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권선옥,김우식,오명기,나종천,이홍기,조욱현,최석구 인제대학교 2006 仁濟醫學 Vol.27 No.-
The use of critical pathways for a variety of clinical conditions has grown rapidly in recent years, particularly pathways for patients with acute myocardial infarction. We intend to determine the impact of a clinical pathway on ST-elevation myocardial infarction (STEMI) and to evaluate the efficacy and safety of facilitated percutaneous coronary intervention (PCI) compared with primary PCI. Low risk STEMI patients (ST elevation >0.1mV in more than 2 limb leads or ST elevation >0.2mV in contiguous precordial lead, chest pain lasting more than 30 min without response to nitroglycerin) will be included. All patients will be also treated medically according to critical pathway. STEMI is one of the common diseases in emergency medicine and so it is necessary to establish realistic treatment guidelines. The use of critical pathways will improve the quality of care.
Koo, Gi-Bang,Morgan, Michael J,Lee, Da-Gyum,Kim, Woo-Jung,Yoon, Jung-Ho,Koo, Ja Seung,Kim, Seung Il,Kim, Soo Jung,Son, Mi Kwon,Hong, Soon Sun,Levy, Jean M Mulcahy,Pollyea, Daniel A,Jordan, Craig T,Yan Springer Science and Business Media LLC 2015 Cell research Vol.25 No.6
<P>Receptor-interacting protein kinase-3 (RIP3 or RIPK3) is an essential part of the cellular machinery that executes 'programmed' or 'regulated' necrosis. Here we show that programmed necrosis is activated in response to many chemotherapeutic agents and contributes to chemotherapy-induced cell death. However, we show that RIP3 expression is often silenced in cancer cells due to genomic methylation near its transcriptional start site, thus RIP3-dependent activation of MLKL and downstream programmed necrosis during chemotherapeutic death is largely repressed. Nevertheless, treatment with hypomethylating agents restores RIP3 expression, and thereby promotes sensitivity to chemotherapeutics in a RIP3-dependent manner. RIP3 expression is reduced in tumors compared to normal tissue in 85% of breast cancer patients, suggesting that RIP3 deficiency is positively selected during tumor growth/development. Since hypomethylating agents are reasonably well-tolerated in patients, we propose that RIP3-deficient cancer patients may benefit from receiving hypomethylating agents to induce RIP3 expression prior to treatment with conventional chemotherapeutics.</P>
백서에서 도서형 피판 작성시 덱사메타손 투여가 세포 자멸사에 미치는 영향
홍기웅,김한구,김승홍 중앙대학교 의과대학 의과학연구소 2003 中央醫大誌 Vol.28 No.1
In order to prevent the damages of the flap tissues due to ischemia following a flap surgery, numerous studies have been conducted for the physiochemical, hemodynamic, and metabolic changes in ischemic flap. There had also been many discussions on the use of different drugs to prevent such damages. Recently apoptosis has been regarded as an important tissue injury mechanism as well as tissue necrosis in flap surgery. In acute tissue injury that can be caused by different reasons, some cells die of tissue necrosis while others may go through a time period, which will determine whether die of apoptosis or not. So survival of certain tissues will depend on the degree of apoptosis. In the post flap surgery period, the degree of apoptosis may influence the survival of ischemic flap with tissue necrosis. The author studied the effects of steroids (dexamethasone) on apoptosis in ischemic skin flap after a flap surgery. Steroids are known to increase the survival of flap by increasing tissue tolerance against tissue necrosis of ischemic flap. For the control group (N=15), after elevating an island skin flap with inferior epigastric vessels as pedicle on the abdominal area of a rat, the pedicle is clamped to create an ischemic state. Microscopical observations confirmed apoptosis as well as tissue necrosis of the flap. For the experimental group (N=l5), dexamethasone, a steroid matter was administered before the the clamping of the pedicle. As a result of microscopic observations and comparison of the effects of dexamethasone on the apoptotic area of ischemic flap between the control and experimental group, apoptosis increased significantly in the experimental group. In this respect, steroids, that are known to increase the survival of flap by reducing tissue necrosis, seem to weaken the survival of a flap by increasing the number of dead cells from apoptosis since they stimulate apoptosis of ischemic flap. Results of this study call for related studies on other drugs that can influence apoptosis of ischemic flap.
이홍규(Hong-Kyu Lee),구향옥(Hyang-Ohk Koo),김선영(Sun-Young Kim),김영기(Young-Gi Kim),오창석(Chang-Suk Oh) 한국컴퓨터정보학회 2005 韓國컴퓨터情報學會論文誌 Vol.10 No.3
본 논문에서는 IPv6 기반 자동화된 공격 대응도구 알고리즘을 제안하였다. 현재는 IPv6에서 사용할 응용 프로그램 및 표준화에 초점을 두고 연구가 진행중에 있어 향후 IPv6의 보안에 대해서는 아직 연구가 미흡한 상태이다. 본 논문에서 제안한 방법은 IPv6에서 발생할 수 있는 공격과 기존 IPv4에서의 공격을 탐지하고 자동화된 대응방법을 통해 개인의 정보보호가 가능하다. 일반적으로 침입 탐지 시스템의 경우 탐지만 하기 때문에 피해는 계속 반복적이다. 따라서 본 연구에서는 이러한 문제점을 직시하고 조기에 연구함으로써 문제 해결방안을 제시하고자 한다. 본 논문에서 제안한 알고리즘은 리눅스 기반에서 IPv6망을 구축하여 실험 하였다. 실험 결과, 제안한 알고리즘을 이용하여 효율적으로 공격을 검출할 수 있었다. In this paper proposed automated attack reaction tool based on IPv6. Currently, much researches are performing focused on application program and standardization for IPv6. But, It is not enough for future IPv6 security. The proposed method detect attacks on IPv6 and conventional IPv4, therefore it is possible to protect personal information using automated reaction method. Usually, IDS just perform detection, therefore damages may be repeated. However, this paper considered the problems described above, and suggested solution for this problems. The proposed algorithm suggested in this paper is simulated on IPv6 network based on Linux. As a simulation result, it is proved that proposed algorithm can detect attacks efficiently.
The Beneficial Effects of Nardostachys jatamansi Extract on Diet-Induced Severe Acute Pancreatitis
Bae, Gi-Sang,Park, Kyoung-Chel,Koo, Bon Soon,Jo, Il-Joo,Choi, Sun Bok,Lee, Dong-Sung,Kim, Youn-Chul,Kim, Jong-Jin,Shin, Yong Kook,Hong, Seung-Heon,Kim, Tae-Hyeon,Song, Ho-Joon,Park, Sung-Joo Lippincott Williams Wilkins, Inc. 2013 Pancreas Vol.42 No.2