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A Phenylpropanoid Glycoside with Antioxidant Activity from Picria tel-ferae
Nguyen Duy Thuan,Do Thi Ha,Phuong Thien Thuong,나민균,Jong Pill Lee,Jeong-Hun Lee,Hyo-Won Seo,민병선,김진철,배기환 대한약학회 2007 Archives of Pharmacal Research Vol.30 No.9
A phytochemical study on Picria tel-ferae resulted in the isolation of a phenylpropanoid glycoside (1), which was reported for the first time from this plant. The structure of compound 1 was identified as 1-O-3,4-(dihydroxyphenyl)-ethyl-β-D-apiofuranosyl-(1→4)-α-L-rharmnopyranosyl- (1→3)-4-O-caffeoyl-β-D-glucopyranoside on the basis of spectroscopic analyses. In addition, it was found that 1 exhibited a remarkable inhibitory effect on lipid peroxidation initiated by either a free radical [AAPH; 2,2'-azobis-(2-amidinopropane)dihydrochloride] or generated hydroxyl radical (Fe2+/ascorbate). These findings, together with those of previous studies, suggest that P. tel-ferae possesses abundant phenylpropanoid glycosides, and the plant might be used beneficially in the treatment of oxidative stress-related human diseases.
A Phenylpropanoid Glycoside with Antioxidant Activity from Picria tel-ferae
Thuan, Nguyen Duy,Ha, Do Thi,Thuong, Phuong Thien,Na, Min-Kyun,Lee, Jong-Pill,Lee, Jeong-Hun,Seo, Hyo-Won,Kim, Jin-Cheol,Bae, Ki-Hwan,Min, Byung-Sun 대한약학회 2007 Archives of Pharmacal Research Vol.30 No.9
A phytochemical study on Picria tel-ferae resulted in the isolation of a phenylpropanoid glycoside (1), which was reported for the first time from this plant. The structure of compound 1 was identified as $1-O-3,4-(dihydroxyphenyl)-ethyl-{\beta}-D-apiofuranosyl-(1{\rightarrow}4)-{\alpha}-L-rharmnopyranosyl-(1{\rightarrow}3)-4-O-caffeoyl-{\beta}-D-glucopyranoside$ on the basis of spectroscopic analyses. In addition, it was found that 1 exhibited a remarkable inhibitory effect on lipid peroxidation initiated by either a free radical [AAPH; 2,2'-azobis-(2-amidinopropane)dihydrochloride] or generated hydroxyl radical ($Fe^{2+}/ascorbate$). These findings, together with those of previous studies, suggest that P. tel-ferae possesses abundant phenylpropanoid glycosides, and the plant might be used beneficially in the treatment of oxidative stress-related human diseases.