Respiratory syncytial virus 세기관지염에서비세척액내 호산구성 염증에 대한 TNF-α 역할

최준기,허경,김효빈,윤운기,김창근 대한 소아알레르기 호흡기학회 2008 Allergy Asthma & Respiratory Disease Vol.18 No.1

Purpose:Tumor necrosis factor-α (TNF-α) and eosinophilic inflammation have their role in asthma, but there were no studies on respiratory syncytial virus (RSV) bronchiolitis. The aim of our study was to investigate whether TNF-α has a role in eosinophilic inflammation of lower respiratory tract infections with RSV and has the correlation with other cytokines. Methods:Fifty children with first RSV bronchiolitis (RSV group) and 18 healthy children without any respiratory symptom and sign (control group) were enrolled. Clinical data, such as eosinophil-derived neurotoxin (EDN), eosinophil cationic protein (ECP), were analyzed. We measured interleukin (IL)-5, IL-8, TNF-α, granulocyte macrophage-colony stimulating factor (GM-CSF), interferon (IFN)-γ, eotaxin, and regulated on activation, normal T cell expressed and secreted (RANTES) in nasal lavage fluid in both groups. Results:Eotaxin, GM-CSF, IL-8, IFN-γ and TNF-α were higher in the RSV group than the control group. TNF-α correlated with an eosinophil-active cytokine, GM-CSF (r=0.86, P< 0.0001), IFN-γ (r=0.90, P<0.0001), and with eosinophil-active C-C chemokines such as eotaxin (r=0.50, P<0.0001). TNF-α also correlated with proinflammatory cytokines such as IL-8 (r= 0.81, P<0.0001). Conclusion:TNF-α correlated with eosinophil-active chemokines and cytokines. Therefore, TNF-α may have a role in eosinophilic inflammation in children with RSV bronchiolitis. Purpose:Tumor necrosis factor-α (TNF-α) and eosinophilic inflammation have their role in asthma, but there were no studies on respiratory syncytial virus (RSV) bronchiolitis. The aim of our study was to investigate whether TNF-α has a role in eosinophilic inflammation of lower respiratory tract infections with RSV and has the correlation with other cytokines. Methods:Fifty children with first RSV bronchiolitis (RSV group) and 18 healthy children without any respiratory symptom and sign (control group) were enrolled. Clinical data, such as eosinophil-derived neurotoxin (EDN), eosinophil cationic protein (ECP), were analyzed. We measured interleukin (IL)-5, IL-8, TNF-α, granulocyte macrophage-colony stimulating factor (GM-CSF), interferon (IFN)-γ, eotaxin, and regulated on activation, normal T cell expressed and secreted (RANTES) in nasal lavage fluid in both groups. Results:Eotaxin, GM-CSF, IL-8, IFN-γ and TNF-α were higher in the RSV group than the control group. TNF-α correlated with an eosinophil-active cytokine, GM-CSF (r=0.86, P< 0.0001), IFN-γ (r=0.90, P<0.0001), and with eosinophil-active C-C chemokines such as eotaxin (r=0.50, P<0.0001). TNF-α also correlated with proinflammatory cytokines such as IL-8 (r= 0.81, P<0.0001). Conclusion:TNF-α correlated with eosinophil-active chemokines and cytokines. Therefore, TNF-α may have a role in eosinophilic inflammation in children with RSV bronchiolitis.

Hamlet에 나타난 Simile, Metaphor와 Image의 Contrast에 관한 考察

崔俊基 漢陽大學校 人文科學大學 1984 人文論叢 Vol.7 No.-

Shakespeare, as we all know, was a great poet as well as a great dramatist, and it is his combination of these two skills that gives his plays their extraordinary power and richness. It is scarcely cecessary to say that he used language poeticaIIy and the different kinds of theatrical (or dramatical) effects he could achieve, by forming the contrasts of images, for they mirror the richest experience and the most proforund imagination known to man, The purpose of this paper is to point out the contrast of images showing the opposites of light and shade, light and darkness, order and chaos, appearance and reality, good and evil, holiness and brutishness, heaven and earth, purity and dirtiness, etc. by a detailed examination of Shakespeare's images found in Hamlet. To do this properly, this paper deals chiefly with suggestions as to light thrown by the imagery on the themes and major characters of the play. For the purpose of comparison, however, some meaningful examples of similes, metaphors and images employed by his contemporaries in their plays are referred to.

MSR(Mechanical Stress Relieving)을 이용한 LPG carrier cargo tank의 용접잔류응력 완화 연구

최준기,송시명,김종화,강성구,양종수 대한조선학회 2011 대한조선학회 학술대회자료집 Vol.2011 No.11

The residual stress of welding structure causes the brittle fracture and the reduction in fatigue strength and corrosion resistance by overlapping with working loads. PWHT(Post Weld Heat Treatment) is a general method to relieve the residual stress; however, that is restricted by the size of structure. Therefore, MSR(Mechanical Stress Relieving) is applicable as an alternative method to relieve the residual stress. In this study, MSR test for relieving the residual stress of LPG carrier cargo tank was carried out according to IGC code and the technical procedure, and the field applicability of MSR was studied.

EPIC 아키텍쳐를 위한 적극적 레지스터 할당 알고리듬

최준기,이상정,Choe, Jun-Gi,Lee, Sang-Jeong 한국정보처리학회 1999 정보처리논문지 Vol.6 No.2

최근 많은 명령어 수준 병렬 처리 기술들이 개발되면서 ILP 프로세서 성능이 급격히 증가하고 있다. 특히, 새로운 기술로 주목 받고 있는 EPIC(Explicitly Parallel Instruction Computing) 아키텍쳐는 조건실행 (Predicated Execution)과 투기적실행(Speculative execution)을 하드웨어와 접목하여 성능 향상을 시도하고 있다. 본 논문에서는 EPIC 아키텍쳐의 특성을 최대로 활용하여 코드 스케줄 가능성을 높이는 새로운 레지스터 할당 알고리듬을 제안한다. 그리고, 제안된 레지스터 할당 알고리듬은 조건실행의 적용으로 인하여 더욱 효율을 높일 수 있음을 실험을 통하여 입증한다. 실험 결과 기존의 레지스터 할당 방법에 비하여 평균 19%의 성능 향상을 보임으로써 제안된 레지스터 할당 방법이 효과적임을 검증한다. Recently, many parallel processing technologies were developed, ILP(Instruction level Parallelism) processor's performance have been growed very rapidly. especially, EPIC(Explicitly Parallel Instruction computing) architectures attempt to enhance the performance in the predicated execution and speculative execution with the hardware. In this paper to improve the code scheduling possibility by applying to the characteristics of EPIC architectures, a new register allocation algorithm is proposed. And we proves that proposed register allocation algorithm is more efficient scheme than the conventional scheme when predicated execution is applied to our scheme by experiments. In experimental results, it shows much more performance enhancement, about 19% in proposed scheme than the conventional scheme. So, our scheme is verified that it is an effective register allocation method.

정신지체 특수학교 중․고등부 교과 수업 실태와 교과전담제에 대한 인식 및 개선방안

최준기,곽승철,강민채 한국재활심리학회 2009 재활심리연구 Vol.16 No.2

The purpose of this study is to recognize the actual class situation in secondary school of special school for mental retardation, and teacher's awareness and improvements of whole class responsibility. The subject of the study was selected by this researcher a special school for mental retardation that operates a secondary school at 16 cities. and the research paper was based on 200 papers. Data is as following. First, in the actual class situation, a teacher was teaching various subjects, and it has difficulty by lack of text and place. Second, according to the recognition of teachers about the departmental system, it is necessary, and resulting higher educational performance, and it should be for all the subjects. Third, about the device of improving managing departmental system, it must be practiced by reflecting specialty and particularity, increase the whole responsible class teacher, and supported by school and authorities for staying departmental system.

비례적 투영 기법을 이용한 우편번호 인식에 관한 연구

최준기,공용해 한국컴퓨터정보학회 1997 韓國컴퓨터情報學會論文誌 Vol.2 No.1

FHD법으로 형성된 실리카 유리미립자의 특성에 관한 연구

최준기,정명영,최태구,Choe, Jun-Gi,Jeong, Myeong-Yeong,Choe, Tae-Gu 한국재료학회 1997 한국재료학회지 Vol.7 No.10

수직형 FHD증착법을 사용하여 SiO$_{2}$, SiO$_{2}$-P$_{2}$O$_{5}$, SiO$_{2}$P$_{2}$O$_{5}$-B$_{2}$O$_{3}$-GeO$_{2}$계 실리카 유리미립자를 형성하였으며, SEM, ICP-AES, XRD, TGA-DSC을 사용하여 그 특성을 분석하였다. XRD측정을 통해, 미립자 형성시 사용된 화염온도(130$0^{\circ}C$-150$0^{\circ}C$)와 기판온도(-20$0^{\circ}C$)가 SiO$_{2}$-P$_{2}$O$_{5}$계 미립자를 비정질상태로 형성하였으며, SiO$_{2}$P$_{2}$O$_{5}$-B$_{2}$O$_{3}$와 SiO$_{2}$P$_{2}$O$_{5}$-B$_{2}$O$_{3}$-GeO$_{2}$계 미립자에서는 B$_{2}$O$_{3}$, BPO$_{4}$, GeO$_{2}$의 결정성피크들을 관찰하였다. TGA-DSC 열분석을 통해, SiO$_{2}$와 SiO$_{2}$-P$_{2}$O$_{5}$는 온도변화에 따른 질량변화가 없었으며, SiO$_{2}$P$_{2}$O$_{5}$-B$_{2}$O$_{3}$-GeO$_{2}$계의 경우 질량감소를 동반한 유리전이에 따른 분자이완현상 및 결정화나 회복반응을 나타내고 있다. 질량감소는 미립자가 결정상태일때 가속되는 경향을 나타냈으며, DSC열분석을 통해 SiO$_{2}$, SiO$_{2}$-P$_{2}$O$_{5}$, SiO$_{2}$P$_{2}$O$_{5}$-B$_{2}$O$_{3}$-GeO$_{2}$계 유리미립자들의 고밀화가 시작되는 온도를 각각 1224$^{\circ}C$, 1151$^{\circ}C$, 953$^{\circ}C$, 113$0^{\circ}C$에서 관찰하였다.

정보검색 기법과 동적 보간 계수를 이용한 N-gram 언어모델의 적응

최준기,오영환,Choi Joon Ki,Oh Yung-Hwan 대한음성학회 2005 말소리 Vol.56 No.-

The goal of language model adaptation is to improve the background language model with a relatively small adaptation corpus. This study presents a language model adaptation technique where additional text data for the adaptation do not exist. We propose the information retrieval (IR) technique with N-gram language modeling to collect the adaptation corpus from baseline text data. We also propose to use a dynamic language model interpolation coefficient to combine the background language model and the adapted language model. The interpolation coefficient is estimated from the word hypotheses obtained by segmenting the input speech data reserved for held-out validation data. This allows the final adapted model to improve the performance of the background model consistently The proposed approach reduces the word error rate by $13.6\%$ relative to baseline 4-gram for two-hour broadcast news speech recognition.

CTI 호출 제어 방식을 이용한 행정 업무 지원 시스템의 개발

최준기,조성범 외2명 한국컴퓨터정보학회 1999 韓國컴퓨터情報學會論文誌 Vol.4 No.2

임베디드 STEP 컨버터의 개발에 관한 연구

최준기 한국컴퓨터정보학회 2002 韓國컴퓨터情報學會論文誌 Vol.7 No.2