수술 전 진단된 충수돌기 점액류종 1례

허광식,손현화,김동규,박찬국,김만우,김정용,기근홍 조선대학교 부설 의학연구소 2000 The Medical Journal of Chosun University Vol.25 No.1

Primary unruptured appendiceal mucocele is a rare disease. It is very difficult to diagnose preoperatively because of the rarity of classical symptoms and low incidence. Usually it is discovered incidentally during abdominal ultrasonography(US), computed tomography(CT), or appendectomy for acute appendicitis. If untreated, one type of mucoceles may rupture producing a potentially fatal entity known as pseudomyxoma peritonei, therefore preoperative diagnosis is very important. With the advent of colonoscopy, abdominal US and CT, it has been possible to preoperatively diagnose mucocele of appendix. We experienced a case of appendiceal mucocele in a 60 year-old woman who had symptoms of lower abdominal discomfort and right lower quadrant abdominal pain, and it was diagnosed preoperatively by colonoscopy, abdominal US and CT. So we present this case with review of literature.

洛東江 高水敷地(洛東江河口둑-華明地區)의 河川標高變化에 따른 水面積 및 貯留量分析에 관한 硏究

이상화,신동수,허상기 동아대학교 공과대학 부설 한국자원개발연구소 1995 硏究報告 Vol.19 No.2

The Eulsukdo was the paradise for migrating birds as the damp zone before the construction of the estuary barrage. After the construction of the estuary barrage, it was dreged and elevated the ground level. the management buildings on the Eulsukdo is taken advantage of the exibition hal, the resting place, the parking area, besides the Nakdong river flood control office and the Nakdong gang estuary barrage office. The part of the high level of the Eulsukdo is utilized for the recreation area. The necessity of development of the rest area is demanded to secure the relaxation place of the citizen. In proportion to make efficient use of the land, the plane arrangement will affect the conveyance of the river. The study is provided for forcasting the volume of dredging, the reasonable flow reaction and plane arragement with water surface area-storage.

水稻 直播栽培에 關한 硏究 : (Ⅰ)栽培方法이 節間長에 미치는 影響

趙東三,許華永,朴成圭,尹洪載,金泰秀 충북대학교 농업과학기술연구소 1989 農業科學硏究 Vol.7 No.2

Data on internode length obtained from cultural experiments on seeding date, seeding method and seeding rate in direct seeding cultivation of rice in 1989 were analyzed to investigate the rela-tionship between internode length and lodging. In general, internode length appeared to be longer in earlier plantings except May 11 planting which had longer internode than those of other plantings. Seeding in flooded condition as well as higher seeding rate resulted in longer internode length. Culm diameter leas greater in the order of April 21 > May 11 > May 21 > May 1 plantings, and drilled in upland condition > broadcasting in upland condition > seeding in flooded condition, while the higher the seeding rate, the greater the culm diameter was. Except seeding in upland condition and seething rate of 3kg/10a which showed lodging degree of 1, all other treatments resulted in severe lodging with degree of 7.

우리나라 사람면역결핍바이러스(Human Immunodeficiency Virus) 감염환자에서 발병한 악성종양

최평균,송진수,조재현,김성한,박경화,방지환,박완범,김홍빈,김동완,김태유,허대석,오명돈,김남중,최강원 대한감염학회 2006 감염과 화학요법 Vol.38 No.6

Background : Since highly active antiretroviral therapy has lengthened the life span of individuals infected with human immunodeficiency virus (HIV), the importance of malignancy associated with HIV has been increased. The relative frequencies of malignancies in HIV infected patients may vary in different race and region. The aim of this study is to determine the prevalence and characteristics of malignancies in patients with HIV infection in South Korea. Materials and Methods : To identify HIV patients with malignancy, we reviewed the electronic database of pathological reports for all HIV-infected patients seen from January 1986 to December 2005 at the Seoul National University Hospital. We retrospectively reviewed the medical records of them. Results : Among 850 patients infected with HIV, 33 episodes of malignant diseases were diagnosed in 32 patients (3.76%). Thirty were males, and median age was 46 years (range 29-70). At the time of the diagnosis of malignancy, median CD4^(+) lymphocytes count was 100/uL (range 5-620) and in 27 (82%) patients, CD4^(+) lymphocytes count were less than 200/uL. For 13 patients (40%), malignancy was initial presentation of HIV infection. Excluding patients initially diagnosed as malignancy, median follow-up duration from the first visit to diagnosis of malignancy was 36 months (range 3-96). Non-Hodgkin's lymphoma was the most frequent malignancy (13 patients), followed by Kaposi's sarcoma (7), Hodgkin‘s disease (3), acute myeloid leukemia (1), and other solid cancer (9) including one case of anal cancer associated with human papillomavirus. Among 13 patients with non- Hodgkin's lymphoma, 4(31%) achieved the complete remission after chemotherapy and/or radiation therapy, and had been followed without evidence of recurrence. Conclusion : Malignancy was diagnosed in 3.76% of patients infected with HIV. Non-Hodgkin‘s lymphoma is the most prevalent malignancy in HIV patients in South Korea. 목적 : 효과적인 항레트로바이러스 다제요법이 도입됨에 따라, HIV 감염환자들의 수명이 증가되었고, 이에 따라 HIV 감염환자에서 악성종양의 중요성 또한 증가하고 있다. 본 연구의 목적은 우리나라 HIV 감염환자에서 악성종양의 유병률과 호발하는 악성종양의 특성을 밝히는 것이다. 재료 및 방법 : 1986년부터 2005년까지 서울대학교병원에서 치료를 받은 HIV 감염환자의 의무기록을 후향적으로 분석하였고, 병리학적 검사 결과를 검토하여 악성종양이 진단된 환자들을 대상으로 연구를 시행하였다. 결과 : 총 850명의 환자 중, 32명(3.76%)에서 33예의 악성종양이 진단되어, 악성종양의 발병률은 1,000인년 당13.0명(95% 신뢰구간: 8.6∼17.4명)이었다. 그 중 남자는 30명이었고, 악성종양 진단 당시 연령의 중간값은 46 (29-70)세이었다. 악성종양 진단받을 당시, CD4 림프구 수의 중간값은 lOO/uL (5-620 uL) 이었고, CD4 림프구수가 200/ uL 미만인 환자가 27명(82%)이었다. 악성종양에 대한 검사 도중에 HIV 감염사실이 밝혀진 환자가 13명(40%)이었다. HIV를 진단 받은 후 악성종양이 발병한 환자들에서, HIV 진단 후 악성종양의 발병까지는 평균 36개월(3-96개월)이 걸렸다. 13명의 HIV 감염 환자에서 진단된 비호지킨림프종이 가장 흔한 악성종양이었고, 이외에 카포시육종이 7명, 호지킨병이 3명, HPV와 연관된 항문암이 1명의 HIV 환자에서 진단되었다. 그 밖에 급성백혈병, 방광암, 췌장장, 폐암, 진행성위암, 갑상선암, 간세포암, 후두암이 각각 1예씩 진단되었다. 비호지킨림프종이 진단된13명 환자 중, 4명(31%)은 항암치료 및 방사선치료를 받아 완전관해가 되었고, 현재 재발의 증거 없이 외래에서 경과 관찰 중이다. 결론 : 우리나라 HIV 감염환자에서 악성종양의 유병률은 3.76%이었고, 비호지킨림프종이 가장 흔한 악성종양이었다.

Segmental Artery Injury Following Percutaneous Vertebroplasty Using Extrapedicular Approach

Heo, Dong-Hwa,Cho, Yong-Jun The Korean Neurosurgical Society 2011 Journal of Korean neurosurgical society Vol.49 No.2

We performed a percutaneous vertebroplasty at the compressed L2 vertebral body of a 73-year-old female using a left-sided unilateral extrapedicular approach. She complained severe radiating pain and a tingling sensation in her left leg two hours after the vertebroplasty. Spinal computed tomographic scan showed a large retroperitoneal hematoma, and a subsequent spinal angiography revealed a left L2 segmental artery injury. Bleeding was successfully controlled by endovascular embolization. Recently, extrapedicular approaches have been attempted, allowing for the avoidance of facet and pedicle injury with only a unilateral approach. With this approach, however, the needle punctures the vertebral body directly. Therefore, this procedure carries the potential risk of a spinal segmental artery.

Preparation of Thermosensitive Gelatin-Pluronic Copolymer for Cartilage Tissue Engineering

Kim, Dong-Hwa,Heo, Su-Jin,Shin, Jung-Woog,Mun, Chi-Woong,Park, Kyung-Min,Park, Ki-Dong,Jee, Kyoung-Soo 한국고분자학회 2010 Macromolecular Research Vol.18 No.4

In this study, a gelatin conjugated $Pluronic^{(R)}$ thermosensitive polymer(Gelatin-Pluronic, GP) was synthesized by the direct coupling of gelatin to monocarboxylated $Pluronic^{(R)}$(MP) and characterized. The use of thermosensitive polymers has recently been proposed for many applications including tissue engineering, gene therapy, novel drug delivery systems, implantable devices, such as scaffoldds for cartilage regeneration and nanotechnology. Water soluble thermosensitive GP was developed as an injectable scaffold using EDC/NHS as a coupling reagent for catilage regeneration. $^1H$ NMR, and FTIR were used to characterize the chemical structure of the modified gelatins. The GP solution showed a reversible sol-gel transition behavior around body temperature. The cell viability was evaluated using methylthiazolyldiphenyl tetrazolium bromide (MTT) assay. The optical density (O.D.) of GP was significantly higher than that of $Pluronic^{(R)}$ at 1, 3 and 5 days, indicating that the cell viability on GP was better than on $Pluronic^{(R)}$. Therefore, the OP copolymer can be used as an injectable cell-containing scaffold owing to its thermally reversible properties and good biocompatibility.

Antimicrobial resistance of Staphylococcus aureus isolated from domestic and imported raw meat in Korea

Heo, Hee Jin,Ku, Bok Kyung,Bae, Dong Hwa,Park, Cheong Kyu,Lee, Young Ju The Korean Society of Veterinary Science 2008 大韓獸醫學會誌 Vol.48 No.1

The rapid evolution of antibiotic resistance in Staphylococcus (S.) aureus is of considerable concern. Methicillin-resistant S. aureus (MRSA) strains are especially one of the greatest public concerns since the treatment of infections is more difficult when encountering resistance. In this study, we conducted a nationwide survey on the antimicrobial resistance of S. aureus isolated from raw meat samples collected from 16 countries, including Korea, and investigated the prevalence of MRSA as a possible source of human infection. Of 1,984 meat samples, S. aureus was isolated from 218 (11.0%) samples consisting of 23 (12.1%) from domestic meat and 195 (10.9%) from imported meat. The isolation rates of poultry meat, pork and beef were 12.8%, 7.0% and 10.0%, respectively. With regard to imported meat, the incidence varied from 4.8% to 16.6% from 13 countries, with the exception of Austria and Poland. In a resistance test to 20 antimicrobial agents, one hundred and eighty-four isolates (84.4%) were resistant to one or more antimicrobial agents tested. Especially, 17 (7.8%), 124 (56.9%) and 28 (12.8%) isolates showed a resistance to 3, 2 and 1 drugs, respectively. One isolate originating from domestic beef was resistant to 7 drugs. Another isolate originating from imported poultry meat showed resistance to oxacillin and methicillin by the disk diffusion test and minimal inhibition concentration methods, but showed negative for detection of the mecA gene.

Comparison of Residual Patterns of the Insecticide Cyenopyrafen in Minor Crops

Dong-Ju Lee,Se-Yeon Kwak,Sang-Hyeob Lee,Ye-Jin Heo,Jae-Won Choi,Kee Sung Kyung,Tae-Hwa Kim,Jang-Eok Kim 한국농약과학회 2021 한국농약과학회 학술발표대회 논문집 Vol.2021 No.5

Fabrication and characterization of novel nano- and micro-HA/PCL composite scaffolds using a modified rapid prototyping process

Heo, Su-Jin,Kim, Seung-Eon,Wei, Jie,Hyun, Yong-Taek,Yun, Hui-Suk,Kim, Dong-Hwa,Shin, Ji Won,Shin, Jung-Woog Wiley Subscription Services, Inc., A Wiley Company 2009 Journal of biomedical materials research. Part A Vol.a89 No.1

<P>Novel three-dimensional scaffolds consisting of nano- and microsized hydroxyapatite (HA)/poly(ε-caprolactone) (PCL) composite were fabricated using a modified rapid-prototyping (RP) technique for bone tissue engineering applications. The size of the nano-HA ranged from 20 to 90 nm, whereas that of the micro-HA ranged from 20 to 80 μm. The scaffold macropores were well interconnected, with a porosity of 72–73% and a pore size of 500 μm. The compressive modulus of the nano-HA/PCL and micro-HA/PCL scaffolds was 3.187 ± 0.06 and 1.345 ± 0.05 MPa, respectively. The higher modulus of the nano-HA/PCL composite (n-HPC) was to be likely caused by a dispersion strengthening effect. The attachment and proliferation of MG-63 cells on n-HPC were better than that on the micro-HA/PCL composite (m-HPC) scaffold. The n-HPC was more hydrophilic than the m-HPC because of the greater surface area of HA exposed to the scaffold surface. This may give rise to better cell attachment and proliferation. Bioactive n-HA/PCL composite scaffold prepared using a modified RP technique has a potential application in bone tissue engineering. © 2008 Wiley Periodicals, Inc. J Biomed Mater Res, 2009</P>

Residue Patterns and Risk Assessment of Cyflumetofen, Oxolinic acid and Flometoquin in Minor Crops

Dong-Ju Lee,Se-Yeon Kwak,Sang-Hyeob Lee,Ye-Jin Heo,Jae-Won Choi,Ji-Eun Oh,Kee-Sung Kyung,Tae-Hwa Kim,Jang-Eok Kim 한국농약과학회 2021 한국농약과학회 학술발표대회 논문집 Vol.2021 No.11

In this study, food intake risk for each age and gender was derived based on the implementation of GAP in minor crops such as Korean cabbage, spinach, perilla leaves, water dropwort and shallot. By using pesticides residue analysis and risk assessment results, it will be contributed to set additional MRL. Cyflumetofen(0.02L a.i./10 a) and flometoquin(0.012 a.i./10 a) were sprayed twice and oxolinic acid(0.04kg a.i./10 a) was sprayed three times with 7 days interval at 21, 14, 10, 7, 3 and 0 days, before harvest, respectively. Based on the “principle of establish standard and application for food” announced by the MFDS, MRL was recommended as a value that is three times of maximum residue amounts when sprayed twice or three times within 10 or 17 days. Chronic toxicity assessment of spinach in oxolinic acid using STMR was 0.0 ~ 6.3%, which was far below 100%. On the other hand, chronic toxicity assessment using HR was 0.0 ~ 21.2%, which was close to 100%. For Korean cabbage, water dropwort and shallot in cyflumetofen, 30.0, 40.0 and 20.0mg/kg were recommended as MRLs, and the %ADI was less than 80% as a result of dietary exposure assessment. For spinach and perilla leaves in oxolinic acid, 50.0 and 60.0mg/kg were recommended as MRLs. As a result of the dietary exposure assessment, the %ADI was less than 80% in all other groups. But, for infants, it was 66.0% before including the %ADI of spinach, and rose to 202.6% after inclusion, which was over 80%. And it was 7.0% before including perilla leaf and 143.6% after inclusion. For spinach, perilla leaves and water dropwort in flometoquin, 7.0, 10.0, and 15.0mg/kg were recommended as MRLs, and the %ADI was less than 80% as a result of dietary exposure assessment.