positive and Gram-negative bacteria. From the culture supernatant, L79-290 was purified by silicagel column chromatography follow after solvent and water extraction. In the pH stability test, L79-290 showed good stability over 80% under acidic and alkali conditions, respectively. Based on the spectroscopic measurement including ultraviolet(UV), infrared(IR), and fast atomic bombardment mass(FAB-Mass) spectrom analyses, L79-290 was identified as novobiocin. Novobiocin, also known as albamycin or cathomycin, is an aminocoumarin antibiotic that is produced by Streptomyces niveus.

Streptomyces sp. L79-333 배양액 유래의 항균활성물질의 분리정제

장흥배(Hung Bae Chang) 산업기술교육훈련학회 2016 산업기술연구논문지 (JITR) Vol.21 No.3

The strain designated as Streptomyces sp. L79-333 produced a water-insoluble compound, named as KP-2, which showed anti-microbial activities against several Gram-positive and negative bacteria under paper disk anti-microbial assay. The production of KP-2 in Streptomyces sp. culture broth was exarnined using several carbon and nitrogeo sources such as maltose and skim milk for their effects on growth of Streptomyces sp. as well on antibiotic activity. KP-2 was purified from the culture supernatant by 2-step silica gel column chromatography followed by solvent extraction. KP-2 represented a high pH stability under acidic and alkaline conditions showing more than 80%. Based on the studies of its spectroscopic properties using ultraviolet(UV) and infrared(IR), and fast atomic bombardment mass(FAB-Mass) spectrum analyses, KP-2 was identified as echinomycin. Echinomycin, also known as quinomycin A, is ao quinoxaline group antibiotic.

Assessing Vascular Changes Associated with Healthy Aging using 7T Magnetic Resonance Angiography

So-Ra Jang,Chan-A Park,Kyung-Jin Lee,Yeong-Bae Lee,Hang-Keun Kim,Chang-Ki Kang 한국자기학회 2018 Journal of Magnetics Vol.23 No.1

Aging is known to produce changes in the cerebral vasculature and circulation. We aimed to quantitatively assess age-related changes in the morphology of small perforating vessels, lenticulostriate arteries (LSAs). LSA images were acquired using ultra-high field 7-Tesla magnetic resonance imaging (7T MRI) from 24 young healthy volunteers (young group: YG) and 25 old healthy volunteers (old group: OG). Vessel-related factors such as curvature and tortuosity were analyzed using two-dimensional images. Our quantitative results demonstrated a fewer in their branches and a significantly more pronounced curvature in the OG compared to the YG. These findings were further confirmed qualitatively using image analysis. Our study findings show that MR angiography utilizing ultra-high field MRI can provide high-resolution images that can identify morphological characteristics of small perforating vessels. Based on these features, it is possible to document ageinduced changes in cerebral small vessels.

Animal Systematics, Evolution and Diversity (ASED)

Hang Lee,Chang-Bae Kim 한국동물분류학회 2012 Animal Systematics, Evolution and Diversity Vol.28 No.1

당귀,지황,홍삼 첨가에 따른 발효 청국장의 기능성 변화 연구

최은지 ( Eun Ji Choi ),이정숙 ( Jung Sook Lee ),장흥배 ( Hung Bae Chang ),이미숙 ( Mee Sook Lee ),장해동 ( Hae Dong Jang ),권영인 ( Young In Kwon ) 한국미생물생명공학회 ( 구 한국산업미생물학회 ) 2010 한국미생물·생명공학회지 Vol.38 No.4

일반 청국장과 한약재를 첨가한 CKJ-DD, CKJ-RG, CKJDD+RG, CKJ-RED의 기호도 및 기능성을 측정하였다. 색도분석 결과, 5가지 청국장 모두 브라운 계열이었으며, a값(redness), b값(yellowness)은 5가지 청국장에서 모두 유의적인 차이를 나타냈다. 유리아미노산 분석 결과, 구수한 맛을 나타내는 Aspartic acid, Glutamic acid의 함량이 CKJ보다 한약재를 첨가한 청국장(CKJ-DD, CKJ-RG, CKJ-DD+RG, CKJ-RED)이 더 많은 함량을 나타났으며, 단맛을 나타내는 alanine, glycine, lysine 또한 CKJ에 비해 한약재를 첨가한 청국장(CKJ-DD, CKJ-RG, CKJ-DD+RG, CKJ-RED)이 3~4.5배 더 많은 함량을 나타냈다. 반면, 한약재의 고유한 향에 의해서 쓴맛을 나타내는 leucine은 CKJ에 비해 CKJ-DD, CKJ-RED이 2배의 함량을 더 나타냈다. 한편 혈당강하 조절 기전과 관련된 항당뇨 활성 결과에서는 농도 의존적으로 혈당상승억제효과가 증가하는 경향을 나타내지만, CKJ과 한약재를 첨가한 청국장(CKJ-DD, CKJ-RG, CKJ-DD+RG, CKJRED) CKJRED) 간의 큰 유의적인 차이는 나타나지 않았다. 또한 5종의 청국장의 기능성을 알아보기 위해, 총 피놀릭성분의 함량 분석 결과, CKJ에 비해 한약재를 첨가한 청국장(CKJDD, CKJ-RG, CKJ-DD+RG, CKJ-RED)의 총 피놀릭 함량이 유의적으로 증가하는 경향을 나타냈다. 항산화 활성 (Peroxyl radical 소거능)을 측정한 결과, 10 μg/mL 농도에서 대조군인 CKJ과 비교하여 CKJ-DD은 비슷한 활성을 보였으나 CKJ-RG는 1.5배, CKJ-DD+RG은 3배 높은 항산화 활성을 나타냈다. 이상의 결과로 다양한 한방청국장 제품의 표준화 및 제품화를 위한 다양한 지표들을 확인 할 수 있었다. Cheonggukjang is one of the traditional fermented soy-based foods in Korean diets. Studies in cell cultures, humans have revealed anti-hypertension, anti-stress, anticancer, antioxidant, immune enhancing effects. Angelica gigas, Rehmanniae radix, and Red ginseng are popular medicinal plants and widely used for oriental medicine. In this study a strategy had been developed to mobilize beneficial phenolics from Angelica gigas, Rehmanniae radix, and Red ginseng combined with fermented soy by Cheonggukjang fermentation for antioxidant and Type II diabetes management. The quality and functional characteristics of Chenggukjang fermented with Angelica gigas, Rehmanniae radix and Red ginseng. Cheonggukjang (CKJ), Angelica gigas Cheonggukjang (CKJ-DD), Rehmanniae radix Cheonggukjang (CKJ-RG), Angelica gigas and Rehmanniae radix Cheonggukjang (CKJ-DD+RG) and Red ginseng Cheonggukjang (CKJ-RED) were evaluated. The mobilized phenolic profile was evaluated for antioxidant activity and the potential to inhibit α-amylase linked to hyperglycaemia. This research has important implications for the development of functional soy-based-fermented foods enriched with Angelica gigas, Rehmanniae radix and Red ginseng phenolics for oxidative stress - induced diabetic complications. Furthermore, Hunter`s color values of 5 types cheonggukjang, lightness (L-values), redness (a-values) and yellowness (b-values) were evaluated. Free amino acid content of CKJ-RED (0.993 mg/gd. w.) showed higher than that of CKJ (0.205 mg/g-d.w.).

색상정보를 이용한 영상 데이터 검색시스템의 설계 및 구현

장항배(Hang-bae Chang),권영빈(Young-bin Kwon) 한국정보과학회 1999 한국정보과학회 학술발표논문집 Vol.26 No.1B

내용기반 영상 검색 시스템은 영상을 분석하여 특징을 추출한 다음, 이를 색인하고 유사한 특징의 영상을 검색하는 기술이다. 색상 정보는 내용기반 영상 검색에서 가장 많이 사용되는 방법으로서 영상내의 조명변화나 관측위치, 크기변화 등에 어느 정도 무관하게 적용 가능하다는 장점을 가지고 있다. 본 연구에서는 영상을 RGB 컬러 정보를 이용하여 각각의 채널로부터 색상 정보를 추출에 낸 다음, 영상의 크기에 영향을 받지 않는 전역적인 색상 정보를 이용하여 색인화하는 방법을 제안하였다. 이 방법은 색상값의 양자화나 영상 크기의 정규화에 따른 정보 손실을 줄일 수 있다. 실험 데이터는 콜롬비아대학의 Webseek 이미지 DB를 사용하였으며, 실험결과 Recall은 0.85, AVRR은 2.70의 결과값을 얻을 수 있었다. 특히 색상분포 곡선이 RGB 중 어느 한축에 기울어져 있을 때 결과값이 우수하였다.