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박철연,권정석,정진욱,이충기,현대성,최정윤 영남대학교 의과대학 2008 Yeungnam University Journal of Medicine Vol.25 No.2
Dermatomyositis is characterized by progressive, symmetric, Proximal muscle weakness and a nonsuppurative inflammatory myopathy of unknown etiology involving predominantly skeletal muscles. It is also characterized by typical skin lesions. Interstitial lung disease has a poor prognosis when it is associated with dermatomyositis. Organizing pneumonia is a disease in which granulation tissue fills the lumina of terminal and respiratory bronchioles and extends into the distal airspaces. The cryptogenic nature of the process is appreciated in that organizing pneumonia patterns of injury can be seen in secondary forms of the disease (secondary organizing pneumonia). Organizin pneumonia has been reported to occur in 5~10% in dermatomyositis-polymyositis patients Anti-histidyl tRNA synthetase antibody (anti-Jo-1) is a Predictive disease marker that is reported to occur in up to 70% of patients. We describe a 49-year-old male dermatomyosits patient who presented with organizing pneumonia and was found to have negative anti-Jo-1 antibody.
Yun Hwan Kang,Kyoung Kon Kim,Dae Jung Kim,Myeon Choe 한국영양학회 2015 Nutrition Research and Practice Vol.9 No.6
BACKGROUND/OBJECTIVES: Several medicinal properties of Smilax china L. have been studied including antioxidant, anti-inflammatory, and anti-cancer effects. However, the antiobesity activity and mechanism by which the water-soluble fraction of this plant mediates its effects are not clear. In the present study, we investigated the lipolytic actions of the water-soluble fraction of Smilax china L. leaf ethanol extract (wsSCLE) in 3T3-L1 adipocytes. MATERIALS/METHODS: The wsSCLE was identified by measuring the total polyphenol and flavonoid content. The wsSCLE was evaluated for its effects on cell viability, lipid accumulation, glycerol, and cyclic adenosine monophosphate (cAMP) contents. In addition, western blot analysis was used to evaluate the effects on protein kinase A (PKA), PKA substrates (PKAs), and hormone-sensitive lipase (HSL). For the lipid accumulation assay, 3T3-L1 adipocytes were treated with different doses of wsSCLE for 9 days starting 2 days post-confluence. In other cell experiments, mature 3T3-L1 adipocytes were treated for 24 h with wsSCLE. RESULTS: Results showed that treatment with wsSCLE at 0.05, 0.1, and 0.25 mg/mL had no effect on cell morphology and viability. Without evidence of toxicity, wsSCLE treatment decreased lipid accumulation compared with the untreated adipocyte controls as shown by the lower absorbance of Oil Red O stain. The wsSCLE significantly induced glycerol release and cAMP production in mature 3T3-L1 cells. Furthermore, protein levels of phosphorylated PKA, PKAs, and HSL significantly increased following wsSCLE treatment. CONCLUSION: These results demonstrate that the potential antiobesity activity of wsSCLE is at least in part due to the stimulation of cAMP-PKA-HSL signaling. In addition, the wsSCLE-stimulated lipolysis induced by the signaling is mediated via activation of the β-adrenergic receptor.
Barbiturate 정주, 초저체온 및 순환 정지를 이용한 거대 뇌동맥류 수술의 마취 1예
윤대영,정순호,최영군,김영재,박진우,신치만,박주열 인제대학교 1997 仁濟醫學 Vol.18 No.1
영구적인 뇌손상의 위험 때문에 일반적으로 거대 뇌 동맥류는 외과적 처치를 피해왔었다. 그러나 마취 및 체외순환이 개선되고 발전하여 순환 정지를 이용한 방법이 거대 뇌 동맥류의 결찰의 부작용을 감소시켰다. 본 병원에서 뇌 보호 및 안전한 수술을 위해 barbiturate를 병용한 마취와 체외 순환을 이용하여 중심 체온을 18℃까지 하강시킨 저체온하에서 순환 정지 동안에 시행한 거대 뇌동맥류 결찰의 마취 1예를 경험하였기에 보고하는 바이다. Because of the various risks of permanent neurological injury, neurosurgeons generally hale avoided any attempts at surgical ablation of giant cerebral aneurysms. But techniques of special anesthesia and cardiopulmonary bypass have been developed to make this operative procedure safe during temporary circulatory arrest. We report 1 case of anesthesia using special anesthetic with barbiturate and deep hypothermia to 18℃ that protect the brain during temporary cardiac arrest for surgical ablation of giant cerebral aneurysm.