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Gi Ja Lee,Seok Keun Choi,Yun Hye Eo,Sung Wook Kang,Samjin Choi,Jeong Hoon Park,Ji Eun Lim,Kyung Won Hong,Hyun Seok Jin,Berm Seok Oh,Hun Kuk Park 대한생리학회-대한약리학회 2009 The Korean Journal of Physiology & Pharmacology Vol.13 No.1
During operations, neurosurgeons usually perform multiple temporary occlusions of parental artery, possibly resulting in the neuronal damage. It is generally thought that neuronal damage by cerebral ischemia is associated with extracellular concentrations of the excitatory amino acids. In this study, we measured the dynamics of extracellular glutamate release in 11 vessel occlusion (VO) model to compare between single occlusion and repeated transient occlusions within short interval. Changes in cerebral blood flow were monitored by laser-Doppler flowmetry simultaneously with cortical glutamate level measured by amperometric biosensor. From real time monitoring of glutamate release in 11 VO model, the change of extracellular glutamate level in repeated transient occlusion group was smaller than that of single occlusion group, and the onset time of glutamate release in the second ischemic episode of repeated occlusion group was delayed compared to the first ischemic episode which was similar to that of single 10 min ischemic episode. These results suggested that repeated transient occlusion induces less glutamate release from neuronal cell than single occlusion, and the delayed onset time of glutamate release is attributed to endogeneous protective mechanism of ischemic tolerance.
Clinicoradiological Features of Pulmonary Cryptococcosis in Immunocompetent Patients
Hong Seok Choi,Yun-Hyeon Kim,Won Gi Jeong,Jong Eun Lee,Hye Mi Park 대한영상의학회 2023 대한영상의학회지 Vol.84 No.1
Purpose To assess the clinicoradiological features of pulmonary cryptococcosis in immunocompetent patients. Materials and Methods This retrospective study included immunocompetent patients who had been diagnosed with pulmonary cryptococcosis on the histopathologic exam and underwent chest CT between January 2008 and November 2019. Imaging features were divided into major imaging patterns, distributions, and ancillary imaging findings. Univariable analysis was performed to evaluate clinicoradiological features according to the presence of serum cryptococcal antigen. Results Thirty-one patients were evaluated (mean age: 60 years, range: 19–78 years). A single nodular lesion confined to a single lobe was the most common imaging pattern (14/31, 45.2%). Serum cryptococcal antigen tests were performed in 19 patients (19/31, 61.3%). The presence of serum cryptococcal antigen was observed in six patients (6/19, 31.6%), all of whom showed a consolidation-dominant pattern. The presence of serum cryptococcal antigen was significantly associated with the consolidationdominant pattern compared to those associated with a nodule-dominant pattern (p = 0.011). Conclusion A combination of CT findings of consolidation and a positive serum cryptococcal antigen test may be helpful for diagnosing pulmonary cryptococcosis in immunocompetent patients.
Hong, Sang Hee,Han, Gi Myung,Yim, Un Hyuk,Lim, Dhong-Il,Ha, Sung Yong,Kim, Nam Sook,Shim, Won Joon 한국해양학회 2014 Ocean science journal Vol.49 No.3
The assessment of sediment quality by considering chemical contaminants is required for the effective management of coastal environments. In this study, complex data sets of heavy metals and organic pollutants were integrated to evaluate sediment quality. Thirty-two target pollutants were quantitatively determined in surface sediments from 80 stations in Jinhae Bay, South Korea. A sediment quality index (SQI) was derived by combining the functions of "scope" (the number of variables that do not meet guideline objectives) and "amplitude" (the magnitude by which these variables exceed the guideline objective). The SQI reflects the spatial gradient and differences in the contamination status with regard to heavy metals and organic pollutants in Jinhae Bay. Fifty-nine out of eighty stations surveyed (74%) were classified as being in "excellent" or "good" condition according to the SQI, and no stations were in a "poor" condition. The mean sediment quality guideline quotient (mSGQq) ranged from 0.06 to 0.31 (from nontoxic to marginally toxic). Acute sediment toxicity leading to amphipod mortality was recorded at 17 stations (21%) of the 80 surveyed, where the mortality rate was slightly over 20%. No significant relationship was observed between sediment toxicity and the concentration of each toxicant or mSQGq.
Hong, Yun-Gi,Kim, Hyun-Joong,Jeon, Jong-Min,Moon, Yu-Mi,Hong, Ju-Won,Joo, Jeong-Chan,Song, Bong-Keun,Park, Kyung-Mooon,Lee, Sang-Hyun,Yang, Yung-Hun Elsevier 2018 Journal of industrial and engineering chemistry Vol.64 No.-
<P><B>Abstract</B></P> <P>Efficient extraction and purification process is still a major bottleneck for economical production of cadaverine. We examined 10 different organic solvents to determine which one might be a suitable solvent for cadaverine extraction. Methyl ethyl ketone (MEK) was a very selective solvent for cadaverine. High pH was critical factor for cadaverine extraction with high purity. Cadaverine extraction efficiency of more than 70.1% with 99% of purity was successfully achieved by applying optimized extraction condition (pH 13.5, 58°C, 200rpm incubation for 6h). Cadaverine extraction using MEK seems quite feasible and promising for the preparation of polyamide monomers for environmental process.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>