Development and in vitro/in vivo evaluation of loxoprofen extended release tablets

KIM Tae Hwan,SEO Won Sik,CHOI Jin Ho,SHIN Jeong Cheol1. KIM Min Gi. YOO Sun Dong. SHIN Beom Soo 대한약학회 2012 大韓藥學會 總會 및 學術大會 Vol.2012 No.1

Subcutaneous emphysema related to dental procedures

Cheol Hee Jeong,Seung kyu Yoon,Seung Won Chung,Jae Young Kim,Kwang Ho Park,Jong Ki Huh 대한구강악안면외과학회 2018 대한구강악안면외과학회지 Vol.44 No.5

Objectives: The objective of this study was to analyze 11 cases of subcutaneous emphysema associated with dental procedures from a single hospital and discuss approaches for accurate diagnosis and treatment of the condition. Materials and Methods: The medical records of 11 patients who were treated for subcutaneous emphysema related to dental procedures between January 2009 and April 2017 were analyzed retrospectively. Patients with subcutaneous emphysema within the facial area or that spread to the neck and beyond, including the facial region, were assigned to two groups and compared in terms of age, sex, and durations of antibiotic use, hospitalization, and follow-up until improvement. The correlation between location of the origin tooth and range of emphysema spread was analyzed. Results: The average durations of antibiotic use during conservative treatment and follow-up until improvement were 8.55 days (standard deviation [SD], 4.46 days) and 1.82 weeks (SD, 1.19 weeks), respectively. There was no intergroup difference in duration of antibiotic use (P=0.329) or followup (P=0.931). Subcutaneous emphysema was more common after dental procedures involving the maxilla or posterior region than after those involving the mandible or anterior region. There was no significant difference in air distribution according to location of the air orifice (maxilla, mandible, or both; P=0.106). Conclusion: Upon adequate conservative treatment accompanied by prophylactic antibiotic treatment considering the risk of infection, patients showed signs of improvement within a few days or weeks. There was no significant difference in treatment period between patients with subcutaneous emphysema localized to the facial region and those with subcutaneous emphysema spreading to the neck or beyond. These findings need to be confirmed by analysis of additional cases.

A SIMULATION ON EFFICIENCY OF CIRCULATING FLUIDIZED-BED CO₂ CAPTURE PROCESSES DIFFERENT IN SCALE

Jeong-Hoo Choi,A-Reum Jeong,Yoo-Sube Won,Chang-Keun Yi,Sung-Ho Jo,Young Cheol Park 한국신재생에너지학회 2014 AFORE Vol.2014 No.-

Studies on the Toxicity and Distribution of Indium Compounds According to Particle Size in Sprague-Dawley Rats

Cheol Hong Lim,Jeong-Hee Han,Hae-Won Cho,Mingu Kang 한국독성학회 2014 Toxicological Research Vol.30 No.1

Objectives: The use of indium compounds, especially those of small size, for the production of semiconductors, liquid-crystal panels, etc., has increased recently. However, the role of particle size or the chemical composition of indium compounds in their toxicity and distribution in the body has not been sufficiently investigated. Therefore, the aim of this study was to examine the effects of particle size and the chemical composition of indium compounds on their toxicity and distribution. Methods: Male Sprague-Dawley rats were exposed to two different-sized indium oxides (average particle sizes under 4,000 nm [IO_4000] and 100 nm [IO_100]) and one nano-sized indium-tin oxide (ITO; average particle size less than 50 nm) by inhalation for 6 hr daily, 5 days per week, for 4 weeks at approximately 1 mg/㎥ of indium by mass concentration. Results: We observed differences in lung weights and histopathological findings, differential cell counts, and cell damage indicators in the bronchoalveolar lavage fluid between the normal control group and IO- or ITO-exposed groups. However, only ITO affected respiratory functions in exposed rats. Overall, the toxicity of ITO was much higher than that of IOs; the toxicity of IO_4000 was higher than that of IO_100. A 4-week recovery period was not sufficient to alleviate the toxic effects of IO and ITO exposure. Inhaled indium was mainly deposited in the lungs. ITO in the lungs was removed more slowly than IOs; IO_4000 was removed faster than IO_100. IOs were not distributed to other organs (i.e., the brain, liver, and spleen), whereas ITO was. Concentrations of indium in the blood and organ tissues were higher at 4 weeks after exposure. Conclusions: The effect of particle size on the toxicity of indium compounds was not clear, whereas chemical composition clearly affected toxicity; ITO showed much higher toxicity than that of IO.

Collaborative Filtering for Credit Card Recommendation based on Multiple User Profiles

Won Cheol Lee(이원철),Hyoup Sang Yoon(윤협상),Seok Bong Jeong(정석봉) 한국산업경영시스템학회 2017 한국산업경영시스템학회지 Vol.40 No.4

Collaborative filtering, one of the most widely used techniques to build recommender systems, is based on the idea that users with similar preferences can help one another find useful items. Credit card user behavior analytics show that most customers hold three or less credit cards without duplicates. This behavior is one of the most influential factors to data sparsity. The ‘cold-start’ problem caused by data sparsity prevents recommender system from providing recommendation properly in the personalized credit card recommendation scenario. We propose a personalized credit card recommender system to address the cold-start problem, using multiple user profiles. The proposed system consists of a training process and an application process using five user profiles. In the training process, the five user profiles are transformed to five user networks based on the cosine similarity, and an integrated user network is derived by weighted sum of each user network. The application process selects k-nearest neighbors (users) from the integrated user network derived in the training process, and recommends three of the most frequently used credit card by the k-nearest neighbors. In order to demonstrate the performance of the proposed system, we conducted experiments with real credit card user data and calculated the F1 Values. The F1 value of the proposed system was compared with that of the existing recommendation techniques. The results show that the proposed system provides better recommendation than the existing techniques. This paper not only contributes to solving the cold start problem that may occur in the personalized credit card recommendation scenario, but also is expected for financial companies to improve customer satisfactions and increase corporate profits by providing recommendation properly.

RISER PRESSURE DROP OF DIFFERENT SCALE CIRCULATING FLUIDIZED-BEDS CAPTURING CO₂ FROM FLUE GAS

Jeong-Hoo Choi,Pil-Snag Youn,A-Reum Jeong,Yoo-Sube Won,Chang-Keun Yi,Sung-Ho Jo,Young Cheol Park 한국신재생에너지학회 2014 AFORE Vol.2014 No.-

Region-wise evaluation of gamma-ray exposure dose in decontamination operation after a nuclear accident

Jeong, Hae Sun,Hwang, Won Tae,Han, Moon Hee,Kim, Eun Han,Lee, Jo Eun,Lee, Cheol Woo Korean Nuclear Society 2021 Nuclear Engineering and Technology Vol.53 No.8

The gamma-ray exposure doses in decontamination operation after a nuclear accident were evaluated with a consideration of various geometrical conditions and specific gamma-ray energies. The calculation domain is organized with three residence types and each form is divided into two kinds of geometrical arrangements. The position-wise air KERMA values were calculated with an assumption of evenly distributed gamma-ray source based on Monte Carlo radiation transport analysis using the MCNP code. The radioactivity is initially set to be unity to be multiplied by the deposition value measured in the actual accident condition. The workforce data set depending on the target object was determined by modifying the Fukushima report. The external exposure doses for decontamination workers were derived from the calculated KERMA values and the workforce analysis. These results can be used to efficiently determine the workforce required by the characteristics of the area and the structure to be decontaminated within the dose limits.

Poster Session : PS 0337 ; Hematology : Treatment of Primary Testicular Diffuse Large B Cell Lymphoma without Prophylactic Intrathecal Chemotherapy: A Single Center Experience

( Jeong Seok Kim ),( Dok Hyun Yoon ),( In Keun Park ),( Shin Kim ),( Jung Sun Park ),( Sang Wook Lee ),( Joor Yung Huh ),( Chan Sik Park ),( Cheol Won Suh ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

Background: Primary testicular diffuse large B-cell lymphoma (DLBCL) is a kind of rare but aggressive extranodal lymphoma. Relapse in central nervous system (CNS) is majorconcerns in the treatment of primary testicular DLBCL. However, the role of intrathecal prophylaxis is still controversial issue. Methods: We retrospectively reviewed the medical records of 14 patients with primary testicular DLBCL diagnosed between November 2000 and June 2012. We analyzed CNS relapse rate in the patients treated without intrathecal prophylaxis. Survival curves were estimated using the Kaplan-Meier method. Results: The median age at diagnosis was 57 years (range, 41-79 years). Unilateral testicular involvement was observed in 13 patients. Nine (64. 3%) patients were in stage I, 1 in stage II, and 4 in stage IV. The international prognostic index was low or low-intermediate risk in 12 patients, and high-intermediate risk in 2 patients. Thirteen patients underwent orchiectomy. All of the patients received systemic chemotherapy without intrathecal prophylaxis. And, prophylactic radiotherapy was administered to the contralateral testis in 12 patients. The median follow-up period of surviving patients was 39 months (10-139 months). Median overall survival had not been reached and median progression-free survival was 3. 8 years. Four patients experienced relapse, but CNS relapse was observed in only one patient (7. 1%) with stage IV disease at 27 months after a complete response. Conclusions: Even without intrathecal prophylaxis, the rate of relapse in the CNS appears not to be high in Korean patients with primary testicular DLBCL compared with prior reports.

Increased risk for subclinical atherosclerosis in subjects with high visceral adiposity index

( Jeong In Lee ),( Ji Hyun Kim ),( Eun Jin Han ),( Hye-jeong Park ),( Se Eun Park ),( Cheol-young Park ),( Won-young Lee ),( Ki-won Oh ),( Sung-woo Park ),( Eun-jung Rhee ) 대한내과학회 2015 대한내과학회 추계학술대회 Vol.2015 No.1

Background: Visceral adiposity index (VAI) is a mathematical model that uses simple anthropometric and functional parameters, proposed to reflect visceral adiposity and insulin resistance. Recent studies report the association of VAI with cardiovascular events. We analyzed the association of VAI with coronary artery calcium score (CACS) in Korean adults. Methods: In 33,468 participants in a health screening program, VAI was calculated with the following formula: [waist circumference (WC)/{36.58+(1.89 * body mass index (BMI))}] * (triglyceride/0.81) * (1.52/HDL-C). Coronary artery calcium score was measured with multi-detector computed tomography. Other metabolic parameters were measured. Results: Mean age of the subjects was 42 years old. Age, BMI, blood pressure, WC, fasting blood glucose, insulin, lipid profiles showed positive correlation, and HDL-C showed negative correlation with VAI. CACS showed positive correlation with VAI (r=0.027, p<0.01). Subjects with CACS>0 had worse metabolic parameters compared as subjects with CACS=0. Subjects with CACS>0 showed significantly higher VAI compared as those with CACS=0 (2.05±1.92 vs. 1.68±1.50, p<0.01). In logistic regression analyses with CACS>0 as the dependent variable, the highest tertile of VAI (>1.777) showed significantly increased odds ratio for CACS>0 compared with the lowest tertile (<0.967) even after adjustment for confounding variables {1.160 (1.015-1.327)}. Conclusions: The subjects with high VAI showed increased risk for subclinical atherosclerosis assessed by CACS.

The Predictive Parameters of Erythropoietin Hyporesponsiveness in Patients on Continuous Ambulatory Peritoneal Dialysis

(Jeong Ki Kim),(Byoung Seok Park),(Mi Jung Park),(Won Choi),(Seong Kwon Ma),(Myong Yon Nah),(chung Ho Yeum),(Kwon Jung),(Seong Cheol Lee),(Soo Wan Kim),(Nam Ho Kim),(Young Joon Kang),(Ki Chul Choi) 대한내과학회 2001 The Korean Journal of Internal Medicine Vol.16 No.2

N/A Background : The present study was aimed at investigating the predictive parameters of erythropoietin (epoetin) hyporesponsiveness in patients on continous ambulatory peritoneal dialysis (CAPD). Methods : We studied 40 patients with end-stage renal disease who had been receiving CAPD for at least 6 months and epoetin therapy for at least more than 2 months. Pearson’s simple correlation and multiple stepwise linear regression analysis was used to discover what parameter can predict epoetin resistance. We expressed epoetin resistance index (ERI) as ‘weekly epoetin dose/hematocrit/ body weight’. The dose of epoetin is titrated by about 25% every 2 to 4 weeks to maintain a target hematocrit level between 33% and 36%. Results : We analyzed the relationship between ERI and other predictive parameters by Pearson’s correlation. These results showed ERI has a statistically significant correlation with transferrin saturation (TS) (r=-0.327, p=0.042), total weekly Kt/Vurea (r=-0.423, p=0.018), serum albumin level (r=-0.458, p= 0.003), normalized protein catabolic rate (nPCR) (r=-0.479, p=0.006), normalized protein equivalent of total nitrogen appearance (nPNA) (r=-0.488, p=0.005) and serum C-reactive protein (CRP) (r=0.332, p=0.036). Regression analysis was performed using stepwise linear regression for multiple variables to discover the most independent variable which is correlated with ERI. ERI was entered as a dependent variable, whereas the other parameters (age, duration of peritoneal dialysis, serum albumin level, CRP, serum ferritin, total weekly Kt/Vurea, nPCR, nPNA, serum iPTH, serum aluminium, TS) were entered as independent variables. This analysis showed CRP is the most significant variable and, if CRP is excluded, nPNA is the significant variable. CRP has a statistically significant correlation with serum albumin level (r=-0.418, p=0.007) and total weekly Kt/Vurea (r=-0.366, p=0.043). High CRP group has more increased level of ERI (p<0.05), age (p<0.05) and serum creatinine level (p<0.05) than normal control, but more decreased level of serum albumin (p<0.01) and serum iron levels (p<0.05). Conclusion : These results indicate that CRP is the most important predictor of epoetin hyporesponsiveness.