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- 저자 : 최경규(Kyung Gui Choi) (검색결과 2 건)
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결핵성 뇌막염 진단에 있어서 뇌척수액 Adenosine Deaminase 활성도에 관한 연구
배선우(Seon Woo Bae),김원천(Won Tsen Kim),전근재(Geun Jae Jeon),성낙억(Nak Uk Sung),최경규(Kyung Gui Choi),최일생(Il Saing Choi) 대한내과학회 1988 대한내과학회지 Vol.34 No.4
N/A The prognosis of tuberculous meningitis is closely linked to the stage at which treatment is started. The cerebrospinal fluid findings, however, are often ambiguous, It has been suggested by recent investigations that ADA activities in cerebrospinal fluid may help differentiate tuberculous meningitis from aseptic meningitis. In this study, cerebrospinal fluid adenosine deaminase activities were measured in 23 cases of tuberculous meningitis, 9 cases of aseptic meningitis, 9 cases of purulent meningitis, 24 cases of miscellaneous neurologic conditions and 23 cases of normal controls. The results obtained were as follows: 1) The mean ADA activity in tuberculous meningitis was 17.39±10,34 U/L, in bacterial meningitis 7.87±8.52 U/L, in aseptic meningitis 2.83±1.92U/L, in miscellaneous neurologic conditions 2.80±5.61U/L and in control 1,09±0.51U/L. 2) The ADA activitiies in tuberculous meningitis showed significantly higher values than in other groups (P<0.001), 3) Cerebrospinal fluid ADA activities differentiated tuberculous meningitis from those with aseptic meningitis being higher than 4.5U/L in all and higher than 6.5U/L in 96% case of tuberculous meningitis, but lower than 6,5U/L in aseptic meningitis and less than 3.5U/L in normal controls. 4) In tuberculous meningitis, ADA activities showed significant correlation with protein in cerebrospinal fluid (P<0.01), but in other groups, no significant correlation with available routine parameters in cerebrospinal fluid. It is suggested that measurement of ADA activity in cerebrospinal fluid is a available test which is relatively easily performed for diagnosis of tuberculous meningitis, especially differential diagnosis with aseptic meningitis.
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흰쥐말초신경에서 반복검사가 가능한 운동 및 감각신경의 비침습 전기생리검사
박기덕,최경규 梨花女子大學校 醫科大學 醫科學硏究所 1995 EMJ (Ewha medical journal) Vol.18 No.1
There has been a need for animal experimental models to study the peripheral nerves to evalute the peripheral neuropathy. However, electrophysiologic test methods to confirm peripheral neuropathy in small experimental animals has mot been properly addressed due to technical difficulties and also the limitation of numbers of examinations due to the invasive natures of previous techniques of peripheral nerve conduction studies in experimental animals. The purpose of this experiment is to find out easy, reliable and noninvasive repeatable technical of nerve conduction study of peripheral nerves of rat. The electrophysiologic tests including motor and sensory nerve conduction studies were performed in both hind limbs of 64 rats. And the results were reported with detailed description of techniques. The mean value(±SD) of motor nerve conduction velocity was 41.8±3.0m/sec and that of the sendory nerve conduction velocity was 29.7±1.7m/sec and they showed stable results. In addition to its accuracy, this technique is a relatively simple and nonivasive repeatable methods of nerve conduction study of rat. But the amplitudes of compound muscle action potential(CMAP) and compound nerve action potential(CNAP) revealed wide ranges of variability.
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