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Ha, Eun Jin,Gwak, Ho-Shin,Rhee, Chang Hun,Youn, Sang Min,Choi, Chang-Woon,Cheon, Gi Jeong The Korean Neurosurgical Society 2013 Journal of Korean neurosurgical society Vol.54 No.3
Objective : Intracavitary injection of beta-emitting radiation source for control of cystic tumors has been tried with a benefit of localized internal radiation. The authors treated cystic brain tumor patients with Holmium-166-chitosan complex (Ho-166-chico), composed of a beta-emitting radionuclide Holmium-166 and biodegradable chit polymer, and evaluated the safety and effective measurement for response. Methods : Twenty-two patients with recurrent cystic brain tumor and/or located in a deep or eloquent area were enrolled in this pilot study. The cyst volume and wall thickness were determined on CT or MRI to assess radiological response. The activity of Ho-166-chico injected via Ommaya reservoir was prescribed to be 10-25 Gy to the cyst wall in a depth of 4 mm. Results : There was neither complications related to systemic absorption nor leakage of Ho-166-chico in all 22 patients. But, two cases of oculomotor paresis were observed in patients with recurrent craniopharyngioma. Radiological response was seen in 14 of 20 available follow-up images (70%). Seven patients of 'evident' radiological response experienced more than 25% decrease of both cyst volume and wall thickness. Another 7 patients with 'suggestive' response showed decrease of cyst volume without definitive change of the wall thickness or vice versa. All patients with benign tumors or low grade gliomas experienced symptomatic improvement. Conclusion : Ho-166-chico intracavitary radiation therapy for cystic tumor is a safe method of palliation without serious complications. The determination of both minimal effective dosage and time interval of repeated injection through phase 1 trial could improve the results in the future.
High-precision quality assurance of robotic couches with six degrees of freedom
Cheon, Wonjoong,Cho, Junsang,Ahn, Sung Hwan,Han, Youngyih,Choi, Doo Ho NUCLITAL S.R.L. GRUPPO NUCLETRON HOLDING-OLANDA 2018 PHYSICA MEDICA Vol.49 No.-
<P>The mean error and standard deviation of linear and rotational motions, as well as couch sagging were analyzed from continuously acquired images in the moving couch. The accuracy of VTS was 0.024 mm deviation for the sinusoidal motion, and the accuracy of the transformation matrix was 0.02 mm. In a cross-comparison, the difference between Laser Tracker (FARO) measurements was 0.14 +/- 0.12 mm for translation and 0.032 +/- 0.026 degrees on average for yaw rotation. The new system provides QA of yaw, pitch and roll motion as well as sagging of the couch and sub-millimeter/degree accuracy together with precision.</P>
Fabrication and Characterization of Alumina/Silver Nanocomposites
Cheon, Seung-Ho,Han, In-Sub,Woo, Sang-Kuk The Korean Ceramic Society 2007 한국세라믹학회지 Vol.44 No.7
Alumina/silver nanocomposites were fabricated using a soaking method through a sol-gel route to construct an intra-type nanostructure. The pulse electric-current sintering (PECS) technique was used to sinter the nanocomposites. Several specimens were annealed after sintering. The microstructure, mechanical properties, critical frontal process zone (FPZ) size, and thermo-mechanical properties of the nanocomposites were estimated. The relative densities of the specimens sintered at 1350 and $1450^{\circ}C$ were 95% and 99%, respectively. The maximum value of the three-point bending strength was found to be 780 MPa for the $2{\times}2{\times}10 mm$ specimen sintered at $1350^{\circ}C$. The fracture toughness of the specimen sintered at $1350^{\circ}C$ was measured to be $3.60 MPa{\cdot}m^{1/2}$ using the single-edge V-notched beam (SEVNB) technique. The fracture mode of the nanocomposites was transgranular, in contrast to the intergranular mode of monolithic alumina. The fracture morphology suggested that dislocations were generated around the silver nanoparticles dispersed within the alumina matrix. The specimens sintered at $1350^{\circ}C$ were annealed at $800^{\circ}C$ for 5 min, following which the maximum fracture strength became 810 MPa and the fracture toughness improved to $4.21 MPam^{1/2}$. The critical FPZ size was the largest for the specimen annealed at $800^{\circ}C$ for 5 min. Thermal conductivity of the alumina/silver nanocomposites sintered at $1350^{\circ}C$ was 38 W/mK at room temperature, which was higher than the value obtained with the law of mixture.
( Sang Hyok Lim ),( Hong Woo Cheon ),( Ho Sung Lee ),( Jae Sung Choi ),( Ki Hyun Seo ),( Yong Hoon Kim ),( Ju Ock Na ) 대한내과학회 2013 대한내과학회 추계학술대회 Vol.2013 No.1
Metastatic squamous cell carcinoma of intrathoracic lymph node with cancer of unknown primary (CUP) is very rare. We report a case of metastatic squamous cell carcinoma of hilar lymph node with CUP and review of the associated literatures. Abnormal mass in the right hilar was incidentally detected. The patient was performed a right pneumonectomy and mediastinal lymph node dissection. Microscopically, metastatic squamous cell carcinoma at hilar lymph nodes without primary lung or other lesion was diagnosed. He has currently been received adjuvant chemotherapy under diagnosis of T0N1M0 Lung cancer.
Structure-Activity Relationship Studies of Isoquinolinone Type Anticancer Agent
Cheon, Seung Hoon,Park, Joon Suck,Lee, Joon Yeol,Lee, You Na,Yi, Hyo,Chung, Byung-Ho,Choi, Bo-Gil,Cho, Won-Jea,Choi, Sang-Un,Lee, Chong-Ock 전남대학교 약품개발연구소 2001 약품개발연구지 Vol.10 No.-
Substituted isoquinolin-1 -ones (1) were synthesized to test their in vitro anticancer activity. 3-Biphenyl-N-methylisoquinolin-1-one (7) showed the most potent anticancer activity against five different human cancer cell lines.
A New Rice Variety Adaptable to Late Planting with High Quality, "Mananbyeo"
Sang Jong Lim,Jong Rae Kang,Byong Geun Oh,No Bong Park,Un Sang Yeo,Sae Jun Yang,Ho Yeong Kim,Hung Goo Hwang,Yon Cheon Song,Do Yeon Kwark,Woon Goo Ha,Jae Ki Chang,Jeom Sig Lee 한국육종학회 2003 한국육종학회지 Vol.35 No.1
Mananbyeo was developed from a three way cross ilyang110/Yeongdeog7//Milyang110 in 1999. It has short growing duration about 71 days from seeding to heading and short culm length of 75 cm. It has almost similar number of panicles per hill , spikelets per
춘천지역 모유 중 폴리브롬화디페닐에테르(PBDEs)의 이성체별 분포특성과 노출경로
Sung-Ug We(위성욱),In-Cheon Baek(백인천),Sang-Ah Park(박상아),Seong-Hoon Kang(강성훈),Yu-Jin Cho(조유진),Bong-Hui Cho(조봉회),Cho-Hee Yoon(윤조희),Ki-Ho Kim(김기호),Byung-Yoon Min(민병윤) 한국생명과학회 2010 생명과학회지 Vol.20 No.3
본 연구는 비교적 청정한 지역인 춘천시에 거주하는 일반인 모유 중 PBDEs의 노출 경로를 확인하기 위해 처음으로 시도된 연구이다. 본 연구지역의 모유 중 ∑PBDEs의 수준은 북아메리카지역에 비하여 낮은 수준이었으나 일부 아시아, 유럽국가와 유사하였다. 모유 내 PBDEs의 축적은 산모의 특성과 상관관계가 나타나지 않았으나, 상업용 PBDEs 제품을 포함하여 여러 복합적 인자에 의하여 노출되고 있었으며, 식품 섭취와 같은 식이노출은 한국인에 있어 중요한 노출 경로의 하나로 판단되었다. 따라서 본 연구 결과는 한국인의 PBDEs 노출 경로 파악에 중요한 정보를 제공하여, 장차 PBDEs 및 관련 브롬계 난연제의 노출에 따른 인체 위해성 평가를 수행함에 있어 중요한 참고자료가 될 것이다. 또한, 한국 내의 PBDEs에 대한 인체노출 경로를 명확하게 하기 위한 연구는 계속적으로 이루어져야 할 것이다. This study was carried out to investigate the exposure pathway of PBDEs in human breast milk collected from new mothers residing in Chuncheon, a comparatively clean area in Korea. The congeners of PBDE in 22 human breast milk samples were analyzed using a high resolution gas chromatography with a high resolution mass detector. The residue level of ΣPBDEs was higher in primipara subjects than in multipara subjects (p<0.05). The levels in this study were similar to those of people in some Asian and European countries, but were lower than those of people in north America. In the congener profiles, BDE-47 (mean contribution=36.1%) was predominant, followed by BDE-153 (27%), BDE-99 (11.7%), BDE-100 (11.1%), BDE-28 (7.9%) and BDE-183 (3.5%). The sum of BDE-47 and BDE-153 accounted for more than 50% of ΣPBDEs in most samples. BDE-47 was highly correlated with ΣPBDEs (r=0.94, p<0.001). No strong trend was observed between PBDE levels and a number of key biological factors (women’s age, weight, height and body mass index) examined in this study, however, weak correlations were observed in PBDE levels measured against dietary habits, particularly in fish consumption frequency. It seems that Korean people might be exposed to multiple sources including products of PBDEs, and particularly food resources.