가축식별시스템 계획 및 실행지침

하혜경,Ha, Hye-Gyeong 대한수의사회 2007 대한수의사회지 Vol.43 No.7

유사조골세포와 파골세포를 이용한 한약추출물의 효과

하혜경 상명대학교 대학원 1999 祥明論集 Vol.6 No.-

境界線 人格 障碍 : 精神分析學的 개념을 중심으로 Centered on Psychanalytic Concept

하혜경 인제대학교 1985 仁濟醫學 Vol.6 No.3

We reviewed about history, symptoms, developmental dynamics, diagnosis and treatment of borderline personality disorder under the psychoanalytic concept. It is an increasing tendency that many authers suppose that borderline patient has an unique personality structure and defined as a specific disease entity. We find most of them advised that structural diagnosis is very useful method for confirming accurate diagnosis, which is composed of traditional mental status extuamination and psychoanalytically oriented interview. According to developmental dynamics, many authors point out that pregenital aggression is the most basic constitional deficit and maternal libidinal availability is crucial environmental factor. There are controversial opinion about treatment method of borderline personality disorder. Then, some claim supportive psychotherapy and other assert modified psychoanalytically oriented psychotherapy. We learned, of late, most of authors approve psychoanalytically oriented psychotherapy which focuses on interpretation of defense mechanism and transference reaction.

Anti-inflammatory Effects in LPS-treated RAW 264.7 Cells and the Influences on Drug Metabolizing Enzyme Activities by the Traditional Herbal Formulas, Yongdamsagan-Tang and Paljung-san

하혜경,진성은,서창섭,신현규 대한한의학회 2021 대한한의학회지 Vol.42 No.4

Objectives: Yongdamsagan-tang (YST) and Paljung-san (PJS) in traditional medicine and finasteride in modern medicine are used to treat benign prostatic hyperplasia (BPH). In recent, the use of combination herbal remedies with conventional drugs has been increasing. Therefore, we investigated the anti-inflammatory effects of these drugs to treat BPH and the influence of herbal formulas on finasteride metabolism. Methods: The inhibitory effects of the herbal formulas and finasteride on the production of inflammatory mediators and cytokines were determined in lipopolysaccharide (LPS)-treated RAW 264.7 cells. Additionally, the influence of herbal formulas on activities of human drug metabolizing enzymes (DMEs) was assessed using human microsomal enzymes. Results: We observed that YST, PJS and finasteride inhibited the production of nitric oxide (NO), prostaglandin E2 (PGE2) and interleukin-6 (IL-6) in RAW 264.7 cells. The half maximal inhibitory concentration (IC50) of YST on PGE2 production was calculated to be below 25 μg/mL. YST inhibited the activity of uridine diphosphate- glucuronosyltransterase (UGT) 1A4 with an IC50 value of 49.35 μg/mL. The activities of cytochrome P450 (CYP) 1A2, CYP2B6, CYP2C19, CYP3A4, and UGT1A1 were inhibited by PJS (IC50 < 100 μg/mL, each). Although PJS and YST inhibited the activities of CYP3A4 and UGT1A4, respectively, these formulas may not influence the metabolism of finasteride because the IC50 values of herbal formulas on DMEs are too high to affect metabolism. Conclusions: Our results suggest that the combination of finasteride and YST or PJS might not influence their drug metabolism and that the drugs may have synergistic effects against BPH.

hERG 칼륨채널 활성도 변화에 따른 31종 한약처방의 심장독성 평가

하혜경,진성은,이시온,김동현,서창섭,신현규 대한한의학회 2022 대한한의학회지 Vol.43 No.1

Objectives: Drug-induced blockade of the human ether-à-go-go related gene (hERG) potassium ion channel causes acquired long QT syndrome, which is known to cause cardiac arrhythmias and be fatal. To establish safety evidence of herbal formulae, we evaluated the effects of 31 herbal formulae on hERG channel activity. Methods: The current through hERG channel was measured by changing the membrane voltage before and after treatment with 31 herbal formulae in HEK 293 cell overexpressing hERG channel using a whole-cell patch clamp system. The current-voltage curves and the activity curves were fitted, and the hERG activity and 50% inhibitory concentration (IC50) according to each herbal formula were calculated. Results: Chokyungjongok-tang, Oncheong-eum, and Cheongsangbangpung-tang strongly inhibited the hERG activity, with IC50 values of 67.67, 141.2, and 296.3 μg/mL, respectively. Yeonkyopaedok-san, Eunkyo-san, Ukgan-san gajinphibanha, Daegunjoong-tang (except Oryzae gluten), Insamyangyoung-tang, Banhahubak-tang, SokyungHwalhyul -tang, Jodeung-san, Hyeonggaeyeongyo-tang, and Bangkeehwangkee-tang weakly inhibited hERG activity, with IC50 values ranging from 400 to 1000 μg/mL. The other 18 herbal formulae showed very weak hERG activity inhibition of less than 50% at the highest concentration (1000 μg/mL). Conclusion: This study provided safety information on cardiotoxicity by cardiac arrhythmia risk assessment of herbal formulae, and is expected to be a reference data for predicting the safety and risk of herbal formulae.

기록매체를 통해 본 일제강점기진주의 명소 특성

하혜경 부경역사연구소 2020 지역과 역사 Vol.- No.47

This study identified the tourist attractions of Jinju through administrative records, tourist guides, tourist guide postcards, and newspaper records of the Japanese colonial period, and analyzed the characteristics of attractions recognized by local residents. To this end, the history and spatial changes of Jinju-gun were documented to derive what attractions are and where they are distributed. The types of attractions were largely divided into historical, natural, and living attractions. In order to clarify the characteristics of the perception of the attraction through the records reproduced by subjective memory, the interpretation was performed through the viewing object of the attraction, the activities of the people, and the meaning given to the attraction. As a result of the analysis, first, the representative attractions of Jinju County during the Japanese colonial period were divided into 'Jinjuseong Park (historic attraction)', 'Namgang(natural attraction)', and 'Main town and Jinju Station area(living attraction)' with Chokseokru. Second, during the Japanese colonial period, the famous attraction of Jinju will be moved to Namchon, which is connected to the south of the Nam River, centering around the existing Chokseokru, where the main shrine is located, and the area around Jinju Station, which was newly built in Bukchon, the center of Jinjuseong. Third, it is necessary to connect Bukchon, Namgang, and Namchon, where the origin and development characteristics of the Jinju landscape are found most condensedly, as one original city center and connect them to regional regeneration. 본 연구는 일제 강점기 진주군을 기록한 기행록, 여행안내서, 지역안내서, 관광안내엽서, 신문 기록을 통해 진주의 명소를 파악하여 장소적 특성을 분석하였다. 이를 위해 진주군의 역사와 공간변화에 기초한 사실적인 문헌자료를 통해 명소 분포를 도출하였으며, 역사명소, 자연명소, 생활명소 등으로 유형을 구분하고 시대별·집단별로 인식한 명소의 특성을 파악하였다. 분석 결과 첫째, 일제강점기 진주군의 대표명소는 촉석루가 있는 ‘진주성공원(역사명소)’, ‘남강(자연명소)’, ‘본정과 진주역일대(생활명소)’로 구분된다. 이들은 일제강점기 진주경관의 발달 특징을 가장 압축적으로 보여주며 진주민의 일상적 삶의 궤적이 중첩된 장소였다. 둘째, 일제강점기 진주의 명소는 본정이 위치한 촉석루, 진주성 중심의 北村에서 신설된 진주역일대를 중심으로 남강 남쪽에 있는 南村으로 이전되면서 역사명소에서 생활명소로 관심이 이전되었음을 알 수 있다. 셋째, 1910~1920년대에는 자연명소와 역사명소 중심이었다면, 1930~1940년대는 생활명소들이 일상의 중심역할을 하였다. 진주지역 조선인은 역사적장소를 명소로 인식한 반면, 조선총독부 관료 및 일본인은 근대시설을 강조하였다. 본 연구는 진주가 가지고 있던 전통적 행정중심도시로서의 기능은 탈각되어 간 반면 보편적인 근대도시로 발달을 보여줌과 동시에 미래 진주의 도시재생사업 추진에 있어 진주성이 있는 남강 북쪽 권역뿐만 아니라 남강 남쪽 권역의 진주역 일대까지 확대하여 하나의 원도심으로 바라볼 필요성을 설명한다.

항공사 전략적 제휴 진화에 관한 문헌 연구

하혜경,김지희 한국항공경영학회 2020 한국항공경영학회지 Vol.18 No.3

After deregulation, airlines formulate strategic alliances to acquire competitive advantage in the market. Such strategic alliances have evolved form from dyadic code-sharing to global alliances and strategic merger and acquisition (M&A) among airlines. However, as a way to increase the efficiency of cooperation and strategic flexibility, strategic alliance among airlines has also developed the form of joint-venture that incorporates all operation routines in individual route. This study reviews and critiques research on strategic alliances among airlines. We reviewed 56 academic papers published from 2000 to 2017 including codesharing, global alliances, airline M&A, and airline joint venture as a key word. We categorized the reviewed academic papers by two criteria: the forms of strategic alliance and main themes of strategic alliance. In terms of the forms of strategic alliance, 26% of the reviewed papers discuss code-sharing, 48% for global alliances, 13% for airline M&A and 13% for joint venture subsequently. In terms of main theme, 21% of the reviewed paper examine regulation policies, 32% for the performances of airlines and alliances, 10% for air-fare, and 29% for the strategies of airlines. Based on the literature review, this study summarizes three things: first, out of 15 reviewed papers related to code-sharing, 11 papers (74%) are related to the performance and output of airlines or air-fare. Second, out of 27 papers related to global alliances, relatively small number of papers (11%) are related to air fare while 30%, 26% and 22% are related to the performance and output of strategic alliance, competitive strategy, and regulation policies subsequently. Third, 7 papers discuss M&A of airlines, out of which 3 papers examine the performances of airlines and alliances and other 3 papers discuss the strategies of airlines. Lastly, among 7 papers related to joint venture among airlines, most papers (4 out of 7) investigate the effect of regulation policies. it is caused by the fact that joint ventures are heavily determined by the government regulation policies. Comparing the research method, quantitative research methods are mostly adopted in the study of code-sharing and global alliances, while qualitative research methods are usually adopted in the study of M&A and joint venture. The lack of studies on joint venture among airlines is caused by the tendency that academic research is often investigated after the real phenomenon has been evolved. As a hybrid strategy between conventional strategic alliance and M&A, joint venture is rising as an attractive option among airlines. That is, joint venture compromises the disadvantages of conventional strategic alliances and M&A while conventional strategic alliance is arms-length contract, M&A disrupts the boundary of organization. Accordingly, more academic research is expected as the joint venture among airlines evolves in business. 항공산업 규제 완화 이후 항공사들은 경쟁우위를 확보하기 위해 지속적으로 전략적 제휴를 진행하고 있다. 항공사의 전략적 제휴는 양자 간 좌석공유(code share)에서 글로벌 동맹체(global alliance)로발전하였으며 전략적 인수합병도 부분적으로 이루어졌다. 그러나 협력의 효과성은 높이면서 전략적유연성을 확보하는 새로운 방식으로 개별 노선 내에서 모든 운영을 통합하는 조인트벤처가 등장하고있다. 본 연구에서는 항공사의 전략적 제휴 진화 과정에 대한 학술적 연구 흐름을 문헌고찰 방식으로정리하였다. 이를 위해 2000년부터 2017년까지 code share, airline alliance, airline M&A, airline joint venture를 주제어로 항공산업과 관련된 주요 해외 학술지 논문들을 구글 스칼라로 탐색하였다. 본 연구의 대상이 된 논문은 총 56편이다. 이를 전략 유형으로 구분하면, 좌석공유(26%), 글로벌 동맹체(48%), 인수합병(13%), 조인트벤처(13%)의 분포였고, 주제별로 구분하면 규제정책(21%), 항공사 및 제휴사의성과(32%), 항공사 운임(10%), 항공사 전략(29%)이었다. 첫째, 좌석 공유 분야의 15편 논문은 ‘항공사성과’와 ‘항공사 운임’을 주제로 연구로 한 연구가 11편(74%)으로 다수를 차지했다. 둘째, 글로벌 동맹체 관련 27편의 논문은 항공사 및 제휴 성과 8편(30%), 항공사 전략 7편(26%), 규제정책이 6편(22%)으로 다수를 차지했고, 항공사 운임은 3편(11%)으로 상대적으로 부족했다. 셋째, 인수합병과 관련된 논문은 7편으로 상대적으로 적었는데, 항공사 성과 3편, 항공사 전략 3편이었다. 마지막으로 조인트벤처에 관한 연구는 7편인데, 규제정책 관련 논문이 4편으로 가장 많았다. 이는 조인트벤처 자체가 정부의규제가 적용되면 성립하기 어렵기 때문이다. 연구방법론으로 비교해 보면, 좌석공유와 글로벌 동맹체관련 연구는 주로 실증연구를 중심으로 이루어졌고, 인수합병이나 조인트벤처 연구는 사례연구의 비중이 높았다. 항공사 전략적 제휴 진화의 가장 마지막 단계인 조인트벤처에 관한 연구가 다소 미미한것은 학술논문이 현상을 뒤따르는 경향이 있기 때문이다. 전통적인 제휴와 인수합병의 중간 형태인 하이브리드형 전략인 조인트벤처는 항공사의 새로운 전략적 선택으로 부상하고 있다. 즉, 제휴는 한시적인 협력전략이고, 인수합병은 본체를 상실하는 극단적인 결합전략이기 때문에 두 가지 유형의 장점을혼합하는 협력전략으로 조인트벤처에 관한 관심이 높아지고 있는 것이다. 따라서 향후 현실에서의 제휴 진화와 더불어 학술연구에서도 조인트벤처에 관한 연구가 활발해질 것으로 기대된다.

시호추출물의 ICR 발암생쥐의 생존율 및 J774A.1 세포와 L1210 세포의 증식에 미치는 영향

하혜경,정대영,박시원 한국생약학회 2004 생약학회지 Vol.35 No.4

The current investigation was carried out to find out the anticancer activity of the methanol extract from Bupleurum falcatum against cancered ICR mouse and cancer cell lines such as J774A.1 and L1210 cells. Extract of Buplerum falcatum displayed the considerable augmentation(134%) of the survival of ICR mouse bearing Sarcoma 180 cancer. In addition, the cytotoxic effects of methanol extract of Buplerum falcatum against J774A.1 cells and L1210 cells were found to show IC50 values of 57.3 μg/ml and 54.6 μg/ml, respectively. In contrast to such cytotoxicity against cancer cells, the extract exerted only meagre toxicity against normal lymphocytes. The increased generation of O2 − and the considerably increased activities of superoxide dismutase(SOD) and glutathione peroxidase(GPx) of both J774A.1 cells and L1210 cells in the presence of Buplerum falcatum extract implied that the observed cytotoxicities may have resulted from the detrimental effect of reactive oxygen species(ROS) evoked by Buplerum falcatum extract on the cancer cells.

Rat에서의 Propranolol 염산염의 비강흡수에 관한 연구

하혜경,김재백 圓光大學校 藥品硏究所 1987 藥品硏究所報 Vol.2 No.1

Nasal absorption of Propranolol was evaluated in rat by perfusing method of Propranolol solution. And the effect of additives (Epinephrine, Sodium lauryl sulfate, Span 20 and Tween 80) were estimated for Nasal absorption by perfusion method. Each solution was circulated through the nasal cavity of rat by means of a peristaltic pump at the rate of 2.0ml/min. and kept at 37.5˚C. The absorption rate was determined from perfusing solution by Ultraviolet spectrophotometer at 288 nm versus time. As a result is follows 1 . Nasal absorption rate coustant of Propranolol (Kα) is 1.78 × 10^-3 μ g/ ml/min. 2 . Kα of solution contained Epinephrine is 1.13 × 10^-3 μg/ml/min. 3 . Kα of solution contained Sodium lauryl sulfate is 6.10 × 10^-3 μ g/ml/min. 4 . Kα of solution contained Span 20 is 3.07 × 10^-3 μg/ml/min. 5 . Kα of solution contained Tween 80 ,s 2.45 × 10^-3 μg/ml/min.

한기의 유입으로 인한 불안정역에서 발생한 선형 대류성에코

하혜경 한국기상학회 2001 대기 Vol.11 No.3