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Experimental Applications of in situ Liver Perfusion Machinery for the Study of Liver Disease
최원묵,은혁수,이영선,김선준,김명호,이준희,심영리,김희훈,김예은,이현승,정원일 한국분자세포생물학회 2019 Molecules and cells Vol.42 No.1
The liver is involved in a wide range of activities in vertebrates and some other animals, including metabolism, protein synthesis, detoxification, and the immune system. Until now, various methods have been devised to study liver diseases; however, each method has its own limitations. In situ liver perfusion machinery, originally developed in rats, has been successfully adapted to mice, enabling the study of liver diseases. Here we describe the protocol, which is a simple but widely applicable method for investigating the liver diseases. The liver is perfused in situ by cannulation of the portal vein and suprahepatic inferior vena cava (IVC), with antegrade closed circuit circulation completed by clamping the infrahepatic IVC. In situ liver perfusion can be utilized to evaluate immune cell migration and function, hemodynamics and related cellular reactions in each type of hepatic cells, and the metabolism of toxic or other compounds by changing the composition of the circulating media. In situ liver perfusion method maintains liver function and cell viability for up to 2 h. This study also describes an optional protocol using densitygradient centrifugation for the separation of different types of hepatic cells, allowing the determination of changes in each cell type. In summary, this method of in situ liver perfusion will be useful for studying liver diseases as a complement to other established methods.
최원묵 세계기독교통일신령협회 2001 統一世界 Vol.- No.7
죽어 부활 강림한 예수 말고 육신 쓴 예수를 중심하고 오순절을 기념했다면 하나님의 섭리가 어떻게 전개되었을까? 참부모님 재세시에 참 부모님 모시고 오순절을 기념하게 하심은 우리의 후손에게 황금 면류관을 보증하시려는 참사라이요 축복이 아니겠는가? 온고이지신은이럴 때 써먹는 속담인 것 같다.
차세대 전력반도체 SiC MOSFET의 스위칭 특성 및 효율에 관한 연구
최원묵,안호균,Choi, Won-mook,Ahn, Ho-gyun 한국정보통신학회 2017 한국정보통신학회논문지 Vol.21 No.2
Recently, due to physical limitation of Si based power semiconductor, development speed of switching power semiconductors is falling and it is difficult to expect any further performance improvements. SiC based power semiconductor with superior characteristic than Si-based power semiconductor have been developed to overcome these limitations. however, there is not method to apply for real system. Therefore, suggested the feasibility and solution for SiC-based power semiconductor system. design to 1kW class DC-DC boost converter and demonstrated the superiority of SiC MOSFET under the same operating conditions by analyzing switching frequency, duty ratio, voltage and current, and comparing with Si based power semiconductor through experimental efficiency according to each system load. The SiC MOSFET has high efficiency and fast switching speed, and can be designed with small inductors and capacitors which has the advantage of volume reduction of the entire system. 최근 Si기반 전력반도체의 물성적 한계로 인해 스위칭 반도체의 발전 속도가 떨어지고, 더 이상의 성능향상을 기대하기 어려운 실정이지만 Si기반보다 우수한 물성을 가진 SiC 기반 전력반도체가 개발되고 있다. 하지만 실제 시스템에 적용하기 위해서는 아직 뚜렷한 방법이 제시되지 못하고 있다. SiC기반 전력반도체의 시스템 설계에 대한 타당성과 솔루션을 제안하기 위하여, 1kW급의 DC-DC컨버터를 설계 및 제작하고 스위칭 주파수, 듀티비, 전압, 전류의 변화 조건 속에서 Si기반 전력반도체와 실험을 통해 비교 분석하였다. 각 시스템 부하별 입․출력을 통한 효율을 분석 및 Si MOSFET 대비 SiC MOSFET의 우수한 스위칭 성능을 확인하였고, 이를 통해 동일한 구동 조건에서 SiC MOSFET의 우수성을 검증하였다.
Microfabrication of polypyrrole using patterned ITO substrate by the soft-imprint technique
최원묵,박오옥 한국물리학회 2006 Current Applied Physics Vol.6 No.4
This paper represented an eective and versatile method to fabricate the microstructures of conducting polymer, polypyrrole(Ppy). We prepared polymer patterns as an insulating template on ITO glass using soft-imprint technique that is a simple methodto create the polymeric microstructures. After the residual layer of polymer patterns on ITO was removed with reactive ion etching(RIE) process in order to expose selectively the bare ITO, the electropolymerization of Ppy was conducted using the patterned ITOas an electrode. As a results, Ppy grew selectively only on the bare ITO, not on the remaining polymer features. In other words, thepolymer patterns formed by the soft-imprint are acting as good barrier during the electropolymerization. Thus, two-/three-dimen-sional various microstructures of Ppy were fabricated with good resolution over a large area.