수종(數種) 한약재(韓藥材)가 기관지평골근(氣管支平滑筋)에 미치는 영향(影響)(I)

한종현,송호준,강성용,김공수,오광수,Han, Jong-Hyun,Song, Ho-Jun,Kang, Sung-Yong,Kim, Gong-Soo,Oh, Kwang-Soo 대한한방내과학회 1996 大韓韓方內科學會誌 Vol.17 No.1

Several medicinal Plants in Jeonbuk are screened for the contraction or relaxation to the acetylcholine and histamine induced contraction in the isolated rat and guinea pig's trachea smooth muscle. Contractions evoked by acetylcholine and histamine were inhibited by Flos Farfarae, Poria and Rhizoma alismatis, but contractions were increased Tuber Pinelliae, Herba Chelidonii, Fructus Qusqualis, Radix Asari, Semen Perillae, Folium Artemisiae and Fructus Schizamdrae increased the contractions evoked by acetylcholine and histamine. Radix Puerariae, Radix Osterici Koreani, Rhizoma Zingiberis siccatum, Radix Sanguisorbae, Rhizoma Atractylodis, Fructus gardeniae and Cortex Magnoliae did not effect the contractions evoked by acetylcholine and histamine.

관동화전탕액(款冬花煎湯液)이 기관지평골근(氣管支平滑筋)에 미치는 영향(影響)

한종현,강성용,유광석,진상식,하경화,이경자,Han, Jong-Hyun,Kang, Sung-Yong,Yu, Kwang-Suk,Jin, Sang-Sik,Ha, Kyung-Hwa,Lee, Kyung-Ja 대한한방내과학회 1996 大韓韓方內科學會誌 Vol.17 No.1

Farfarae Flos, a traditional herb medicine, has been used in Korea and China for many centuries as a treatment for respiratory disease. The purpose of the present study was to determine the effect of Farfarae Flos on histamine-induced tracheal smooth muscle contraction in rats. Guinea pigs(500g, female) were killed by CO2 exposure and a segment (8-10mm) of the thoracic trachea from each guinea pig was cut into equal segments and mounted 'in pairs' in a tissue bath. Contractile force was measured with force displacement transducers under 0.5g loading tension. The dose of histamine which evoked 50% of maximal response (ED50) was obtained from cumulative dose response curves for histamine (10-7-10-4M). Contractions evoked by histamine(ED50) were inhibited significantly by Farfarae Flos. The mean percent inhibition was 8.7% after 1.5mg/ml Farfarae Flos, and 33.5% (p<0.05) after 5.0mg/ml Farfarae Flos. Propranolol (10-7M) slightly but significantly attenuated the inhibitory effects of Farfarae Flos. Following treatment with propranolol, the mean percent inhibition caused by 5.0mg/ml Farfarae Flos. Indomethacin and methylene blue (10-7M) did not significantly alter the inhibitory effect of Farfarae Flos. These results indicate that Farfarae Flos can relax histamine-induced contraction of guinea pig tracheal smooth muscle, and that this inhibition involves, in part, symphathetic nerve system.

파절된 임프란트 고정체의 분석과 처치

한종현,김성현,허성주,구영,Han Chang-Hyun,Kim Sung-Hyun,Hee Seong-Joo,Ku Young 대한치과보철학회 2001 대한치과보철학회지 Vol.39 No.1

Among the numerous factors contributing to implant failure, the most common are infection, failure of proper healing and overload. These factors may occur combined. Implant fractures are one of the complications resulting from overload. Implant fracture is not a common feature, but once it occurs it causes very unpleasant circumstances for the patient as well as for the practitioner. Only few studies have been reported regarding this subject. Thus, little is known about its solutions. It is important that analyzing reasons for implant fracture and finding appropriate solutions. Factors leading to implant fracture are design, material defects, nonpassive fit of prosthetic framework and biomechanical overload. Previous studies have reported that implant fractures ares associated with marginal bone loss and occur mostly in the posterior regions and that most patients showing parafunctional habits also have implant fracture. Abutment and gold screw loosening or fracture were also observed in some of the cases previous to implant fracture. Similar observations were seen in our hospital as well. The following cases will present implant fracture cases which have been successfully treated regarding function and biomechanics. This was achieved by means of using increased number of futures, increasing fixture diameter and establishing proper occlusion.

가토에 이식된 Titanium plasma Sprayed IMZ 임프란트와 골의 계면 접촉 양상에 따른 결합력에 관한 연구

한종현,한동후,Han, Chong-Hyun,Han, Dong-Hoo 대한치과보철학회 1991 대한치과보철학회지 Vol.29 No.2

In recent years immediate implantation has been tried by a few clinicians. This study placed IMZ implants in the rabbit femur with and without bony defects around the implant for simulating fresh extraction site. And one group with bony defects used porous hydroxyapatite ganules(HA) to fill if and the other group left the bony defects around the implant. The purpose of this study was to compare the shear bond strength and the bony contact and formation around the implant. Fifteen rabbits were divided into three groups and placed 10 IMZ implants to each group. Implant sites were surgically prepared with IMZ drills kit and implants were placed(Control), artificial bony defect was created with Apaceram drills kit around the implant sites and implants were placed(Experimental I), bony defect was filled with porous hydroxyapatite granules(Experimental II). Thereafter, rabbits were sacrificed at 8th week and specimens were prepared and pushout tested for shear bond strength of bone-implant interface immediately. Undecalcified and decalcified specimens were prepared with Vilanueva and hematoxylin-eosin stain for light microscopic finding. The results of this study were as follows. 1. In the control group, mean shear strength of bone-implant interface was $2.614{\pm}0.680$ MPa, experimental I was $0.664{\pm}0.322$ MPa, and experimental II was $2.281{\pm}0.606$ MPa. There was significant difference between control and experimental I, between experimental I and experimental II, but did not show significant difference between control and experimental II statistically. 2. In the bony formation surrounding IMZ implant of the three groups, that of cortical bone is more advanced than cancellous bone area. 3. In the histological findings of undecalcified specimens, control and experimental II showed more than 50% of bony or osteoid formation at the bony-implant interface. 4. In the histological findings of undecalcified specimens, experimental I showed less than 50% of bony or osteoid formation at the interface, and observed partial bony defect in the coronal zone. 5. In the experimental II group, were observed direct bony contact to hydroxyapatite granules, and infiltration of a few giant cells. 6. No inflammatory responses were seen around the titanium implants and the hydroxyapatite granules.

특집 - 꼭 알아두어야 할 계육분야 정책들 - 동물복지 축산농장 인증제 소개

한종현,Han, Jong-Hyeon 한국육계협회 2012 월간 닭고기 Vol.18 No.2

치과용 골유착성 임플랜트 고정체 형상의 응력 분산에 관한 연구

한종현,전흥재,정신영,허성주,최용창,정종평,구영,류인철,김명호,Han, Chong-Hyun,Chun, Hung-Jae,Jung, Sin-Young,Heo, Seong-Joo,Choi, Yong-Chang,Chung, Chong-Pyung,Ku, Young,Ryu, In-Chul,Kim, Myung-Ho 대한치과보철학회 2000 대한치과보철학회지 Vol.38 No.4

Finite element analyses were performed to study effects on stress distribution generated in jaw bone for various shapes of dental implants: plateau type, plateau with small radius of curvature, triangular thread screw type in accordance with ISO regulations and square thread screw filleted with small radius partially. It was found that square thread screw filleted with small radius was more effective on stress distribution than other dental implants used in analyses. Additional analyses were performed on the implant with square thread screw filleted with small radius for very-ing design parameters, such as the width of thread end, the height of the thread of the implant and load direction, to determine the optimum dimensions of the implant. The highest stress concentration occurred at the region in jaw Pone adjacent to the first thread of the implant. The maximum effective stress induced by a 15 degree oblique load of 100 N was twice as high as the maximum effective stress caused by an equal amount of vertical load. Stress distribution was more effective in the case when the width of thread end and the height of thread were p/2 and 0.46p, respectively, where p is the pitch of thread. At last, using tensile force calculated from the possible insert torque without breading bone thread, finite element analysis was performed on the implant to calculate pre-stress when the primary fixation of the implant was operated in jaw bone. The maximum effective stress was 136.8 MPa which was proven to be safe.

특집: 농장동물복지 국제동향 및 국내정책 방향

한종현,Han, Jong-Hyeon 대한수의사회 2010 대한수의사회지 Vol.46 No.10

우리나라는 1991년 동물에 대한 학대행위 방지 등 동물을 적정하게 보호 관리하기 위하여 필요한 규정을 만들어 동물의 생명과 그 안전을 보호하고, 생명의 존중 등 국민의 정서 함양에 이바지하게 함을 목적으로 '동물보호법'을 제정하였다. 그러나 당시 법에서는 반려동물과 실험동물을 대상으로 한 동물학대 금지 및 유기동물 등에 대한 조치와 동물을 교육 학술연구 및 기타 과학적 목적으로 이용시 고통을 주지 않토록 하는 내용을 규정하고 있다. 그 후 우리 국민의 동물보호 복지에 대한 관심과 의식수준이 점차적으로 향상되면서 국민들의 요구에 따라 그 간 수차례 법령을 개정하였고, 2008년에 전면 개정된 법령에는 반려동물과 실험동물뿐아니라 농장동물에 대하여도 동물학대 금지 및 해당 동물을 적정하게 보호 관리토록하는 동물보호 복지 개념을 도입하게 되었다. 우리가 이처럼 농장동물복지에 대해 초보단계에 있는 것과 달리, 이미 세계동물보건기구(OIE) 및 동물복지 선진국은 농장동물복지 정책에 대해 많은 기준을 만들고 다양한 연구를 수행하고 있다. 또한 한-EU FTA 협상과정에서 EU측이 농장동물복지를 의제화 할 것을 요구하는 등 국가간 통상에서도 농장동물 복지가 중요한 이슈로 작용하고 있어 이 분야에 대한 깊은 관심과 정책개발이 필요하다고 하겠다. 따라서 일반 국민뿐아니라 축산업계에서도 '과연 농장동물복지란 무엇인가'에 대한 궁금증과 더불어 '국내 소비자 및 축산농가에 큰 부담을 주지 않을까'하는 우려를 하고 있는 것이 현실이다. 이에 동물복지란 무엇인가에 대하여 간략히 알아보고, 농장동물 복지에 대한 국제동향 및 국내정책의 방향에 대해서도 논의하고자 한다.

한의학 문헌정보의 전자도서관 구축

한종현,윤용갑,한성국,주수종,Han Jong-Hyeon,Yun Yong-Gap,Han Seong-Guk,Ju Su-Jong 대한한의학방제학회 1999 大韓韓醫學方劑學會誌 Vol.7 No.1

타이태늄 합금의 생체적합도에 관한 연구

한종현,허성주,구영,최용창,정종평,박중근,Han, Chong-Hyun,Heo, Seong-Joo,Ku, Young,Choi, Young-Chang,Chung, Chong-Pyong,Park, Chung-Keun 대한치주과학회 1998 Journal of Periodontal & Implant Science Vol.28 No.3

Screw shaped implants of Titanium-13Zirconium-6Niobium(newly developed), Titanium-6Zirconium-6Sn-6Niobium(newly developed) and Titanium-6Aluminum-4Vanadium were machined with square top and inserted in rabbit bone for 3 months. Biomechanical tests(removal torque) showed Titanium-13Zirconium-6Niobium and Titanium-6Zirconium-6Sn-6Niobium to be more stable in the bone bed than those of Titanium-6Aluminum-4Vanadium. Titanium-13Zirconium-6Niobium implants demonstrated a mean removal torque of 31.59Ncm while Titanium-6Aluminum-4Vanadium demonstrated a mean removal torque of 25.27Ncm and Titanium-6Zirconium-6Sn-6Niobium revealed a mean removal torque of 37.44Ncm and were statistically significance in Wilcoxon Signed Rank test(P<0.05). Histomorphometrical comparisons were performed on $10\;{\mu}m$ thick undecalcified ground sections in the light microscope and Titanium-13Zirconium-6Niobium showed more mean bone-tometal contact ratio than to other twotitanium alloys but had no statistically significant differences were found among the three materials(P>0.01).

수종 한약재가 혈관에 미치는 영향

한종현,최민호,남태선,유도곤,Han Jong-Hyun,Choi Min-Ho,Nam Tae-Sun,Ryu Do-Gon 대한한의학방제학회 1999 大韓韓醫學方劑學會誌 Vol.7 No.1

Rhizoma Arisaematis, Lignum Akebiae, Rhizoma Zedoariae, Cortex Eucommiae, Folium Perillae, Radix Sophorae Subprostratae, Radixi, Radix Ledeboutriellae, Rhizoma Atractylodis, Herba Ephedrae, Radix Puerariae and Radi Aconitx Bupleuri have been used in Korea for many centuries as a treatment for various disease. The purpose of the present study is to determine the effect of several herbs on norepinephrine(NE) induced blood vessel contraction in rabbits and pigs. Rabbit(2 kg, male) were killed by $CO_2$ exposure and a segment (8-10mm) of each rabbit was cut into equal segments and mounted in a tissue bath. Contractile force was measured with force displacement transducers under 2-3 g loading tension. The dose of norepinephrine(NE) which evoked 50% of maximal response $(ED_{50})$ was obtained from cumulative dose response curves for NE $(10^{-6}{\sim}10^{-3}M)$. Contractions evoked by NE $(ED_{50})$ were inhibited significantly by Rhizoma Arisaematis, Lignum Akebiae, Rhizoma Zedoariae, Cortex Eucommiae, Folium Perillae, Radix Sophorae Subprostratae and Herba Ephedrae in abdominal aorta. Contractions evoked by NE $(ED_{50})$ were inhibited significantly be Lignum Akebiae, Rhizoma Zedoariae, Cortex Eucommiae, Herba Ephedrae, Radix Puerariae and Radix Bupleuri in femoral artery. Contractions evoked by NE $(ED_{50})$ were inhibited significantly by Radix Sophorae Subprostratae, Radix Aconiti and Herba Ephedrae in renal artery. These results indicate that each herb can relax NE induced contraction of rabbit and pig blood vessel selectively, and that this relaxation relates to Gui-Gyung(歸經).