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황금희,임현숙 全南大學校家政科學硏究所 1992 生活科學硏究 Vol.2 No.-
This study was conducted to analyze the riboflavin content of major foods which suppling riboflavin to Korean diet. It has been pointed out that the values of riboflavin content in the Food Composition Tables are different from the real contents. Riboflavin is destructed easily by exposure to oxygen or light. Therefore the ribofavin content of foods might be decreased during cooking. So the riboflavin content of the experimental diets consumed by 8 subjects, adult Korean women, during 1 week was analyzed by AOAC method and compared to the values of 2 Food Composition Tables published by Korean Population Institute and by Rural Nutrition Institute respectively. And also, the riboflavin content of 22 major foods was analyzed by the above method and compared to the values of the above Food Com-position Tables. The mean analyzed value of riboflavin of the experimental diets was 0.74 mg, and calculated values according to the above Food Composition Tables were 1.30 mg and 1.34 mg, respectively. The analyzed values were 56.6% and 55.2%, respectively, of the above 2 calculated values according to 2 Food Composition Tables. The major sources of riboflavin were milk, egg, Korean cabbage, rice, beef and so on. Among the foods of riboflavin sources, the values of 9 foods such as pork, hair-tail(fresh), cucumber, lettuce, leek, stem of sweetpotato, red-pepper(dried), tangle(fresh), apple(Fuji) were consistent well with the values of Food Composition Table. But the values of 13 foods such as milk, egg, Korean cabbage, rice, beef, laver, onion, large green onion, Korean radish, galric, green-pepper, carrot, shrimps(soued) were considerably different from the values of Food Composition Tables.
Metabolomic profiling analysis for biomarker discovery in human disease
Geum-Sook Hwang(황금숙) 한국분석과학회 2021 학술대회논문집 Vol.2021 No.11
Metabolomics is the technology of studying, profiling, and fingerprinting metabolites in various physiologic states. This approach has recently demonstrated enormous potentials in many fields such as genotype discrimination, toxicological mechanism, disease processes, and drug discovery. Metabonomic approaches have been used to generate comprehensive biochemical profiles of low molecular weight endogenous metabolites for biofluides and tissue. This metabolic profile is perturbed in a characteristic fashion in disease, toxic process and drug efficacy, and this shift in position can be readily visualized and modeled using chemometric techniques. The metabolic profile of biofluids shows changes of their composition in response to toxic or disease-induced stress due to the system"s attempt to maintain homeostasis. These methods constitute a metabolomic approach to study the quantitative metabolic consequences of patho-physiological insult. Understanding the biochemical reason for such a shift in metabolic space leads to the identification of biomarkers of disease or drug efficacy. ¹H NMR and Mass spectrometry (MS) were used to generate a molecular fingerprint of biofluid or tissue samples, and then pattern recognition technique was applied to identity molecular signatures associated with the specific diseases or drug efficiency. Several metabolites that differentiate disease samples from the control were thoroughly characterized and the metabolic changes in human and animal model were investigated using ¹HNMR and MS. Spectral data were applied to targeted profiling and spectral binning method, and then multivariate statistical data analysis (MVDA) was used to examine in detail the modulation of small molecule candidate biomarkers. The metabolic profiling produces robust models, generates accurate metabolite concentration data, and provides data that can be used to help understand metabolic differences between healthy and disease or drug treated models. Such metabolic signatures could provide diagnostic markers for a disease state or biomarkers for drug response phenotypes, and mechanistic information on cellular perturbations and pathways.
Optimization of extraction conditions for the UPLC Analysis of Anti-diabetic Compounds
Nam-Sook Kim,Kyu Yeon Kim,Geum Joo Yoo,Ji Hyun Lee,Hyoung-Joon Park,Taeik Hwang,Seok Heo,Jeong-Hwa Cho,Jun-hyoung Kim,Dong Woo Shin,Chang-Yong Yoon,Sung-Kwan Park,Sun Young Baek 한국식품영양과학회 2016 한국식품영양과학회 학술대회발표집 Vol.2016 No.10
한국인 젊은 여성의 리보플라빈 섭취 상태와 EGRAC에 관한 연구
황금희(Geum-Hee Hwang),오승호(Seung-Ho Oh),임현숙(Hyeon-Sook Lim),장유경(Yu-Kyung Chang) 한국식품영양과학회 1991 한국식품영양과학회지 Vol.20 No.2
우리나라 젊은 여성의 리보플라빈 영양상태를 평가하기 위하여 광주시에 거주하는 젊은 여성 8명을 대상으로 3주간의 식이섭취조사와 임상검사를 실시하고 EGRAC를 측정하여 다음과 같은 결과를 얻었다.<br/> 본 실험 대상자의 평균연령은 22.1세였으며 신장은 154.4㎝, 체중은 49.2㎏, 흉위는 81.2㎝, 상완 하부, 견갑골 하부 및 복부 피부두께의 합은 79.5㎜, BMI는 20.6이었다. Hb함량은 13.0g/100㎖, Hct 치는 44.0%, A/G ratio는 1.4, GOT, GPT 및 alkaline phosphatase활성은 각각 14, 11.0 및 6.5로서 혈액학적 및 임상적으로 이상이 없었다.<br/> 에너지, 단백질 및 리보플라빈의 1일 평균 섭취량은 각각 1745㎉, 56.1g 및 1.14㎎으로 한국인 영양 권장량에 비해 낮았다. 리보플라빈의 주요 급원 식품은 우유로서 27.7%의 리보플라빈이 우유로부터 공급되었고, 기타 달걀, 배추, 쌀, 쇠고기 등의 순으로 기여도가 높았다.<br/> EGRAC는 평균 1.2784이었으며 EGRAC는 1.20이상으로 생화학적인 리보플라빈 결핍상태인 대상자는 62.5%이었다. 이들에게 1일 6㎎의 리보플라빈을 1주간 투여한 결과 EGRAC는 모두 1.20이하로 감소되었다.<br/> 에너지, 단백질 및 리보플라빈 섭취량은 상호간에 고도의 유의적인 정상관을 보였고, 이들은 모두 EGRAC와 유의적인 정상관을 보였고, 이들은 모두 EGRAC와 유의적인 부적상관을 보였다. 그러나 에너지 섭취량 1,000㎉을 단위로 나타낸 리보플라빈 섭취량은 에너지 섭취량과는 유의적인 부적상관을 보인 반면 단백질 섭취량과는 상관을 보이지 않았고 EGRAC와도 유의적인 상관을 보이지 않았다.<br/> 본 연구결과는 한국인 젊은 여성의 리보플라빈 영양상태를 생화학적 방법으로 평가한 결과 상당수가 결핍상태에 있음을 보여주었다. 또한 리보플라빈 섭취량은 에너지 및 단백질 섭취량과 고도의 유의적인 정상관을 가지므로 리보플라빈 섭취량을 늘리기 위해서는 에너지 또는 단백질섭취량을 증가시켜야 한다는 점이 시사되었다. 한편 에너지 섭취가 낮은 경우에 리보플라빈 섭취량에 특히 유의해야 한다는 점도 시사되었다. This study was conducted to determine riboflavin status of young healthy Korean women. Eight subjects consumed general Korean diet for 3 weeks. Riboflavin intake was measured during the period and Erythrocyte Glutathione Reductase Activity Coefficient (EGRAC) was analyzed at the end of experimental period. The subjects who showed EGRAC value above 1.20 were supplemented 6 ㎎ riboflavin per day for 1 week. The average age of subjects was 22.1 years old, height was 154.4㎝, weight was 49.2㎏, chest circumference was 81.2㎝, the sum of skinfold thickness of 3 parts was 79.5㎜ and Body Mass Index(BMI) was 20.6. Hemoglobin concentration was 13.0g/100㎖, hematocrit value was 44.0%, A/G ratio was 1.4, and the activity of sGOT, sGPT and alkaline phosphatase was 14.3, 11.0 and 6.5, respectively. The average daily intake of energy, protein and riboflavin was 1745㎉, 56.1g and 1.14㎎, respectively. The major source of riboflavin were milk, egg, Korean cabbage, rice, beef and so on. The average EGRAC value was 1.2748. Percentages of subjects who showed EGRAC value above 1.20 was 65.2%. After oral administration of 6㎎ riboflavin, the EGRAC value of all these subjects was returned to normal range. Riboflavin intake was correlated positively with energy as well as protein intake, and correlated negatively with EGRAC value. However, riboflavin intake per 1, 000㎉ was not correlated with EGRAC value.
Development of the Simultaneous Analysis method for Antidiabetic Compounds by LC-MS/MS
Nam-Sook Kim,Geum Joo Yoo,Kyu Yeon Kim,Ji Hyun Lee,Hyoung-Joon Park,Taeik Hwang,Seok Heo,Jeong-Hwa Cho,Jun-hyoung Kim,Dong Woo Shin,Chang-Yong Yoon,Sung-Kwan Park,Sun Young Baek 한국식품영양과학회 2016 한국식품영양과학회 학술대회발표집 Vol.2016 No.10