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논문(論文) : 과학기술사적 관점에서 바라본 4 체액설(體液說)과 사상의학(四象醫學)이론 체계의 비교 연구
백진웅 ( Jin Ung1 Baek ) 대한한의학원전학회(구 대한원전의사학회) 2012 대한한의학원전학회지 Vol.25 No.3
Objective : This study was conducted to compare Sasang Constitutional Medicine (SCM) and Four Humor Theory (FHT). Method : 1. The theoretical comparison was focused on the central pillars of both theories, i.e., the theories of Hippocrates and his successor Galenos as well as Lee Je-ma. 2. Research papers on SCM and FHT were collected as follows. First, relevant papers were searched for using several electronic databases: Pubmed (http://www.pubmed.org.), NDSL (http://www.ndsl.kr/index.do), KISS (http://kiss.ksstudy.com), and RISS (http://www.riss4u.net.). Keywords were ``Sasang``, ``constitution``, ``constitutional medicine``, ``humor theory``, ``Hippokrates``, ``Galenos``, and "Dongeuisusebowon".In addition, relevant papers were searched for using the websites of The Korean Society for the History of Medicine(http://medhist.kams.or.kr), The Korean society of Oriental medical classics (http://www.wonjeon.or.kr), The Society of Sasang Constitutional Medicine (http://www.esasang.or.kr/new_home/main.htm),and The Korean Association of Oriental Medical Physiology (http://www.ksomp.or.kr). As a result, a total of 32 papers were included in the final selection. Result & Conclusion : In this study, a comparison was made between FHT and SCM in terms of physiology, pathology and therapy. We showedthat the theories share similarities as well as differences. However, in a practical sense, the two should be characterized based on their differences rather than their similarities. In conclusion, the two have something in common, but overall, they are remarkably different from each other.
『東醫寶鑑』 處方의 약재 용량 분석을 통한 四象方 적응증 확장 연구 Ⅱ
백진웅(Jin-Ung Baek),이병욱(Byung-Wook Lee) 한국의사학회 2013 한국의사학회지 Vol.26 No.2
Objectives : The purpose of this study is to extend indications of Four-Constitution Medicinal formulas by comparing with formulas on Dongeuibogam(東醫寶鑑), focusing on their composition. Methods : 1. We analyzed the composition of Four-Constitution Medicine formula which are mentioned on Donguisusebowon(東醫壽世保元), focusing on their composition. 2. We analyzed the composition of formulas on Dongeuibogam(東醫寶鑑) comparing with 24 formulas for So-Eum type, 17 formulas for So-Yang type, 24 formulas for Tae-Eum type, 2 formulas for Tae-Yang type. Results & Conclusions : 1. We finally selected 14 formulas and its effect as similar formulas with Bojungyikgi-tang, Insamjinpi-tang, Cheongunggyeji-tang, Palmulgunja-tang, Hwanggigyejibuja-tang, Hwanggigyeji-tang for So-Eum type. 2. We finally selected 4 formulas and its effect as similar formulas with Dokwaljihwang-tang, Sukjihwanggosam-tang for So-Yang type.
백진웅(Jin-ung Baek),신상우(Sang-woo Shin),이병욱(Byung-wook Lee) 한국한의학연구원 2011 한국한의학연구원논문집 Vol.17 No.3
Through analyzing the frequencies of medicinal herb combinations in the prescriptions of "Wenbingtiaobian(溫病條辨)", we could understand the characteristics of prescription composition and author's medical thoughts. So we conducted this study that analyze combination of 258 medicinal herbs in 206 prescriptions, and found meaningful combinations of 700. Among these, the most meaningful combinations are the two of 8 herbs. One consists of Glycyrrhiza uralensis Fischer, Platycodon grandiflorum, Lonicera japonica Thunberg, Sojae Semen Praeparatum, Mentha piperascens (Malinv.) Holmes, Forsythia suspensa, Phyllostachys nigra var henonis, Schizonepeta tenuifolia var. japonic, the other consists of Glycyrrhiza uralensis Fischer, Platycodon grandiflorum, Lonicera japonica Thunberg, Mentha piperascens (Malinv.) Holmes, Forsythia suspensa, Arctium lappa, Phyllostachys nigra var henonis, Schizonepeta tenuifolia var. japonica. The former is Yeonkyo-san without Arctium lapp, the letter is Yeonkyo-san without Sojae Semen Praeparatum. It means these combinations are kind of modified Yeonkyo-san which is effective in outthrustting through the exterior with pungent-cool and clearing heat and detoxify. In conclusion, prescriptions of "Wenbingtiaobian(溫病條辨)" involve herbs mostly used to outthrust through the exterior with pungent-cool and clear heat and detoxify. Through this study, we know the author' s one of medical view points on outthrustting through the exterior with pungent-cool and clearing heat and detoxify.
『방약합편(方藥合編)』 수록(收錄) 처방(處方) 내(內)의 약물(藥物) 조합 빈도(頻度) 연구
백진웅 ( Jin Ung Baek ),이병욱 ( Byung Wook Lee ) 대한한의학원전학회(구 대한원전의사학회) 2011 대한한의학원전학회지 Vol.24 No.4
Through analyzing the frequencies of medicinal herb combinations in the prescriptions of 『Bangyakhappyeon(方藥合編)』, we could understand the characteristics of prescription composition and author`s medical thoughts. So we conducted this study that analyze combination of 324 medicinal herbs in 467 prescriptions, and found meaningful combinations of 5,045. Among these, the most meaningful combination is the one of 10 herbs, Glycyrrhiza uralensis Fischer, Angelica gigas Nakai, Ziziphus jujube Mille, Atractylodes japonica Koidzumi, Poria cocas Wolf, Zingiber officinale, Rehmanniae radix preparata, Cinnamomum loureirii, Panax ginseng C.A.Meyer, Astragalus membranaceus. This combination is Sibjeondaebo-tang(Shiquandabu-tang) without Cnidium officinale and Paeonia japonica which compose Samul-tang(Siwu-tang). It means this combination is kind of modified Sibjeondaebo-tang(Shiquandabu-tang), which is more effective in tonifying qi than tonifying blood. Prescriptions of 『Bangyakhappyeon(方藥合編)』 involve herbs mostly used to improve weak and frail health and the herbs which are more effective in tonifying qi than tonifying blood. Through this study, we know the author`s one of medical view points on tonifying qi and blood, attaching importance to tonifying qi relatively to tonifying blood.
요오드 -β- 시클로덱스트린 포접 복합체의 제조 및 안정성
지웅길,박경래,박목순,백명기,박진규 한국약제학회 1995 Journal of Pharmaceutical Investigation Vol.25 No.3
To increase the solubility of iodine and iodine releasing agents, which are used widely as a topical broad spectrum antiseptics and disinfectant sanitizers, its inclusion complexes were prepared and studied. Inclusion complexes of iodine with β-cyclodextrin were prepared by coprecipitation method and complex formation was acertained by differential scanning calorimetry and microscopic observation. Iodine content of inclusion complex was determined by means of iodometry. Tablets containing inclusion complex were manufactured with sugar, citric acid. magnesium stearate, dextrose. Stability of inclusion complexes and tablets was evaluated by accelerated stability test, and comparing with PVP-iodine. During preparation, use of 50% ethanol solution is preferable to water as the medium because theformer resulted in more stable complex for a month under accelerated storage conditions. Solubility of iodine in KI aqueous solution was 0.048 g/㎖ and lower than in 50% ethanol solution. Inclusion complex and its tablets were very stable at severe condition for one month, and comparable to PVP-iodine in the aspect of stability. Inclusion complex tabletswere not affected with citric acid, sugar, dextrose, and direct tableting method was recommendable because wet granulation using ethanol gave some release of included iodine during process.
『동의보감(東醫寶鑑)』을 이용한 『동의수세보원(東醫壽世保元)』 수록(收錄) 사상방(四象方)의 적응증(適應證)확장에 관한 연구(硏究) -보중익기탕(補中益氣湯)을 예(例)로 들어-
홍진우 ( Jin Woo Hong ),이명렬 ( Myeong Ryeol Lee ),이병욱 ( Byung Wook Lee ),백진웅 ( Jin Ung Baek ) 대한한의학원전학회(구 대한원전의사학회) 2011 대한한의학원전학회지 Vol.24 No.3
『Donguisusebowon(東醫壽世保元)』 doesn`t have pretty large quantity of contents, so indications of Four-Constitution Medicine formulas on that medical book are small. Therefore, indications of Four-Constitution Medicine formula need to be extended for broader clinical use of Four-Constitution Medicine. There would be some methods to do that, and we could review the literatures that Four-Constitution Medicine formulas are based on. We reviewed Bojungyikgi-tang on 『Dongeuibogam (東醫寶鑑)』, and we found that if the Four-Constitution Medicine formula is based on Sanghan formula(傷寒方) or non-classical formula(後世方), it is worth adding more indications of base formulas to those of Four-Constitution Medicine formula. For exmaple, Indications of Bojungyikgi-tang for So-Eum type could be extended by indications of non-classical formula(後世方) Bojungyikgi-tang and modified formula(加減方) Bojungyikgi-tang on Dongeuibogam, We supposed 23 indications of non-classical formula(後世方) Bojungyikgi-tang, and 20 indications of modified formula(加減方) Bojungyikgi-tang as possible indications of Bojungyikgi-tang for So-Eum type.
요오드-β-시클로덱스트린 포접 복합체의 제조 및 안정성
지웅길,박경래,박목순,백명기,박진규 충남대학교 약학대학 의약품개발연구소 1995 藥學論文集 Vol.11 No.-
To increase the solubility of iodine and iodine releasing agents, which are used widely as a topical broad spectrum antiseptics and disinfectant sanitizers, its inclusion complexes were prepared and studied. Inclusion complexes of iodine with β-cyclodextrin were prepared by coprecipitation method and complex formation was acertained by differential scanning calorimetry and microscopic observation. Iodine content of inclusion complex was determined by means of iodometry. Tablets containing inclusion complexwere manufactured with sugar, citric acid, magnesium stearate, dextrose. Stability of inclusion complexes and tablests was evaluated by accelerated stability test, and comparing with PVP-iodine. During preparation, use of 50% ethanol solution is preferable to water as the medium because theformer resulted in more stable complex for a month under accelerated storage conditions. Solubility of iodine in KI aqueous solution was 0.048 g/㎖ and lower than in 50% ethanol solution, Inclusion complex and its tablets were very stable at severe condition for one month, and comparable to PVP-iodine in the aspect of stability. Inclusion complex tabletswere not affected with citric acid, sugar, dextrose, and direct tableting method was recommendable because wet granulation using ethanol gave some release of included iodine during process.