정신장애 환자의 심리사회적 문제사정 도구개발

김창곤,유수현,이혜원,채정호 大韓神經精神醫學會 2008 신경정신의학 Vol.47 No.4

Objeetives : There have been no consistent reliable and valid tool for examining the psychosocial problems for the patients with mental disorders in Korea. The purpose of the present study is to develop a scale that examine the psychosocial problems for the patients with mental disorders and to test its reliability and validity. Methods : To identify the psychosocial problems for 1,100 patients with mental disorders were selected in university hospitals and professional training institutes. And the items of the psychosocial problems were taken from them and divided them into individual and environmental categories. The representative items were established among these items of psychosocial problems and a questionnaire for a pilot study was made based on the representative items. The pilot study was done for 306 patients with mental disorders using the questionnaire to investigate reliability of the questionnaire. After the pilot study items and format of the questionnaire were revised and complemented. The revised questionnaire was given to 600 patients with mental disorders to test its validity and reliability and new scale for psychosocial problems was developed. Results : At the pilot study, which was performed with 1,100 patients, 3,200 items of psychosocial problems of 205 types were selected. Among these items 78 representative psychosocial problems items were withdrawn. Fifty-eight psychosocial problem items were finally set for the questionnaire after discussing them with the expert groups and examining its content reliability. Forty-seven psychosocial problems items were finally selected and given to 306 subjects at the pilot study. At the main study in which 600 subjects were tested inner-reliability. Correlation between items and scale was relevant and correlation coefficient between test and retest was high. The finally developed psychosocial problems testing scales were consisted of 46 testing items into 9 areas. Conclusion : The Psychosocial Problems Assessment Scale, which were developed at this study is proved to be valid and reliable and it will be able to be used to examine overall psychosocial problems for the patients with mental disorders in Korea.

Clinical relevance of necrotizing change in patients with community‐acquired pneumonia

Seo, Hyewon,Cha, Seung‐,Ick,Shin, Kyung‐,Min,Lim, Jae‐,Kwang,Yoo, Seung‐,Soo,Lee, Jaehee,Lee, Shin‐,Yup,Kim, Chang‐,Ho,Park, Jae‐,Yong,Lee, Won‐,Kee BLACKWELL SCIENCE 2017 RESPIROLOGY Vol.22 No.3

<P><B>ABSTRACT</B></P><P><B>Background and objective</B></P><P>Few studies have analysed a large number of patients with necrotizing pneumonia (NP) diagnosed based on computed tomography (CT) scans. The aim of the present study was to document the incidence and clinical features of NP in patients with community‐acquired pneumonia (CAP).</P><P><B>Methods</B></P><P>This retrospective study was conducted on CAP patients who had been admitted to a tertiary referral centre and who had available enhanced CT scan images. Patients were allocated into NP and non‐NP groups, and they were compared with respect to various clinical variables.</P><P><B>Results</B></P><P>Of the 830 patients included in the present study, necrotizing change was observed in 103 patients (12%). Patients with NP experienced more symptoms of pneumonia, had higher blood levels of inflammatory markers and more often required pleural drainage compared to patients with non‐NP. Although the use of mechanical ventilation, vasopressor infusion, 30‐day mortality, in‐hospital mortality and clinical deterioration did not differ between the NP and non‐NP groups, the median length of hospital stay (LOS) was significantly longer in the NP group. Multivariate analysis using Cox proportional hazards model showed that necrotizing change independently predicted LOS in patients with CAP.</P><P><B>Conclusion</B></P><P>NP affects approximately one‐tenth of hospitalized CAP patients. It may be associated with more severe clinical manifestations and may increase the need for pleural drainage. NP was found to be an independent predictor of LOS, but not of mortality in CAP patients.</P>

Metabolic Engineering of Corynebacterium glutamicum for Co-production of L-Lysine and Heterologous Squalene Using CRISPR-Cas Systems

Hyewon CHANG,Jaehyun PARK,Han Min WOO 한국생물공학회 2023 한국생물공학회 학술대회 Vol.2023 No.4

Synergistic Hybrid Pathway for Enhanced Sustainable Biochemical Production and CO₂ Conversion

Hyewon CHANG,Hyunjeong LEE,Yubeen HEO,Hanmin WOO 한국생물공학회 2023 한국생물공학회 학술대회 Vol.2023 No.10

3~5세 연령별 누리과정과 교사용 지도서의 연계 분석 -"수학적 탐구하기" 를 중심으로-

장혜원 ( Hyewon Chang ),임미인 ( Miin Lim ),이화영 ( Hwayoung Lee ) 서울敎育大學校 初等敎育硏究所 2015 한국초등교육 Vol.26 No.2

본 연구는 누리과정의 수학적 탐구하기와 그에 따른 교사용 지도서의 연계성을 양방향으로 분석하여 향후 누리과정 개정 및 교사용 지도서 집필, 수정을 위한 시사점을 제안하는 것을 목적으로 한다. 분석 대상은 3~5세 연령별 누리과정에 따른 교사용 지도서 32권이며, 분석틀은 누리과정의 수학적 탐구하기의 세부 내용을 상세화, 구체화한 재구성 성취기준이다. 분석 내용은 누리과정 재구성 성취기준이 교사용 지도서에 모두 구현되었는지, 그 역방향으로 교사용 지도서의 수학 관련 활동이 재구성 성취기준의 범위를 벗어나지 않는지에 대한 분석의 두 가지이다. 각각에 대한 분석 결과를 제시하고, 그에 기초한 논의로부터 누리과정 개정 및 교사용 지도서 개발을 위한 시사점을 제안하면 다음과 같다. 첫째, 누리과정 재구성 성취기준 중 교사용 지도서에 적절히 구현되지 못한 요소가 발견되었으므로 이에 대한 조치가 요구되며, 교사용 지도서 집필시 누리과정의 의도를 명확히 전달할 수 있도록 누리과정 세부 내용의 구체화와 세분화를 제안한다. 또한 누리과정에서 제시한 연령과 일치하지 않는 다수의 지도서 활동은 교사용 지도서 집필시 연령별 발달 단계에 맞게 구성한 누리과정의 의도를 고려할 필요가 있다. 둘째, 교사용 지도서의 수학 관련 활동 중 누리과정을 벗어난 내용에 대해서는 유아의 수준을 고려한 검토를 제안한다. 셋째, 교사용 지도서의 수학 관련 활동 집필시 유아교육의 바탕이 되는 놀이 활동에 대한 심도 있는 고찰이 필요하다. 넷째, 누리과정 개정 및 교사용 지도서 집필시 다루는 대상이나 표현상의 일관성을 보완할 것을 제안한다. 다섯째, 교사용 지도서 활동의 유치원, 어린이집 적용을 통한 누리과정에의 피드백을 고려할 것이 요구된다. This study aims to suggest some didactical implications for revising curriculum for early childhood and its manuals based on the analysis on connection of Nuri curriculum for ages 3 to 5 and its manuals for teachers in the perspective of mathematics education. The methodology of this study is a kind of critical analysis of literature. We reviewed the domain which is called ‘mathematical exploration’ of Nuri curriculum and reconstructed its sub-contents for analyzing the manuals for teachers. We renamed them ‘reconstructed achievement criteria’ as a framework of analysis and applied them to analyze 32 manuals for teachers of Nuri curriculum for ages 3 to 5. The results of analyses show that there are a lot of poor connections between Nuri curriculum and its manuals for teachers. Therefore this study includes several suggestions based on the results. Firstly, considering poor connections between Nuri curriculum and its manuals for teachers, we have to take proper steps for the relevant elements. We also suggest refinement and actualization of sub-contents of Nuri curriculum. Secondly, math-related activities of the manuals for teachers which are beyond the range of Nuri curriculum need examinations in relation to the cognitive levels of young children. Thirdly, the disagreement of ages between Nuri curriculum and its manuals for teachers suggests that writers need to consider intentions of Nuri curriculum in relation to young children’s developmental phases when they write the manuals for teachers. Fourthly, we notice the needs for supplementing consistency of concepts or representations when revising Nuri curriculum and its manuals. Finally, we had better take a feedback from specific application of the manuals for teachers to many children.

구조감각의 관점에서 인수분해 과정의 인지적 특성 분석

장혜원 ( Hyewon Chang ),강정기 ( Jeonggi Kang ) 한국수학교육학회 2015 수학교육 Vol.54 No.4

Factorization asks the recognition of the structure of polynomials, compared to polynomial expansion with process characteristic. Therefore it makes students experience a lot of difficulties. This study aims to figure out causes of the difficulties by identifying students`` cognitive characteristics in factorizing in the perspective of ``structure sense``. To do this, we gave six factorizing problems of three types to middle school students and selected six participants as interviewees based on the test results. They were classified into two categories, structure sense and non-structure sense. Through this interview, we figured out the interviewee``s cognitive characteristics and the causes of difficulty in the perspective of structure sense. Furthermore, we suggested some didactical implications for encouraging structure sense in factorizing by identifying assistances and obstacles for recognition of structures.

초등수학교육에서 인공지능 활용의 실제 - 초등수학 수업지원시스템 ‘똑똑! 수학탐험대’를 중심으로-

장혜원 ( Chang Hyewon ),남지현 ( Nam Jihyun ) 서울교육대학교 초등교육연구원 2021 한국초등교육 Vol.31 No.특별호

오늘날 인공지능은 우리 사회 전반에서 키워드가 되었고, 교육 분야도 예외가 아니라 인공지능의 교육적 활용은 미래 교육의 대비에서 필수적인 논의라 하겠다. 본 연구는 국내 공교육 최초의 인공지능 활용 초등수학 수업지원시스템인 ‘똑똑! 수학탐험대’를 분석하고, 수학교육에서 인공지능 활용이 지향해야 할 방향에 대해 논의하는 것을 목적으로 한다. 이를 위해, ‘똑똑! 수학탐험대’의 이해 및 현장 적합성 탐색을 주요 내용으로 한다. ‘똑똑! 수학탐험대’는 학습 측면과 관리 측면에 해당하는 양 기능을 모두 포함하고 있으며, 탑재된 콘텐츠는 활용 주체에 따라 교사 주도적 활용 콘텐츠와 학생의 자율적 활용 콘텐츠로 구별할 수 있었다. 특히 ‘교과활동’ 및 ‘평가’ 콘텐츠의 경우 2015 개정 교육과정에 따른 교과서의 단원 및 차시에 따라 구성되어 있어 교실에서 유용하게 활용될 수 있을 것으로 판단된다. 또한 ‘인공지능 추천활동’은 학생의 진단 활동 결과를 기반으로 학생의 수준을 진단, 분석하여 학습 콘텐츠를 제공하는 것으로, 이를 통해 학습 데이터를 축적하고 축적된 데이터에 기초하여 학생 개인의 수준에 적합한 맞춤형 학습을 제공할 것이 기대된다. 한편, ‘똑똑! 수학탐험대’의 현장 적합성을 파악하고자 활용 경험이 있는 교사 3명을 대상으로 반구조화된 면담을 실시하였다. 면담 내용은 ‘똑똑! 수학탐험대’의 활용 정도, 콘텐츠 활용, 시스템의 전반적인 활용에 관한 것이다. 면담 분석 결과, 주로 각차시에서 학습한 개념이나 원리를 익히고 적용하는 시간에 교과서의 보조교재로서의 활용 빈도가 높은 것으로 나타났다. 가장 많이 사용한 콘텐츠는 ‘교과활동’이며, 가장 효과적인 콘텐츠로 ‘평가’, ‘교구’, ‘교과활동’을 꼽았다. 시스템의 가장 큰 장점으로 학생들이 흥미롭게 참여한다는 점, 수업시간 내내 학습이 지속적으로 이루어질 수 있다는 점을 들었다. 그러나 단순한 형태로 반복되는 콘텐츠, 복잡한 회원 가입 절차, 불안정한 시스템 등의 단점도 발견되어 보완이 필요하다고 하였다. 이러한 결과를 바탕으로 ‘똑똑! 수학탐험대’가 효과적인 수업 보조도구로 개선될 가능성을 제안하였다. 또한, 이를 위해 물리적 환경 구축 및 적극적 교사 연수가 필수적이며, 학교 현장의 실질적 요구인 평가와의 연계방안에 대한 고려 또한 필요함을 주장하였다. Nowadays, artificial intelligence(AI) has become a keyword in our society, and the educational use of AI requires essential discussions in preparation for future education. This study aims to analyze "Knock-knock! Math Expedition," the first AI based elementary mathematics class support system in Korea, and discuss where to the use of AI in math education. To this end, the main focus is on understanding the system "Knock-knock! Math Expedition" and exploring its suitability to school. "Knock-knock! Math Expedition" contains the functions in relation to both the learning and its management, and also the contents both teacher-led and students-driven. In particular, in the case of "math activity" and "evaluation" contents, their organization according to the textbooks under the 2015 revised curriculum can be useful in the classroom. In addition, “AI Recommendation Activity” diagnoses students' levels based on the results of their activities, which are expected to accumulate learning data and provide adaptive learning suitable for each student’s level. In order to figure out its suitability to school, semi-structured interviews were conducted for three teachers who had experience in using the system. The interview was about the method and frequency of utilization of "Knock-knock! Math Expedition", the use of contents, and the overall utilization of the system. The interview analysis showed that the frequency of use as auxiliary tools is high, the most used content was “math activity”, and the most effective contents were “evaluation”, “teaching instrument” and “math activity”. The biggest advantage of the system was students’ spontaneous participation. However, shortcomings such as repetition of simple exercises, complexity of membership procedures, and unstable systems were also found. Based on these results, we discussed the needs and possibility for improvement of the "Knock-knock! Math Expedition" as an effective teaching aid.

Impact of Genetic Variants in Immune Checkpoint Genes on Small Cell Lung Cancer: CD155 A67T and CD226 G307S were Associated with Clinical Outcome of the Patients

( Seung Soo Yoo ),( Jae Yong Park ),( Jang Hyuck Lee ),( Mi Jung Hong ),( Jin Eun Choi ),( Sun Ha Choi ),( Yong Hoon Lee ),( Hyewon Seo ),( Jaehee Lee ),( Shin Yup Lee ),( Seung Ick Cha ),( Chang Ho K 대한결핵 및 호흡기학회 2020 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.128 No.-

Background This study was conducted to investigate the impact of genetic variants in immune checkpoint genes on the treatment outcome of patients with small cell lung cancer (SCLC). Methods Two hundred sixty-one patients who treated with platinum doublet were enrolled. Ninety-six polymorphisms in 33 immune checkpoint related genes were selected and their association with chemotherapy response and overall survival were analyzed. Results Among polymorphisms studied, CD155 rs1058402G>A and CD226 rs763361C>T were significantly associated with the treatment outcome of SCLC. The rs1058402G>A had worse chemotherapy response and worse overall survival (under a dominant model, odds ratio [OR] = 0.52, 95% confidence interval [CI] = 0.27 - 0.99, P = 0.05; hazard ratio [HR] = 1.55, 95% CI = 1.12 - 2.14, P = 0.01, respectively). The rs763361C>T had better chemotherapy response and better overall survival (under a dominant model, OR = 2.03, 95% CI = 1.10 - 3.75, P = 0.02; HR = 0.69, 95% CI = 0.51 - 0.94, P = 0.02, respectively). When the rs1058402GA/AA and rs763361CC genotype were combined, the chemotherapy response and overall survival were significantly decreased as the number of bad genotypes increased (OR = 0.52, 95% CI = 0.33 - 0.81, Ptrend = 0.004; HR = 1.48, 95% CI = 1.19 - 1.84, Ptrend = 4 × 10-4, respectively). CD155 rs1058402G>A and CD226 rs763361C>T are both non-synonymous mutations and change the protein sequence CD155 A67T and CD226 G307S, respectively. 3D structural model showed that CD155 A67T created new hydrogen bond and structural change on CD155. These changes resulted in extending the distance and losing the hydrogen bonds between CD155 and CD226, thus would weaken the binding activity of CD155/ CD226. Conclusions CD155 rs1058402G>A (A67T) and CD226 rs763361C>T (G307S) may be useful for predicting the clinical outcome of SCLC after chemotherapy.

Carbon Monoxide Ameliorates 6-Hydroxydopamine-Induced Cell Death in C6 Glioma Cells

( Hyewon Moon ),( Jung-hee Jang ),( Tae Chang Jang ),( Gyu Hwan Park ) 한국응용약물학회 2018 Biomolecules & Therapeutics(구 응용약물학회지) Vol.26 No.2

Carbon monoxide (CO) is well-known as toxic gas and intrinsic signaling molecule such as neurotransmitter and blood vessel relaxant. Recently, it has been reported that low concentration of CO exerts therapeutic actions under various pathological conditions including liver failure, heart failure, gastric cancer, and cardiac arrest. However, little has been known about the effect of CO in neurodegenerative diseases like Parkinson’s disease (PD). To test whether CO could exert a beneficial action during oxidative cell death in PD, we examined the effects of CO on 6-hydroxydopamine (6-OHDA)-induced cell death in C6 glioma cells. Treatment of CO-releasing molecule-2 (CORM-2) significantly attenuated 6-OHDA-induced apoptotic cell death in a dose-dependent manner. CORM-2 treatment decreased Bax/Bcl2 ratio and caspase-3 activity, which had been increased by 6-OHDA. CORM-2 increased phosphorylation of NF-E2-related factor 2 (Nrf2) which is a transcription factor regulating antioxidant proteins. Subsequently, CORM-2 also increased the expression of heme oxygenase-1 and superoxide dismutases (CuZnSOD and MnSOD), which were antioxidant enzymes regulated by Nrf2. These results suggest that CO released by CORM-2 treatment may have protective effects against oxidative cell death in PD through the potentiation of cellular adaptive survival responses via activation of Nrf2 and upregulation of heme oxygenase-1, leading to increasing antioxidant defense capacity.

P-141 Clinical features of hospitalized adult patients with community-acquired pneumonia by chest computed tomographic findings

( Hyewon Seo ),( Seung-ick Cha ),( Seung-soo Yoo ),( Jaehee Lee ),( Shin-yup Lee ),( Chang-ho Kim ),( Jae-yong Park ) 대한결핵 및 호흡기학회 2017 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.124 No.-

Background: Data regarding the clinical and microbiologic features of community-acquired pneumonia (CAP) by computed tomography (CT) findings are limited. The aim of the present study was to investigate the clinical and microbiologic features of patients with mainly ground-glass opacity (GGO) or mainly centrilobular nodules or tree-in-bud pattern on CT scan. Methods: According to CT findings at presentation, hospitalized CAP patients were retrospectively classified into consolidation, GGO, and bronchiolitis groups, and the clinical parameters and causative agents were compared between the GGO or bronchiolitis and consolidation groups. Results: The incidences of the bronchiolitis and GGO groups were 2.4% (n=40) and 2.8% (n=46), respectively. The most common pathogen of the bronchiolitis group was Mycoplasma pneumoniae (16/37 [43%]). The bronchiolitis group was characterized by lower pneumonia severity index and lower blood levels of inflammatory markers. Compared with the consolidation group, the GGO group had no differences in pathogens, severity, and outcome variables. Complicated parapneumonic effusion or empyema did not occur in the bronchiolitis and GGO groups. Conclusions: The bronchiolitis group was characterized by a higher frequency of M. pneumoniae as a causative agent and a less severe form of CAP. The GGO group was similar to the consolidation with respect to the causative microorganisms, severity, and prognosis of CAP. None of the bronchiolitis and GGO groups exhibited complicated parapneumonic effusion or empyema.