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최은서,최영희,신용진 한국물리학회 2009 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.55 No.6
We propose a light manipulation method in the light guide panel (LGP) of a liquid crystal display (LCD) using three-dimensional inner scatterers and surface scatterers without any thin optical sheets, and we demonstrate the feasibility of using the proposed method to improve the LGP performance, such as uniformity and average brightness in illumination. The use of the three-dimensional scatterers enhances the uniformity on the LGP, and engraved surface scatterers improve the average brightness, where the scatterers within and on the LGP are formed by using a 2nd-harmonic pulsed Nd:YAG laser engraving system and CO2 laser system. We suggest a simplified simulation model for the performance expectation of the designed LGP. Compared with experimentally measured brightness, a high efficiency was demonstrated for the proposed method. The utilization of laser-induced scatterers may be promising for the control of light scattering in the transparent medium of a LGP. We propose a light manipulation method in the light guide panel (LGP) of a liquid crystal display (LCD) using three-dimensional inner scatterers and surface scatterers without any thin optical sheets, and we demonstrate the feasibility of using the proposed method to improve the LGP performance, such as uniformity and average brightness in illumination. The use of the three-dimensional scatterers enhances the uniformity on the LGP, and engraved surface scatterers improve the average brightness, where the scatterers within and on the LGP are formed by using a 2nd-harmonic pulsed Nd:YAG laser engraving system and CO2 laser system. We suggest a simplified simulation model for the performance expectation of the designed LGP. Compared with experimentally measured brightness, a high efficiency was demonstrated for the proposed method. The utilization of laser-induced scatterers may be promising for the control of light scattering in the transparent medium of a LGP.
Development of Digital Holographic Microscopy on an All-Optical Phase Shifter
최은서,마혜준,이승석,박소희 한국물리학회 2019 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.75 No.9
We propose an all-optical phase-shifting method using Yb-doped optical bers and demonstrate its potential in on-axis digital holography microscopy (DHM) system. The Yb-doped optical ber induces a phase change under optical pumping conditions. The induced phase shift shows a good linear response to applied pumping currents, and N-step phase-shifting up to 2 can be properly performed. Four-, six-, and eight-step phase-shifting methods are performed, and the phase re- trievals from their phase-shifted interferograms are achieved using an interframe correlation matrix method. An 8-step phase shifting-based reconstruction, which is effective for background noise re- duction, is used for 3D imaging of an indium tin oxide (ITO) thin lm and an organic light-emitting diode (OLED) thin lm. The reconstructed surface prole was in agreement with the step structure of the samples. The proposed all-optical phase-shifting method is expected to be applied to various optical imaging systems using ber-based phase-shifting interferometers.
최은서,최영희,신용진 한국물리학회 2009 새물리 Vol.59 No.2
We demonstrated the feasibility of the simplified simulation model for the calculation of light guide panel (LGP) without laborious computational loads with providing the effect of LED's arrangement condition on the LGP performance. From the results of this simulation, the optimized condition of the position and incidence angle of LED was determined. In this simulation, we used linear or curved scatterer-plane experiencing Gaussian scattering on the surface. The distance between LED's and incidence angle of LED are varied with calculating the average brightness and the uniformity. The calculation results present that the optimal distance and incidence angle are 13 mm and 5 degree. Under the conditions, the better results was obtained in the case of curved scatterer-plane, where the wider area was covered having improved uniformity. As a result, the LGP performance was very sensitive to the LED arrangement condition. We could make use of this basic calculation result to design an optimized inner-scatterer-based LGP and to improve the LGP performance. 본 연구는 단순산란평판과 그 평판에서의 가우시안 산란효과를 이용한 도광판 성능 예측 전산모사 기법을 바탕으로 광원의 배치조건에 따른 도광판 성능의 변화를 관찰함으로써 도광판에 입사되는 광원의 최적 배치 조건을 찾고자 하였다. 이를 위해서 산란평판을 선형과 곡면 이렇게 두 가지로 마련하였고 광원의 배치조건으로 광원간의 거리와 광원의 입사각을 변화시키면서 광원 배치에 따른 도광판 효율을 평균밝기와 균일도를 통해서 비교 분석하였다. 광원간의 거리차이는 13 mm이고 입사각은 5˚인 경우 가장 좋은 성능을 가짐을 확인할 수 있었다. 이 조건하에서 곡면의 경우 보다 넓은 면적에 향상된 균일도를 가지게 됨을 알 수 있었으며 광원의 배치조건에 매우 민감하게 도광판 성능이 변화됨을 확인할 수 있었다. 이러한 결과를 바탕으로 도광판 광원을 보다 효율적으로 이용하기 위한 최적 조건을 도출하는데 유용하게 사용될 것으로 예상된다.
최은서,강윤영,목혜정 한국생물공학회 2018 Biotechnology and Bioprocess Engineering Vol.23 No.2
In this study, we compared the antioxidant activities of curcumin (Cur) and a Cur formulation using a fluorescence analysis assay. The Cur formulation was prepared by a simple incorporation of Cur into exosomes (EXO) to produce Cur/EXOs. Free Cur had a low fluorescence intensity in aqueous solution because of its poor stability as a result of its autoxidation, whereas a significantly higher fluorescence intensity was observed for Cur/EXOs. Compared to free Cur, the increased level of intact Cur in EXOs allowed for enhanced antioxidant activity in H2O2 scavenging activity and DPPH assays. Compared to Cur at high concentration (200 μM), Cur/ EXOs were significantly less cytotoxic. The antioxidant activity of Cur or Cur/EXOs in cells could be easily demonstrated by monitoring decreases in their fluorescence intensity. Following subcutaneous injection, the fluorescence intensities of Cur/EXOs were much higher than that of Cur, suggesting that Cur/EXOs improve Cur stability in vivo. Taken together, we have demonstrated the superiority of Cur/EXOs over free Cur in terms of aqueous stability and antioxidant activity using fluorescence monitoring both in vitro and in vivo.
40세 이전 유방 침윤성 관암종 환자의 임상적 및 병리학적 특징
최은서,김권천,조현진,김성환,민영돈,장정환,김경종 조선대학교 2003 The Medical Journal of Chosun University Vol.28 No.1
Purposes : It is controversial whether breast cancer in young women is more aggressive than that in older women this study was performed to investigate characteristic prognostic factors of early onset breast cancer and correlated factors with prognosis of young age Method : Between 1996 and 2002, a retrospective study of 106 patients with breast cancer, underwent operation in Department of Surgery, Chosun University Hospital was conducted. The patients were divided into two groups, yound age group(<40 yr) and old age group(> yr). We investigated TNM stage, tumor size, number of lymph node metastasis(N-stage), histologic grades, hormonal receptor, PTEN and HER-2/neu expressions and NPI(Nottingham Prognostic Index) and compared them between two groups. Results : The 27 patients were included in the young age group(median age. 36 yr) and 79 in the old age group(median age. 54 yr) The young age group had more advanced N-stage(N2, N3) and more poor histologic grade(grade Ⅲ) than the old age group with significancy(P<0.05). There were no differences in TNM stage, tumor size, hormone receptor, PTEN and HER-2/neu expressions and NPI between two groups. Conclusion : Prognostic factors(histologic or biologic factor) are more likely to be found in breast cancers of young women and it is implicated the young patients with breast cancer have more poor prognosis than in older patients.