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최광성,이문희,김순기,김철수,이홍식,임문환,길혜윤,성도환,이종록,김우철,이민걸,송순욱 연세대학교의과대학 2005 Yonsei medical journal Vol.46 No.6
A novel combined treatment of conventional chemotherapy with an intratumoral injection of syngeneic dendritic cells (DCs) has emerged as a potent cancer treatment strategy. In this study, we evaluated the synergistic effect of an intraperitoneal (i.p.) injection of a chemotherapeutic drug, paclitaxel, and an intratumoral (i.t.) injection of syngeneic bone marrow- derived DCs for the treatment of pre-existing fibrosarcoma. Subcutaneous tumors were established using MCA102 fibrosarcoma cells in syngeneic C57BL/6 mice. The results demonstrated that the combined treatment of paclitaxel chemotherapy and the injection of DCs led to complete tumor regression, in contrast to only partial eradication of the tumors with chemotherapy or DCs alone. Furthermore, the tumor-free mice were able to resist a repeat challenge with the same type of tumor. These findings suggest that a combination therapy of systemic chemotherapy along with the intratumoral administration of DCs is a potent treatment strategy for fibrosarcoma.
공동주택 인동간격에 따른 세대내 일사 유입량과 난방부하에 관한 연구 - 판상형 아파트를 중심으로
최광성,오준걸 한국생태환경건축학회 2017 한국생태환경건축학회 논문집 Vol.17 No.6
Purpose: Building energy saving standard is being strengthened every year. But, there is not enough inflow solar radiation standard for saving heating load of residential part. The purpose of this study is to analyze the effect of the shadow according to the distance between apartment, to compare the Window Transmitted Solar Radiation Energy and the heating load. So as to do verify solar radiation and heat load, Design Builder simulation was conducted. The results of the this study are as follows. First, The Korean Building ACT and energy saving standard proposes the minimum building distance for sunshine, but, there is not enough standard about solar energy for heating energy saving. The solar standard is needed for is not daylight hour but solar radiation energy. Secondly, when the distance between apartment increased by 150%, solar radiation increased by 17 % and heating load was reduced by 15%. Finally, when the distance between apartment increased by 125%~150%, the middle floor is effective to reduce heating loads according to the solar radiation energy and lower floor is not effective. The lower floor is required other plan for reduce heating load
Novel Bumping Material for Solder-on-Pad Technology
최광성,Sun-Woo Chu,Jong-Jin Lee,Ki-Jun Sung,Hyun-Cheol Bae,Byeong-Ok Lim,Jong-Tae Moon,Yong-Sung Eom 한국전자통신연구원 2011 ETRI Journal Vol.33 No.4
A novel bumping material, which is composed of a resin and Sn3Ag0.5Cu (SAC305) solder power, has been developed for the maskless solder-on-pad technology of the fine-pitch flip- chip bonding. The functions of the resin are carrying solder powder and deoxidizing the oxide layer on the solder power for the bumping on the pad on the substrate. At the same time, it was designed to have minimal chemical reactions within the resin so that the cleaning process after the bumping on the pad can be achieved. With this material, the solder bump array was successfully formed with pitch of 150 µm in one direction.
Interconnection Technology Based on InSn Solder for Flexible Display Applications
최광성,이학선,배현철,엄용성,이진호 한국전자통신연구원 2015 ETRI Journal Vol.37 No.2
A novel interconnection technology based on a 52InSn solder was developed for flexible display applications. The display industry is currently trying to develop a flexible display, and one of the crucial technologies for the implementation of a flexible display is to reduce the bonding process temperature to less than 150°C. InSn solder interconnection technology is proposed herein to reduce the electrical contact resistance and concurrently achieve a process temperature of less than 150°C. A solder bump maker (SBM) and fluxing underfill were developed for these purposes. SBM is a novel bumping material, and it is a mixture of a resin system and InSn solder powder. A maskless screen printing process was also developed using an SBM to reduce the cost of the bumping process. Fluxing underfill plays the role of a flux and an underfill concurrently to simplify the bonding process compared to a conventional flip-chip bonding using a capillary underfill material. Using an SBM and fluxing underfill, a 20 μm pitch InSn solder SoP array on a glass substrate was successfully formed using a maskless screen printing process, and two glass substrates were bonded at 130°C.
New Impedance Matching Scheme for 60 GHz Band Electro-Absorption Modulator Modules
최광성,정용덕,Young-Shik Kang,Dong-Suk Jun,Byoung-Tae Ahn,Jong-Tae Moon,Jeha kim 한국전자통신연구원 2006 ETRI Journal Vol.28 No.3
This letter proposes a new impedance matching scheme of a traveling wave electro-absorption modulator (TWEAM) module for a 60 GHz band radio-overfiber (ROF) link. A microstrip band pass filter (BPF) was used to achieve impedance matching at the 60 GHz band, and termination resistance was carefully designed to obtain an input impedance close to 50 Ω.. Also, a bias circuit for the device was designed in the module. The measured return loss and frequency response show that the modulator module observes the characteristics of a filter without the need of a further tuning process.
최광성,심우영,강훈,허창훈,이양원,Sumitra Shantakumar,Yu-Fan Ho,Eun-Jeong Oh,Mei Sheng Duh,Wendy Y. Cheng,Priyanka Bobbili,Philippe Thompson-Leduc,Gary Ong 대한피부과학회 2022 Annals of Dermatology Vol.34 No.5
Background: Dutasteride improves hair growth compared with finasteride in maleandrogenic alopecia (AGA) and is well tolerated. However, real-world evidence for longtermdutasteride use in AGA is lacking. Objective: To describe baseline characteristics, treatment patterns and long-term safety andeffectiveness of dutasteride versus finasteride. Methods: This was a multicentre, retrospective medical chart review study conductedin South Korea. The index date was the first prescription of dutasteride or finasteride. Baseline characteristics were assessed 6 months prior to index. Safety and effectiveness(improvements in basic and specific [BASP] classification) data were collected from indexthroughout the observation period. Results: Overall, 600 male adult patients were included (dutasteride, n=295; finasteride,n=305). Dutasteride-treated patients were older (p<0.001) and more likely to have moderate/severe BASP classification at baseline (p=0.010) compared with finasteride-treated patients. Among patients treated with recommended, on-label dosing exclusively (n=535: dutasteride,n=250; finasteride, n=285), dutasteride-treated patients showed greater improvementin hair growth than finasteride-treated patients, as measured by the BASP basic M classification(adjusted incidence rate ratio [95% confidence interval]: 2.06 [1.08, 3.95]; p=0.029). Among this same subset, overall occurrence of adverse events (AEs) during the observationperiod were not statistically equivalent between groups (dutasteride 7.6%, finasteride 10.5%;p=0.201), although reports of AEs of special interest were equivalent (p<0.001). Conclusion: Dutasteride showed greater effectiveness than finasteride in improving BASP classificationin treating male AGA and had a similar or possibly lower occurrence of overall AEs. Dutasteride may provide an effective and safe treatment option for male patients with AGA.