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이승현(Seung Hyeon Lee),손동우(Dong Woo Son),은병욱(Byung Wook Eun),심소연(So Yeon Sim),최덕영(Deok Young Choi),선용한(Yong Han Sun),조강호(Kang Ho Cho0, 류 일(Eell Ryoo),전인상(In Sang Jeon0, 차 한(Hann Tchah) 대한소아신경학회 2009 대한소아신경학회지 Vol.17 No.2
목적:발작의 분류는 발작의 원인, 예후를 추정하거나 항경련제를 선택하는 데 있어 매우 중요하며 뇌파검사는 발작의 종류를 구분하고 적절한 치료를 하기 위해 시행하는 중요한 검사이다. 저자들은 소아에서 임상적 발작이 확실한 경우 간질발작의 임상양상과 뇌파검사 간의 일치 정도를 알아보고자 한다. 방법:2000년 1월 1일부터 2008년 9월 30일까지 1회 이상의 간질발작을 주소로 가천의대 길병원 소아청소년과에 방문한 환자 중 본원에서 처음으로 뇌파검사를 시행한 환자를 대상으로 하였다. 발작의 임상양상은 목격자와 본인의 설명을 기록한 의무기록지를 기준으로 하여 부분발작과 전신발작으로 분류하였고 뇌파검사는 발작간간질양방전을 기준으로 정상과 비정상으로 분류하였으며 각성과 수면상태 모두에서 시행하였다. 결과:총 461명의 환자의 뇌파검사 시의 평균 연령은 6.7세였고 남자는 247명, 여자는 214명이었다. 전체 환자에서 발작의 임상양상은 부분발작이 310명, 전신발작이 187명이었다. 각성뇌파검사에서 비정상은 158명으로 부분발작파가 118명, 전신발작파가 59명, 두 가지 발작파가 한 환자에서 나온 경우가 19명이었고, 수면뇌파검사에서는 비정상이 239명으로 부분발작파가 196명, 전신발작파가 77명, 두 가지 발작파가 한 환자에서 나온 경우가 34명이었으며 전체 환자에서는 비정상이 273명으로 부분발작파가 216명, 전신발작파가 97명, 두 가지 발작파가 한 환자에서 나온 경우가 40명이었다. 간질증후군은 전체 환자 중 90명에서 관찰되었다. 146명(41.5%)의 부분발작과 44명(23.4%)의 전신발작 및 79명(87.8 %)의 간질증후군이 뇌파소견과 일치하였다. 결론:영유아 및 소아에 있어 발작을 진단할 때에는 발작양상 분 아니라 정확한 뇌파소견을 세심하게 고려하여야 한다. Purpose:Electroencephalography(EEG) is an essential method carried out for classifying seizures and taking appropriate treatment. The aim of this study is to investigate the concordance between clinical findings of epileptic seizures and EEG in children. Methods:We enrolled 461 patients from those who visited Gil hospital from January 1, 2000 to September 30, 2008 with the chief complaint of epileptic seizure more than once and checked their first EEG at the same hospital. The clinical findings of seizure were based on the charts and interictal waking and sleep EEGs were done. Results:The mean age of the patients was 6.7 years old. 497 epileptic seizures occurred and its clinical finding included 310 of partial seizures and 187 of generalized seizures. In 315 waking EEG 158 were abnormal including 118 of partial seizures, 59 of generalized seizures and 19 of both seizures, in 431 sleep EEG 239 were abnormal including 196 of partial seizures, 77 of generalized seizures and 34 of both seizures, and in waking and/or sleep EEG 273 were abnormal including 216 of partial seizures, 97 of generalized seizures and 40 of both seizures. Epileptic syndromes were observed in 90 patients. 146(41.5%) of partial seizures, 44(23.4%) of generalized seizures, and 79(87.8%) of epileptic syndromes accorded with EEG. Conclusion:When diagnosing seizures in children, we must consider not only clinical findings but also accurate EEG findings.
( Sung Bae Cho ),( Jong Min Lee ),( Hyeon Hui Kang ),( Hwa Sik Moon ),( Sang Haak Lee ) 대한결핵 및 호흡기학회 2014 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.118 No.-
Background: Recent researches suggest that chronic obstructive pulmonary disease (COPD) is associated with an increased risk of peptic ulcer disease, but limited data exist on affecting factors in COPD patient with peptic ulcer disease on gastroduodenoscopy. Methods: We retrospectively reviewed medical records on 237 COPD patients who performed gastroduodenoscopy in 2003-2013. Patients were divided into two groups accordingly: peptic ulcer (gastric and/or duodenal ulcer) group and non-ulcerative disease group. Statistical analyses were performed with the logistic regression model to obtain the factors affecting peptic ulceration in COPD patients, controlling confounding factors. Results: The prevalence of peptic ulcer disease was 99 of 237 COPD patients (41.7%) and a male sex had a positive association with peptic ulcer disease (odds ratio[OR], 2.270, 95% confidence interval[CI], 1.189 to 4.332). There was independent relationships between the presence of peptic ulcer disease and both liters of predicted forced expiratory volume in 1s (FEV1) (OR, 0.407, 95% CI, 0.229 to 0.724) and liters of functional vital capacity (FVC) (OR, 1.029, 95% CI, 1.011 to 1.048). Smoking status and corticosteroids, known risk factors of peptic ulcer disease in general population, did not showed expected affect on peptic ulceration. Conclusions: Our findings provide further evidence that COPD is associated with peptic ulcer disease and there is an increased risk for peptic ulcer associated with COPD severity.
Sung, Jin-Hee,Cho, Eun-Hae,Cho, Jae-Hyeon,Won, Chung-Kil,Kim, Myeong-Ok,Koh, Phil-Ok The Society ; Maruzen Co. [distributor] 2012 The Journal of veterinary medical science Vol.74 No.11
<P>Ferulic acid plays a neuroprotective role in cerebral ischemia. The aim of this study was to identify the proteins that are differentially expressed following ferulic acid treatment during ischemic brain injury using a proteomics technique. Middle cerebral artery occlusion (MCAO) was performed to induce a focal cerebral ischemic injury in adult male rats, and ferulic acid (100 mg/kg) or vehicle was administered immediately after MCAO. Brain tissues were collected 24 hr after MCAO. The proteins in the cerebral cortex were separated using two-dimensional gel electrophoresis and were identified by mass spectrometry. We detected differentially expressed proteins between vehicle- and ferulic acid-treated animals. Adenosylhomocysteinase, isocitrate dehydrogenase [NAD(+)], mitogen-activated protein kinase kinase 1 and glyceraldehyde-3-phosphate dehydrogenase were decreased in the vehicle-treated group, and ferulic acid prevented the injury-induced decreases in these proteins. However, pyridoxal phosphate phosphatase and heat shock protein 60 were increased in the vehicle-treated group, while ferulic acid prevented the injury-induced increase in these proteins. It is accepted that these enzymes are involved in cellular metabolism and differentiation. Thus, these findings suggest evidence that ferulic acid plays a neuroprotective role against focal cerebral ischemia through the up- and down-modulation of specific enzymes.</P>
The trend of prevalence of pain in Korea from 2005 to 2016
Cho, Sang-Hyeon,Kim, Yong-Min,Lee, Jae-Ho,Kim, Hyun-Soo,Song, Jae-Seok The Korean Pain Society 2020 The Korean Journal of Pain Vol.33 No.4
Background: Korean society is afflicted with rapid aging. Aging is a risk factor for pain, and pain can reduce patients' quality of life. Thus, adequate management and monitoring of changing trends accompanying the demographic shift are highly valuable. However, this study was conducted because no studies have investigated the recent changes in the prevalence of pain. Methods: The extent of the prevalence of pain was determined by questions related to quality of life based on the data derived from the Korea National Health and Nutrition Survey (KNHNS) from 2005 to 2016. The annual frequencies of the pain group and severe pain group were calculated using the survey questionnaire. Multiple logistic regression analysis was performed to determine possible differences in prevalence by year. Results: The prevalence of pain in all populations was 30.6% in 2005 and 18.9% in 2016. The average prevalence from 2005 to 2016 was 21.9%. A declining trend occurred over time with an odds ratio of 0.929 per year (95% CI: 0.921-0.938). The prevalence of severe pain was 2.35% in 2005 and 1.88% in 2016. Likewise, a decrease was observed over time, with an odds ratio of 0.920 per year at 95% CI 0.901-0.939. The decline in age-/sex-stratified analysis also showed a statistically significant trend in all groups. Conclusions: The prevalence of pain in Korean society, based on the KNHNS, has declined since 2005. Such a trend was observed in all ages and sexs, and was most significant in the elderly.
Hot corrosion behavior of magnesia-stabilized ceramic material in a lithium molten salt
Cho, Soo-Haeng,Kim, Sung-Wook,Kim, Dae-Young,Lee, Jong-Hyeon,Hur, Jin-Mok Elsevier 2017 JOURNAL OF NUCLEAR MATERIALS Vol.490 No.-
<P><B>Abstract</B></P> <P>The isothermal and cyclic corrosion behaviors of magnesia-stabilized zirconia in a LiCl-Li<SUB>2</SUB>O molten salt were investigated at 650 °C in an argon atmosphere. The weights of as-received and corroded specimens were measured and the microstructures, morphologies, and chemical compositions were analyzed by scanning electron microscopy, X-ray energy dispersive spectroscopy, and X-ray diffraction. For processes where Li is formed at the cathode during electrolysis, the corrosion rate was about five times higher than those of isothermal and thermal cycling processes. During isothermal tests, the corrosion product Li<SUB>2</SUB>ZrO<SUB>3</SUB> was formed after 216 h. During thermal cycling, Li<SUB>2</SUB>ZrO<SUB>3</SUB> was not detected until after the completion of 14 cycles. There was no evidence of cracks, pores, or spallation on the corroded surfaces, except when Li was formed. We demonstrate that magnesia-stabilized zirconia is beneficial for increasing the hot corrosion resistance of structural materials subjected to high temperature molten salts containing Li<SUB>2</SUB>O.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Corrosion mechanism of MSZin LiCl-Li<SUB>2</SUB>O molten salt is proposed. </LI> <LI> Formation of Li<SUB>2</SUB>ZrO<SUB>3</SUB>is main corrosion mechanism. </LI> <LI> There were no cracks, pores and spallation after corrosion test. </LI> <LI> MSZ shows high corrosion resistance to LiCl-Li<SUB>2</SUB>O molten salt. </LI> </UL> </P>
The functional study of O-GlcNAcylated nucleocytoplasmic O-GlcNAc Transferase
Hyeon Gyu Seo,Sang Yoon Park,Jin Won Cho 한국당과학회 2008 한국당과학회 학술대회 Vol.2008 No.1
It has been reported that one downstream effector produced from glucose is uridine diphosphate-N-acetly glucosamine (UDP-GlcNAc) via the hexoamine biosynthetic pathway (HBP). The dynamic cycle of addition and removal of O-linked-N-acetlyglucosamine (O-GlcNAc) to Ser/Thr residues is involved in regulating nuclear and cytoplasmic proteins. Nucleocytoplasmic O-linked GlcNAc transferases(ncOGT) which add a single GlcNAc to hydroxyl groups of serine and threonine residues. ncOGT is characterized by an amino terminuns bearing tetratricopeptide repeats (TPR), possible nuclear trafficking motifs, and a catalytic domain within its C-terminus. Interestingly, O-GlcNAc glycosylation occurs in nucelocytoplsmic O-linked GlcNAc transferase (ncOGT) as well and several sites have been identified mainly within TPR domain. We found O-GlcNAcylated site in ncOGT outside of TPR by using Q-TOF MS. Now we focus on the activities and function of ncOGT by mutagenesis studies. This ongoing effort would give us clear understanding of the key enzyme of O-GlcNAc metabolism and how the O-GlcNAc modification may be regulated.