서울의 Penicillinase Producing Neisseria gonorrhoeae 발생빈도(1998)

김재홍,김준호,반재용,이정우,황성주,정준규,정성태,강진문,조흔정,홍창의,정혜신,이한승,김이선,이봉길,이종호,선영우,한기덕,윤성필,이성훈,안종성,박석범,문승현,조항래,김형섭,류지호,황재영,박준홍,손상욱 한양대학교 의과대학 2001 한양의대 학술지 Vol.21 No.1

In recent years, gonorrhea has been pandemic and remains one of the most common STDs in the world, especially in developing countries. For the detection of a more effective therapeutic regimen and assessing the prevalence of Penicillinase Producing Neisseria gonorrhoeae(PPNG), we have been trying to study the patients who have visited the Venereal Disease Clinic of Choong-Ku Public Health Center in Seoul since 1980 by menas of the chromogenic cephalosporin method. In 1998, 93 strians of N. genorrhoeae were isolated, among which 60(64.5%) were PPNG. The prevalence of PPNG in Seoul, which had been decreased to 39% in 1996 after a peak of 74.3% in 1993, is increased to 64.5% in 1998.

톨루엔 노출 근로자에서 유전자적 요인, 생활습관 및 식이가 요중 마뇨산 배설에 미치는 영향

임현우,박정일,노영만,이강숙,이정민,이원철,이세훈,정치경 大韓産業醫學會 2000 대한직업환경의학회지 Vol.12 No.3

목 적 : 본 연구는 생물학적 지표 특성 연구를 위한 단면조사 연구로서 톨루엔 노출과 톨루엔의 생물학적 모니터링으로 이용되는 요중 마뇨산 농도간의 양-반응 관계에서 효과 변경인자로서 작용하는 유전자 ALDH2, CYPIAI, CYP2El의 다양성 분포를 조사하고, 이들 유전자가 요중 마뇨산 배설 농도에 미치는 영향을 알아보고자 하였다. 방 법 : 연구대상자는 경인지역에 위치한 22개의 사업체에서 페인트 제조 72명, 제조업에서 도장작업 50명, 인쇄업 12명, 접착작업 12명, 벽지의 코팅작업 14명등 160명의 근로자이었다. 성, 연령, 유기용제 작업장 근무경력, 흡연습관, 음주습관, 검사일 이전 밤에 음주 여부, 시료 채취전 6시간 이내에 섭취한 식품조사, 측정일 개인보호구의 착용 여부에 대하여 설문조사를 시행하였다. 톨루엔에 대한 개인노출량은 passive air sampler로 측정하였고, 요중 마뇨산은 요중 크레아틴으로 보정하여 측정하였다. 또한 aldehyde dehydrogenase 2 (ALDH2) , cytochrome P45O IAI(CYPIAI), 그리고 cytochrome P45O 2El(CYPfEl)의 유전적 다양성은 혈액으로부터 백혈구의 DNA를 추출하여 제한 효소 절단 길이 다양성 (restiction fragment length polymorphism, RFLP)법으로 검사하여 다음의 결과를 얻었다. 결 과 : 연구대상자의 요중 마뇨산 농도의 기하평균은 0.44g/g creatinine, 기하표준편차 2.80이었다. 톨루엔 노출 농도, 개인 보호구 착용여부, 안식향산이 함유된 식품의 섭취여부중 요중 마뇨산 배설농도에 영향을 미치는 인자는 톨루엔 노출 농도뿐이었다. ALDH2, CYPIAI, CYPfEl, 연령, 흡연, 근무기간에서 회귀계수간에 차이를 보이는 경향이 있었다. 요중 마뇨산 농도에 대한 다중회귀분석에서 톨루엔, ALDH2, CYPIAI, CYP2El유전자형의 회귀계수가 통계적으로 유의하였다. 결 론 : 톨루엔 노출로 인한 요중 마뇨산 배설 농도는 ALDH2, CYPIAI, CYP2El유전자 다양성에 의해 영향을 받기 때문에, 유전자형의 대사능의 차이를 고려하여 마뇨산 기준 농도를 찾는 연구가 이루어져야 하겠다. Objectives The purpose was to investigate the distributions and the effects of genetic polymorphism of aldehyde dehydrogenase 2(ALDH2), cytochrome P45O IAI (CYPIAI), and cytochrome P45O 2El (CYPfEl) on the toluene metabolism. Methods : The subacts consisted of 160 workers who were exposed to toluene in different industries such as paint manufacturing, painting on steel and wood products, printing, bonding, and coating. The exposed toluene level was monitored by passive air sam paler, and the questionnaire variables were age, sex, smoking, drinking, previous night's drinking, use of personal protectlve equipment, work duration, and taking benzoic acid containing food. The urinary hippurric acid collected in the end of shift was corrected by urinary creatinine concentration. The genotypes of ALDH2, CYPIAI, and CYP2El were investigated using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) methods with DNA extracted from venous blood. Results'The geometric mean and the geometric standard deviation of urinary hippuric acid concentration were 0.44 g/g creatinine and 2.80. The urinary hippuric acid concentration was significantly related to personal exposed toluene level among personal exposed toluene level, use of personal protective equipment, and benzoic acid containing food diet. The slope differences of the regression for ALDH2, CYPIAI, and CYP2E1 genetic polymorphism, age, smoking, and work duration tended to be significant. In multiple regression analysis, the regression coefficient of toluene, ALDH2, 7YPIAl, CYP2E1 genetic polymorphism were significant. Conclusions : From the above results, urinary hippuric acid level after toluene exposure was significantly affected by the genetic polymorphism of ALDH2, CYPIAI, CYPfEl. It is needed further investigation of the urinary hippuric acid level considering the effect of genetic polymorphism.

단어출현빈도분석과 AHP를 통한 기술 연구 동향과 기대 효과 분석: 바이오 에너지 분리막을 중심으로

이인우(Lee, In-Woo),서한결(Seo, Han-Gyeol),장수진(Jang, Soo-Jeen),조철희(Cho, Churl-Hee),정양헌(Chung, Yang-Hon) 한국경영교육학회 2020 경영교육연구 Vol.35 No.5

[연구목적] 본 연구는 과학 기술 연구 동향과 기술 도입 기대 효과를 함께 분석하는 방안을 바이오 에너지 분리막 분야에 적용하여 연구개발 전략 제시에 도움이 되는 연구 방안을 제시하고자 하였다. [연구방법] 본 연구는 분리막 기술 연구 방향과 기대효과를 분석하기 위해 각각에 대해 두 가지 연구방법을 이용하였다. 우선 텍스트 마이닝을 통해 단어출현 빈도분석으로 선행연구의 연구 방향을 확인하였고, AHP를 통해 기대효과를 알아보았다. [연구결과] 분석결과 분리막 기술의 연구 방향은 주로 분리막 관련 다양한 공정과 공정개선을 통한 성능 향상에 있는 것으로 확인되었다. 분리막 기술을 통한 기대 효과는 바이오 에너지 공정에서 발생하는 환경 문제 해결이 주된 것으로 나타났다. [연구의 시사점] 분리막 관련 연구는 분리막 성능에 중점을 두고 진행되고 있으며 분리막을 실제 공정에 도입하는 측에서 기대하는 부분은 분리막 도입으로 인한 효과와 분리성능 향상에 의한 효과에 중점을 두고 있음을 확인하였다. 이는 분리막 기술 연구가 실제 니즈를 잘 반영하여 이루어지고 있음을 보여준다. 이처럼 특정 기술의 연구 방향과 도입에 따른 기대효과를 함께 분석할 수 있으며, 이는 연구개발 전략 제시에 도움이 될 수 있음을 확인하였다. [Purpose] Purpose of this study is to propose a research methodology that is helpful in presenting the R&D strategy by applying analysis on research trends and expected effect of technology introduction together in the field of bioenergy membranes. [Methodology] For this purpose, we used two research methodologies. Word frequency analysis of text mining was used to analyze the research trends of previous studies, and the expected effect was investigated through AHP. [Findings] This study found that the research trends of membrane is mainly to improve performance through various processes and expected effect focus on environmental problem solving arising from bioenergy process. [Implications] It was confirmed that main research trends of membrane is performance of membrane and expected effect is performance improvement by introduction of membrane in bioenergy processes. This shows that research on membrane is well reflected in actual needs. This methodology can be helpful in presenting the consumer-oriented R&D strategy.

대나무 활성탄의 산 개질이 납과 구리 이온의 흡착에 미치는 영향

이명은ㆍ정재우(Myoung Eun LeeㆍJae Woo Chung) 유기성자원학회 2016 유기물자원화 Vol.24 No.1

질산과 염산에 의한 대나무활성탄(bamboo-based activated carbon, BAC)의 개질이 Pb(Ⅱ)와 Cu(Ⅱ)의 흡착특성에 미치는 영향을 규명하기 위해 회분식 흡착실험을 수행하였다. 산 개질에 의해 BAC의 탄소함량은 감소하고 산소함량은 증가하며 pH는 감소하는 것으로 나타났다. 염산에 의한 개질은 BAC에 뚜렷한 표면 작용기를 첨가시키지 않았으나 질산에 의한 개질은 카르복실기와 OH 작용기를 첨가시키는 것으로 나타났다. BAC와 산으로 개질된 BAC의 중금속 이온 흡착속도는 2차 속도모델에 의해 적절하게 설명될 수 있는 것으로 나타나 흡착반응의 속도가 물리적 흡착보다는 흡착제와 금속이온들 사이의 전자들의 공유나 교환을 포함하는 화학적 흡착에 의해 결정되는 것으로 나타났다. 실험에 사용된 모든 흡착소재의 등온흡착특성은 Langmuir와 Freundlich 모델에 의해 적절하게 설명될 수 있으며 BAC의 염산에 의한 개질은 중금속 이온의 흡착용량에 큰 영향을 미치지 않으나 표면작용기를 첨가시킨 질산에 의한 개질은 Pb(Ⅱ)와 Cu(Ⅱ)의 흡착용량을 각각 36.0%와 27.3% 증가시키는 것으로 나타났다. Effects of acid (HNO3 and HCl) modification on the adsorption properties of Pb(Ⅱ) and Cu(Ⅱ) onto bamboo-based activated carbon (BAC) were investigated through a series of batch experiments. The carbon content increased and oxygen content decreased with acid treatment. HNO3 induced carboxylic acids and hydroxyl functional groups while HCl added no functional group onto BAC. The pseudo-second order model better described the kinetics of Pb(Ⅱ) and Cu(Ⅱ) adsorption onto experimented adsorbents, indicating that the rate-limiting step of the heavy metal sorption is chemical sorption involving valency forces through sharing or exchange of electrons between the adsorbate and the adsorbent. The equilibrium sorption data followed both Langmuir and Freundlich isotherm models. The adsorption capacities of BAC were affected by the surface functional groups added by acid modification. The adsorption capacities were enhanced up to 36.0% and 27.3% for Pb(Ⅱ) and Cu(Ⅱ), respectively by the HNO3 modification, however, negligibly affected by HCl.

전국 10개 종합병원 중환자실 환자의 직장내 Vancomycin-resistant Enterococci(VRE) 보균율, 보균의 위험요인 및 유전적 다양성 조사

정희진,송준영,엄중식,김우주,최선주,최정현,이혁,정문현,이광미,신동현,손보라,최종성,우흥정,권정아,이경원,최강원,박승철 대한감염학회 2002 감염 Vol.34 No.5

야뇨증 환아들의 심리사회적 특성에 대한 다기관 연구 : 행동 및 정서 문제를 중심으로

조수철,김재원,신민섭,황준원,한상원,박관현,이상돈,김경도,김건석,서홍진,이유식,정재용,김영균,문두건,남궁미경,한창희,조원열,김영식,배기수,이종국,정우영,신의진 大韓神經精神醫學會 2005 신경정신의학 Vol.44 No.6

Objectives : The aim of this study was to examine the behavioral and emotional problems associated with nocturnal enuresis in Korean children. Methods : Three hundred eighteen children with nocturnal enuresis, together with their parents, completed the Child Behavior Checklist (CBCL), Disruptive Behavior Disorder Scale according to DSM-IV (DBDS), Children's Depression Inventory (CDI), State-Trait Anxiety Inventory for Children (STAIC), and Piers-Harris Children's Self-Concept Scale (PHCSC). Ninety-three normal students were selected as the control group. Results : Compared to the normal control group, the mean scores with regard to the withdrawn, social problems, attention problems, delinquent behavior, aggressive behavior, externalizing problems and total problems profiles were significantly higher in the nocturnal enuresis group according to the CBCL results. The nocturnal enuresis group also scored significantly higher in the ADHD and ODD profiles of the DBDS. The nocturnal enuresis group was more depressed and anxious than the control group according to the results of the CDI and STAI. The mean score of the PHCSC was significantly lower in the nocturnal enuresis group when compared to the normal control group. Conclusion : The results of this study suggest that children with nocturnal enuresis in Korea have clinically relevant behavioral and emotional problems. The findings support the link between nocturnal enuresis and psychopathology in Korean children.

토양보존을 위한 환경교육 교수 · 학습 프로그램

이우붕,정원우 慶北大擧校 師範大學 科學敎育硏究所 2000 科學敎育硏究誌 Vol.24 No.-

Humus serves important purposes in the life of soil, all of which contribute to its fertility. It retains essential plant nutrients such as potassium, nitrogen and phosphorus. It holds moisture easily and so prevents soils from drying out rapidly. It also keeps soil porous and permits the ready flow of air needed for root growth. The pores also help in the percolation of water downward to provide good drainage. The middle school program of education with environment should be action oriented program between knowledge and attitude, which means from knowledge to action. The aim of open class education with environment program must consist of structural system mode(fact·concept·generalization), pedagogy(explanation·participation) and evaluation(criticism·prediction).

??형 超音波 噴霧器에 依한 세탄液滴의 微粒化 特性

李智弘,鄭鎭度,羅又禎 慶尙大學校 1991 論文集 Vol.30 No.2

This study was performed to figure out the atomization characteristics of free-falling oetane droplets from a π-type ultrasonic vibrator dircted downwards. Droplets were collected by the magnesium oxide immersion method. The diameter and distribution of droplets were measured and analyzed. The results are summarized as following : 1. The shape of free-falling oetane droplets in space from the π-type ultrasonic vibrator was fully developed promixed spray column, showing almost the same diameter as the outer diameter of the horn through its whold length. 2. The mean of the Sauter mean diameter of the collected cetane droplets was 52.8㎛, and, its maximum and minimum droplet diameters were approximately 95 ㎛ and 15 ㎛, respectively. 3. The distribution types of droplet size were right-skewed Gaussian distribution curve in all cases with small variace. The Sauter mean diameters ranged from 48 ㎛ to 59 ㎛.

근로자 건강증진전략을 위한 행동변화에 대한 요구도 평가

이강숙,임현우,구정완,홍현숙,이정민,이원철,박정일,맹광호,M, O'Donnel 大韓産業醫學會 1999 대한직업환경의학회지 Vol.11 No.4

Objectives : In order to evaluate the stage of behavior change for health promotion strategy in workplace Methods : Questionnaire survey was carried out for 309 workers who employed in H Electronics company in Kyong-in area from September to October 1998. Results : According to need assessment of four step such as precontemplation stage, contemplation stage, action stage, maintenance stage which were to change of behavior for health promotion, the percent for quitting smoking were observed 48.8%, 43.1%, 8.1%, 0%, and for the restriction of drinking were 29.8%, 10.6%, 9.3%, 5.3%; for fitness 11.1%, 31.0%, 37.3%, 20.6% in male 26.6%, 27.8%, 26.6%, 19.0% in female, for regular diet 26.1%, 19.8%, 38.7%, 15.3% in male, 27.8%, 22.2%, 40.0%, 10.0% in female and for stress management 5.8%, 10.6%, 8.7%, 75.0% in male, 13.6%, 22.7%, 19.7%, 44.0% in female. In heavy smoker(p=0.017) and heavy drinker,(p=0.021) the percent of precontemplation stage was significantly higher than in lower drinker and light smoker. Conclusions : This study suggested that company support for health promotion in workplace was and workers of high risk group for smoking and drinking were in precontemplation stage. So before conducting the health promotion program, health risk appraisal and need assessment for stage of behavior change should be taken for the efficient health promotion strategy.

XLPE 절연 케이블의 전기적인 특성

이우선,정창수,김남오 조선대학교 에너지.자원신기술연구소 1999 에너지·자원신기술연구소 논문지 Vol.21 No.2

Electrical characteristics of metal impurities in insulation of distribution cables on electrical conduction of distribution cables was investigated. Samples of Al, Cu, Fe are fabricated as metallic impurities, and measured electrical conductivity in the voltage range of 0~10 ㎸. Capacitance characteristics of hysteresis curves and the relationship between forward and reverse current due to impurity content are discussed.