소아 요로감염에서 발열과 신반흔의 관계

정지인,임동희,임형은,박만식,유기환,홍영숙,이주원,Jung, Ji-In,Lim, Dong-Hee,Yim, Hyung-Eun,Park, Man-Sik,Yoo, Kee-Hwan,Hong, Young-Sook,Lee, Joo-Won 대한소아신장학회 2008 Childhood kidney diseases Vol.12 No.1

목적 : 요로감염은 소아 발열의 흔한 원인이며 합병증으로 초래되는 신 반흔은 고혈압이나 만성신부전으로 진행할 수 있다. 본 연구에서는 요로감염에 의한 발열지속기간이 신 반흔이나 방광요관역류 등 위험요소에 영향을 미치는지 알고자 하였다. 방법 : 2002년 3월부터 2007년 3월까지 소아 청소년과에 입원한 15세 미만 초진환자 중 1) 발열을 주소로 하고 2) 입원 전 발열 기간 및 항생제 사용의 정확한 병력을 알 수 있으며 3) 요로감염으로 처음 진단된 환아 143명을 대상으로 항생제 사용 전, 후 발열 지속기간에 따라 초기 신 결손 및 6개월 후 신 반흔 여부, CRP, 말초 혈액 백혈구, 방광요관역류 유무 등에 차이가 있는지 알아보았다. 결과 : 1) 항생제 사용 후 발열 지속기간이 길수록(P=0.014) 초기 신 결손은 증가하였다. 그러나 항생제 사용 전 발열기간은 상관이 없었다. 2) 항생제 사용 전(P=0.006)과 후(P=0.015)의 발열 지속기간이 길수록 신 반흔 발생은 증가하였다. 3) 항생제 사용 후 발열 지속기간이 길수록 CRP도 높았다(r=0.287, P=0.003). 4) 말초 혈액 백혈구 수 및 방광요관역류 및 등급은 항생제 사용 전, 후 발열 지속기간에 따라 차이를 보이지 않았다. 결론 : 소아 요로 감염에서 항생제 사용 전과 후의 발열 기간이 길어질수록 신 반흔의 위험이 증가한다. 그러므로 지속적인 열을 동반한 요로 감염 환아는 보다 적극적인 치료와 관찰이 요구된다. Purpose: Urinary tract infections(UTIs) are not uncommon findings in febrile pediatric patients and approximately one third of patients with UTI may have renal scars. This research was intended to establish the relationship between duration of fever and renal scars. Methods: The medical records of 143 patients were reviewed retrospectively. Inclusion criteria were as follows: 1) fever as defined by an axillary temperature $\geq37.5^{\circ}C$, 2) accurate history of fever duration and the use of antibiotics 3) no previous history of UTI and 4) positive urine culture. We observed whether the longer fever duration could be associated with the development of initial renal defects and subsequent renal scars, increased C-reactive protein(CRP), leukocytosis and the presence of vesicoureteral reflux(VUR). Results: 1) Patients with longer fever duration after antibiotics showed more frequent initial renal defects(P=0.014). However, fever duration before antibiotic use was not associated with the development of initial renal defects(P=0.244). 2) Incidence of renal scar increased with fever duration before antibiotic use(P=0.006) and fever duration after antibiotic use(P=0.015). 3) CRP correlated with the fever duration after antibiotic use(r=0.287, P=0.003). 4) There was no relationships between fever duration and VUR(P>0.05). Conclusion: Our data suggest that fever duration before/after antibiotic use is significantly associated with the increased development of renal scars in pediatric UTI.

위에 발생한 원발성 융모막암

전경화,정지한,진형민,김욱,박조현,전해명,박승만,임근우,박우배,김승남,Jun, Kyong-Hwa,Jung, Ji-Han,Chin, Hyung-Min,Kim, Wook,Park, Cho-Hyun,Jeon, Hae-Myung,Park, Seung-Man,Lim, Keun-Woo,Park, Woo-Bae,Kim, Seung-Nam 대한위암학회 2008 대한위암학회지 Vol.8 No.1

융모막암은 임신과 연관되어 발생하는 악성 종양으로 주로 자궁에서 발생한다. 위장관에서도 융모막암이 발생할 수 있는데 매우 드물고 다른 장기의 융모암과 다른 발생 기전을 가진다. 원발성 위융모암은 치료 성적이 나쁘고 전이 속도가 빨라서 예후가 매우 나쁘다. 저자들은 혈변, 상복부 통증을 주소로 내원한 69세 여자 환자에서 수술전 진행성 저분화형 위선암으로 진단되어 위아전절제술을 시행하였으나 수술 후 위 전정부의 원발성 융모막암으로 진단된 증례를 경험하였기에 문헌고찰과 함께 보고하는 바이다. 융모막암 치료 원칙은 수술적 절제술과 보조적 항암 화학치료이지만 생존율 증가가 입증된 치료 방법은 아직 없는 실정이다. 그러므로 저분화도를 보이거나 출혈 경향을 보이는 위암인 경우에는 융모막암의 가능성도 염두에 두고 적극적인 검사가 이루어져야 할 것으로 생각된다. The majority of choriocarcinomas occur in the uterus as gestational malignant tumors. Rarely, a choriocarcinoma appears in the gastrointestinal tract, and the tumor is assumed to arise from a different histogenetic origin as compared to tumors of other sites. A primary gastric choriocarcinoma is a rare aggressive, widely metastatic malignant tumor, and has a poor prognosis. Reported here is a case of a 69-year-old woman with a primary gastric choriocarcinoma who presented with melena, epigastric pain, and was diagnosed with a poorly differentiated adenocarcinoma based on a preoperative endoscopic biopsy. Gastrectomy with lymph node dissection, followed by postoperative chemotherapy, is the treatment of choice. Therefore, in the case of a poorly differentiated adenocarcinoma with a bleeding tendency, a meticulous examination with the suspicion of a choriocarcinoma should be undertaken.

진주시 수돗물 불소농도조정사업의 11년간 비용편익 분석

김만경 ( Man Kyong Kim ),정지인 ( Ji In Jung ),김민지 ( Min Ji Kim ),전은주 ( Eun Joo Jun ),김한나 ( Han Na Kim ),김세연 ( Se Yeon Kim ),한동헌 ( Dong Hun Han ),정승화 ( Seung Hwa Jeong ),김진범 ( Jin Bom Kim ) 대한예방치과·구강보건학회 2014 大韓口腔保健學會誌 Vol.38 No.2

Objectives: The aim of this study was to estimate the economic costs and benefits of a water fluoridation program in the city of Jinju, Korea. Methods: In 2009, dental surveys were conducted on 2,315 children aged 6-12 years in Jinju, which had been fluoridated for 11 years. The decayed/missing/filled teeth (DMFT) scores of children in Jinju were compared to the DMFT scores of same-aged children in non-fluoridated small- and mediumsized cities in the fourth Korean National Health and Nutrition Examination Survey conducted from 2007 to 2009 by the Korea Centers for Disease Control and Prevention. The reduced number of decayed permanent teeth by the water fluoridation program was estimated as the difference between the DMFT scores of children in Jinju and those in non-fluoridated small- and medium-sized cities. The economic benefits were estimated by the savings from reduced dental treatment costs by using the reduced number of decayed permanent teeth from the water fluoridation program. All annual costs and benefits were calculated from 1998 to 2009. The social rate and untreated rate of decayed teeth were applied as 3% and 20%, respectively. The annual benefit-cost ratio was estimated by using the annual benefits and cumulative program costs. Results: The economic benefit in 2009 from a water fluoridation program was estimated as 57,496,000,000 Korean Won (KRW), and the cumulative cost in 2009 was estimated as 1,387,000,000 KRW. The net present value in 2009 from a water fluoridation program was 56,109,000,000 KRW. The benefit-cost ratio in 2009 was estimated as 41.4. Conclusions: The economic benefit of a water fluoridation program in Jinju city was evaluated as excellent.

초고층 주거건물 커튼월의 창호부 전열 및 결로 성능평가에 관한 연구

정만석(Man-Seok Chung),정차수(Cha-Su Jeong),정지나(Ji-Na Jung),석호태(Ho-Tae Seok) 대한설비공학회 2005 대한설비공학회 학술발표대회논문집 Vol.2005 No.6

위암에서 혈청 렙틴 레벨과 조직 내 렙틴 발현과의 상관관계

김지현,정헌,전경화,김성근,진형민,정지한,김욱,전해명,박조현,박승만,박우배,임근우,김승남,Kim, Ji-Hyun,Jung, Hun,Jun, Kyong-Hwa,Kim, Sung-Keun,Chin, Hyung-Min,Jung, Ji-Han,Kim, Wook,Jeon, Hae-Myung,Park, Cho-Hyun,Park, Seung-Man,Park, Woo-B 대한위암학회 2008 대한위암학회지 Vol.8 No.4

목적: 지방세포에서 분비되는 렙틴은 식이 조절과 에너지 소비를 통해 체질량의 항상성을 유지할 뿐만 아니라 세포증식을 조절하여 종양의 진행에서도 중요한 역할을 한다. 위암에서 렙틴과 그 수용체가 높게 발현된다고 보고되고 있으나 조직내 발현과 혈장내 렙틴 레벨과의 상관관계에 대해서는 많이 알려져 있지 않다. 본 연구에서는 위암 환자에서 혈청 렙틴 레벨을 측정하고 조직내 렙틴과 렙틴수용체의 발현과의 상관 관계를 알아보고자 하였다. 대상 및 방법: 본원에서 2005년 10월부터 2007년3월까지 위암으로 근치적 위절제술을 시행 받은 사람 중에서 파라핀 포매 보관상태가 양호한 72명을 대상으로 하였다. 면역측정법을 이용하여 혈청 렙틴 레벨을 측정하였고 위암 조직내 렙틴과 렙틴 수용체의 발현상태는 면역조직화학 염색을 시행하여 확인하였으며 임상병리학적 특성과의 연관성을 분석하였다. 결과: 체질량지수가 높은 환자의 혈청내 렙틴 레벨이 높았으며(P=0.01), 렙틴의 혈청 레벨은 Helicobacter pylon (H. pylori) 감염군에서 감소하였다(P=0.008). 위벽 침윤도와 병기가 증가할수록 렙틴 발현율이 높았으며(P=0.014), 렙틴 수용체의 발현은 장형 71.4%, 미만형 28.6%로 장형인 경우에 높았다(P=0.033) 결론: 위암에서 혈청 렙틴과 조직내 렙틴 발현은 상관관계가 없었고 렙틴의 조직내 발현은 병기와 연관이 있었으나 그 작용 기전을 규명하기 위해서는 앞으로 후속적인 연구가 필요할 것으로 생각된다. Purpose: The adipocyte-derived cytokine leptin plays a major role in the control of stable body weight by suppressing food intake and increasing energy metabolism. Leptin regulates the cell proliferation of various epithelial cells and it may be involved in the promotion of cancer. Leptin and its receptor are highly expressed in gastric adenocarcinoma, but the association between the serum leptin level and the tissue expression of leptin is uncertain. We evaluated the serum leptin level and the expressions of leptin and leptin receptor in gastric cancer, and we explore the possible mechanism and role of leptin in the carcinogenesis of gastric cancer. Materials and Methods: 72 carcinomas that were curatively resected at our hospital from October 2005 to March 2007 were included in this study. By immunoassay and immunohistochemical staining, we evaluated the serum leptin level and the expressions of leptin and its receptor, and we analyzed their relationship together with the clinicopathological variables. Results: The serum leptin level was increased as the patient's BMI increased and it was decreased in H. pylori infected patients. The expression of leptin was increased as the TNM stage increased (P=0.014), and the expression of leptin receptor in the intestinal type gastric adenocarcinoma was higher than that in the diffuse type gastric adenocarcinoma (71.4% vs 28.6%, respectively, P=0.033). Conclusion: There was no significant correlation between the serum leptin level and expression of leptin in gastric cancer patients. The expression of leptin was associated with the TNM stage, but its role in the pathogenesis of gastric cancer has to be elucidated.

낙동강교 ILM 가설에 따른 시공 중 계측

김형태(Kim Hyung-Tae),조남소(Cho Nam-So),정지만(Jung Ji-Man),양성만(Yang Sung-Man) 한국철도학회 2007 한국철도학회 학술발표대회논문집 Vol.- No.-

As the volume of traffic in southern part of the republic of Korea grew, expansion of transportation was required. In that purpose, the railway between Samnangjin and Gwangyang is being extended to a double-track line. This construction includes Nakdong bridge located across Nakdong river. This truss bridge is constructed in incremental launching method (ILM) and composed of two sections, straight line and curved one. Bridge construction in the method goes with the shift of roller supports which results in the change of structural system. To accomplish safe construction, the measurement during the whole launching stages. The locations of member in severe condition and the corresponding response values were estimated through the preliminary construction stage analysis. Based on the analysis, the measurement during construction was planned. Several sensors and measurement devices were installed at appropriate locations. During the whole launching stages, the measurement was performed and the corresponding data were monitored and stored in real time. The comparison of the responses from the analysis and the measurement showed no indication of yielding of the structural members. Consequently, the construction of Nakdong bridge was concluded to be relevant.

웹 기반 원격강의 학습 시스템의 설계 및 구현

김정지(jung-ji kim),박만곤(man-kon Park) 한국멀티미디어학회 2001 한국멀티미디어학회 학술발표논문집 Vol.2001 No.2