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최경종,은선진,이성형,송계원 영남대학교 의과대학 1991 Yeungnam University Journal of Medicine Vol.8 No.1
In 1962, a case of "generalized skeletal dysplasia with multiple anomalies" was reported by Taybi as a new clinical syndrome. The most characteristic features of the syndrome seemed to be hearing loss, cleft palate and peculiar digital anomalies, so, the syndrome designated as otopalatodigital syndrome by Dudding, et al. Recently, The authors have experienced a case OPD syndrome who visited Yeungnam University Hospital with the chief complaint of hypernasality, and underwent pharyngoplasty for correction of VPI. We present here a new case and review the literature on the subject.
인체 호흡기상피세포에서 Interleukin-1β에 의한 MUC2 유전자 및 단백 발현
김용대,권은진,조중석,이재억,우현재,최경종,송시연,윤석근,백석환 대한이비인후과학회 2002 대한이비인후과학회지 두경부외과학 Vol.45 No.1
Background and Objectives:Mucin secretion is regulated by the mucin genes (MUC) in the respiratory, gastrointestinal and reproductive system. Inflammation induces mucin hypersecretion in the human body. This study demonstrates the efects of IL-1βMaterials and Method:Analysis of MUC2 gene was done by RT-PCR and the protein analysis was done by a flow cyto-metric analysis and an immunoasay method using cultured human airway epithelial cells, and NCI-H292 cells. Results:The expresion of MUC2 mRNA and protein induced by IL-1β increased in a dose-and time-dependent maner. The maxi-mum mRNA level of the MUC2 gene was approximately 3-fold, compared to that of the control cell. The IL-1β-mediated MUC2 protein started at 6 hours of exposure to IL-1β (20 ng/ml) and the maximum level was 12 hours. The MUC2 protein data of flow cytometric analysis coresponded to that of immunoassay analysis. The expresion of MUC2 gene was suppr-esed by actinomycin D, but not attenuated by cycloheximide. Conclusion:These results suggest that the IL-1β-mediated MUC2 gene and protein expresion were increased in a dose- and time-dependent pattern and regulated by transcriptional step. (Korean J Otolaryngol 2002;45:35-40)