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EGFR Gene Amplification and Protein Expression in Invasive Ductal Carcinoma of the Breast
황보원,김인선,이정현,안상정,김서진,박경화,김철환 대한병리학회 2013 Journal of Pathology and Translational Medicine Vol.47 No.2
Background: The epidermal growth factor receptor (EGFR) is a surrogate marker for basal-like breast cancer. A recent study suggested that EGFR may be used as a target for breast cancertreatment. Methods: A total of 706 invasive ductal carcinomas (IDC) of the breast were immunophenotyped, and 82 cases with EGFR protein expression were studied for EGFR gene amplification. Results: EGFR protein was expressed in 121 of 706 IDCs (17.1%); 5.9% were of luminal type, 25.3% of epidermal growth factor receptor 2 (HER-2) type, and 79.3% of basal-like tumors. EGFR gene amplification and high polysomy (fluorescent in situ hybridization [FISH]-positive) were found in 18 of 82 cases (22.0%); 41.2% of the HER-2+, EGFR+, cytokeratin 5/6– (CK5/6–) group, 11.2% of the HER-2–, EGFR+, CK5/6– group, and 19.1% of the HER-2–, EGFR+, CK5/6+ group. FISH-positive cases were detected in 8.3% of the EGFR protein 1+ expression cases, 15.9% of 2+ expression cases, and 38.5% of 3+ expression cases. In group 2, the tumors had a high Ki-67 labeling (>60%), but the patients showed better disease-free survival than those with tumors that co-expressed HER-2 or CK5/6. Conclusions: EGFR-directed therapy can be considered in breast cancer patients with EGFR protein overexpression and gene amplification, and its therapeutic implication should be determined in HER-2 type breast cancer patients.
[생산기술부문] 박판 스템핑 공정의 주름 발생 예측에 관한 연구
황보원(Bowon Hwang),금영탁(Youngtag Keum) 한국자동차공학회 2000 한국자동차공학회 춘 추계 학술대회 논문집 Vol.- No.-
A wrinkling is the phenomenon of instability influenced by material properties, part geometry, forming conditions, stress state, etc. In this study, the region in biaxial plane stress state is modeled with a rectangular plate introducing the effective dimension, and critical stress values for the wrinkling are calculated using energy method. Prediction index for the wrinkling is then evaluated by normalizing the actual stress with respect to critical stress.