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RISS 인기검색어
- 검색키워드
- 저자 : Byoung Doo Rhee (검색결과 118 건)
- 무료
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가열유와 Vitamin E 투여가 흰쥐의 혈청 GOT, GPT 및 Alkaline Phosphatase 활성에 미치는 영향
이순재,박미향,정병두 대구효성가톨릭대학교 응용과학연구소 1991 응용과학연구논문집 Vol.1 No.-
가열유 투여에 따른 흰쥐 간장 조직의 과산화적 손상에 대한 연구와 식이중 V-E의 수준에 따라 가열유로 인한 간장조직의 과산화적 손상에 대한 항산화적 방어현상을 관찰하기 위하여 열화된 가열유(산가 4.02, carbonyl value 27.9, peroxide value 52.7)를 하루 총열량의 10%을 그리고 dl-α-tocopheryl acetate의 양을 달리하여 (0, 40, 200mg/kg of diet : OH group, 40H group, 200 H group) tube feeding하면서 3, 6주간씩 사육하고 실험종료후 혈청을 얻어 GOT, GPT, alkaline phosphatase 활성변화를 관찰하였다. 1. 가열유를 투여한 식이군은 대조군에 비해 혈청 GOT, GPT, AL-pase 활성도가 높았다. 2. V-E가 결핍된 OH식이군이 대조군에 비해 GOT, GPT, ALP 활성이 가장 높았고, 40H, 200H순위로 V-E첨가 수준이 높을수록 비례하여 이를 효소활성이 감소하였다. 3. 가열유의 투여기간이 길어질수록 효소 활성이 전반적으로 상승되었다. In order to investigate the liver damage due to heated oil intake and the antioxidative effect of vitamin E on it, rats were fed for 3 and 6 weeks by intubating heated corn oil with acid value of 4.02 at the level of 10Ca% and three different levels of vitamin E : 0, 40 and 200 mg/kg diet. Control group was fed fresh corn oil and 40 mg/kg diet of vitamin E. After each feeding period, serum glutamic oxaloacetatic transaminase(GOT), glutamic pyruvic transaminase(GPT), and alkaline phosphatase(AL-pase) activities were measured. GOT, GPT and AL-pase activities were higher in heated oil groups than control group. As dietary vitamin E level was increased, GOT, GPT and AL-pase activities were decreased progressively. These phenomena were more remarkable in 6 weeks of feeding than 3 weeks.
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유리지방산이 원형질막 Na+ , K+ - ATPase 에 미치는 효과에 대한 알부민의 역할
이병두(Byoung Doo Rhee),임성희(Sung Hee Ihm),장학철(Hak Chul Jang),박경수(Kyong Soo Park),김성연(Seong Yeon Kim),조보연(Bo Youn Cho),이홍규(Hong Kyu Lee),고창순(Chang Soon Koh),민헌기(Hun Ki Min) 대한내과학회 1988 대한내과학회지 Vol.35 No.1
N/A There is increasing evidence that free fatty acids (FFA) inhibit the activity of plasma membrane Na+, K+-ATPase in vitro and thereby could be a control agent of metabolism. However, in several recent studies, physiological conclusion were drawn from the effect of FFA in systems in which albumin was absent. To explore the role of albumin in modulating the effect of FFA on the activity of this enzyme, the activities plasma membrane Na+, K+-ATPase were measured in the presence of various concentrations of FFA and/or albumin. 1) The activities of Na+, K+-ATPase in the presence of 4% bovine serum albumin (BSA) were inhibited by oleic and linoleic acid at concentrations ranging from 0.05 to 2.0mM. 2) The inhibitory effects of oleic acid at each concentration on the activities of Na+, K+-ATPase were increased as the concentration of BSA was decreased from 4% to 0%. 3) The activities of Na+, K+-ATPase were not inhibited when the FFA to albumin molar ratio was less than 1.0 but were inhibited to less than 50% when the ratio exceeded 3.5. The above results shows that, in vitro, the activities of plasma membrane Na+, K+-ATPase are inhibited by unsaturated FFA and albumin has a protective role on this inhibition. This suggests that in vivo unsaturated FFA could be a regulator of cellular metabolism by inhibition of Na+, K+-ATPase under the pathologic condition in which the FFA to albumin molar ratio is increased markedly.
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