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( Na Ri Kim ),( Eon Jeong Nam ),( Jong Wan Kang ),( Hyun Seok Song ),( Churl Hyun Im ),( Young Mo Kang ) 대한내과학회 2014 The Korean Journal of Internal Medicine Vol.29 No.6
Background/Aims: We investigated the electromyography (EMG) findings and demographic, clinical, and laboratory features that may predict the development of malignancy in patients with idiopathic inflammatory myopathy (IIM). Methods: In total, 61 patients, 36 with dermatomyositis and 25 with polymyositis, were included. Patients were divided into those with and without malignancies, and comparisons were made between the groups in terms of their demographic, clinical, laboratory, and EMG findings. Results: The frequencies of malignancies associated with dermatomyositis and polymyositis were 22% and 8%, respectively. Patients with malignancies showed a significantly higher incidence of dysphagia (odds ratio [OR], 21.50; 95% confi- dence interval [CI], 3.84 to 120.49), absence of interstitial lung disease (ILD; OR, 0.12; 95% CI, 0.01 to 0.98), and complex repetitive discharge (CRD) on the EMG OR, 26.25; 95% CI, 2.67 to 258.52), versus those without. After adjustment for age, dysphagia and CRD remained significant, while ILD showed a trend for a difference but was not statistically significant. Multivariate analysis revealed that the CRD conferred an OR of 25.99 (95% CI, 1.27 to 531.86) for malignancy. When the frequency of malignancy was analyzed according to the number of risk factors, patients with three risk factors showed a significantly higher incidence of malignancy, versus those with fewer than two (p = 0.014). Conclusions: We demonstrated for the first time that CRD on the EMG was an additional independent risk factor for malignancy in IIM. Further studies on a larger scale are needed to confirm the importance of CRD as a risk factor for malignancy in IIM.
Bilateral Involvement of Juvenile Temporal Arteritis Associated with Kimura Disease
( Na Ri Kim ),( Churl Hyun Im ),( Jong Wan Kang ),( Ji Hun Kim ),( Tae-in Park ),( Han-ik Bae ),( Eon Jeong Nam ),( Young Mo Kang ) 대한류마티스학회 2018 대한류마티스학회지 Vol.25 No.1
Juvenile temporal arteritis (JTA) is a localized nodular arteritis confined to the temporal artery without evidence of systemic inflammation, and it occurs mainly in patients younger than 50 years. From the first case report, the pathological features of JTA have been suspected to be the morphological equivalent of Kimura disease (KD), which has been supported further by the concurrent cases of JTA with KD. We present the first case of bilateral JTA accompanying KD, which was confirmed by histological and ultrasound evaluations and supports the hypothesis that JTA is a manifestation of KD. The un-excised JTA lesion was resolved completely after corticosteroid therapy with no recurrence. (J Rheum Dis 2018;25:65-68)
김나용(Na-Yong Kim),전현무(Hyeon-Mu Jeon),배창식(Chang-Sik Bae),박규철(Gyu-Churl Park),정용식(Young-Seek Chung),양훈기(Hoon-Gee Yang) 한국전자파학회 2017 한국전자파학회논문지 Vol.28 No.7
레이다의 레이돔 형상으로 인한 플래쉬 부엽(flash lobe)으로 인해 수신신호에는 표적 성분 외에 클러터(clutter) 성분이 포함된다. 클러터는 재머와 달리 표적성분과 동일한 시간에 입력될 수 있으므로 이 경우 조향방향과 표적방향의 방향오차를 추정하는 모노펄스(monopulse) 레이다의 성능 열화를 일으킨다. 본 논문에서는 클러터 환경에서 GSC(Generalized Sidelobe Canceller) 기반 모노펄스 레이다 시스템의 성능을 개선할 수 있는 클러터 추정 알고리즘을 제시한다. 직교투영(orthogonal projection) 과정을 반복하는 알고리즘에 의해 클러터 추정 성능이 개선될 수 있는 근거를 제시하며 시뮬레이션에 의해 클러터 추정 과정이 포함된 GSC 기반 시스템이 기존 모노펄스 시스템보다 방향 추정 성능을 개선할 수 있음을 보인다. Due to the existence of flash lobe caused by the radome structure, a radar return in general contains clutter component added to target echo. Unlike jammer, clutter is apt to simultaneously coexist with target echo, which hinders a monopulse radar from estimating the angle difference between target echo direction and radar steering direction. In this paper, we propose a clutter estimation algorithm applicable to generalized sidelobe canceller(GSC) based monopulse radar. We show that clutter estimation can be achieved via iterative process of the orthogonal projections. Through simulations, the proposed GSC-based system combined with the clutter estimation can outperform the conventional monopulse system in terms of target angle estimation.
Biocompatibility of 13-93 Bioactive Glass-SiC Fabric Composites
Park, Jewon,Na, Hyein,Choi, Sung-Churl,Kim, Hyeong-Jun The Korean Ceramic Society 2019 한국세라믹학회지 Vol.56 No.2
Bioactive glass (BG) finds limited use as a bone replacement material owing to its low mechanical properties. In order to solve this problem, the micro-sized 13-93 BG was prepared as a fabric composite with SiC microfibers, and its mechanical properties and biocompatibility were investigated in this study. The tensile strengths of BG-SiC fiber-bundle composites increased in proportion to the number of SiC fibers. In particular, even when only one SiC fiber was substituted, the tensile strength increased by 81% to 1428 MPa. In the early stage of the in-vitro test, a silica-rich layer was formed on the surface of the 13-93 BG fibers. With time, calcium phosphate grew on the silica-rich layer and the BG fibers were delaminated. On the other hand, no products were observed on the SiC fibers for 7 days, therefore, SiC fibers are expected to maintain their strength even after transplantation in the body.
마우스에서 Cisplatin과 방사선조사로 유발된 구내염에 대한 재조합 표피성장인자의 효과
나재범(Jae Boem Na),김혜정(Hye Jung Kim),채규영(Gyu Young Chai),이상욱(Sang Wook Lee),이강규(Kang Kyoo Lee),장기철(Ki Churl Chang),최병옥(Byung Ock Choi),장홍석(Hong Seok Jang),정배권(Bea Keon Jeong),강기문(Ki Mun Kang) 대한방사선종양학회 2007 Radiation Oncology Journal Vol.25 No.4
목 적: 마우스 모델에서 cisplatin과 방사선조사로 구내염을 유발시킨 후 재조합 표피성장인자 (recombinant human epidermal growth factor, rhEGF)을 처치하여 그 효과를 알아보고자 하였다. 대상 및 방법: 마우스 24마리를 대상으로 정상대조군 8마리와 실험군은 각각 rhEGF 처치군과 미처치군으로 8마리씩 분류하였으며 실험군은 10 mg/kg의 cisplatin을 방사선조사 첫날 동시에 1회 복강 내 투여하였고, 방사선조사는 5일간 1회 5 Gy씩, 5일간 25 Gy를 조사하였다. RhEGF 처치군은 방사선조사 2일 전부터 2일간 1 mg/kg의 rhEGF를 피하주사하였으며 방사선조사 3일째부터 3일간 1 mg/kg를 피하주사하여 총 5 mg/kg의 rhEGF를 투여하였다. 마우스의 체중변화, 먹이섭취 및 조직학적 변화를 평가하였다. 결 과: 마우스 체중변화는 rhEGF 처치군이 실험 3일째부터 5일간 rhEGF 미처치군과 비교하여 통계적으로 유의한 체중의 차이를 관찰할 수 있었다. 먹이섭취는 실험군(rhEGF 처치군과 미처치군)에서 실험 5일째까지 감소하였다가 13일째부터 먹이섭취의 증가를 보여주었다. Cisplatin과 방사선조사 후 7일째의 조직학적 검사에서는 rhEGF 처치군 에서 마우스의 점막 표피층의 변성이 관찰되었으나 rhEGF 미처치군에서는 점막층의 염증 반응이 관찰되었다. 결 론: Cisplatin과 방사선 조사로 마우스에서 발생한 구내염에서 rhEGF를 투여한 경우 체중 변화와 먹이섭취의 유의한 개선을 관찰 하였으며 조직학적 검사에서 점막 손상의 회복을 확인하였다. 향후 임상적으로 rhEGF가 항암화학요법과 방사선치료로 인한 구내염을 줄일 수 있는 가능성을 확인하였다. Purpose: To study the effect of recombinant human epidermal growth factor (rhEGF) on oral mucositis induced by cisplatin and radiotherapy in a mouse model. Materials and Methods: Twenty-four ICR mice were divided into three groups— the normal control group, the no rhEGF group (treatment with cisplatin and radiation) and the rhEGF group (treatment with cisplatin, radiation and rhEGF). A model of mucositis induced by cisplatin and radiotherapy was established by injecting mice with cisplatin (10 mg/kg) on day 1 and with radiation exposure (5 Gy/day) to the head and neck on days 1∼5. rhEGF was administered subcutaneously on days -1 to 0 (1 mg/kg/day) and on days 3 to 5 (1 mg/kg/day). Evaluation included body weight, oral intake, and histology. Results: For the comparison of the change of body weight between the rhEGF group and the no rhEGF group, a statistically significant difference was observed in the rhEGF group for the 5 days after day 3 of the experiment. The rhEGF group and no rhEGF group had reduced food intake until day 5 of the experiment, and then the mice demonstrated increased food intake after day 13 of the of experiment. When the histological examination was conducted on day 7 after treatment with cisplatin and radiation, the rhEGF group showed a focal cellular reaction in the epidermal layer of the mucosa, while the no rhEGF group did not show inflammation of the oral mucosa. Conclusion: These findings suggest that rhEGF has a potential to reduce the oral mucositis burden in mice after treatment with cisplatin and radiation. The optimal dose, number and timing of the administration of rhEGF require further investigation.