심미적 음악교육에 관한 연구 : 중학생에게 적용될 수 있는 심미적 음악수업안 연구

최소진 건국대학교 교육대학원 1994 敎育論叢 Vol.22 No.-

천안 제 2산업단지에서 발생하는 악취물질의 농도분포에 관한 연구

최소진,정진도,홍정희,김수영 대한환경공학회 2006 대한환경공학회 학술발표논문집 Vol.2006 No.12

한국 약용식물 추출물의 알도즈 환원 효소 억제 효능 검색(IX)

최소진,김영숙,김주환,김진숙 한국생약학회 2014 생약학회지 Vol.45 No.4

Aldose reductase (AR) has been demonstrated to play important role in the development of the diabetic complications such as diabetic retinopathy, diabetic neuropathy and diabetic nephropathy. To discover novel treatments for diabetic complications from natural sources, 69 Korean herbal medicines have been investigated for inhibitory activities on AR. Among them, 7 herbal medicines, Eleutherococcus sessiliflorus (stems), Artemisia japonica (whole plants), Wisteria floribunda (leaves), Eurya japonica (stems, twigs and leaves, leaves), Ampelopsis brevipedunculata (stems) exhibited a significant inhibitory activity compared with 3,3-tetramethyleneglutaric acid as positive control.

중국 약용식물 추출물의 알도즈 환원 효소 억제 효능 검색(X)

최소진,김영숙,김주환,김진숙 한국생약학회 2014 생약학회지 Vol.45 No.4

Aldose reductase (AR) is the key enzyme of the polyol pathway in the development of the diabetic complications. Sixty seven Chinese herbal medicines have been investigated for inhibitory activities on AR. Among them, 7 herbal medicines, Buddleja crispa (twigs and leaves), Taiwania flousiana (twigs and leaves), Sloanea hemsleyana (fruits), Euphorbia nemetocypha (whole plants), Photinia glomerata (twigs and leaves), Vitex yunnanensis (twigs and leaves) exhibited a significant inhibitory activity against AR. Particularly, S. hemsleyana and V. yunnanensis showed 1.2-4.5 times more potent inhibitory activity than the positive control, 3,3-tetramethyleneglutaric acid (TMG).

베트남 약용식물 추출물의 알도즈 환원 효소 억제 효능 검색(XI)

최소진,김영숙,김주환,김진숙 한국생약학회 2014 생약학회지 Vol.45 No.4

Aldose reductase (AR) has been indicated the critical enzyme of the polyol pathway in the development of the diabetic complications. In this study, 119 Vietnamese herbal medicines have been investigated for inhibitory activities on AR. Among them, 7 herbal medicines, Synedrella nodiflora (stems and leaves), Combretum sundaicum (stems and leaves), Argyreia acuta (stems and leaves), Platea latifolia (whole plants), Linociera sangda (whole plants), Rhaphiolepis indica (whole plants), Harrisonia perforata (stems and leaves) and 2 fractions from Harrisonia perforata (stems and leaves) with EtOAc and BuOH, exhibited a significant inhibitory activity against AR. Particularly, S. nodiflora, A. acuta and H. perforata (stems and leaves) showed 1.0-1.8 times more potent inhibitory activity than the positive control, 3,3-tetramethyleneglutaric acid (TMG).

한국약용식물의 최종당화산물 생성저해활성 검색 (XI)

최소진,김주환,김진숙,김영숙,송유진 한국생약학회 2013 생약학회지 Vol.44 No.4

In this study, the inhibitory effect on advanced glycation end products (AGEs) formation of 43 Korean herbal medicines has been evaluated. Among them, 16 Korean herbal medicines were showed to have significant effect (IC50; <50 µg/ml)compared to positive reference, aminoguandine (IC50: 76.47±4.81 µg/ml). Especially, five herbal medicines, Rubus coreanus (leaves, IC50: 4.49±0.03 µg/ml), Rubus coreanus (twigs, IC50: 3.80±0.34 µg/ml), Ampleopsis brevipedunculata (stems, IC50:7.43±0.09 µg/ml), Lindera erythrocarpa (leave, IC50: 8.14±0.20 µg/ml), and Lindera erythrocarpa (stems, IC50: 3.69±0.14 µg/ml) showed more potent inhibitory activity (approximately 9-20 fold) than the positive control aminoguanidine.

한국약용식물의 최종당화산물 생성저해활성 검색(VII)

최소진,김영숙,송유진,이윤미,김주환,김진숙 한국생약학회 2012 생약학회지 Vol.43 No.4

In this study, 49 Korean herbal medicines have been investigated with an in vitro evaluation system using glycation end products (AGEs) formation inhibitory activity. Of these, 18 herbal medicines (IC_50<50 µg/ml) were found to have significant AGEs formation inhibitory activity. Of these, five herbal medicines (IC_50<10 µg/ml) were found to have significant AGEs formation inhibitory activity. Particularly, Mallotus japonicus (twigs and leaves), Rhus javanica (twigs and leaves), Boehmeria nivea (whole plants), Quercus acuta (stems), and Eurya japonica (stems) showed more potent inhibitory activity (approximately 9-37 fold) than the positive control aminoguanidine (IC_50=76.47 µg/ml).

중국·베트남 약용식물의 최종당화산물 생성저해활성 검색(VIII)

최소진,송유진,김영숙,김주환,Sun Hang,Tran The Bach,김진숙 한국생약학회 2012 생약학회지 Vol.43 No.4

Advanced glycation end products (AGEs) have been postulated to play a central role in the development of diabetic complications. A variety of different agents that inhibit AGEs have been under investigation. In this study, 62 herbal medicines from China and Vietnam have been investigated with an in vitro evaluation system using AGEs formation inhibitory activity. Of these, 5 herbal medicines (IC_50<5 µg/ml) were found to have significant AGEs formation inhibitory activity. Particularly,herbal medicines Albizia odoratissima (twigs and leaves), Rhododendron spinuliferum (twigs and leaves), Dioscorea cirrhosa (stems and leaves), Illicium verum (stems and leaves) and Aglaia perviridis (stems and leaves), showed more potent inhibitory activity (approximately 16-26 fold) than the positive control aminoguanidine (IC_50=76.47 µg/ml).

Megacystis-Microcolon-Intestinal Hypoperistalsis Syndrome: A Rare Case Report

오다솔,김소연,최소진,원혜성 대한주산의학회 2023 Perinatology Vol.34 No.3

Megacystis-microcolon-intestinal hypoperistalsis syndrome (MMIHS) is an extremely rare congenital disorder characterized by an enlarged bladder without renal obstruction, decreased intestinal motility, and microcolon. This genetic disease is challenging to diagnose prenatally because of its nonspecific ultrasonographic findings and low incidence. In a case study, a 36-year-old nullipara who was at 24 weeks of gestation and referred to Asan Medical Center with a chief complaint of fetal enlarged bladder. Fetal ultrasonography showed megacystis without definite renal obstruction, normal female genitalia, and a normal amniotic fluid index. Follow-up ultrasonography at 30 weeks of gestation revealed worsening bladder distention accompanied by hydronephrosis. At 34 weeks of gestation, ultrasonography showed dilatation of the stomach and small bowel and polyhydramnios. The final prenatal diagnosis was megacystis associated with hydronephrosis and additional small bowel obstruction. Thus, MMIHS was prenatally suspected. The patient underwent an elective cesarean section at 37 weeks of gestation. A female newborn was delivered, with a birth weight of 2,300 g, and was admitted to the neonatal intensive care unit. No urethral obstruction was confirmed by Foley catheter insertion; however, on neonatal abdominal ultrasonography, a long segment of the microcolon was observed. The newborn failed to defecate and urinate, and genetic testing was performed, which was ultimately diagnosed with MMIHS with an ACTG2 (actin gamma 2, smooth muscle) gene mutation. While MMIHS was once a fatal disease, treatments such as intestinal rehabilitation and transplantation have improved the survival rate. Therefore, prenatal diagnosis is crucial for counseling, early postnatal diagnosis, and treatment.

Potentiation of T Cell Stimulatory Activity by Chemical Fixation of a Weak Peptide-MHC Complex

황인규,김광미,최소진,Maria Lomunova 한국분자세포생물학회 2017 Molecules and cells Vol.40 No.1

The stability of peptide-MHC complex (pMHC) is an important factor to shape the fate of peptide-specific T cell immune response, but how it influences on T cell activation process is poorly understood. To better understand that, we investigated various T cell activation events driven by Ld MHCI loaded with graded concentrations of P2Ca and QL9 peptides, respectively, with 2C TCR Tg T cells; the binding strength of P2Ca for Ld is measurably weaker than that of QL9, but either peptides in the context of Ld interact with 2C TCR with a similar strength. When their concentrations required for early T cell activation events, which occur within several minutes to an hour, were concerned, EC50s of QL9 were about 100 folds lower than those of P2Ca, which was expected from their association constants for Ld. When EC50s for late activation events, which takes over several hours to occur, were concerned, the differences grew even larger (> 300 folds), suggesting that, due to weak binding, Ld/P2Ca dissociate from each other more easily to lose its antigenicity in a short time. Accordingly, fixation of Ld/P2Ca with paraformaldehyde resulted in a significant improvement in its immunogenicity. These results imply that binding strength of a peptide for a MHC is a critical factor to determine the duration of pMHC-mediated T cell activation and thus the attainment of productive T cell activation. It is also suggested that paraformaldehyde fixation should be an effective tool to ameliorate the immunogenicity of pMHC with a poor stability.