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Choi, Sojoong,Chung, Heesung,Hong, Heejeong,Kim, So Yeon,Kim, Seong-Eun,Seoh, Ju-Young,Moon, Chang Mo,Yang, Eun Gyeong,Oh, Eok-Soo The Federation of American Societies for Experimen 2017 The FASEB Journal Vol.31 No.4
<P>Chronic inflammation is known to be a key causative factor in tumor progression, but we do not yet fully understand the molecular mechanism through which inflammation leads to cancer. Here, we report that the dextran sulfate sodium (DSS)-induced mouse model of chronic colitis is associated with increases in the serum level of IL-1 beta and the colonic epithelial expression of the cell-surface heparan sulfate proteoglycan, syndecan-2. We further show that IL-1b stimulated the transcription of syndecan-2 via NF-kappa B-dependent FOXO3a activation in CCD841CoN normal colonic epithelial cells and early-stage HT29 colon cancer cells. Inflammatory hypoxia was observed in the colonic epithelia of mice with chronic colitis, suggesting that hypoxic stress is involved in the regulation of syndecan-2 expression. Consistently, experimental inflammatory hypoxia induced hypoxia inducible factor-1 alpha-dependent FOXO3a expression and the p38 MAPK-mediated nuclear localization of FOXO3a. FOXO3a directly mediated syndecan-2 expression in both cell lines and the colonic epithelia of mice with DSS-induced colitis. Moreover, syndecan-2 expression was detected in azoxymethane/ DSS-induced colon tumors. Together, these data demonstrate that inflammatory hypoxia upregulates syndecan-2 via the IL-1 beta-NF-kappa B-FOXO3a pathway. These findings provide new mechanistic insights into inflammatory hypoxia-mediated syndecan-2 expression to connect chronic inflammation and the development of colon cancer.-Choi, S., Chung, H., Hong, H., Kim, S. Y., Kim, S.-E., Seoh, J.-Y., Moon, C. M., Yang, E. G., Oh, E.-S. Inflammatory hypoxia induces syndecan-2 expression through IL-1b-mediated FOXO3a activation in colonic epithelia. FASEB J. 31, 1516-1530 (2017). www.fasebj.org</P>
Lee, Heesung,Kim, Jaewon,Choi, Sungju,Kim, Seong Kwang,Kim, Junyeap,Park, Jaewon,Choi, Sung-Jin,Kim, Dae Hwan,Kim, Dong Myong IEEE 2017 IEEE electron device letters Vol.38 No.2
<P>We report a model for the band-bending effect (BBE) for improved extraction of the subgap density-of-states (DOS) in amorphous semiconductor thinfilm transistors (TFTs). In previous works, the potential (Psi(x)) across the amorphous active layer was assumed to be the same as the surface potential (Psi S) over the active layer without the BBE. Due to the distributed DOS (g(E)) over the bandgap and the modulation of the quasiFermi level (E-F(x,V-GS)) by the gate bias, the non-uniform potential distribution should be considered in the characterization of DOS. We propose an empirical quadratic potential model (Psi(x,V-GS) =Psi S(V-GS)(1 - x/t(IGZO))(2)) for the BBE and extract a corrected distribution of DOS [ g(E)]. We applied the BBE model to the amorphous indiumgallium- zinc oxide TFTs through the differential ideality factor technique. We extracted a corrected DOS as a superposition of two exponential functions with tail and deep state densities (N-To = 8.8 x 10(17) eV(-1)cm(-3), and N-Do = 9x10(16) eV(-1)cm(-3)) at the tail and deep state characteristic energy (kT(T) = 18 meV and kT(D) = 280 meV), respectively. We confirmed the potentialmodel and extracted DOS parameters by the TCAD simulation.</P>
Heesung Lee,Junyeap Kim,Jaewon Kim,Seong Kwang Kim,Yongwoo Lee,Jae-Young Kim,Jun Tae Jang,Jaewon Park,Sung-Jin Choi,Dae Hwan Kim,Dong Myong Kim IEEE 2017 IEEE electron device letters Vol.38 No.5
<P>Amorphous InGaZnO (a-IGZO) thin-film transistors (TFTs) are investigated for a possible application to infrared (IR) photodetector through subgap density-ofstates over the forbidden bandgap. The origin of the sub-bandgap(hν <;E<SUB>g</SUB>) photo-response in a-IGZO TFTs is due to optically pumped electrons from the photo-responsive subgap states (E<SUB>C</SUB>-E<SUB>ph</SUB><;E<SUB>t</SUB><;E<SUB>F</SUB>). Among the sub-bandgap lights, we investigate the reproducible IR photo-response in a-IGZO TFTs as a photodetector without the persistent photoconductivity(PPC) effect. In this letter, we characterize the IR photo-response mechanism through various optical and electrical measurements on the wavelength, optical power, bias-modulated quasi-Fermi level, and photoresponsive states. This result is expected to provide independent and/or integrated IR detector with transparent substrate combined with a-IGZO TFTs.</P>
A Study of Control Method of SRM for Variable Speed Control
Heesung Park,Yeongseong Hwang,Sejin Seong,Jaedong Choi 전력전자학회 1998 ICPE(ISPE)논문집 Vol.- No.-
In this paper, the fuzzy control logic of Switched Reluctance Motor(SRM) is introduced to apply the variable speed drive system Since the speed-torque property of SRM has high speed variation to the changes of torque like a DC motor, to apply SRM to the var table speed driving system, the optimal speed-torque control method is required<br/> As the control method like this, the fuzzy logic and PI control are proposed, and characteristics of them are c ompared and verified through the experimental results.<br/>
Song, Heesung,Choi, Joon Hyouk,Kim, Young Suk The Korea Society of Nuclear Medicine 2016 핵의학 분자영상 Vol.50 No.2
$^{99m}Tc$-labeled red blood cell scintigraphy, a sensitive and specific diagnostic test, is useful for patients suspected of suffering from active gastrointestinal bleeding. This study follows a case of a patient who was suspected of gastrointestinal bleeding after an inferior vena cava filter was inserted due to a deep vein thrombosis of the femoral vein. To evaluate an exact focus of bleeding, $^{99m}Tc$-labeled red blood cell scintigraphy was executed. Herein, an unanticipated finding of $^{99m}Tc$-labeled red blood cell scintigraphy probably due to a thrombus on the inferior vena cava filter is reported.