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조원용(Won Yong Cho),김인옥(In Ok Kim),정동국(Dong Guk Chung),김형규(Hyoung Kyu Kim),원남희(Nam Hee Won),박희봉(Hee Bong Park) 대한내과학회 1987 대한내과학회지 Vol.33 No.5
N/A To assess the clinical significance of immune doposits in the clinical course of minimal change nephrotic syndrome, we have studied 27 patients with minimal change nephrotic syndrome, aged from 13 to 51 years. The clinical course of 13 patients with mesangial immune deposits was compared with those of 14 patients without mesangial immune deposits. The results obtained in this study were as follows 1) In IF positive group, serum abumin level was 1.57±0.25 gm/dl and 24 hour urine protein 9.50±4.45 gm/day. In IF negative group, serum albumin level was 1.40±0.34 gm/dl and 24 hour urine protein 11.44±8.67 gm/day. There were no significant differences between two groups. 2) The presenting symptoms such as hypertension, hematuria, and azotemia were appeared in variable ratio, but no significant difference in two groups were noted. 3) In IF positive group, all cases had IgM deposits in mesangium, and two cases had IgA deposits in mesangium. There were no significant differences in symptoms, signs and responses to therapy according to varieties of immunoglobulin or complement deposits. 4) In the clinical course along the steroid therapy, there were no significant differences in the two groups, namely, in IF positive group, complete remission occurred in 46%, and in IF negative group complete remission occurred in 61.5%, somewhat higher ratio, but had no significant difference. There were no difference in any particular clinical onset, histologic pattern on light microscopy, therapy response or clinical course in two groups in our relatively short follow up period. So we concluded that immune deposits is not a marker for response to therapy in patients with idiopathic nephrotic syndrome and that to define new disease entity, IgM nephropathy, further study and follow up were required.
조원용(Cho, Won-yong) 韓國不動産法學會 2015 不動産法學 Vol.19 No.-
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