제 12 회 해운의 날 해운진흥촉진대회 치사 : 흑자경영 기반을 다질 수 있다는 새로운 기대와 자신감을 얻어

이범준 한국해사문제연구소 1988 (月刊)海洋韓國 Vol.175 No.-

A consensus guideline of herbal medicine for coronavirus disease 2019

이범준,Ju Ah Lee,김관일,최준용,정희재 한국한의학연구원 2020 Integrative Medicine Research Vol.9 No.3

Background: The Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV-2), which originated in Wuhan, Hubei Province, China in late December 2019, is the cause of ongoing pandemic. We analyzed the symptoms of SARS-CoV-2, a classification of the Chinese medicine dialectic and treatment regimen, and promptly enacted the recommendation of Korean medicine preparations in herbal medicine covered under domestic medical insurance benefits depending on the circumstances in our country. Method: The clinical practice guideline (CPG) for the treatment of SARS-CoV-2 was developed based on consensus from a group of experts. Results: Two kinds of herbal medicines (HM) were recommended for the prevention of SARS-CoV-2; Youngyopaedoc-san plus Bojungikgitang, and Youngyopaedoc-san plus Saengmaek-san. Two herbal preparations were recommended for people with a history of exposure to SARS-CoV-2; Youngyopaedoc-san plus Bulhwangeumjeonggi-san, and Youngyopaedoc-san plus Bojungikgi-tang. Three herbal preparations were recommended for mildly symptomatic COVID-19 patients; Youngyopaedoc-san plus Galgunhaegui-tang was recommended for those without pneumonia with wind-warmth disease invading the lungs; Sosiho-tang plus Bulhwangeumjeonggi-san was recommended for those with dampness-heat disease in the lungs. For the recovery stage, Samchulkunbi-tang plus Saengmaek-san, or Samchulkunbi-tang plus Chungseuiki-tang was recommended. Conclusion: The CPG was developed to guide the use of Korean herbal medicine in the treatment of SARS-CoV-2, and it is expected that this will be the basis for providing proper treatment of similar infectious diseases in the future.

식육에서 피틴산염의 Salmonella typhimurium균에 대한 항균효과

이범준,허진주,이예은,이기남,남상윤,윤영원,정재황,이상화,백동진 한국식품위생안전성학회 2007 한국식품위생안전성학회지 Vol.22 No.4

The approval of use of certain food-grade phosphates as food additives in a wide variety of meathosphates in foods. Phytic acid is a natural plant inositolhexaphosphate constituting 1-5% of most cereals, nuts, legumes, oil seeds, pollen, and spores. In this study, we inves-tigated antibacterial activity of sodium phytate (SPT) against Salmonella typhimurium in tryptic soy broth with difer-ent pHs and in chicken, pork and beef. In tryptic soy broth, SPT at the concentrations of 0.1, 0.5, and 1.0% effectivelyinhibited the growth of Salmonella typhymurium in a concentration-dependent manner. At pH 5.5-7.0 similar to meatpHs, 1% SPT almost completely inhibited the bacterial growth. The inhibitory effect of SPT was stronger at pH 7.0than pH 5.5. In chicken, pork, and beef, SPT at the concentrations of 0.1, 0.5, and 1% significantly inhibited thegrowth of Salmonella typhimurium in a dose-dependant manner (p<0.01). The addition of 1% SPT in the meats sig-as a muscle food additive for increasing food safety and functions.

동맥경화증이 유발된 ApoE^((-/-)) mouse에서 血府逐瘀湯과 Aspirin의 병용투여 효과에 대한 연구

이범준,윤승연,박현우,박지혁,조인영,이정숙,류재환 대한한의학회 2011 대한한의학회지 Vol.32 No.1

Objective: The antiplatelet agent aspirin has been widely used for treating atherosclerosis in western medicine, and its efficacy has been proven in cardiac and extracardiac vascular diseases. On the other hand, Hyeolbuchukeo-tang has been widely used for treating blood stasis syndrome in traditional medicine. Therefore we investigated whether Hyeolbuchukeo-tang could have a synergic effect along with aspirin. Methods & Materials: Male ApoE^((-/-)) mice were randomly divided into three different experimental groups: a non-treated group(Control group), an aspirin-treated group(AP group), and an aspirin with Hyeolbuchukeo-tang-treated group(APH group). The control group was fed only an atherogenic diet, the AP group an atherogenic diet plus Aspirin 5 ㎎/㎏,and the APH group an atherogenic diet plus Aspirin 5 ㎎/㎏ with Hyeolbuchukeo-tang 100 ㎎/㎏. We investigated plasma lipid with liver function test, and performed the histological investigation of liver and abdominal aorta. Results:1. We investigated photomicrographic changes of liver and abdominal aorta tissue. They showed that histological injury of aorta and lipid accumulations of the liver were lower in the AP and APH groups than in the control group. 2. In the APH group, plasma triglyceride levels were significantly lower than those in the control and AP groups. 3. There were no differences in aspartate aminotransferase and alanine aminotransferase levels among the control, AP and APH groups. Conclusion: The above results show that a combined treatment of Hyeolbuchukeo-tang and aspirin has a somewhat synergic effect in terms of inhibiting vessel injury and decreasing lipid deposits on liver cells without liver toxicity.

Alveolar Bone Preservation Using an Orthodontic Mini-implant in an Adolescent Patient with Multiple Missing Teeth

이범준,김영택,유진주,이지연 대한구강악안면임플란트학회 2021 대한구강악안면임프란트학회지 Vol.25 No.3

After tooth extraction, the alveolar ridge undergoes a series of structural changes, including the inevitable vertical and horizontal loss of alveolar bone. In this case, growth modification was performed on an 11-year-old patient with skeletal Class II malocclusion with multiple congenitally missing teeth and early loss of a deciduous tooth without succedaneous replacement using an intraoral orthopedic appliance. The space from the lost deciduous teeth was effectively maintained. At the age of 14 years, an orthodontic mini-implant with a diameter and length of 1.6 and 7 mm, respectively, was inserted into the alveolar bone to prevent additional alveolar bone resorption and maintain alveolar bone height until growth completion. At the age of 18 years, the second phase of orthodontic treatment was started to properly set the time of dental implant placement and the completion of orthodontic treatment. At the age of 19 years, the alveolar bone height was properly maintained until dental implant placement. The dental implant was successfully placed without additional vertical bone augmentation. Therefore, we successfully preserved the alveolar bone by inserting an orthodontic mini-implant into the site of early deciduous tooth loss without succedaneous replacement in an adolescent patient.

동맥경화증이 유발된 ApoE(-/-) mouse에서 疎風活血湯과 Clopidogrel의 병용투여 효과에 대한 연구

이범준,오세춘,김영찬,이정숙,강덕희,이우경,이영일,류재환 대한한의학회 2010 대한한의학회지 Vol.31 No.5

Background and Objective: Atherosclerosis is a diffuse, systemic disease that affects the coronary, cerebral, and peripheral arterial trees. Clopidogrel is widely used antiplatelet agent and its efficacy has been proven in cardiac and extracardiac vascular diseases, but it has several side effects. Therefore we investigated whether Sopunghwalhyeol- tang, which is widely used for treating the blood stasis syndrome in traditional medicine, could decrease the side effect of antiplatelets and have a synergic effect. Methods & Materials: Male ApoE(-/-)mice were randomly divided into three different experimental groups, non-treated group (Control group), clopidogrel-treated group (CP group) and clopidogrel with Sopunghwalhyeol-tang treated group (CPS group). The control group was fed with only an atherogenic diet, the CP group an atherogenic diet plus clopidogrel 25㎎/㎏ and the CPS group an atherogenic diet plus clopidogrel 25㎎/㎏ with Sopunghwalhyeol-tang 100㎎/㎏. We investigated plasma lipids with liver function test, and performed a histological investigation of liver and abdominal aorta. Results:1.Photomicrographs of liver and abdominal aorta tissue showed lower histological injury and lipid accumulation in the CP and CPS groups than those in the Control group. 2.In the CPS group, plasma triglyceride level was significantly lower than in the Control and CP groups. 3.In the CPS group, the plasma aspartate aminotransferase (AST) level was significantly lower than in the CP group. Conclusions: The above results shows that a combined treatment of Sopunghwalhyeol-tang and clopidogrel have a synergic effect through inhibiting vessel injury and decrease the side effects of clopidogrel alone.

알고리즘과 저널리즘

이범준 서울대학교 기술과법센터 2022 Law & technology Vol.18 No.3

The power of legacy media originated from material foundations, not contents. Legacy media has exercised its power through the control of means of publishing, namely rotary machines. Article 21 (3) of the Constitution reflects this. It states that “The standards of news service and broadcast facilities and matters necessary to ensure the functions of newspapers shall be determined by Act.” In the past, newspapers controlled production of information, publication of article, and distribution of newspaper. However, as big technology corporations virtually monopolized the news publishing and distribution process, the nature of legacy media has changed to be in charge of only production of information. The Constitutional Court of the Republic of Korea concluded, “Media diversity is an indispensable premise for democratic society based on pluralism.” However, as big technology corporations and algorithms intervened in news distribution, the market for diversity of opinions market has collapsed. The monopoly of the algorithm’s distribution of articles is unconstitutional. In order to realize diversity of public opinion in a new media environment, regulation must target an algorithm not a rotary press.

도쿄대학에서 보낸 과거와 미래

이범준 관훈클럽 2020 관훈저널 Vol.- No.157

근위축성 측삭 경화증 1예

이범준,전진희,류재환,김태연,Lee, Beom-Jun,Jeon, Jin-Hee,Lew, Jae-Hwan,Kim, Tae-Yun 대한한방내과학회 2000 大韓韓方內科學會誌 Vol.21 No.4

Amyotrophic Lateral Sclerosis(ALS) is a fatal neuromuscular disease characterized by progressive muscle weakness resulting in paralysis. ALS is characterized by both upper and lower motor neuron damage. Diagnostic tests include magnetic resonance imaging(MRI) electromyogram(EMG), muscle biopsy, and blood tests. In order for a definitive diagnosis of ALS to be made, damage must be evident in both upper and lower motor neurons. When three limbs are sufficiently affected, the diagnosis is ALS. There is no cure for ALS. We recently experienced one case of ALS, The patients was diagnosed as ALS by EMG and Symptoms. We diagnosed her as Wea jeung and treated by Herbal-medication based on the differentiation of symtoms. we report change of his symptoms through both western medical treatment and oriental medical treatment.

The British counterinsurgency in Malaya : The emergency, 1948~1960

李範俊 이화여자대학교 한국문화연구원 1966 韓國文化硏究院 論叢 Vol.7 No.-

第二次 大戰直後 世界共産主義는 戰後의 民族主義와 反植民主義的 感情을 포착 利用해서 局部的 侵略手段을 通해 所謂 「 民族解放戰爭」을 선동했던 것이다. 特히 1948年 2月 印度 칼컷타에서 開催된 國際共産主義者 以來 印度지부, 인도네시아, 馬來, 以律성에서 共産主義反亂이 거의 같은 時期에 연달아 터진 事實을 想起할 수 있을 것이다. 오늘에는 自由越南政府가 그와 꼭 같은 種類의 共産反亂에 봉착해있으며 앞으로도 世界 어느 곳에서 언제 그러한 反亂이 發生할지 모르는 것이다. 이와 같은 戰後의 共産主義者들의 侵略戰術 卽 게리라 戰에 있어 中國과 印度支部는 自由陣營이 敗北한 典型的 例이며 自由陣營이 勝利한 케이스로서는 희랍, 비율빈, 馬來를 들 수가 있다. 그러므로 自由陣營의 關心이 共産反亂鎭壓法에 集中되고 있는 이때 馬來에서의 英國의 成功的 反亂鎭壓經驗을 硏究分析하므로서 未來의 같은 事態에 適用할 수 있는 原則을 發見하기 위해 馬來의 非常時期를 綜合的으로 取級해 본 것이다. 먼저 馬來國內 共産主義運動의 歷史的 背景을 考察한 後 1948年 6月에 宣布해서 1960年 8月에 解除된 非常事態期에 英國과 馬來政府가 對抗한 共産反亂軍의 組織,策略, 戰術等을 分析하고 政府側이 수행한 反亂鎭壓法에 對해 상세히 檢討해 보았다. 制限된 紙面關係上 政治面에 關한 部分을 이곳에 包含시키지 못한 點 유감스럽게 생각하는 바이다.