Trophic Effect of Bee Pollen on Small Intestine in Broiler Chickens

Heng Wang,Jue Wang,Shenghe Li,Qifa Wang,Baozhong Xin 한국식품영양과학회 2007 Journal of medicinal food Vol.10 No.2

In this study, the effects of bee pollen on the development of digestive organs were evaluated in broiler chick-ens. A total of 144 1-day-old AA broiler chickens were randomly and equally divided into two groups, assigned as the con-trol group and the pollen group, respectively. The control group was fed with a basic diet, while the pollen group was fedwith a basic diet supplemented with 1.5% bee pollen over a period of 6 weeks. At the end of each week, the digestive organswere obtained for comparison from 12 broilers randomly selected from each group. The results demonstrated that comparedto the control group, the small intestine villi from the duodenum, jejunum, and ileum were longer and thicker in the pollengroup. This difference was more significant during early development, especially through the first 2 weeks. Bee pollen in-creased the length of the villi by 37.1% and 29.4% in the duodenum, 28.1% and 33.7% in the jejunum, and 18.6% and 16.2%in the ileum in week 1 and 2, respectively. Furthermore, the small intestinal glands were developed at a higher density in thepollen group, and the depth of the glands was significantly increased by bee pollen in the first 2 weeks. These findings sug-gest that bee pollen could promote the early development of the digestive system and therefore is a potentially beneficial foodsupplement for certain conditions, such as short bowel syndrome.

Aberrant DNA Methylation and Epigenetic Inactivation of hMSH2 Decrease Overall Survival of Acute Lymphoblastic Leukemia Patients via Modulating Cell Cycle and Apoptosis

Wang, Cai-Xia,Wang, Xiang,Liu, Hai-Bai,Zhou, Zhi-Heng Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.1

Objective: Altered regulation of many transcription factors has been shown to play important roles in the development of leukemia. hMSH2 can modulate the activity of some important transcription factors and is known to be a regulator of hematopoietic differentiation. Herein, we investigated epigenetic regulation of hMSH2 and its influence on cell growth and overall survival of acute lymphoblastic leukemia (ALL) patients. Methods: hMSH2 promoter methylation status was assessed by COBRA and pyrosequencing in 60 ALL patients and 30 healthy volunteers. mRNA and protein expression levels of hMSH2, PCNA, CyclinD1, Bcl-2 and Bax were determined by real time PCR and Western blotting, respectively. The influence of hMSH2 on cell proliferation and survival was assessed in transient and stable expression systems. Results: mRNA and protein expression of hMSH2 and Bcl-2 was decreased, and that of PCNA, CyclinD1 and Bax was increased in ALL patients as compared to healthy volunteers (P<0.05). hMSH2 was inactivated in ALL patients through promoter hypermethylation. Furthermore, hMSH2 hypermethylation was found in relapsed ALL patients (85.7% of all cases). The median survival of patients with hMSH2 methylation was shorter than that of patients without hMSH2 methylation (log-rank test, P=0.0035). Over-expression of hMSH2 in cell lines resulted in a significant reduction in growth and induction of apoptosis. Conclusions: This study suggests that aberrant DNA methylation and epigenetic inactivation of hMSH2 play an important role in the development of ALL through altering cell growth and survival.

T-spline surface smoothing based on 1-ring neighborhood space angle

Wang Aizeng,Li Ling,Chang Heng,Zhao Gang,Wang Wei,Yang Jiaming 한국CDE학회 2022 Journal of computational design and engineering Vol.9 No.4

The prominent properties owned by T-spline, such as flexibility, continuity, local refinement, water tightness, make it extensively applied in Computer Aided Design (CAD)- and Computer Aided Engineering (CAE)-integrating scenarios. But the local fairness may dissatisfy in damaged areas or even on the entire surface of industry applications. Under these circumstances, local protrusion and sharp features appeared seriously affect the fairness of T-spline surfaces. Derived from the geometric properties of T-spline control points, we propose a smoothing algorithm based on the 1-ring neighborhood space angle to deal with local abruptions of T-spline surfaces. We also demonstrate the availability of the proposed algorithm through several experiments. Results show that this method is suitable for removing sharp features and smoothing unstructured T-spline surfaces.

BRONCHOPULMONARY SEQUESTRATION ASSOCIATED WITH ASPERGILLOMA : A CASE REPORT

Wang, Tung Heng,Hwang, Jhi Jhu,Wu, Chung Chieng,Chen, Chang Yi 대한핵의학회 1984 핵의학 분자영상 Vol.18 No.1

Encirclement - We are Murdering the Earth

Heng Wang 한국콘텐츠학회 2011 ICCC International Digital Design Invitation Exhib Vol.2011 No.5

Strong, and recyclable thermosets cross-linked by MWCNT/poly(aryl ether ketone) containing furan based on Diels-Alder cycloaddition

Wang Yongpeng,Wang Heng,Zhang Qingwen,Zhang Yingyuan,Yan Pengtao,Liu Mengzhu,Zhang Haibo 한국화학공학회 2023 Korean Journal of Chemical Engineering Vol.40 No.8

Multi-walked carbon nanotube (MWCNT)/poly(aryl ether ketone) networks cross-linked by Diels-Alder cycloaddition possess outstanding mechanical and rheological properties. Poly(aryl ether ketone) containing pendant furan (PAEK-Fu) was synthesized, which had excellent thermal and mechanical properties, and a series of cross-linked materials with reversible covalent cross-linked crosslinking network were synthesized through a furan/MWCNTs Diels-Alder (D-A) reaction between PAEK-Fu and MWCNTs. Thermal and mechanical properties for MWCNT/PAEK-Fu composites were studied, and after crosslinking, MWCNT/PAEK-Fu composites exhibited good flexibility and resistance against organic solvents. After heating to 180 °C, the cross-linked MWCNT/PAEK-Fu composite membranes could be dissolved in NMP. This work demonstrates that the poly(aryl ether ketone)s can be made into recyclable thermoset materials using the concept of associative dynamic bonding. Given the dramatically increasing interest in environmentally sustainable materials, this MWCNT/poly(aryl ether ketone) interaction mode provides a robust approach to high performance engineering plastics with improved performance compared with the thermoplastic counterparts.

New Safrole Oxide Derivatives: Synthesis and in vitro Antiproliferative Activities on A549 Human Lung Cancer Cells

Wang, Li-Ying,Wang, Xiu-Hua,Tan, Jia-Lian,Xia, Shuai,Sun, Heng-Zhi,Shi, Jin-Wen,Jiang, Ming-Dong,Fang, Liang,Zuo, Hua,Dupati, Gautam,Jang, Kiwan,Shin, Dong-Soo Korean Chemical Society 2012 Bulletin of the Korean Chemical Society Vol.33 No.11

A number of novel small molecules, safrole oxide derivatives 4a-c, 6a-c, 9a-h, were synthesized by the reaction of safrole oxide with anilines 3 and 5, or its alkyl allyl ether derivative 7 with alkyl bromide 8 in moderate yields. The antiproliferative effects of all the target molecules on A549 cell growth were investigated and it was found that the 14 novel compounds could suppress A549 lung cancer cell growth. Among them, compound 6b was the most effective compound in inhibiting the proliferation of A549 cells.

Detection of a new genetic locus for the high amylose content in rice mutant.

Heng Wang,SeongGyu Jang,DaEun Lim,Ji-Ung Jeung,Soon-Wook Kwon 한국육종학회 2015 한국육종학회 심포지엄 Vol.2015 No.07

Goami 2 is now well known as its extinguishing endosperm characteristics - it is far from the wild type, Ilpum, a premium taste Korean japonica cultivar. The endosperm of Goami 2 is high in fat, protein, and indigestible carbohydrate contents. One of the most extraordinary endosperm characteristic of Goami 2 is high level of amylose content, even though the hulled rice (brown rice) is totally opaque. There have been many studies to address the unique physico-chemical properties and possible usages as a healthy and functional food ingredient, especially, the high-amylose rice had a positive effect on lowering the blood glucose response in obesity and type 2 diabetes. Genetic analysis by using 44 SSR markers, crude linkage map (3~5 anchor markers per chromosome) was then constructed based on the genotypes detected among 112 F2 progenies derived from Goami 2 / Milyang 23 showed that major chromosomal regions on Chromosome 2 responsible for the variation of amylose contents. M2-53 on Chromosome 2 explains the highest variation and this region has not been reported as a putative QTL for amylose contents yet. More closely markers for application to breeding program can be developed using MutMap or Re-sequence methods.

Optimization of a Fluid Distribution Manifold

Heng Wang,Samuel D. Marshall,Rerngchai Arayanarakool,Lakshmi Balasubramaniam,Xin Jin,Poh Seng Lee,Peter C. Y. Chen 한국유체기계학회 2018 International journal of fluid machinery and syste Vol.11 No.3

This paper presents two optimized designs of a commonly-used fluid distribution manifold having one entrance and six exits. Numerical simulations were carried out to optimize the dimensions and mechanisms of these proposed designs for the sake of enhancing the uniformity of fluid distribution amongst the exits and reducing the formation of dead zones inside the manifold cavities. Particularly, to make the fluid distribution amongst exits more uniform, this study explored the relationship between entrance diameter and exit diameter. Furthermore, in order to reduce dead zone formations inside the manifold whilst still maintaining uniform fluid distribution, a conical cavity was designed. After that, blockers were designed to replace some exits, permitting a variable number of fluid distribution manifold exits, depending on the specific application. Both designs were found to be able to improve flow uniformity and dead zone reduction compared to the original commonly-used fluid distribution manifold, with the central-feeding distributor performing slightly better than the lateral-feeding distributor overall. From the perspective of manufacturing, each of these two fluid manifolds was made of two pieces with glue and rubber O ring used respectively as the bond between separate pieces. Preliminary experiments with these devices suggest similar results to those from the numerical studies. Based on real application requirements and limitations, the different fluid manifold designs with tunable dimensions can be utilized in various mechanical or biochemical devices to distribute fluid equally amongst several parallel components.

Rapid construction delivery of COVID-19 special hospital: Case study on Wuhan Huoshenshan hospital

Wang, Chen,Yu, Liangcheng,Kassem, Mukhtar A.,Li, Heng,Wang, Ziming Techno-Press 2022 Advances in computational design Vol.7 No.4

Infectious disease emergency hospitals are usually temporarily built during the pneumonia epidemic with higher requirements regarding diagnosis and treatment efficiency, hygiene and safety, and infection control.This study aims to identify how the Building Information Modeling (BIM) + Industrialized Building System (IBS) approach could rapidly deliver an infectious disease hospital and develop site epidemic spreading algorithms. Coronavirus-19 pneumonia construction site spreading algorithm model mind map and block diagram of the construction site epidemic spreading algorithm model were developed. BIM+IBS approach could maximize the repetition of reinforced components and reduce the number of particular components. Huoshenshan Hospital adopted IBS and BIM in the construction, which reduced the workload of on-site operations and avoided later rectification. BIM+IBS integrated information on building materials, building planning, building participants, and construction machinery, and realized construction visualization control and parametric design. The delivery of Huoshenshan Hospital was during the most critical period of the Coronavirus-19 pneumonia epidemic. The development of a construction site epidemic spreading algorithm provided theoretical and numerical support for prevention. The agent-based analysis on hospital evacuation observed "arched" congestion formed at the evacuation exit, indicating behavioral blindness caused by fear in emergencies.