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A Comparative Evaluation of the Anticancer Properties of European and American Elderberry Fruits
Mary Ann Lila,Julie M. Thole,Tristan F. Burns Kraft,Lilly Ann Sueiro,Young-Hwa Kang,Joell J. Gills,Muriel Cuendet,John M. Pezzuto,David S. Seigler 한국식품영양과학회 2006 Journal of medicinal food Vol.9 No.4
European elderberry (Sambucus nigra), recognized in Europe for its health-promoting properties for many gen-erations, is known to contain a range of anthocyanins, flavonoids, and other polyphenolics that contribute to the high antiox-idant capacity of its berries. American elderberry (Sambucus canadensis), on the other hand, has not been cultivated, bred,and promoted as a medicinal plant like its better-characterized European counterpart. In this study, aqueous acetone extractsof the berries from these two species were fractionated and tested in a range of assays that gauge anticarcinogenic potential.Both cultivated S. nigraand wild S. canadensisfruits demonstrated significant chemopreventive potential through strong in-duction of quinone reductase and inhibition of cyclooxygenase-2, which is indicative of anti-initiation and antipromotion prop-erties, respectively. In addition, fractions of S. canadensisextract showed inhibition of ornithine decarboxylase, an enzymemarker related to the promotion stage of carcinogenesis. Analysis of active fractions using mass spectrometry and liquid chro-matography-mass spectrometry revealed, in addition to flavonoids, the presence of more lipophilic compounds such assesquiterpenes, iridoid monoterpene glycosides, and phytosterols.
English as a Medium of Instruction : Challenges for Vietnamese Tertiary Lecturers
Nha T. T. Vu,Anne Burns 아시아영어교육학회 2014 The Journal of Asia TEFL Vol.11 No.3
The development of English as a medium of instruction (EMI) is of great interest to language and language policy researchers in an era of globalization and internationalization. Despite recognition of a number of implementational problems and constraints, EMI has been widely introduced into various non-native English-speaking (NNES) countries. The question of what challenges face stakeholders in the implementation of EMI was our major focus in a two-year project that investigated a new EMI undergraduate program in Vietnam. Selected findings from the study’s interview component reveal that lecturers were challenged by their own language abilities, students’ language competence and learning styles, pedagogical issues, and resource availability. Based on these findings, suggestions are made for enhancing the success of similar programs.
Intravenous delivery of a multi-mechanistic cancer-targeted oncolytic poxvirus in humans
Breitbach, Caroline J.,Burke, James,Jonker, Derek,Stephenson, Joe,Haas, Andrew R.,Chow, Laura Q. M.,Nieva, Jorge,Hwang, Tae-Ho,Moon, Anne,Patt, Richard,Pelusio, Adina,Le Boeuf, Fabrice,Burns, Joe,Evgi Nature Publishing Group, a division of Macmillan P 2011 Nature Vol.477 No.7362
The efficacy and safety of biological molecules in cancer therapy, such as peptides and small interfering RNAs (siRNAs), could be markedly increased if high concentrations could be achieved and amplified selectively in tumour tissues versus normal tissues after intravenous administration. This has not been achievable so far in humans. We hypothesized that a poxvirus, which evolved for blood-borne systemic spread in mammals, could be engineered for cancer-selective replication and used as a vehicle for the intravenous delivery and expression of transgenes in tumours. JX-594 is an oncolytic poxvirus engineered for replication, transgene expression and amplification in cancer cells harbouring activation of the epidermal growth factor receptor (EGFR)/Ras pathway, followed by cell lysis and anticancer immunity. Here we show in a clinical trial that JX-594 selectively infects, replicates and expresses transgene products in cancer tissue after intravenous infusion, in a dose-related fashion. Normal tissues were not affected clinically. This platform technology opens up the possibility of multifunctional products that selectively express high concentrations of several complementary therapeutic and imaging molecules in metastatic solid tumours in humans.