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Hue, Jin Joo,Lee, Hu-Jang,Jon, Sangyong,Nam, Sang Yoon,Yun, Young Won,Kim, Jong-Soo,Lee, Beom Jun The Korean Society of Veterinary Science 2014 大韓獸醫學會誌 Vol.54 No.4
This study was investigated the change of concentration and toxicity of thermally cross-linked superparamagnetic iron oxide nanoparticles (TCL-SPION) on tissues of Sprague-Dawley rats. TCL-SPION at the dose of 15 mg/kg body weight was intravenously injected into the tail vein of the male Sprague-Dawley rats. The fate of TCL-SPION in serum, urine and tissues was observed during 28 days. Serum iron level was maximal at 0.25 h post-injection and gradually declined thereafter. In addition, the sinusoids of liver and the red pulp area of spleen were mainly accumulated iron from 0.5 h to 28-day post-injection. In kidney, iron deposition was detected in the tubular area until 0.5 h after injection. Malondialdehyde concentration in the liver slightly increased with time and was not different with that at zero time. In the liver and spleen, TNF-${\alpha}$ and IL-6 levels of TS treated with TCL-SPION were not different with those of the control during the experimental period. From the results, TCL-SPION could stay fairly long-time in certain tissues after intravenous injection without toxicity. The results indicated that TCL-SPION might be useful and safe as a contrast for the diagnosis of cancer or a carrier of therapeutic reagents to treat diseases.
( Hue Thi My Van ),( Hyun Jung Woo ),( Hyung Min Jeong ),( Daulat Bikram Khadka ),( Su Hui Yang ),( Caho Zhao ),( Yi Feng Jin ),( Eung Seok Lee ),( Kwang Youl Lee ),( Young Joo Kwon ),( Won Jea Cho ) 전남대학교 약품개발연구소 2014 약품개발연구지 Vol.23 No.-
A series of 3-heteroarylisoquinolinamines were designed. synthesized and evaluated for cytotoxicity, topoisomerases (topos) inhibitory activities and cell cycle inhibition, Several of the 3heteroarylisoquinolines exhibited selective cytotoxicity against human ductal breast epithelial tumor (T47D) cells over non-cancerous human breast epithelial (MCF-10A) and human prostate cancer (DU14S) cells. Most of the derivatives showed greater cytotoxicity in human colorectal adenocarcinoma (HCT-1S) cells than camptothecin (CPT), etoposide and doxorubicin (DOX). Generally, 3-heteroarylisoquinolinamines displayed greater affinity for topo I than topo n. 3-Heteroarylisoquinolinamines with greater topo 1 inhibitory effect exhibited potent cytotoxicity. Piperazine-substituted derivative. Sb, with potent topo 1 and moderate topo n activities intercalated between DNA bases and interacted with topos through H-bonds at the DNA cleavage site of a docking model. Moreover. flowcytometry indicated that cytotoxic 3heteroarylisoquinolinamines led to accumulation of human cervical (HeLa) cancer cells in the different phases of the cell cycle before apoptosis. Taken together. 3-heteroarylisoquinolinamines possessed potent cytotoxicity with topos and cell cycle inhibitory activities. ⓒ 2014 Elsevier Masson SAS. All rights reserved.
Biosynthesis of fucosyllactose in engineered Corynebacterium glutamicum
Hue Thi Nguyen,Obed Jackson Amoah,Su Yeong Ma,Jae Kyung Sohng 한국당과학회 2022 한국당과학회 학술대회 Vol.2022 No.07
Human milk oligosaccharides (HMOs) have been proven to be a key ingredient found in breast milk and beneficial to infant health. Structurally, the fucose-containing oligosaccharides are major components, with a proportion of approximately 50–80% in the HMOs. In particular, 2-fucosyllactose (2’-FL) and 3-fucosyllactose (3-FL) are 2 major components of the abundant HMO component. Importantly, 2’-FL is approved for use in infant formula for improving probiotic functions by the FDA of the USA and the European Food Safety Authority, while 3-FL can be used as a prebiotic to improve the growth of beneficial microorganisms. Over the last decade, various approaches have been conducted for fucosyllactose (FL) production, including chemical synthesis, enzymatic conversion, and microbial fermentation. Most studies were performed in Escherichia coli due to the simple culture conditions and availability of various genetic tools. Besides E. coli, Bacillus subtilis and Saccharomyces cerevisiae have also been selected as the hosts for the production of FL due to their generally regarded safe (GRAS) status. As a type of GRAS strain, Corynebacterium glutamicum has been widely used in the biosynthesis of food-grade, high-value-added products, including lysine, glutamic acid, violacein and resveratrol. In this study, the biosynthetic enzymes of FL were condon-optimized and heterologously expressed in engineered C. glutamicum for the production of FL. The trace amount production of FL was confirmed by TLC, HPLC in this study.
Plasma Rotation in Plasma Centrifuge with an Annular Gap
Hue Yeon Lee,Sang Hee Hong Korean Nuclear Society 1982 Nuclear Engineering and Technology Vol.14 No.2
정상상태의 플라즈마의 이론적 해석을 통해서 플라즈마의 회전과 동위원소 분리기로서의 적합성을 분석하였다. 이 장치는 두개의 동심원통형 전극과 이들 사이의 원통형 공동으로 구성되었으며, 축 방향으로 외부자장이 걸려 있다. 두 전극사이에 생성되는 전류밀도는 전기방전의 형태로 동위원소 혼합물로부터 플라즈마를 생성하고, 자장과 교차되어 발생하는 Lorentz힘에 의해서 플라즈마를 회전시킨다. 자기 유체역학 방정식을 바탕으로 이 계를 설명하는 두개의 연립편미분방정식을 얻었고, 네 경계조건을 사용하여 Fourier-Bessel로 표현된 이차원적 전류밀도와 속도분포의 해를 얻었다. 실제로 가능한 조건하에서 플라즈마 회전속도는 $10^4$m/sec 정도에 달하고, Hartmann수가 커짐에 따라 플라즈마회전 속도도 커진다. 이 같은 고속의 회전속도를 감안해 볼때 플라즈마 원심분리기는 기계적으로 회전되는 가스원심분리기보다 훨씬 높은 효율을 가지게 될 것이다. The steady-state rotation of plasma centrifuge is theoretically analyzed to understand the physics of rotating plasmas and its feasibility for isotope separation. The centrifuge system under consideration consists of an annular gap between coaxial cylindrical anode and cathode in the presence of an externally-applied axial magnetic field. A problem for coupled partial differential equations describing centrifuge fields is formulated on the basis of the magnetohydrodynamic equations. Two-dimensional solutions are found analytically in the form of Fourier-Bessel series. The current density and velocity distributions are discussed in terms of the Hartmann number and the geometrical parameter of the system. At typical conditions, rotational speeds of the plasma up to the order of 10$^4$m/sec are achievable, and increase either with increasing Hartmann number, or with increasing ratio of the axial length to the inner radius of the cylinder. In view of much higher speeds of rotation which can be achieved in plasma centrifuge, it is expected that its efficiency is superior to mechanically driven gas centrifuges.
Hue, Nguyen Thi Ngoc,Derva Jarvis,Bhuwon Sthapit 한국생태학회 2004 Journal of Ecology and Environment Vol.27 No.1
Understanding farmer household and community management of crop diversity is necessary in order to effectively strengthen the local plant genetic resources management system in Vietnam. Assessment and management for distribution of farmer s cultivars of rice, taro and tropical tree species were conducted in four different agro-ecological zones in Vietnam using participatory approaches, focus surveys, diversity fairs, agro-morphological field trials, isozyme analysis to understand why Vietnamese farmers grow diverse types of these crop cultivars, when and where these crops cultivars are grown and how farmers maintain and use them. Results showed significant differences in the extent, distribution and use pattern crop cultivars diversity in contrasting environments and between community farmer households. Seed system is an important role in the access and use of diversity in eco-geographical regions.