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추교석,김민영 陸軍士官學校 2001 한국군사학논집 Vol.57 No.-
Because of the restrictions of space and time, previous development environments for embedded applications cannot use development resources effectively. To solve this problem, we propose and implement a web-based virtual development environment system.
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김민영,추교석 陸軍士官學校 2001 한국군사학논집 Vol.57 No.-
In SET protocol, every transaction between a cardholder and a merchant is authorized by an authentication server. In order to authorize a transaction, this authentication server performs RSA secret-key operations which require heavy computations. Unfortunately, the authentication server becomes a bottleneck of the whole system when a rush for authorization requests appears to it. In this paper, in order to improve the performance and the security of the authentication server, the emerging SASC(Server Aided Secret Computation) method is adopted. The SASC method enables to compute an RSA secret-key operation with the aid of an assistant server without revealing the secret key to it. We expand the original single-server SASC model to a multiple-server model for suitability in SET environment.
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양규현,원정훈,윤한국,류종현,추교석,김재신 연세대학교의과대학 2007 Yonsei medical journal Vol.48 No.4
Purpose: Bisphosphonates have been used to treat osteoporosis for more than ten years. However, complications associated with long-term administration of bisphosphonates, such as nonunion after pelvic insufficiency fracture or osteonecrosis of the jaw, have been recently reported in the literature. We investigated the relationships among the mechanical properties of the intact rat femur as well as healing fracture calluses and the intraosseous concentration of pamidronate (ICP), after long-term administration of pamidronate in a rat osteoporosis model. Materials and Methods: We performed bilateral ovariectomy in 25 3-month-old female Sprague-Dawley rats. Beginning three months after ovariectomy, disodium pamidronate (0.5mg/kg) was injected every month. After the six-month administration period, the left femoral shaft was fractured using the closed fracture technique. Five weeks after fracture, 23 rats were euthanized and both femora were removed. We checked the mechanical properties of the intact (right) and fractured (left) femora using a three-point bending technique. Intraosseous concentration of pamidronate was checked by high-performance liquid chromatography. Results: The mean ICP was 61.8±15.7ng/mg of bone. High ICP decreased the ultimate load to failure, stiffness, and ultimate stress of the intact femora (p=0.015, 0.027, 0.039, respectively). There was a tendency to decrease the ultimate load to failure in the healing callus when the ICP increased (p= 0.183). High ICP decreased the bone mineral density of the femoral head (p=0.005). Conclusion: High concentrations of pamidronate in intact bone decreased the bone mineral density and weakened the mechanical strength of the rat femora. The mechanical strength of the early healing callus was not correlated with concentration of pamidronate in the bone.
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Kyu Hyun Yang(양규현),Si Young Park(박시영),Je Hyun Yoo(유제현),Tae Hwan Kim(김태환),Hui Wan Park(박희완),Jong Hyeon Ryu(유종현),Kyo Seok Choo(추교석) 대한정형외과학회 2005 대한정형외과학회지 Vol.40 No.8
목적: 백서 골다공증 모델에서 파미드로네이트의 장기간 투여가 장관골의 강도와 골절 치유에 미치는 영향을 알아보고자 하였다. 대상 및 방법: 양측성 난소 제거술을 시행하여 골다공증을 유발시킨 생후 3개월된 Sprague-Dawley계 암컷 백서 66마리를 대상으로,3개월 후 무작위로 실험군(n=33)과 대조군(n=33)으로 나누었다. 실험군은 6개월 동안 매달 파미드로네이트(0.5 ㎎/㎏)를 복막내 투여를 하였고, 대조군은 생리 식염수를 투여하였다. 6개월의 투여기간 후에 좌측 대퇴골을 도수 골절 방법으로 골절 시키고 K-wire를 이용하여 골수강내 고정술을 시행하고, 5주 후 양측 대퇴골을 적출하였다. 정상 대퇴골과 골절을 유발시킨 대퇴골사이의 역학적인 특성을 측정하였고, 우측 대퇴골두의 골밀도를 측정하였다. 파미드로네이트의 골내 농도는 high performance liquid chromatography를 이용하여 측정하였다. 결과: 정상 대퇴골에서 최대강도는 실험군에서 154.4±17.5 N, 대조군에서는 129.7±28.0 N였으며(p=0.0002), 강성은 실험군에서 452.5±122.8 N/㎜, 대조군에서는 378.6±126.2 N/㎜였다(p=0.036). 좌측 대퇴골의 가골에 대한 평가는 정상 대퇴골과 비교하여 최대 강도는 실험군에서 22.7±7.2%, 대조군에서는 29.7±3.5%였다(p=0.025). 골밀도 검사에서는 실험군에서 230±9 ㎎/㎠, 대조군에서 219±13 ㎎/㎠였다(p=0.0007). 파미드로네이트의 평균 골내 농도는 62.3±15.2ng/㎎였고 농도와 대퇴골의 최대 강도 사이에는 상관관계를 보였지만 통계적으로 유의하지 않았다 (p=0.067). 결론: 파미드로네이트는 난소 적출술 후 골 흡수로부터 대퇴골을 효과적으로 보호하였고, 강도와 강성을 유지하였지만, 파미드로네이트의 장기 투여로 골절 치유가 지연되었다. Purpose: We investigated the effects of the long-term administration of pamidronate on long bone strength and fracture healing in a rat osteoporosis model. Materials and Methods: We performed bilateral ovariectomies in sixty-six 3-month-old female Sprague-Dawley rats. Three months after the ovariectomies, the animals were randomized into two groups. Disodium pamidronate or saline was injected into the rats every month for 6 months. The left femoral shafts were fractured by a closed fracture technique. Five weeks after the fractures, the rats were euthanized and both femurs were removed. We evaluated the mechanical properties of the normal and fractured femurs and the bone mineral densities of the right femoral heads. Pamidronate concentration was determined by high performance-liquid-chromatography. Results: The maximum strength and stiffness of the right femurs were 154.4±17.5 N, 452.5±122.8 N/㎜ in the pamidronate-treated group and 129.7±28.0 N, 378.6±126.2 N/㎜ in the control group (p<0.05). The maximum strength of the calluses compared with the right femurs and the mean bone mineral density of the right femoral heads were 22.7±7.2%, 230±9 ㎎/㎠ in the pamidronate-treated group and 29.7±13.5%, 219±13 ㎎/㎠ in the control group (p<0.05). Conclusion: Pamidronate effectively protected the femurs from bone resorption and preserved bone strength and stiffness after ovariectomies. However, fracture healing was impaired during the early stage of healing after long-term administration of pamidronate.
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