위암세포에서 세포유착물질의 발현 및 위암세포의 복막 내피세포에 대한 결합 능에 미치는 retinoicacid의 영향

홍영선,박조현,박진노,이경식,김인철,Hong, Young Seon,Park, Cho Hyun,Park, Jin-No,Lee, Kyung Shik,Kim, In Chul 대한면역학회 2001 Immune Network Vol.1 No.1

Background : Peritoneal metastasis is one of the maj or types of the stomach cancer recurrence and the role of the adhesion molecules is thought to be very much important in this event. Retinoic acid (RA) has been known to induce the growth inhibition and differentiation of various malignancies, and apoptpsis and the change of expression of adhesion molecules have been reported to be involved in the action of RA. Methods : We studied the adhesion abilities of SNU-1, SNU-5, and SNU-6 cells to the peritoneal endothelial cells as well as the expression of the adhesion molecules (CD44, ICAM-1) in Western blot analysis. And also we studied the expression of apoptosis and the change of expression patterns of the various isoforms of CD44 and the change of the adhsion abilities of the cell line cells after RA treatment. Results: CD44 was expressed in SNU-5 and -16, together with an isoform in SNU-16. ICAM-1 was not expressed in any of the cell line cells tested. After the treatment of RA in the concentration range of $1-5{\times}10^{-5}M$ to three stomach cancer cell lines, growth inhibition, apoptosis and the change of expression of the CD44 were noted. After RA treatment, the expression of CD44H was weakly increased in SNU-1, and was markedly increased in SNU-5. In SNU-16, the expression of CD44H was decreased while that of CD44E were markedly increased. The adhesibility of cells to peritoneal cells was increased in relation with the increase of the CD44H expression, which shows the fact that the adhesibility of tumor cells to peritoneal mesothelial cells is mediated by CD44H recognizing hyaluronic acid. Conclusion : RA induces growth inhibition of stomach cancer cell line cells and increase the adhesiblity of stomach cancer cell line cells to peritoneal mesothelium. It is believed that RA decreases the metastatic ability of stomach cancer cells by upregulating the CD44H expression.

안락사

홍영선,염창환,이경식,Hong, Young-Seon,Yeom, Chang-Hwan,Lee, Kyung-Shik 한국호스피스완화의료학회 1999 한국호스피스.완화의료학회지 Vol.2 No.1

Background : Euthanasia is defined as "a deliberate intervention undertaken with express intention of ending a life so as to relieve intractable suffering". There have been keen debates in the medical literatures on the questions relating to the legalisation and the provision of euthanasia and physician-assisted suicide. Methods : Literatures on the debate of euthanasia published during the last several years were reviewed, and the indications used in performing euthanasia were listed. And the results of a more liberal policy on euthanasia in Netherland were introduced. Results : Other clinical practices are sometimes described as euthanasia but can be distinguished by examination of ethical principles involved. The guidelines for the practice of euthanasia and physician-assisted suicide in the Netherlands were inadquate and were abused, while the Remmelink Committee Report said that euthanasia in the Netherland had been adequate. Conclusions : There are no clinical situations necessitating the legalisation of euthanasia or physician assisted suicide. Comprehensive and mutidisciplinary palliative care can effectively relieve much of the suffering of the terminally ill that is presently cited as justification for euthanasia or physician-assisted suicide.

위암의 선행화학 요법

홍영선,박조현,Hong, Young-Seon,Park, Cho-Hyun 대한위암학회 2005 대한위암학회지 Vol.5 No.3

Gastric cancer is the most prevalent cancer in Korea and comprises the second cause of cancer death. Surgery only can provide chance of cure, but most locally advanced cancers recur after a curative resection, even though important advances in the surgical and nonsurgical treatments of gastric cancer have taken place. Preoperative chemotherapy theoretically can provide the advantages of reducing the bulk of tumor, which might improve the R0 resection rate, and of treating micrometastases early. Also, preoperative chemotherapy is expected to render unresectable tumors resectable without increasing postoperative morbidity and mortality. There are many new chemo-therapeutic agents available for the treatment of advanced gastric cancer, but still the most effective agent, the optimal time and number of cycle for administration are still not known. The addition of postoperative chemotherapy through an intraperitoneal route and/or radiotherapy might affect the outcome of surgery favorably, but that hasn't been proved yet. A multicenter prospective randomized phase III trial should be peformed to answer for those questions and to improve the curability of gastric cancer treatment.

'의사 윤리지침'중 불필요한 치료중단에 대한 견해

홍영선,이경식,Hong, Young-Seon,Lee, Kyung-Shik 한국호스피스완화의료학회 2001 한국호스피스.완화의료학회지 Vol.4 No.1

아시아 문화권에서의 상실과 슬픔

홍영선,염창환,이경식,Hong, Young-Seon,Yeom, Chang-Hwan,Lee, Kyung-Shik 한국호스피스완화의료학회 1998 한국호스피스.완화의료학회지 Vol.1 No.1

Grief is the ordinarily self-limited complex of symptoms and processes that constitute the acute reaction to a significant loss. And it is the reaction of the dying as well as the bereaved. Every culture has had its own ways of grief and mourning. The definition of healthy grief and mourning, in terms of both emotional expression and the length of time it should continue, mostly depend upon the type of culture as well as the type of religion. So the manner of grief and mourning greatly differs from culture to culture. In the most of the Asian countries, influenced by Confucianism, Taoism, and Buddhism, death is traditionally considered the most significant life cycle transition. In Chinese culture, many rituals have evolved to help family members deal with their loss, over the past five thousand years. Confucianism taught the virtues of filial piety and righteousness. These rules and many customs added since the time of Cofucius, have been loyally followed and practiced by many Asian people. However, Buddhists have different ideas. They believe in karma and reincarnation and in predetermination of one's present life by good or bad deeds in the present life and past lives. Display of uncontrollable emotion is not encouraged. Continuity of family relations after death is very important. The ancient practice of the ancestor worship is still followed in many Asian households. Many Buddhist do not practice ancestor worship; family members honor the deceased by placing a memorial plate in the temple for continued chanting purposes. The mourning rituals have been dramatically curtailed in the past 50 years. For example, political, social and economic forces have shaped the current mourning practices of Chinese in different countries. There are many clinical implications in helping Asian to deal better with the emotional strains of the experience of loss. The therapiest must respect the cultural framework through which the client perceives family losses.

아시아 태평양 지역의 호스피스.완화의료에서 한국 호스피스의 역할

홍영선,Hong, Young-Seon 한국호스피스완화의료학회 2011 한국호스피스.완화의료학회지 Vol.14 No.3

Korean hospice care has been greatly developed in a short period of time, thanks to help of foreign specialists and aids from developed countries. With enormous growth in economy, Korea which once received foreign aids now give help to other countries. It is the time for the Korean hospice society to consider ways to make an international contribution. That way, Korea could help terminal patients both in Korea and neighboring countries overcome sufferings, maintain their dignity as human beings until the end of their lives and have a comfortable moment of death. Thus, we need to think about ways to contribute to the international hospice society and make related plans.

호스피스와 윤리 - 사전 의료 지시서를 중심으로 -

홍영선,이동익,Hong, Young-Seon,Lee, Dong-Ik 한국호스피스완화의료학회 2008 한국호스피스.완화의료학회지 Vol.11 No.2

회귀분석에 의한 선로보수장비 유압작동유 교환주기 산정

홍영선(Young-Seon Hong),황욱선(Wook-Sun Hwang),박준성(Jun-Sung Park),유수봉(Su-Bong Ryu),김재문(Jae-Moon Kim) 한국철도학회 2023 한국철도학회 학술발표대회논문집 Vol.2023 No.5

스위치 타이 탬퍼 작업주행용 카르단 샤프트의 고장 데이터 분석에 의한 교환주기 예측

홍영선(Young-Seon Hong),최용은(Hong, Yong-Eun Choi),오효석(Hyo-Seok Oh),김재문(Jae-Moon Kim) 한국산학기술학회 2023 한국산학기술학회논문지 Vol.24 No.10

선로보수 장비는 특수목적용 철도차량으로 여객과 화물을 안전하게 수송할 수 있도록 선로, 구조물 등 철도 시설물의 유지보수 업무를 수행한다. 선로보수 장비의 고장은 철도 운송에 있어 직접적인 피해를 유발할 수 있으므로 적절한 신뢰성 기반의 유지보수를 수행하는 것이 중요하다. 선로보수 장비 중 스위치 타이 탬퍼에 적용되고 있는 작업주행용 카르단 샤프트는 작업을 위한 주행장치에 동력을 전달하는 기능을 하는 장치로 중요한 역할을 하고 있어 신뢰성 확보가 요구된다. 따라서 한국철도공사에서 운영중인 스위치 타이 탬퍼 장비 유지보수 데이터를 기반으로 신뢰성 분석을 수행하였다. 그 결과 고장 데이터 분석을 통해 수명분포는 와이블 분포에 적합함을 확인하였고, 고장률이 증가하는 추세로 열화특성이 있음을 확인하였다. 카르단 샤프트의 교환주기 산정을 위해 최소비용 교환주기와 백분위 수명에 의한 교환주기를 산출한 결과 최소 비용 교환주기는 단위시간당 교체비용이 최소화되는 2,190일, 백분위 수명에 의한 교환주기는 2,012일로 확인되었다. 본 연구에 의한 수명주기 교환 시점은 신뢰도가 반영된 정량화된 기준이므로 유지보수 정책 설정에 도움이 될 것으로 기대한다. A track repair machine is a special-purpose railway vehicle that performs maintenance on railway facilities such as tracks and structures so that passengers and cargo can be safely transported. Proper reliability-based maintenance is important because failure of a track-repair machine can directly damage rail transport. The cardan shaft in switch tie tampers plays an important role as a device for transmitting power, so it is necessary to secure its reliability. Therefore, a reliability analysis was performed based on maintenance data from switch tie tampers operated by the Korea Railroad Corporation. Through fault data analysis, it was confirmed that the life distribution fit a Weibull distribution and that the failure rate was increasing. The degradation characteristics were also confirmed. To calculate the cardan shafts exchange cycle time, we checked the minimum-cost exchange cycle and the percentile life. The minimum-cost exchange cycle time was 2,190 days, and the percentile life exchange cycle time was 2,012 days. The life cycle exchange period according to this study is a quantified standard that reflects reliability, so it is expected to help establish maintenance policies.

잔존수명을 고려한 선로보수 장비 유압작동유의 상태평가

홍영선(Young-Seon Hong),유홍국(Hong-Kuk Yoo),심규석(Kyu-Seok Shim),김재문(Jae-Moon Kim) 한국산학기술학회 2023 한국산학기술학회논문지 Vol.24 No.5

선로보수 장비에 사용중인 유압작동유(이하 작동유)의 교환은 검수 시행 절차서에 의해 사용시간 기준으로 이루어지고 있으며, 최근에는 성상분석과 오염분석을 위한 유분석 시험을 통해 작동유의 상태를 판단하여 교환하는 기준의 적용을 추진하고 있다. 유분석 시험은 작동유의 열화 정도를 정량적으로 표현할 수 있어 교환기준의 판단은 될 수 있으나, 이후 사용 가능한 수명의 평가는 될 수 없다. 따라서 선로보수 장비에 사용된 작동유 교환의 적정성을 판단하기 위해 유분석 시험과 잔존수명 시험을 통해 비교분석한 결과, 유분석 시험에서 양호한 상태를 보인 작동유라 하더라도 잔존수명 시험에서 산화방지제의 소실 상태가 크게 나타나 교환이 요구되는 사례가 발생되었고, 잔존수명이 충분히 남아있음에도 오염도가 불량한 사례도 발생되었다. 본 연구를 통해 작동유의 상태평가에 의한 사용유 교환의 필요여부를 결정하기 위해서는 기존의 유분석 시험만으로는 다음 점검주기까지 사용 가능 여부의 판단은 무리가 있으므로, 유분석 시험과 함께 잔존수명 평가를 추가적으로 시행하여 산화방지제 고갈로 인한 장비의 치명적인 고장을 미연에 방지할 수 있을 것으로 기대한다. The replacement of hydraulic oil that is used for a track repair machine is conducted according to the service time and the inspection procedure of the machine. Recently, the application of criteria for determining and changing hydraulic oil conditions has been promoted through oil analysis tests for the properties and the pollution of oil. An oil analysis test can show the degree of deterioration of hydraulic oil in quantitative terms, so it can be used as an exchange standard, but it cannot be used for evaluation of the remaining useful life. Therefore, a comparative analysis of a hydraulic oil analysis test and the remaining useful life test has been performed to determine the appropriateness of the hydraulic oil replacement used in the machine. Even though the condition was good in the oil analysis test, there were some cases in the life test that required replacement due to significant antioxidant loss. In some cases, the pollution level was high even though the remaining useful life was sufficient. In order to determine the used oil-exchange conditions through this study, fatal failure of the machine due to the depletion of antioxidants can be prevented through not only oil analysis tests, but also remaining useful life tests.