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- 저자 : 차봉연(Bo (검색결과 2 건)
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수술적 치료를 받은 갑상선질환의 임상적 고찰 - 1988 년부터 1992 년까지 갑상선 수술의 경향 -
김형근(Hyung Keun Kim),문성대(Sung Dae Moon),장상아(Sang Ah Chang),안유배(Yoo Bae Ahn),송기호(Ki Ho Song),한제호(Je Ho Han),유순집(Soon Jip Yoo),이종민(Jong Min Lee),손현식(Hyun Sik Son),윤건호(Kun Ho Yoon),강무일(Moo Il Kang),차봉연(Bo 대한내과학회 1998 대한내과학회지 Vol.55 No.6
N/A Objectives: The thyroid disease is the common form of endocrine diseases, which often requires surgical management. Recently, fine needle aspiration biopsy is widely used preoperatively. As a result, some studies show that numbers of thyroid operation have decreased significantly. We performed this study to analyze the clinical features of thyroid diseases and the trend of thyroid operation in Korea. Methods: We reviewed medical records of 1787 cases with thyroid diseases who were managed surgically in Catholic Medical Center, Korea from 1988 to 1992. Results: 1) The percentage of thyroid diseases in total cases undergoing operation in Department of General Surgery was 3%, which tended to decrease with time. 2) 72.9% of thyroid diseases was benign. Among them, the frequency of nodular hyperplasia and follicular adenoma were 67.5% and 18.4%, respectively. 3) The percentage of thyroid cancers in thyroid diseases was 27.1%, which tended to increase with time. The frequency of papillary adenocarcinoma was 78.6%, follicular adenocarcinoma 18.2% and medullary carcinoma 1.5%. 4) Thyroid cancers were most commonly found in the forty and sixty decades. Male: female ratio was 1:8.5. 5) 7.6% of thyroid cancers was accompanied by benign thyroid diseases which were mostly nodular hyperplasia and follicular adenoma. 6) The most common type of operation was lobectomy(82.5%) in benign thyroid diseases, and total thyroidectomy(47.1%) and lobectomy(41.1%) in thyroid cancers. 7) Fine needle aspiration biopsy was performed in 51.7% of thyroid nodules, the frequency of which tended to increase with time. The sensitivity, specificity, false negative rate and false positive rate of this test were 78.3%, 89.4%, 13.7% and 17.2%, respectively. Conclusion: With the use of fine needle aspiration biopsy, numbers of thyroid operation decreased and the percentage of thyroid cancers in thyroid operation increased.
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본태성 고혈압에서의 Ouabain-like Factor 에 관한 연구
강성구,차봉연,윤영석,손호영,홍관수,방병기,최의진,최규보 대한내과학회 1986 대한내과학회지 Vol.30 No.5
To study evidence for the involvement of a circulating ouabain-like factor in the genesis of essential hypertension, we measured, here cyto-chemical Na(+)-K(+) ATPase activity of erythrocyte in 31 hypertensive patients. The results were summarized as follows: 1) The mean arterial blood pressure(MAP) in patients with essential hypertension was 131.4±13. 9 mmHg, and that of control was 85.3±8.6 mmHg, with significant value in essential hypertension(p=0). 2) The Na(+)-K(+) ATPase activity of human erythrocyte membrane in the normotensive control was 0.2165±0.1800μ moles Pi/mg. Protein/hr. and that of hypertensive group was 0.1330±0.375μ mole Pi/mg. Protein/hr., with significantly lower values in hypertensive group(p=0). 3) When an erythrocyte membrane taken from normal human was incubated with supernatantes of boiled plasma from hypertensive individuals, the total and the Mg(++) ATPase activities of erythrocyte membrane were not different from those of normotensive control. However, the Na(+)-K(+) ATPase activity of erythrocyte membrane in the normotensive control was 0.1634±0.0427μ moles. Pi/mg. Protein/hr. and that of hypertensive group was 0.1200±0.0340μ mole Pi/mg. protein/hr, with significantly lower values in hypertensive group (p$lt;0.001). 4) The percent inhibition of Na(+)-K(+) ATPase in the hypertensive group was significantly higher than that of normotensive control; the median values of % inhibition in the hypertensive group was 45.2%(range; 21.6%~76.5%) and that of normotensive was 21.7%(range; -17.5%~53.0%)(p$lt;0.01). 5) The plasma digoxin measured by radioimmunoassay in hypertensive groups was 0.69±0.33ng/ml, and that of the normotensive control was 0.58±0.08ng/ml, without significant value. Based on the above findings, it is suggested that the pathogenesis of essential hypertension is primarily mediated by a circulating ouabain-like factor (or inhibitor of Na(+)-K(-) ATPase, inhibitor of Na(+) pump).
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