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( Tae Seok Lim ),( Yoon Yung Chung ),( Woo Chul Chung ),( Ji Min Lee ),( Seok Jong Lee ),( Dae Bum Kim ),( Dae Young Cheung ),( Kang Moon Lee ),( Sung Soo Kim ),( Jin Il Kim ),( Jae Kwang Kim ),( Seun 대한내과학회 2013 대한내과학회 추계학술대회 Vol.2013 No.1
Background/Aims: Vascular endothelial growth factor (VEGF) the key mediator of angiogenesis, also plays an important role in the progression of gastric cancer. VEGF over-expression is associated with advanced stage and poor survival in gastric cancer. Several studies suggested the association between VEGF polymorphism and risk of gastric cancer, but the results remained still inconclusive. We investigated to determine whether there is an association between the VEGF polymorphism and advanced gastric cancer in Korean population. Methods: The association of functional single nucleotide polymorphism (SNP) of the VEGF gene with stomach cancer development was evaluated in a case-control study. A total of 150 patients with advanced gastric cancer(stage III, IV) diagnosed at St. Vincent Hospital, Suwon,Catholic University of Korea, from January 2010 to January 2013 were enrolled in this study. The control group consisted of 433 individuals who were randomly selected through health screening with esophago-gastroduodenoscopy. Genotypes were determined by polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP) analysis. Results: In advanced gastric cancer, the genotype frequencies of VEGF-936 C>T polymorphism were 64.7% (CC type, 97/ 150), 32.0% (CT, 48/ 150) and 3.3% (TT, 5/ 150), respectively. C allelic frequency of VEGF gene was 80.7%, whereas T allelic frequency was 19.3%. Compared with the control group, there were no significant differences of specific genotype and allelic frequencies(p=0.88, p=0.58). Conclusions: VEGF gene -polymorphism is not associated with advanced gastric cancer risk in Korean populations.
박지상(Park, Ji-Sang),정상수(Cheung, Sang-Su),정재한(Chung, Jae-Han),조성민(Cho, Sung-Min),김태욱(Kim, Tae-Wook) 한국신재생에너지학회 2008 신재생에너지 Vol.4 No.3
The objective of this study is to develop and validate a compressed hydrogen storage system for fuel cell vehicles. The type3 composite cylinder consists of full wrapped composites on a seamless aluminum liner. The key technologies, including design, analysis, and optimized fabrication process for 350bar composite cylinder, were established and verified, and the facilities for fabrication and validation testing have been constructed. Prototype cylinders were fabricated and validated through burst test and ambient cycling test in accordance with international standard.