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      • KCI등재

        Effects on postoperative nausea and vomiting of nefopam versus fentanyl following bimaxillary orthognathic surgery: a prospective double-blind randomized controlled trial

        Choi, Eunhye,Karm, Myong-Hwan,So, Eunsun,Choi, Yoon Ji,Park, Sookyung,Oh, Yul,Yun, Hye Joo,Kim, Hyun Jeong,Seo, Kwang-Suk The Korean Dental Society of Anesthsiology 2019 Journal of Dental Anesthesia and Pain Medicine Vol.19 No.1

        Background: Postoperative nausea and vomiting (PONV) frequently occurs following bimaxillary orthognathic surgeries. Compared to opioids, Nefopam is associated with lower incidences of PONV, and does not induce gastrointestinal tract injury, coagulopathy, nephrotoxicity, or fracture healing dysfunction, which are common side effects of Nonsteroidal anti-inflammatory drugs. We compared nefopam- and fentanyl-induced incidence of PONV in patients with access to patient-controlled analgesia (PCA) following bimaxillary orthognathic surgeries. Methods: Patients undergoing bimaxillary orthognathic surgeries were randomly divided into nefopam and fentanyl groups. Nefopam 120 mg or fentanyl $700{\mu}g$ was mixed with normal saline to a final volume of 120 mL. Patients were given access to nefopam or fentanyl via PCA. Postoperative pain intensity and PONV were measured at 30 minutes and 1 hour after surgery in the recovery room and at 8, 24, 48, and 72 hours after surgery in the ward. The frequency of bolus delivery was compared at each time point. Results: Eighty-nine patients were enrolled in this study, with 48 in the nefopam (N) group and 41 in the fentanyl (F) group. PONV occurred in 13 patients (27.7%) in the N group and 7 patients (17.1%) in the F group at 8 hours post-surgery (P = 0.568), and there were no significant differences between the two groups at any of the time points. VAS scores were $4.4{\pm}2.0$ and $3.7{\pm}1.9$ in the N and F groups, respectively, at 8 hours after surgery (P = 0.122), and cumulative bolus delivery was $10.7{\pm}13.7$ and $8.6{\pm}8.5$, respectively (P = 0.408). There were no significant differences in pain or bolus delivery at any of the remaining time points. Conclusion: Patients who underwent bimaxillary orthognathic surgery and were given nefopam via PCA did not experience a lower rate of PONV compared to those that received fentanyl via PCA. Furthermore, nefopam and fentanyl did not provide significantly different postoperative pain control.

      • SCIESCOPUSKCI등재

        Real-time PCR quantification of 9 periodontal pathogens in saliva samples from periodontally healthy Korean young adults

        Choi, Heeyoung,Kim, Eunhye,Kang, Jihoon,Kim, Hyun-Joo,Lee, Ju-Youn,Choi, Jeomil,Joo, Ji-Young Korean Academy of Periodontology 2018 Journal of Periodontal & Implant Science Vol.48 No.4

        Purpose: Few studies have examined periodontal pathogens from saliva samples in periodontally healthy young adults. The purposes of this study were to determine the prevalence of periodontopathic bacteria and to quantify periodontal pathogens in saliva samples using real-time polymerase chain reaction (PCR) assays in periodontally healthy Korean young adults under 35 years of age. Methods: Nine major periodontal pathogens were analyzed by real-time PCR in saliva from 94 periodontally healthy young adults. Quantification of Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Tannerella forsythia, Treponema denticola, Prevotella intermedia, Fusobacterium nucleatum, Campylobacter rectus, Peptostreptococcus anaerobius, and Eikenella corrodens was performed by DNA copy number measurement. Results: F. nucleatum and E. corrodens were detected in all subjects; the numbers of positive samples were 87 (92.6%), 91 (96.8%), and 90 (95.7%) for P. gingivalis, P. anaerobius, and C. rectus, respectively. Other pathogens were also detected in periodontally healthy subjects. Analysis of DNA copy numbers revealed that the most abundant periodontal pathogen was F. nucleatum, which was significantly more prevalent than all other bacteria (P<0.001), followed by P. anaerobius, P. gingivalis, E. corrodens, C. rectus, and T. denticola. There was no significant difference in the prevalence of each bacterium between men and women. The DNA copy number of total bacteria was significantly higher in men than in women. Conclusions: Major periodontal pathogens were prevalent in the saliva of periodontally healthy Korean young adults. Therefore, we suggest that the development of periodontal disease should not be overlooked in periodontally healthy young people, as it can arise due to periodontal pathogen imbalance and host susceptibility.

      • SCIESCOPUSKCI등재

        Effect of steaming, freezing, and re-steaming on the texture properties of non-glutinous rice cakes

        Choi, Eunhye,Jo, Hye-Eun,Sohn, Kee Hyuk,Kang, Tae-Young,Kim, Bumsik,Lee, Kang Pyo,Han, Jung Sook,Lee, Suyong,Ko, Sanghoon Korean Society of Food Science and Technology 2016 Food Science and Biotechnology Vol.25 No.4

        The effects of steaming time (6, 8, and 10 min), freezing storage period, and re-steaming for thawing on the textural properties of non-glutinous rice cakes (baekseolgi) were investigated. As the steaming time increased, the rice cakes softened. In particular, the sample that was steamed for 10 min showed lower hardness than those steamed for shorter periods. A short period of steaming was insufficient for water bound to the surface of the starch granules to penetrate the granules in the dough. During the re-steaming process of the frozen non-glutinous rice cake samples, the retrogradation of starch and water syneresis contributed to the increased hardness of non-glutinous rice cakes.

      • 대중문화 활용 예술치료가 학교 부적응 청소년의 자기표현과 사회성 향상에 미치는 영향

        최은혜(Eunhye choi),이에스더(Esther Rhee) 한국융합예술치료교육학회 2018 예술과 인간 Vol.4 No.-

        오늘날 청소년들이 살아가고 있는 21세기는 여러 방면에서 빠른 변화를 맞이하여 긍정적인 측면과 동시에 역기능적인 부분이 많아지고 있다. 이러한 현시대를 살아가는 청소년 중에서는 자신이 속한 집단에서 잘 적응하지 못하거나 정서, 심리적 문제를 호소하는 청소년이 증가하고 있으며 이에 청소년들을 위한 예술치료의 필요성은 더욱 높아지고 있다. 본 연구에서는 예술치료(음악, 미술, 문학, 동작, 영상), 게슈탈트 이론(지금-여기 이론), 대중문화(영화, 가요, 미술, 잡지, 만화)를 활용한 초기 1회기, 중기 6회기, 후기 1회기로 구성된 총 8회기의 대중문화 활용 예술치료 프로그램을 C지역 내에 있는 고신 측 교단에 소속된 교회에 다니는 중, 고등학생 청소년 12명을 대상으로 진행하였다. 본 연구의 목적은 대중문화 활용 예술치료프로그램이 학교 부적응 청소년의 자기표현과 사회성 향상에 어떠한 영향을 미치는지 살펴보고 학교 부적응 청소년의 자기표현과 사회성을 향상시켜 바람직한 학교생활의 적응과 원만한 대인관계 형성을 돕는데 있다. 본 연구의 자료처리는 SPSS 24.0 프로그램을 사용하여 분석하였으며 그 결과 대중문화 활용 예술치료프로그램은 학교 부적응 청소년의 자기표현과 사회성 향상에 효과가 있는 것으로 나타났다. The 21st century, where young people are living today, is rapidly changing in many ways, creating both positive and adverse aspects. Among teenagers living in this age, an increasing number are those who can not adapt to their own groups or complain about emotional and psychological problems. Therefore, the need for art therapy for teenagers is becoming even greater. In this study, 12 students attended a church of Goshin"s within the C region of eight sessions of arts therapy programs using art therapy, gestalt theory, and pop culture. Through this program, we will find out how the program affects the improvement of the social skills and self-expression of children who are at school, and to improve the self-expression and social skills of teenagers. The data processing in this study was analyzed using the SPSS 24.0 program, and the results showed that the use of arts therapy programs is effective in improving the self-pression and sociability of young people.

      • KCI등재

        한국 장애인 미충족 의료 현황

        최경화 ( Choi Kyung-hwa ),김미현 ( Kim Mihyeon ),최용준 ( Choi Yong-jun ),조용민 ( Cho Yong Min ),김미소 ( Kim Mi So ),정은혜 ( Jeong Eunhye ),김정애 ( Kim Jung Ae ) 한국보건사회연구원 2021 保健社會硏究 Vol.41 No.3

        본 연구의 목적은 장애인의 미충족 의료율을 파악하여 비장애인과 비교하고, 장애인이 필요로 할 때 의료서비스를 이용하지 못하는 이유가 비장애인과 어떻게 다른지 검토하는 것이다. 전국단위로 실시하고 있는 국민건강영양조사(1998, 2005, 2007~2018), 지역사회건강조사(2008~2019), 장애인실태조사(2000, 2005, 2008, 2011, 2014, 2017), 노인실태조사(2008, 2011, 2014, 2017), 한국의료패널(2008~2017) 자료를 활용하여 장애 또는 활동제한 여부, 장애인의 장애 유형 및 등급에 따라 연도별 미충족 의료율을 산출하였으며, 장애인과 비장애인의 미충족 의료 이유를 연도별로 산출하였다. 미충족 의료율은 감소하고 있으나, 장애인은 비장애인보다, 중증장애인은 경증장애인보다, 외부신체기능 장애인이 다른 장애인보다, 치과 이용에 대한 미충족 의료율은 병의원보다 높았다. 장애인과 비장애인의 미충족 의료율의 격차는 감소하지 않았으며, 치과 이용에서 병의원보다 그 격차가 더 컸다. 미충족 의료의 가장 큰 이유는 장애인은 경제적인 부담, 비장애인은 시간적 제약이었다. 향후 장애인과 비장애인의 미충족 의료율의 격차가 감소하지 않는 이유와 격차 해소를 위한 심층적 연구가 필요하다. This study aims to evaluate the proportion and factors of unmet health care needs (UHCNs) in the disabled and to compare UHCNs between disabled and non-disabled individuals. We conducted the annual proportion and cause of UHCNs by disabled or limited activity, type and grade of disabled using the Korea National Health and Nutrition Examination Survey (1998, 2005, 2007~2018), Community Health Survey (2008~2019), Disabled Health and Welfare Survey (2000, 2005, 2008, 2011, 2014, 2017), Korean Elderly Health and Welfare Survey (2008, 2011, 2014, 2017), Korea Health Panel Study (2008~2017). The proportion of UHCNs has been on the decrease overall, but it was higher in the disabled than in the non-disabled, higher in the severely disabled than in the moderately disabled, higher in those with external impairments than in people with other disability, and higher in dental care than in other health services. The difference in proportion of UHCNs did not decrease in between disabled and non-disabled individuals and was larger in dental care than in other health services. The main cause of UHCNs was “financial” for disabled persons and “not enough time” for non-disabled persons. Based on the results of this study, we suggest that further study is needed to find out the cause of the constant gap in the rate of unmet care needs between the disabled and non-disabled and to find ways to bridge the gap.

      • SCISCIESCOPUS

        CNBP acts as a key transcriptional regulator of sustained expression of interleukin-6

        Lee, Eunhye,Lee, Taeyun A.,Kim, Ji Hyun,Park, Areum,Ra, Eun A.,Kang, Sujin,Choi, Hyun jin,Choi, Junhee L.,Huh, Hyunbin D.,Lee, Ji Eun,Lee, Sungwook,Park, Boyoun Oxford University Press 2017 Nucleic acids research Vol.45 No.6

        <P><B>Abstract</B></P><P>The transcription of inflammatory genes is an essential step in host defense activation. Here, we show that cellular nucleic acid-binding protein (CNBP) acts as a transcription regulator that is required for activating the innate immune response. We identified specific CNBP-binding motifs present in the promoter region of sustained inflammatory cytokines, thus, directly inducing the expression of target genes. In particular, lipopolysaccharide (LPS) induced <I>cnbp</I> expression through an NF-κB-dependent manner and a positive autoregulatory mechanism, which enables prolonged <I>il-6</I> gene expression. This event depends strictly on LPS-induced CNBP nuclear translocation through phosphorylation-mediated dimerization. Consequently, <I>cnbp</I>-depleted zebrafish are highly susceptible to <I>Shigella flexneri</I> infection <I>in vivo</I>. Collectively, these observations identify CNBP as a key transcriptional regulator required for activating and maintaining the immune response.</P>

      • 자폐 환자의 자해로 인한 구강 내 손상

        지은혜(Eunhye Ji),이효설(Hyo-seol Lee),최형준(Hyung-Jun Choi),김성오(Seong-Oh Kim),최병재(Byung-Jai Choi),손흥규(Heung-Kyu Son),이제호(Jae-Ho Lee) Asia association of Disability and Oral health 2012 대한장애인치과학회지 Vol.8 No.1

        자폐증 및 정신 지체가 있는 환자의 입술 깨물기 증상을 mouthguard를 사용하여 성공적으로 조절하였다. 치과적으로 접근 가능한 구강 내 자해 증상의 치료는 가철성 혹은 고정성 장치를 이용하거나 관련 치아의 발치, 악교정 수술 등을 시도할 수 있으며 각 환자에 맞는 적절한 치료법을 선택하는 것이 중요하다. 자해 행동이 일시적으로 개선되었다 해도 재발의 가능성이 높으므로 장기적인 관리와 소아정신과와의 협진 하에 정신심리학적 환경 개선 및 약물 치료가 병행되어야 할 것이다. Self-injurious behavior (SIB) has been defined as the deliberate destruction or alteration of body tissue without conscious suicidal intent. It occurs in conjunction with a variety of psychiatric disorders as well as various developmental disabilities and some syndromes. The behavior is destructive and causes concern and distress to all involved in the care and treatment of the affected individual. A 13-year-old girl with autism, mental retardation and delayed development was reffered from her pediatrician because of severe and painful lower lip biting. An intraoral examination revealed a diffuse swelling of lower lip. It was covered with necrotic slough and the ulcer and scarring of the lower lip was observed. We chose to use an oral removable prosthesis for Conservative treatment. It was decided to use a soft silicone mouthguard in the maxillary arch. Initially, she could not tolerate the appliance inside her mouth but soon adapted with the appliance. After one month, she lost the mouth guard and started lip biting. So we made mouth guard again. There are no standard methods for preventing self-injurious behavior in a patient who is developmentally disabled. Appropriate preventive methods must be developed for each individual patient based on close observation and clinical findings. Behavior modification techniques, pharmacological treatment, extraction of teeth, orthognathic surgery and intra/extra oral appliances can be performed for adjust self-injurious behavior. A suitable oral guard could be tried initially before employing more invasive approaches.

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