Acitretin으로 치료된 다발성 거대각질가시세포종 1예

권은선 ( Eun Sun Kwon ),이경근 ( Kyoung Geun Lee ),고병용 ( Byoung Yong Koh ),명기범 ( Ki Bum Myung ),정승현 ( Seung Hyun Cheong ) 대한피부과학회 2017 대한피부과학회지 Vol.55 No.4

Giant keratoacanthoma is an uncommon variant of keratoacanthoma, which may increase to a diameter of several centimeters. Although keratoacanthomas usually resolve spontaneously, giant keratoacanthoma can be invasive and destructive. A 49-year-old man presented with a 5-year history of multiple large hyperkeratotic and crusted plaques and nodules on sun-exposed areas such as the face, ear, hand, and forearm. Some lesions involuted spontaneously, whereas others became rather enlarged. The biopsy specimen revealed horn-filled crater formation, epidermal extending resembling a buttress, and an eosinophilic glassy appearance in the keratinocytic cytoplasm. We treated the lesions with acitretin, and they almost completely resolved after 13 weeks. Here we describe a case of multiple giant keratoacanthoma treated with acitretin. (Korean J Dermatol 2017;55(4):249∼252)

水平環狀空間의 熱傳達에서 隔板의 影響

權純錫,李範澈,鄭漢植 東亞大學校 大學院 1988 大學院論文集 Vol.13 No.-

A numerical study have been performed onthe effects of spacers on the heat transfer across a horizontal annulus under basic conditions; Ra=10⁴,Pr=0.7 D??/D??=2.6, K??K=48, ??/D??=0.06 and Nu??=122.5. The mode of heat transfer in the annulus is changed from conduction to convection at Ra??10³. The maximum dimensionless temperature districution along (r-r??)/L at Θ=50?? are founded for vertical spacers but at Θ=120??, for horizontal spacers, and the minimum dimensionless temperature distribution along (r-r??)/L at Θ=50?? are founded for horizontal spacers but Θ=120??, for no spacers. The maximum dimensionless angular velocity at Θ=50??, at (r-r??)/L??0.2 near the inner tube and at(r-r??)/L??0.8 near the outer cylinder but at Θ=120??, it shows at (r-r??)L??0.15 near the inner tube and at (r-r??)L??0.7 for no spacers and vertical spacers and at (r-r??)/L??0.8 for horizontal spacers near the outer cylinder. Finally, the heat transfer by natural convection in the plain annulus is maximum but in the annulus with horizontal spacers in munimum.

실내사무환경의 환경성담배연기(ETS)의 지표물질에 관한 연구

하권철,백남원,박동욱,윤충식,김원,최상준,박지영,최인자,김신범,강태선 한국산업위생학회 2003 한국산업보건학회지 Vol.13 No.2

The purpose of this research is to evaluate indoor office environment using the concentrations of nicotine, 3-enthenyl-pyridine(3-EP), and respirable suspended particulate(RSP), which are indicators for environmental tobacco smoke(ETS) and the correlations between indicators and environmental conditions(smoking density, smoking index). The mean air charge per hour (ACH) in smoking rooms was 10.4 and most of the smoking rooms showed non-compliance withe ASHRAE standard value except only one smoking rooms. The concentrations of RSP, 3-EP, nicotine showed log=normal distributions, and became different statistically depending on smoking condition(p〈0.01). The geometric mean concentration of RSP in smoking room was 441.7 ug/㎡ that is far exceeded environmental standard(150 ug/㎡). This implies that fine particulate in smoking room should be carefully controlled considering smoking density and ventilation fate. The mean concentrations of nicotine and 3-EP were 93.4 ug/㎥, respectively. The correlation coefficients between RSP and SI, 3-EP and SI, and Nicotine and SI were 0.67, 0.84 and 0.74, respectively. The correlation coefficient between nicotine and 3-EP, nicotine and RSP, and RSP and 3-EP were 0.76,0.78 and 0.57 respectively.

1. 06㎛ Nd : YAG Laser를 이용한 요추간판탈출증의 경피적 수핵감압술

이흥선,변박장,최순관,신원한,권귀향,이인수,이경석,김범태 순천향대학교 1994 논문집 Vol.17 No.4

The 1.06㎛ Neodymium-YAG Laser(800 micron hemisherical) is revealed a useful tool for percutaneous laser disc decompression(PLDD). Especially PLDD would be applied to the management of lumbar disc herniation with minimal intervention. Total irradiated energy to one level of disc space was bout 1000 to 2000 joules. We performed this method at 10 levels, in 7 cases of patients, consisting of 4 males and 3 females with an average age of 37.7 years. Five cases showed excellent and good results, were observed. In two cases, open surgery was required because of unsatisfactory results. The best results were obtained in the protrusion type of disc herniation. We have summarized some advantages of PLDD: a) safe and simple procedure in an outpatient setting, b) avoiding general anesthesia, late spinal instability, c) possibility of repetitive use.

재발된 전신성 Cryptococcosis 1례

이정권,정순환,김연옥,이상범,권건영 최신의학사 1982 最新醫學 Vol.25 No.11

상온재생 유화아스팔트 개질 혼합물의 배합방법 및 특성에 관한 실험적 연구

박승범,권혁준,이봉춘,김선용 충남대학교 산업기술연구소 1999 산업기술연구논문집 Vol.14 No.2

Recently, the quantities of waste asphalt concrete at construction sites have much increased greatly, but maintaining a filling-up and final disposal place is a difficult problem. Therefore, we are faced with a worsening environmental problem brought about present illegal measures. One of the most effective recycling method is cold recycling. This method will satisfies treatment and recycling of construction waste is a very important question in the preservation of environmental and natural resources. So, in this paper, we dealt cold recycling modified mixtures using emulsified asphalt to concern the effect of adding reclaimed asphalt concrete 30, 40, 50%, and using SBR Latex for modified mixtures.

Seborrheic keratosis like lichen planus-like keratosis

( Byoung Yong Koh ),( Eun Sun Kwon ),( Seung Hyun Cheong ),( Ki Bum Myung ) 대한피부과학회 2015 대한피부과학회 학술발표대회집 Vol.67 No.1

Lichen planus-like keratosis consists of non-pruritic solitary papule or slightly indurated plaque with smooth or verrucous surface. It has brown to erythematous color and occurs predominantly on sun-exposed trunk and upper extremities of adult between the 5th and the 7th decades. A 51-year-old woman presented with about 1 cm x 1 cm sized solitary slightly indurated and pigmented plaque on left forearm with onset of early adulthood. At first visit, our impression was seborrheic keratosis, because it showed sharply demarked brownish plaque with verrucus surface. For definitive diagnosis, skin punch biopsy was done and the epidermis showed focal parakeratosis, hyper granulosis and a few necrotic keratinocytes. Lichenoid infiltrate of lymphocytes obscured the dermoepidermal junction. Small number of plasma cells and solar elastosis were found in the upper dermis. Clinically, lichen planus-like keratosis is confused with seborrheic keratosis. For differential diagnosis, histologic study is necessary. Characteristic histologic features of lichen planus-like keratosis are focal parakeratosis, necrotic keratinocyte and lichenoid infiltration. Although clinical feature of her skin lesion was confused with seborrheic keratosis, histologic findings were consistent with lichen planus-like keratosis. We report a case of seborrheic keratosis like lichen planus-like which is clinically apt to be misdiagnosed with seborrheic keratosis.

隔板을 가진 水平環狀空間에서 自然對流에 관한 實驗的 硏究

鄭泰鉉,金善政,李範澈,權純錫 동아대학교 공과대학 부설 한국자원개발연구소 1988 硏究報告 Vol.12 No.2

Natural convection from a horizontal annulus with spacers has been studied on the effects of Rayleigh numbers and position of spacers by experimental method. In case of vertical spacers, the maximum local Nusselt number appears at θ=150° in a conducting tube and θ=30° in a cylinder. The local spacer Nusselt numbers show positive values on the lower spacer, but negative values on the upper spacer. In case of horizontal spacers, the flow over the spacer is more active than that of under the spacer as the Rayleigh number increase. The maximum local Nusselt number appears at θ=180° In a tube and at θ=0° in a cylinder. The local spacer Nusselt number show positive values on the upward surface of spacer, but negative values on the downward surface of spacer. The mean tube Nusselt numbers and mean cylinder Nusselt numbers with vertical spacer are increased 11% And 2.7%, respectively by those of horizontal spacer.

P026 : Oxidative damage and Nrf2 (Nuclear factor erythroid 2-related factor 2) protein expression in normal skin and keloid tissues

( Sun Bum Kwon ),( Ye Seul Kim ),( Euy Hyun Chung ),( Sung Yul Lee ),( Young Lip Park ),( Moon Kyun Cho ) 대한피부과학회 2014 대한피부과학회 학술발표대회집 Vol.66 No.2

Background: Reactive oxygen species (ROS) play an important role in apoptosis induction under pathologic conditions. Recently, a significant increase in ROS generation and disrupted apoptosis mechanism in keloids has been reported. Nuclear factor erythroid 2-related factor 2 (Nrf2) represents one of the most important cellular defense mechanism against oxidative stress. Objectives: To compare Nrf2 protein expression in normal skin tissues to that in keloid tissues. Methods: ROS generation in keloid tissues was evaluated with oxyblot analysis. Western blots and immunohistochemical staining were used to study expression of Nrf2 in keloid and normal skin tissues. Cellular fractionation was performed to examine subcellular distribution of Nrf2. Transfection of fibroblast with Nrf2-specific siRNA was conducted to find the relationship between Nrf2 expression and apoptosis. Results: Protein oxidation increased in keloid tissues. In Western blot analysis, Nrf2 was clearly downregulated in keloid tissues. Immunohistochemical staining of Nrf2 confirmed the results of Western blot analysis. In Nrf2-specific siRNA transfection assay, increased apoptosis and decreased cell viability were found. Conclusion: Collectively, our data indicate that Nrf2 expression was down-regulated in keloid tissue, and that Nrf2 is involved in the development of apoptosis in siRNA transfected fibroblasts. We suggest that a defective antioxidant system and apoptotic dysregulation may participate in keloid pathogenesis.

Dermal duct tumor occurred on knee

( Sun Bum Kwon ),( Kyung O Kim ),( Euy Hyun Chung ),( Moon Kyun Cho ),( Jong Suk Lee ),( Sang Hoon Lee ) 대한피부과학회 2015 대한피부과학회 학술발표대회집 Vol.67 No.1

Dermal duct tumor (also known as intradermal acrospiroma) is a very rare cutaneous adnexal neoplasm which is a benign proliferation of the eccrine dermal duct. It usually affects elderly female. It commonly occurs on head & neck, and appears as flesh-colored or erythematous, firm nodule or papule measuring up to 2cm in diameter. A 53-year-old Korean female patient had asymptomatic, slowly growing nodule on right knee for 2 years. Physical examination revealed a solitary, non-tender, firm, reddish protruding nodule and the lesion was non-ulcerative and 1.5 × 1.0 × 0.5 cm in size. Complete excisional biopsy was taken and histological examination showed several tumor nodules entirely located in dermis. Tumor nodules consisted of nest of uniform cuboidal cells with round basophilic nuclei, lightly basophilic cytoplasm. Focal ductal differentiation was found in tumor nest and the ductal lumina showed high reactivity in PAS stain. In immunohistochemical stain with S-100 and CEA, the tumor cell showed negative result, while surrounding normal eccrine glands showed positive result. Based on these findings, the lesion was confirmed as a dermal duct tumor. Dermal duct tumor occurred on limb has been rarely reported, so we present the case of dermal duct tumor occurred on knee.