Disruption of collagen alignment by an MMP2-responsive nanosystem to enhance penetration of chemotherapeutic agents in pancreatic ductal adenocarcinoma

Dan WEI,Yinmo YANG 한국간담췌외과학회 2022 Annals of hepato-biliary-pancreatic surgery Vol.26 No.-

Adaptive Pinning Synchronization of Complex Networks with Negative Weights and Its Application in Traffic Road Network

Dan Wang,Wei-Wei Che,Hao Yu,Jia-Yang Li 제어·로봇·시스템학회 2018 International Journal of Control, Automation, and Vol.16 No.2

As local traffic congestion and uncertainty factors existing on roads may lead to cascading failures or even large area traffic network congestion, a pinning control method is proposed to divert the traffic and then restore the smooth flow of traffic. To eliminate the impacts of uncertainties and negative weights for the traffic network performance, the adaptive pinning control and coupling adjustment strategies are designed to estimate controller parameters and adjust coupling strength to compensate for the impacts on the pinned nodes and unpinned nodes. Based on Lyapunov stability theory, adaptive pinning controllers and network adjusters are developed to guarantee the achievement of network synchronization even in the presence of the uncertainties and negative weights. In addition, we investigate the effects of the type of nodes on pinning synchronization performance. Numerical simulations show that if the network’s degree and the single node energy index are considered, better synchronization performance can be obtained by comparing with the pervious pinning schemes.

Distributed Compressive Sensing based Near Infrared and Visible Images Fusion for Face Recognition

Dan Wei 보안공학연구지원센터 2016 International Journal of Signal Processing, Image Vol.9 No.4

In this paper, we propose a novel face recognition method based on fusing the near infrared and visible images of face images with distributed compressive sensing. The near infrared image and visible image of one same subject constitute an ensemble. Both images in one ensemble share a common sparse component while each individual image has an innovation component. To better capture the complementary information of the ensemble, the distributed compressive sensing is used to obtain the common component and the innovation component of near infrared and visible image. The obtained common component contains the complementary information of near infrared and visible image effectively. So the sparse coefficients of the common component obtained by distributed compressive sensing can better capture the intrinsic structures of each image and therefore can obtain better performance than that of only using near infrared image or visible image. The experimental results on several benchmark datasets demonstrate the effectiveness of proposed method.

Implementation of Antitrust Law in Emerging Markets: A Case Study of China

( Dan Wei ) 고려대학교 법학연구원 2014 The Asian Business Lawyer Vol.14 No.-

Since the beginning of the new century, several emerging markets have modernized and reformed their national competition laws. China is a good example of growth and maturity of emerging economies in antitrust enforcement. Just in a period of six years, the implementation of the AML becomes increasingly sophisticated and has already surpassed the infancy stage. China’s experiences of antitrust regime undergo at least three phases: at the outset, merger control was the key area of enforcement, then monopoly agreements were gradually extended, and now the new territory . being the most controversial issues . the abuse of dominance has also been occupied. Due to a development approach instead of a pure efficiency approach, China does not directly copy the experiences of mature jurisdictions. Sometimes, local enforcement agencies have to make compromises among many different and even contradictory objectives. It is a sign of transition period. In the long run, enforcement of antitrust law should be autonomous from and prevail over the industry policy and other non-competition concerns.

The Phytotoxic Effects of Selenium–Mercury Interactions on Root Growth in Brassica rapa (LvLing)

Zhi-Wei Bian,Jian Chen,Hui Li,Dan-Dan Liu,Li-Fei Yang,Yue-Lin Zhu,Wen-Li Zhu,Wei Liu,Zheng-Zheng Ying 한국원예학회 2016 Horticulture, Environment, and Biotechnology Vol.57 No.3

Rapid industrial and agricultural development has dramatically increased the emission of selenium (Se) and mercury (Hg) into the environment. Combined soil pollution by Se and Hg poses a potential threat to crop production. However, no toxic effects of Hg–Se interactions on plants have been reported previously. In this study, we investigated the effects of Hg–Se interactions on biochemical and physiological indices in the roots of Brassica rapa (LvLing). Seedlings were treated hydroponically with solutions of mercury chloride (1 μM), sodium selenite (4 μM), or a combination of the two. Combined Hg+Se treatment significantly inhibited root growth, reduced root biomass, and enhanced reactive oxygen species (ROS) and malondialdehyde accumulation and led to a loss of plasma membrane integrity. The combined treatment increased glutathione peroxidase, glutathione S-transferase, and peroxidase activity, reduced superoxide dismutase activity, and had no effect on catalase activity. In addition, we detected increased glutathione concentrations in root tips and reduced ascorbic acid concentrations in the presence of Hg+Se relative to individual treatments with these elements. Thus, Hg–Se interactions enhanced oxidative injury, cell death, and phytotoxicity in B. rapa roots.

Error Analysis of Multidimensional Evaluation of Pilot’s Workload Based on Objective Measures

Chan Wei,Liming Wei,Zhengxiang Cai,Yanyu Lu,Qi Wu,Dan Huang,Shan Fu 제어로봇시스템학회 2015 제어로봇시스템학회 국제학술대회 논문집 Vol.2015 No.10

Evaluation of pilot’s workload during flight is a significant consideration for the safety of civil aviation. However, some errors may be brought in the measurement and the recording of objective parameters. Based on a multidimensional workload evaluation, the time delay of cardiac activity and its impacts on workload are analyzed. The results suggest that within a certain limit of error around 10s, varying from individual to individual, workload can keep the main information compared to the original workload. As the error increases, the workload may become unreliable. As a consequence, the time-delay error of cardiac activity should be controlled in a limited scale to ensure the validity and reliability of workload.

Lack of Association of the MDR1 C3435T Polymorphism with Susceptibility to Gastric Cancer and Peptic Ulcer: a Systemic Review and Meta-analysis

Wu, Dan-Dan,Zhang, Ji-Xiang,Li, Jiao,Dong, Wei-Guo Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.7

Background: The multidrug resistance 1 gene (MDR1) C3435T polymorphism has been demonstrated to influence the P-glycoprotein (P-gp) activity level which is related to inflammation and carcinogenesis. This meta-analysis was performed to estimate the association between the MDR1 C3435T polymorphism and the risk of gastric cancer (GC) and peptic ulcer (PU). Materials and Methods: A literature search was conducted with PubMed, Embase and the Cochrane library up to November 2013. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of association. Data were analyzed using Review Manager (Version 5.2), and Stata package (version 12.0) for estimation of publication bias. Results: Six case-control studies were included, of which five were for GC and two for PU. Overall, no evidence was found for any association between the MDR1 C3435T polymorphism and the susceptibility to GC and PU. In the stratified analysis by H. pylori infection status, stage and histology classification of GC, and PU type, there was still no significant association between them. Conclusions: This meta-analysis suggested that the MDR1 C3435T polymorphism is not associated with susceptibility to GC and PU. Large and well-designed studies are warranted to validate our findings.

Intelligent energy-saving operation of wheel loader based on identifiable materials

Bing-wei Cao,Xinhui Liu,Wei Chen,Kuo Yang,Dan Liu 대한기계학회 2020 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.34 No.3

This study applies image recognition technology to the shovel loading operation of a wheel loader for the first time. In the proposed method, the wheel loader can automatically select the corresponding engine power curve according to different identifiable materials, thus achieving intelligent energy saving. This study first analyzed the working resistance of the wheel loader, and the analysis results provided theoretical support to the energy-saving operation of the wheel loader. The shovel loading test was carried out for different materials. The test results validated the feasibility of intelligent energy-saving operation of the wheel loader based on identifiable materials. A neural network algorithm based on material identification model was then built and verified, whose material identification rate was 92 %. The model was used as the carrier, and the wheel loader-operating characteristics were considered in view of the existing engine energy-saving mode. Finally, the boom cylinder pressure and bucket angle were used as feedback to future discussion about the intelligent energy-saving operation of the wheel loader. The basic conditions for subsequent designs of wheel loaders are provided.

Functions of Membrane-bound Alcohol Dehydrogenase and Aldehyde Dehydrogenase in the Bio-oxidation of Alcohols in Gluconobacter oxydans DSM 2003

Liu-Jing Wei,Ji-lai Zhou,Dan-ni Zhu,Bai-yi Cai,Jin-Ping Lin,Qiang Hua,Dong-Zhi Wei 한국생물공학회 2012 Biotechnology and Bioprocess Engineering Vol.17 No.6

In this study a new insight was provided to understand the functions of membrane-bound alcohol dehydrogenase (mADH) and aldehyde dehydrogenase (mALDH) in the bio-oxidation of primary alcohols, diols and poly alcohols using the resting cells of Gluconobacter oxydans DSM 2003 and its mutant strains as catalyst. The results demonstrated that though both mADH and mALDH participated in most of the oxidation of alcohols to their corresponding acid, the exact roles of these enzymes in each reaction might be different. For example,mADH played a key role in the oxidation of diols to its corresponding organic acid in G. oxydans, but it was dispensable when the primary alcohols were used as substrates. In contrast to mADH, mALDH appears to play a relatively minor role in organic acid-producing reactions because of the possible presence of other isoenzymes. Aldehydes were, however, found to be accumulated in the mALDH-deficient strain during the oxidation of alcohols.

Four Apolipoprotein B gene polymorphisms and the risk for coronary artery disease: a meta-analysis of 47 studies

Dan Xiao,Kaisen Huang,Qingyong Chen,Baotao Huang,Wei Liu,Yong Peng,Mao Chen,Dejia Huang,Tong Zou,Jiefu Yang 한국유전학회 2015 Genes & Genomics Vol.37 No.7

Apolipoprotein B plays a central role in lipoprotein metabolism. Many studies have evaluated the association between Apolipoprotein B gene polymorphisms (XbaI, EcoRI, SpIns/Del, MspI) and the risk for coronary artery disease and myocardial infarction. However, the results remain inconsistent, particularly among different populations. To more precisely determine the association between Apolipoprotein B gene polymorphisms and coronary artery disease/myocardial infarction risk, we performed a meta-analysis via a comprehensive search of electronic databases (up to February 1st, 2015), odds ratios (OR) and 95 % confidence intervals were calculated using a fixed or random effect model. A total of 47 studies, with 9411 coronary artery disease/myocardial infarction cases and 9082 controls, were included in this meta-analysis. The combined results revealed significant associations between an increased risk of coronary artery disease/myocardial infarction and EcoRI (AA vs GG: OR 1.511, 95 % confidence interval (CI) 1.098, 2.078) and SpIns/Del (DD vs II: OR 1.331, 95 % CI 1.064, 1.665) alleles in the general population. In a subgroup analysis stratified by ethnicity, the T allele of the XbaI variant was associated with a decreased risk in Caucasians, whereas it was associated with an increased risk among the East Asian population. No significant correlation was detected between the A allele of the MspI variant and the coronary artery disease/myocardial infarction risk in either the general population or any ethnic subgroup. The results of our study suggest that Apolipoprotein B gene polymorphisms may affect the coronary artery disease/myocardial infarction susceptibility and these effects may display notable discrepancies among different populations.