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Chae, Sun Young,Choi, Chang-Min,Shim, Tae Sun,Park, Yangsoon,Park, Chan-Sik,Lee, Hyo Sang,Lee, Sang Ju,Oh, Seung Jun,Kim, Seog-Young,Baek, Sora,Koglin, Norman,Stephens, Andrew W.,Dinkelborg, Ludger M. Society of Nuclear Medicine 2016 The Journal of nuclear medicine Vol.57 No.1
<P>We explored system x(C)(-) transporter activity and the detection of inflammatory or infectious lesions using (4S)4-(3-F-18-fluoropropyl)-L-glutamate (F-18-FSPG) PET. Methods: In 10 patients with various inflammatory or infectious diseases, as many as 5 of the largest lesions were selected as reference lesions. F-18-FSPG images were assessed visually and quantitatively. Expression levels of xCT, CD44, and surface markers of inflammatory cells were evaluated by immunohistochemistry. Results: F-18-FSPG PET detected all reference lesions. F-18-FSPG uptake in sarcoidosis was significantly higher than that in nonsarcoidosis. The lesion-to-blood-pool SUV ratio for F-18-FSPG was comparable to that for F-18-FDG in sarcoidosis. In nonsarcoidosis, however, it was significantly lower. In 5 patients with available tissue samples, the SUVmax for F-18-FSPG and CD163 were negatively correlated (p = -0.872, P = 0.054). Conclusion: F-18-FSPG PET may detect inflammatory lesions when activated macrophages or monocytes are present, such as in sarcoidosis.</P>
18F-FDG PET/CT에서 우연히 관찰되는 구개편도의 비대칭적 섭취증가의 임상적 의의
채선영 ( Sun Young Chae ),백소라 ( So Ra Baek ),류진숙 ( Jin Sook Ryu ),문대혁 ( Dae Hyuk Moon ),김재승 ( Jae Seung Kim ) 대한핵의학회 2009 핵의학 분자영상 Vol.43 No.5
목적: 이 연구는 다양한 임상 적응증으로 시행된 전신 18F-FDG PET/CT 영상에서 구개편도의 비대칭적인 섭취증가의 발견빈도와 악성여부를 조사하고, 악성병변을 시사하는 임상 및 PET/CT 영상소견들을 알아보고자 하였다. 대상 및 방법: 1년 동안 18F-FDG PET/CT를 시행한 2,901명(평균연령 58.4±12.3세, 연령범위 20~88세, 남성:여성=1,841:1,060)의 PET/CT영상에서 구개편도의 비대칭적 섭취증가 여부 및 형태를 육안적으로 분석하였다. 구개편도에 비대칭적인 섭취증가를 보이는 빈도와 악성률을 조사하였고 관련된 임상적 소견 및 PET/CT 영상에서 동반된 이상소견과의 연관성을 평가하였다. 결과: 2,901명 중 10.0%(291명)에서 구개편도에 비대칭적인 섭취증가를 보였으며 겨울에 가장 빈번하게 관찰되었다(12.1%). 임상 추적관찰 혹은 조직학적 검사를 통해 최종적으로 악성여부가 확인된 209명 중 2.4%(5명)가 악성병변으로 진단되었고 불규칙한 두개편도의 섭취증가나 경부림프절의 섭취증가 소견이 동반된 경우, 원발미상의 경부림프절전이 환자에서 PET/CT를 시행한 경우 악성률이 높았다. 결론: 전신 18F-FDG PET/CT에서 우연히 관찰되는 구개편도의 비대칭적인 섭취증가는 대부분이 양성으로 악성률은 낮았다. 그러나 원발미상의 경부림프절 전이환자나 PET/CT에서 구개편도의 섭취증가가 불규칙할 경우에는 악성의 가능성이 높기 때문에 적극적인 조직학적 검사가 필요하리라 생각된다. Purpose: The aim of this study was to determine the incidence and malignant rate of incidental asymmetric palatine tonsillar uptake (ATU) on 18F-FDG PET/CT in various clinical indications and to evaluate the clinical and PET/CT findings suggesting malignancy. Materials and Methods: We retrospectively reviewed a total of 2,901 patients (58.4±12.3 yrs, range 20~88 yrs, M:F=1,841:1,060) who underwent 18F-FDG PET/CT during an 1-year period with various indications except primary tonsillar cancer and lymphoma evaluation. On 18F-FDG PET/CT, metabolic abnormality of the palatine tonsil and cervical lymph node were visually assessed. ATU was defined as increased palatine tonsillar uptake with diffuse, focal, or irregular pattern compared to contralateral side. The incidence and malignant ratio of ATU were evaluated according to clinical and PET/CT findings. Results: Of 2,901 cases, 290 (10.0%) showed ATU. The incidence of ATU showed seasonal variation and was high in the winter (12.1%). Of 209 cases with ATU confirmed pathologically and/or clinically, five (2.4%) were malignant lesions. ATU with irregular uptake pattern (2/2) and in cases referred for cervical lymph node metastasis of unknown origin (3/5) were frequently associated with malignant lesion (p<0.05). Conclusion: ATU was not infrequently observed on 18F-FDG PET/CT, and the malignant risk of ATU was low. However, ATU with cervical lymph node metastasis or with irregular pattern on PET/CT would be further evaluated by the histopathologic examination. (Nucl Med Mol Imaging 2009;43(5):402-410)
Laboratory Trials and Evaluations of In-Band Digital Radio Technologies: HD Radio and DRM+
Myung-Sun Baek,Park, S.,Geon Kim,Yong-Hoon Lee,Hyoung-Soo Lim,Yun-Jeong Song,Chae-Hun Im,Yong-Tae Lee IEEE 2013 IEEE transactions on broadcasting Vol.59 No.1
<P>Many countries are converting their analog communication and broadcasting services into digital services. However, digital radio broadcasting service is still an issue to be addressed. In order to provide digital radio broadcasting service, it is very important to choose the most appropriate digital radio method for their frequency environment and listeners. This paper depicts laboratory test results of in-band digital radio technologies, HD Radio and DRM+. To contribute to decision of digital radio standard and design of digital radio transmission network, various results of many test items are expressed.</P>
Performance Evaluation of DRM+ System in Laboratory Trials
Myung-Sun Baek,Sora Park,Yonghoon Lee,Geon Kim,Bo-mi Lim,Yun-Jeong Song,Chae-Hun Im,Yong-Tae Lee 한국방송·미디어공학회 2011 한국방송공학회 학술발표대회 논문집 Vol.2011 No.11
The DRM+ is the newest digital radio standard for in-band environment. Although various state of the art technologies are adopted, the performance evaluation information is not sufficient. It is hard that many countries and stations considering the DRM+ as their digital radio standard check the performance of DRM+. To evaluate the performance of the DRM+ system, this paper depicts the laboratory trial results of DRM+ standard. In the laboratory trial, the rack type DRM+ test bed is built. To reflect the practical broadcasting environment, various tests are executed. Many countries and stations can efficiently use these test results, which are considering converting their analog radio broadcasting to digital broadcasting.