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Jong-Ku Lee,Hyeon-Gyeong Choi,Jae-Yeop Kim,Juhyun Nam,Hee-Tae Kang,Sang-Baek Koh,Sung-Soo Oh 대한직업환경의학회 2016 대한직업환경의학회지 Vol.28 No.-
Background: This study was conducted to check whether self-resilience, one of the characteristics known to affect the occurrence of post-traumatic stress disorder (PTSD) symptoms after experiencing traumatic events, could serve as a protective factor for police officers whose occupational factors are corrected. Methods: We conducted a cross-sectional study in which 112 male police officers in Gangwon Province participated. They visited the Wonju Severance Christian Hospital Occupational Environment Center for medical check-ups from June to December 2015. Their general characteristics were identified using structured questionnaires, and they were asked to fill in the Korean Occupational Stress Scale-Short Form (KOSS-SF). Further, the Center for Epidemiologic Studies-Depression Scale (CES-D), Connor–Davidson Resilience Scale-Korean (CD-RI-K), and Impact of Event Scale-Revised-Korean version (IES-R-K) were used to evaluate their job stress, depression, self-resilience, and PTSD symptoms. Logistic regression analysis was conducted to correct their personal, occupational, and psychological factors to analyze the relationship between self-resilience and PTSD symptoms. Results: Among 112 respondents who experienced a traumatic event, those with low self-resilience had significantly higher rate of PTSD symptoms than those with high self-resilience even after correcting for the covariate of general, occupational, and psychological characteristics (odds ratio [OR] 3.51; 95 % CI: 1.06–19.23). Conclusions: Despite several limitations, these results suggest that a high degree of self-resilience may protect police officers from critical incident-related PTSD symptoms.
( Jong Ki Lee ),( Jin Gyeong Cho ),( Myoung Chong Song ),( Jong Su Yoo ),( Dae Young Lee ),( Hye Joung Yang ),( Kyung Min Han ),( Dong Hyun Kim ),( Young Jun Oh ),( Tae Sook Jeong ),( Nam In Baek ) 한국응용생명화학회 2009 Applied Biological Chemistry (Appl Biol Chem) Vol.52 No.6
The dried and powdered tubers of Corydalis turtschaninovii (C. turtschaninovii) were extracted with 80% aqueous MeOH, and the concentrated extracts were partitioned using the acidity and polarity of the solvents. From the alkaloid fraction, nine alkaloids were isolated through repeated SiO2 column chromatography. Based on NMR, MS and IR spectroscopic data, the chemical structures of the compounds were determined to be (±)-demethylcorydalmine (1), (+)-isocorydine (2), (+)-stylopine (3), (-)-α-N-methylcanadine (4), pseudoprotopine (5), tetrahydroprotopapaverine (6), allocryptopine (7), berberine (8), and pseudocoptisine (9). This was the first report in which compounds 1, 2, 4, 6, and 7 were isolated from the tuber of C. turtschaninovii. And because the NMR data for some compounds have been incorrectly or incompletely identified in previous literature, they were revised on the basis of 2D NMR experiments. Compounds 1, 2, and 3 showed inhibition activity on LDL oxidation with IC50 values of 2.1±0.2, 2.4±0.1, and 2.0±0.2 μM, respectively, which are higher activities than that of the positive control, probucol (6.8±0.1 μM).
Do-Gyeong Lee,박지해,유기현,정인식,이윤형,Jong-Ki Lee,Dae-Seok Han,조승목,Nam-In Baek 한국응용생명화학회 2011 Applied Biological Chemistry (Appl Biol Chem) Vol.54 No.2
Fucosterol (2), oxygenated fucosterol, 24-ethylcholesta-4,24(28)-dien-3,6-dione (3), β-sitosterol (1), and daucosterol (4) were isolated from ethyl acetate (EtOAc) fraction of Osmanthus fragrans var.aurantiacus flower by repeated silica gel, octadecyl silica gel, and Sephadex LH-20 column chromatography. The sterol structures were determined based on spectroscopic methods including nuclear magnetic resonance, infrared spectroscopy, fast atom bombardment mass spectrometry, and electron ionization mass spectrometry. Fucosterol (2), oxygenated fucosterol, and 24-ethylcholesta-4,24(28)-dien-3,6-dione (3) are representative sterols mainly isolated from marine algae, but rarely found in land plants. This is the first reported isolation of these sterols from O.fragrans var. aurantiacus. Interestingly, the oxygenated fucosterol (3) isolated inhibited the in vitro growth of the HCT-116 human colon cancer cell line with higher cytotoxic effects than doxorubicin, a well-known cytotoxic drug.
Lee, Jong-Ki,Cho, Jin-Gyeong,Song, Myoung-Chong,Yoo, Jong-Su,Lee, Dae-Young,Yang, Hye-Joung,Han, Kyung-Min,Kim, Dong-Hyun,Oh, Young-Jun,Jeong, Tae-Sook,Baek, Nam-In The Korean Society for Applied Biological Chemistr 2009 Applied Biological Chemistry (Appl Biol Chem) Vol.52 No.6
The dried and powdered tubers of Corydalis turtschaninovii (C. turtschaninovii) were extracted with 80% aqueous MeOH, and the concentrated extracts were partitioned using the acidity and polarity of the solvents. From the alkaloid fraction, nine alkaloids were isolated through repeated $SiO_2$ column chromatography. Based on NMR, MS and IR spectroscopic data, the chemical structures of the compounds were determined to be (${\pm}$)-demethylcorydalmine (1), (+)-isocorydine (2), (+)-stylopine (3), (-)-${\alpha}$-N-methylcanadine (4), pseudoprotopine (5), tetrahydroprotopapaverine (6), allocryptopine (7), berberine (8), and pseudocoptisine (9). This was the first report in which compounds 1, 2, 4, 6, and 7 were isolated from the tuber of C. turtschaninovii. And because the NMR data for some compounds have been incorrectly or incompletely identified in previous literature, they were revised on the basis of 2D NMR experiments. Compounds 1, 2, and 3 showed inhibition activity on LDL oxidation with $IC_{50}$ values of $2.1{\pm}0.2$, $2.4{\pm}0.1$, and $2.0{\pm}0.2\;{\mu}M$, respectively, which are higher activities than that of the positive control, probucol ($6.8{\pm}0.1\;{\mu}M$).
( Do Gyeong Lee ),( Ji Hae Park ),( Ki Hyun Yoo ),( In Sik Chung ),( Youn Hyung Lee ),( Jong Ki Lee ),( Dae Seok Han ),( Sueng Mock Cho ),( Nam In Baek ) 한국응용생명화학회 2011 Applied Biological Chemistry (Appl Biol Chem) Vol.54 No.2
Fucosterol (2), oxygenated fucosterol, 24-ethylcholesta-4,24(28)-dien-3,6-dione (3), β-sitosterol (1), and daucosterol (4) were isolated from ethyl acetate (EtOAc) fraction of Osmanthus fragrans var. aurantiacus flower by repeated silica gel, octadecyl silica gel, and Sephadex LH-20 column chromatography. The sterol structures were determined based on spectroscopic methods including nuclear magnetic resonance, infrared spectroscopy, fast atom bombardment mass spectrometry, and electron ionization mass spectrometry. Fucosterol (2), oxygenated fucosterol, and 24-ethylcholesta-4,24(28)-dien-3,6-dione (3) are representative sterols mainly isolated from marine algae, but rarely found in land plants. This is the first reported isolation of these sterols from O. fragrans var. aurantiacus. Interestingly, the oxygenated fucosterol (3) isolated inhibited the in vitro growth of the HCT-116 human colon cancer cell line with higher cytotoxic effects than doxorubicin, a well-known cytotoxic drug.
Do Gyeong Lee,Jin Sung Choi,Seung Woo Yeon,En Ji Cui,Hee Jung Park,Jong Su Yoo,In Sik Chung,Nam In Baek 한국응용생명화학회 2010 Journal of Applied Biological Chemistry (J. Appl. Vol.53 No.3
One secoiridoid glycoside was isolated from the EtOAc-soluble fraction of flowers of Osmanthus fragrans var. aurantiacus by repeated silica gel, octadecyl silica gel (ODS) and Sephadex LH-20 column chromatographies. It was identified as (8E)-ligstroside ba