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안문규(Moon Kyu Ahn),문현숙(Hyun Sook Moon),허문희(Moon Hye Hur),김대병(Dae Byung Kim),박승희(Sung Hee Park) 대한약학회 2001 약학회지 Vol.45 No.4
A simple and rapid determination of total retinol from various pharmaceuticals containing retinol derivatives was described. Retinol derivatives were hydrolyzed with alcoholic KOH to alcoholic retinol, which was determined by HPLC. Pretreatments and HPLC conditions depend on the kind of retinols and preparation forms. The total amount of alcoholic retinol could be determined with this method from many pharmaceutical preparation of retinol derivatives. Treating time of KOH, acidic reagents and HPLC conditions were investigated.
이온교환체로서 금속 -디 -2-피리딜케톤옥침 -산성의약품 3원 착물을 이용한 산성의약품의 정량
안문규(Moon Kyu Ahn),오원정(Won Jung Oh),이언경(Eon Kyung Lee),이순영(Soon Young Lee),이재윤(Jae Yun Lee),정문모(Moon Mo Jung),허문희(Moon Hye Hur) 대한약학회 2002 약학회지 Vol.46 No.5
A method for the determination of acidic drug, mefenamic acid and ibuprofen with ion- selective electrode(ISE) using Fe(ll)-di-2-pyridyl ketone oxime complex as a counter ion were developed. Benzyl-2-nitrophenyl ether(BNPE) plasticized membrane was more selective and sensitive than the other tested membranes. The acidic drug selective electrode exhibits a linear response for 10-2 M 510-5 M of acidic drugs, mefenamic acid and ibuprofen with a slope of -55.9 and -56.3 mV/dec. in borate buffer solution (pH 8.9). Potentiometric selectivity measurements revealed negligible interferences from aromatic and aliphatic carboxylic acid salts. The electrodes were found to be useful for the direct determination of mefenamic acid and ibuprofen in pharmaceutical preparations.
철-디피리딜-메페남산 삼원착물을 이용한 메페남산의 정량
남수자,문현숙,이미나,정문모,허문희,안문규,Nam, Su Ja,Moon, Hyun Sook,Lee, Mi Na,Jung, Moon Mo,Hur, Moon Hye,Ahn, Moon Kyu 한국분석과학회 2001 분석과학 Vol.14 No.1
철-디피리딜-메페남산 삼원착물을 이온교환체로, NPOE(o-nitrophenyl octyl ether)를 가소게, PVC[poly(vinyl chloride)]를 지지체로 사용한 메페남산 이온선택성막 전극을 제작하였다. 디피리딜 화합물은 2,2'-디피리딜, 4,4'-디피리딜 그리고 4,4'-디페닐-2,2'-디피리딜을 이용하였다. 이들 막전극은 pH 8.9의 붕산완충액 중에서 $10^{-5}{\sim}10^{-3}mol/L$ 농도의 메페남산에 대하여 감응전위가 -55.98, -49.47 그리고 -59.35mV/decade를 각각 나타내는 직선성이었다. 방향족 및 지방족 카복실산염의 존재는 전극의 감응에 지장을 주지 않았다. A PVC membrane electrodes based on Fe(II)-dipyridyl-mefenamic acid ternary complex as ion exchanger were prepared using o-nitrophenyl octyl ether as a plasticizer. The 2,2'-dipyridyl, 4,4'-dipyridyl and 4,4'-dipyridyl-2,2'-dipyridyl were used as dipyridyl derivative ligand. The electrode dxhibits a fast stable and linear response for $10^{-5}-10^{-3}mol/L$ mefenamate with an anionic slope of -55.98, -49.47, -59.35mV/decade in pH 8.9 borate buffer solution respectively. Potentiometric selectivity measurements revealed negligible interferences from aromatic and aliphatic carboxylic acid salts.
Characterization of Allicin Transformation Products and Determination of Allicin
정주연(Joo-Yeon Jung),김성진(Sung-Jin Kim),허문희(Moon-Hye Hur),이은엽(Eun-Yup Lee),김명수(Myoung-Soo Kim),안문규(Moon-Kyu Ahn) 한국식품영양과학회 1994 한국식품영양과학회지 Vol.23 No.3
마늘 제제중의 주성분인 allicin의 확인 및 정량을 목적으로 standard allicin을 합성하여 direct insertion Prove-Mass Spectrometry(DIP-MS)의 Mass spectra로 확인하였다. Allicin의 transformation products인 diallyl disulfide, 3-vinyl-[4H]-l,2-dithiin과 2-vinyl-[4H]-l,3-dithiin은 cross-linked 5% phenylmethylsilicone capillary column을 사용하여 oven 온도를 40℃에서 150℃까지 10℃/min.으로 상온시킨 후 150℃에서 300℃까지 25℃/min.으로 조절하여 Gas Chromatography-Flame Ionization Detector 및 Gas Chromatography-Mass spectrometry로 확인한 바 그 retention time은 각각 5.03, 6.61, 6.99이었다. 또 다른 transformation product인 ajoene은 Hypersil-ODS column과 65 : 35 비율의 methanol : water containing 0.1% formic acid를 이동상으로 한 High Performance Liquid Chromatography를 이용하여 비교 확인하였다. Allicin은 그 transformation products인 3-vinyl-[4H]-l,2-dithiin과 2-vinyl-[4H]-1,3-dithiin의 비율로 간접 정량하므로, 마늘 제제중 allicin 정량은 solid phase extraction한 후 μ-Bondapak C_(18) column을 이용한 HPLC로 정량한 결과 비교적 양호한 결과를 얻었다. Allicin was synthesized for the purpose of identification and quantitation of a pharmaceutical dosage form in soft capsules. The identified transformed products from allicin were diallyl disulfide, 3-vinyl-[4H]-1,2-dithiin and 2-vinyl-[4H]-1,3-dithiin in gas chromatrographic conditions and diallyl disulfide and ajoene in HPLC. Allicin is thermally unstable, it may be completely decomposed to vinyl dithiin isomers in GC conditions. For that reason, allicin was not found directly in the pharmaceutical dosage forms. In HPLC conditions, mobile phase was methanol/water containing 0.1% formic acid (65/35) and column was μ-Bondapak C_(18). Detection wavelength was 254㎚. The retention time of allicin was 6.98min. The calibration range for allicin was 10㎍/ml to 200㎍/ml and correlation coefficient (r) was 0.987.
이온 교환체로서 Quinine-금속thiocyanate착물을 이용한 Quinine의 정량
허문희,백광진,최현영,안문규 경성대학교 1997 論文集 Vol.18 No.1
The fabrication and performance characteristics of quinine sensitive poly(vinyl chloride) membrane electrodes based on the ion-association complex of quinine with an anionic counter ion, metal thiocyanates (Co(SCN)??, Cd(SCN)??, Fe((SCN)??, Hg(SCN)??, Mn(SCN)??, Ni(SCN)??, zn(SCN)??) was described. The sensing membrane was based on the quinine complex of cobalt thiocyanate plasticized with 65.3% (w/w) tris(2-ethylhexyl) phosphate (TEHP), ferric thiocyanate with 65.3% (w/w) TEHP, nickel thiocyanate with 65.3% (w/w) TEHP and zinc thiocyanate with 49% (w/w) TEHP. These electrodes show a linear response down to 1.2×10?, 1.0×10?, 9.6×10?, 2.0×10?M with Nernstian slope of 55.69, 54.96, 56.63, 55.80 mV/dec. for quinine with relative standard deviation of 3.1, .51, 2.26, 3.16% at pH 5.5∼7.6, respectively. Response time was 10∼20s. The quinine-nickel complex with 65.3% (w/w) TEHP was the optimal ion-exchanger for quinine selective electrode. The electrode exhibits good selectivity for the quinine in the presence of some inorganic cation and organic cations. The quinindine-nickel complex instead of quinine-nickel complex as an ion-exchanger was successfully applied to the direct potentiometric determination of quinidine pharmaceutical preparation giving an average recovery of 101.5% and relative standard deviation of 2.5%.
Dibucaine-selective electrodes based on debenzo-18-crown-6-ether/dibucaine complex as the ionophore
Bae,Yoo-Jin,Kim,Sung-Jin,Hur,Moon-Hye,Hur,Cheoi-Hoi,Ahn,Moon-Kyu 慶星大學校 1996 論文集 Vol.17 No.4
Dibucaine 선택성 전극을 이중 액체막을 사용하여 제작하였다. 내막은 tetrabutylammonium bromide로 구성되면 외막은 dibenzo-18-crown-6-ether/dibucaine complex와 가소제로서 NPOE 그리고 matrix 로서 PVC를 사용하였다. 이 외막이 NaTpB 30mg 함유할 때 이 이중막 전극은 25±1℃에서 dibucaine의 10?²~10??M 농도 범위에서 직선성을 보였으며 그 Nernstian slope와 검출한계 농도는 각각 54.2mV/dec, 10??M이었다. 본 연구에서 안정성, 감을 시간, NaTpB의 영향, 선택성 그리고 막 조성의 영향을 살펴보았다.