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連續線型 k-within-m-out-n :F 시스템을 應用한 緊急斷電 狀況下에서의 信賴度分析
유왕진,강희정 건국대학교 산업기술연구원 1998 건국기술연구논문지 Vol.23 No.-
본 논문은 외적요인이 독립적이고, 지수분포를 따르는 도착시간을 갖는 긴급단전 상황하에서 연속선형 k-within-m-out-of-n:F 시스템을 응용하여 신뢰도분석을 하였다. 기본적인 가정으로, 해당 시스템의 모든 요소는 수리불가능하며, 고장간 평균 동작시간은 분석적으로 구한다고 하였다. 이러한 가정을 전제로 평균고장시간과 시스템의 유효도를 고려하였고, 추가로 수리가능 한 부품을 가진 시스템에 대해서도 제안하였다. 수치 예를 통하여, 본 논문에서 유도한 공식들이 시스템의 신뢰도를 쉽게 구할 수 있음도 보여주었다. This research will deals with the model of a consecutive k-within-m-out-of-n : F system subject to common-mode forced outages, where the interarrival times of external events are independent and exponentially distributed. First, assume that the components of system are not repairable. Then, the mean operating time between failures is analytically derived. The mean failure time and availability of system are then considered. Furthermore, system with repairable components is also presented. Finally, numerical example shows that the system reliability can be easily found by using the derived formula.
중추신경자극제를 사용할 수 없는 주의력결핍과잉행동장애 아동에서의 Modafinil 효과 : 예비 연구
유한익,김진용,박수진,전정원,왕희령,김붕년,홍진표,김성윤,김창윤 大韓神經精神醫學會 2006 신경정신의학 Vol.45 No.6
Objectives : This study was aimed to examine the efficacy and safety of modafinil in psychostimulant-inapplicable children with attention deficit hyperactivity disorder (ADHD) due to insufficient treatment response or intolerable adverse effects. Methods : Fifteen children (8.8±1.8 years, 14 boys, total IQ 107.22±13.4) were recruited for this study. ADHD was confirmed by K-SADS-PL. The efficacy was assessed by ADHD rating scale (ADHDRS), Conner's parental rating scale-revised(CPRS-R), ADHDRS school version, clinical global impression (CGI) and computerized neurocognitive function test. Mean dose of modafnil was 250. 0±103.3 mg. Results : Total score (p=0.012) and hyperactive/impulsive score (p=0.021) of ADHDRS for investigator, as well as CPRS-R score (p<0.01) and CGI-severity score (p<0.01) were significantly reduced after 39.2±8.7 days of modafmil administration. Response time of word color test was also significantly decreased after medication. Decreased appetite (2 subjects), insomnia (2 subjects), irritability (1 subject) and alopecia (1 subject) were observed during this study period. Conclusion : Modafinil was effective and well-tolerated for the psychostimulant-inapplicable children with ADHD.
박수빈,유한익,전정원,최순호,왕희령,김건우,김진용,고태성 大韓神經精神醫學會 2007 신경정신의학 Vol.46 No.6
Objectives : While parents who foster children with epilepsy would have considerable parenting diSiculties, the parenting stress and sense of competence have not been investigated. We investigated matemal parenting stress, Parenting satisfaction and sense of parenting competence in children with seizure disorders, and the associations with seizure-related variables. Methods : Mothers of 79 children with seizure disorders (41 boys, 38 girls ; mean age, 9.9±2.3 years) and 79 healthy comparison subjects matched for age and sex were recruited for this study. The Korean version of the Parenting Stress Index (K-PSI-SF) and the Parenting Sense of Competence (K-PSOC) were used to assess parenting stress, parenting satisfaction and parenting effcacy. Results : Mothers of children with seizure disorders showed higher scores on stress related to difficult child and child leaming and parenting anxiety compared to mothers of healthy children. In addition, scores on stress related to parental-child interaction and child leaming were significantly associated with parental economic status. Scores on stress from parental-child interaction was also correlated with seizure severity, and stress from child leaming was correlated with seizure type. Sense of parenting competence and anxiety scores were correlated with patemal educational status, respectively. Conclusion : These fndings suggest that mothers of children with epilepsy have greater parenting stress and anxiety and social and seizure-associated factors may affect the parenting stress and anxiety.
The Study on Respiratory Function, Spirometric Lung Pattern and Fatigue of Elderly in a Facility
Hee Joon Shin,Ji Sung Kim,Joong San Wang,Yoo Rim Choi,Hong Rae Kim,Si Eun Park,Ho Jung An,Kyung Ok Min 국제물리치료학회 2013 Journal of International Academy of Physical Ther Vol.4 No.1
The purpose of this study was to investigate spirometric lung pattern, respiratory function and degree of fatigue by lung function tests and fatigue tests of 39 elderly people in a care facility aged 65 and over. The respiratory function tests were used to the Spirovit SP-1 and fatigue tests were used modified Piper fatigue scale(mPFS). Regarding the respiratory function, the FVC was 1.41±0.36ℓ, the FVC % predicted was 69.10±14.98%, the FEV1 was 1.02±0.31ℓ, the FEV1 % predicted was 63.27±16.05%, the FEV1/FVC was 72.77±13.40%, and the fatigue score was 5.83±1.09. As for the spirometric lung pattern, 19 patients had a restrictive pattern(48.7%), followed by 11 with a mixed pattern(28.2%), 5 with an obstructive pattern( 12.8%), and 4 with a normal pattern(10.3%). Regarding the respiratory function and fatigue by spirometric lung pattern, the FVC and the FVC % predicted of patients with a normal pattern or an obstructive pattern were greater than other groups at a statistically significant level. As for the FEV1, that of patients with a normal pattern was significantly higher than others, and for the FEV1 % predicted, that of patients with a normal pattern or a restrictive pattern was significantly higher(p<.001). Fatigue score by patients with a normal pattern was significantly less than patients of other patterns(p<.001). Therefore, pulmonary physical therapy is considered necessary to improve respiratory function and fatigue degradation of elderly in a facility.
Yoo, Hee-Wang,Kim, Joonwon,Patil, Mahesh D.,Park, Beom Gi,Joo, Sung-yeon,Yun, Hyungdon,Kim, Byung-Gee Elsevier 2019 Bioresource technology Vol.291 No.-
<P><B>Abstract</B></P> <P>In this study, a signal peptide of AlkL was replaced with other signal peptides to improve the soluble expression and thereby facilitate the transport of dodecanoic acid methyl ester (DAME) substrate into the <I>E. coli</I>. Consequently, AlkL with signal peptide FadL (AlkL<SUB>f</SUB>) showed higher transport activity toward DAME. Furthermore, the promoter optimization for the efficient heterologous expression of the transporter AlkL<SUB>f</SUB> and alkane monooxygenase (AlkBGT) system was conducted and resulted in increased ω-oxygenation activity of AlkBGT system. Moreover, bioinformatic studies led to the identification of novel monooxygenase from <I>Pseudomonas pelagia</I> (Pel), which exhibited 20% higher activity towards DAME as substrate compared to AlkB. Finally, the construction of a chimeric transporter and the expression of newly identified monooxygenase enabled the production of 44.8 ± 7.5 mM of 12-hydroxy dodecanoic acid methyl ester (HADME) and 31.8 ± 1.7 mM of dodecanedioic acid monomethyl ester (DDAME) in a two-phase reaction system.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Bioconversion ofdodecanoic acid methyl esterintovalue-addedchemicals. </LI> <LI> Introduce host-based signal peptide to enhance expression level of transporter. </LI> <LI> Maximize product production by controlling the expression level of multi enzymes. </LI> <LI> Found novel enzymes with good activity to dodecanoic acid methyl ester. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Effect of Myofacial Release and Cryotherapy in Acute Whiplash Injury
Si Eun Park,Joon Hee Lee,Jung San Wang,Yoo Rim Choi,Joo Hyun Park,Ju Hwan Lee,Young Duk Choi,Hyun Sook Hwang,Soon Hee Kim 국제물리치료학회 2014 Journal of International Academy of Physical Ther Vol.5 No.1
The purpose of this study is to provide the case of influence of myofacial release(MFR) and cryotherapy in acute whiplash injury. The subjects were consisted of 3 adults(2 males, 1 female) who had been diagnosed with whiplash injury. The performance period was 1 weeks, 6 times and 1 time is 40min(MFR: 20min, cryotherapy: 20min). We measured neck pain(Visual analogue scale, VAS) and cervical alignment(cervical curvature & line of gravity). All measurements of each subject were measured at pre-treatment and post-treatment. The results are listed below. The neck pain(VAS) index decreased from 7.54cm to 4.11cm. The cervical curvature increased from 23.62°to 29.76°. The line of gravity decreased from 8.03mm to 3.66mm. Based on the results, it can be suggested that both MFR and cryotherapy can be used to neck pain and alignment in acute whiplash injury.