Effect of iron chelators on photodynamic therapy efficiency in tumor cells

정정욱,정영일,김시현,이혜명,강대환 한국공업화학회 2013 한국공업화학회 연구논문 초록집 Vol.2013 No.-

하타요가 수련이 폐기능 및 호흡순환 기능에 미치는 영향

정정욱,신현욱,김훈 한국보건교육건강증진학회 2007 한국보건교육·건강증진학회 학술대회 발표논문집 Vol.- No.-

성장치료를 위한 한약투여의 임상적 효과 및 안전성 평가

정정욱,양태규,구본홍,이세연,Cheong, Jeong-Ook,Yang, Tae-Kyu,Koo, Bon-Hong,Lee, Sea-Yun 대한한방내과학회 2001 大韓韓方內科學會誌 Vol.22 No.4

Objective : Recently many studies of herbal medication to promote growth have been implemented. The purpose of this study was to identify the feasibility and safety of herbal medication on short stature. Methods : 143 patients(87 males, 56 Females)who visited with short stature at Kangnam CHA Oriental Hospital From February 1999 to January 2000 and were treated during 6 months, were available for this study. We treated with 5 herbal medications.(Soeumin hyangbujapalmultang-gagambang, Soyangin yukmijihwangtang-gagambang, Taeumin chungsimyunjatang-gagambang, Boa-tang, Boikyangwi tang) At the begining of the treatment and after 6 months treatment, We measured height, weight and body mass index(BMI). And we investigated changes of aspartate aminotransferase(AST), alanine aminotransferase(ALT), blood urea nitrogen(BUN), alkaline phosphatase(ALP), creatinine. Results: The distribution of ages was from 5 years old to 17 years old. After herbal treatment, mean height, mean weight, mean BMI and mean percentile grade increased $138.5{\pm}15.6$ to $141.9{\pm}15.1$, from $36.9{\pm}13.2$ to $38.9{\pm}13.2$, from $18.5{\pm}3.29$ to $18.7{\pm}3.21$, from $3.2{\pm}1.2$ to $3.4{\pm}1.2$. The contents of AST, ALT, BUN, ALP and Creatinine were not showed any significant change. Conclusions : In the results We recognized Short stature was showed prominent feasibility and safety of herbal medication. Herbal Medication in patients with short stature will improve height velocity without liver and kidney function disorders.

酸棗仁이 CT105에 의한 신경세포 상해 및 白鼠의 기억에 미치는 영향

정정욱,박창국,박치상,이소연,윤현덕,신오철 대한본초학회 2005 大韓本草學會誌 Vol.20 No.1

Objective: This study was designed to research whether demonstrate neuroprotective and memory enhancing effects of Z1BU, suggesting its beneficial actions for the treatment of AD. Methods: The present study investigated effects of the dichloromethane extract of Semen Zizyphi Spinosae(ZIBU) on neurotoxicity and reactive oxygen species(ROS) and nitric oxide(NO) formation in PC 12 cell line overexpressed with carboxyl-terminal 105 amino acid peptide fragment of amyloid precursor protein(CT105). In addition, the present study evaluated its radical scavenging activity and effects on acetylcholinesterase(AChE) activity. Furthermore, effects on neuronal loss in CAl area and cognitive deficits induced by scopolamine treatment were also evaluated in rats. Result: we found in this study that ZIBU significantly inhibited apoptotic neuronal death induced by CT105 overexpression in PC12 cells, with the IC_(50) value of 23 ㎍/ml. Based on phase-contrast and fluorescence microscopic examinations, ZIBU reversed morphological changes of CT105-expressed PC-12 cells. It was also found that Z1BU significantly induced neurite outgrowth and inhibited formation of ROS and NO.Z1BU scavenged DPPH radicals and inhibited AChE activity. Furthermore, it attenuated memory impairment induced by the injection of scopolamine in rats, based on passive avoidance test. Crystal violet staining of rat brain slices exhibited increase in the viability of pyramidal neurons in hippocampal CAI area. Conclusion: these results demonstrate neuroprotective and memory enhancing effects of ZIBU, suggesting its beneficial actions for the treatment of AD.

보익양위탕가미방(補益養胃湯加味方)으로 6개월간(個月間) 저신장증(低身長症) 환자(患者)를 치료(治療)한 치험(治驗) 2례(例)

정정욱,양태규,구본홍,이세연,Cheong, Jeong-Ook,Yang, Tae-Kyu,Koo, Bon-Hong,Lee, Sea-Yun 대한한방내과학회 2000 大韓韓方內科學會誌 Vol.21 No.4

IShort stature is two standard deviations (SD) below the mean for height (below the third percentile) in a population of children. We treated two cases below the third percentile for height with Boikyangwitang-gamibang(補益養胃湯加味方). During treatment Case I grew 4.2cm and became above the third percentile for height. Case II also grew 5.8cm and became above the third percentile for height. In the results We recognized Short status was showed prominent improvement with Boikyangwitang-gamibang(補益養胃湯加味方).

Multiple Infarction과 Small Artery Infarction의 독립적 위험인자로서의 Methylenetetrahydrofolate Reductase Gene Mutation

정정욱,박정미,최병옥,김남근,오도연,정우상,Jung, Jung-Uk,Park, Jung-Mi,Choi, Byung-Ok,Kim, Nam-Keun,Oh, Do-Yeun,Jung, Woo-Sang 대한한방내과학회 2002 大韓韓方內科學會誌 Vol.23 No.1

Objective : Hyperhomocysteinemia has been proven to be an independent risk factor for stroke. The genetic mutation of methylenetetrahydrofolate reductase(MTHFR) elevates serum homocysteine level, but it still remains controversial whether the MTHFR gene mutation could be a predictor of ischemic stroke. Therefore, we studied if this genetic defect could cause ischemic stroke independently. Methods : We gathered ischemic stroke subjects and age, sex-matched controls. Age, gender, past medical history, smoking habit, serum homocysteine level, and the MTHFR genotype were recorded. General characteristics of ischemic stroke subjects were compared to the controls. We classified the stroke according to the related vessels(small and large artery infarction) and single lesion and multiple infraction. Relevant risk of the MTHFR genotype was evaluated in each stroke subtype with multiple logistic regression analysis. Results : When the controls were compared to the whole ischemic stroke, there was no specific difference except some medical histories. However, further analysis based on stroke subtypes showed important results. The small artery infarction group, multiple infraction group had significant odds ratio of the MTHFR TT genotype adjusted for age, gender, medical history and smoking habit. Conclusions : The MTHFR TT genotype is an independent risk factor for certain types of ischemic stroke, small artery infarction and multiple infarction.

Pseudomonas sp. HJ-2를 이용한 고무탄성 Polyhydroxyalkanoate의 생산

정정욱,최강욱,김영백,이영하 한국미생물학회 2000 미생물학회지 Vol.36 No.2

Pseudomonas sp. HJ-2는 heptanoinc acid를 단일탄소원으로 이용하여 3-hydroxybutyrate (3HB),3-hydroxy-velerate (3HV) 및 3-hydroxybutyrate (3HHp)를 구성 단위체로 하는 고무탄성 polyhydroxyalkanoate (PHA)를 생합성한다. 이 미생물 고분자는 poly(3HB-co-3HV)공중합체와 poly(3HHp) 단일중합체로 이루어진 혼합물임이 밝혀졌다. 본 연구에서는 PHA가 고무탄성체로서의 성질을 유지하는데 필용한 단위체 조성과 HJ-2의 배양조건이 PHA의 생산 및 단위체 조성에 미치는 영향에 대하여 조사하였다. 생합성된 PHA의 탄성률은 poly(3HHp)의 존재로 크게 감소되었으나, 3HV의 함량이 높은 poly(3HB-co-3HV) 자체도 최대변형률 740%로서 고무탄성체로서의 성질을 보였다. HJ-2의 생장 및 PHA 생합성은 탄소원인 heptanoic acid의 초기농도가 40mMdlfEo 가장 높았으나, 50mM의 농도에서는 큰 저해를 받았다. PHA 생합성은 질소와 인이 결핍된 조건에서 크게 증가되었다. 배양액의 pH 및 통기는 HJ-2로부터 생합성되는 PHA의 단위체 조성에 큰 영향을 주는 것으로 나타났다. pH 7.5에서 생합성되는 고분자는 poly(3HB-co-38% 3HV)인 반면에 pH8.0에서의 고분자는 3HHp가 95%를 차지하였다. 발효조의 교반속도를 달리한 실험의 결과 고분자 내 3HHp의 함량은 산소전달 속도가 높아질수록 증가하였다. Pseudomnas sp. HJ-2 is capable of producing a rubber-elastic polyhydroxyalkanoate (PHA) consisting of 3- hydroxybutyrate (3HB), 3-hydroxyvalerate (3HV), and 3-hydroxyheptanoate (3HHp) from heptanoic acid as the sole carbon source. The polyester produced was a blend of poly(3HB-co-3HV) and poly(3HHp). Although the mixing of poly(3HHp) fraction to poly(3HB-co-3HV) resulted in a decrease of modulus, the sole fraction of poly(3HB-co-3HV) with a high molar fraction of 3HV was shown to be an elastomer with the maximum percent strain of 740%. The biomass yield and the PHA synthesis were relatively high when the initial heptanoic acid concentration was 40 mM, and were significantly decreased when the substrate concentration exceeded 50 mM. The accumulation of PHA was stimulated by deficiency of nitrogen and phosphorus in the medium. The PHA contents and its monomeric compositions were greatly affected by pH and oxygen transfer rate. At pH 7.5, poly(3HB-~0.38% 3HV) was produced from heptanoic acid and a mixture of 95% 3HHp and 5% 3HV was produced at pH 8.0. Increased conten1 of 3HHp in the polyesters with lhe increasing oxygen transfer rate by agitation speed a1 a fixed aeration rate was observed.

심폐체력에 따른 아디포넥틴 유전자 다형과 비만지표와의 연관성

정정욱(Jung, Jeong-Wook) 한국체육과학회 2012 한국체육과학회지 Vol.21 No.4

The purpose of the study was to investigate whether or not the SNP T45G gene single nucleotide polymorphism in Cardiorespiratory fitness were associated with obesity markers in young 688 korean adults. Body mass index, fasting blood glucose, Adiponectin concentration lipid profiles were measured in every subject, SNP 45T/G in the adiponectin gene were determined by Taqman polymerase chin reaction (Real time PCR) method. The obesity markers was estimated by BMI (body mass index), (%body fat), waist circumference and Waist hip ratio. Wide type of SNP 45T/G was T allele in korean. BMI had significantly higher G allele group that was risk factors. BMI was significantly lower cardiorespiratory fitness low group. In multiple linear regression, Metabolic syndrome scores, adiponectin, and VO2max analyzed as independent variables of BMI. Adiponectin gen SNP 45T/G were related to cardiorespiratory fitness and BMI. BMI was significantly lower in Low cardiorespiratory fitness group. but doesn’t found independent variable. Cardiorespiratory fitness is low in populations with G allele was higher association between insulin resistance and could not find it.

준비운동 형태가 등속성 근기능에 미치는 영향

정정욱(Jung Jeong-Wook),김태영(Kim Tae-Young) 한국체육과학회 2009 한국체육과학회지 Vol.18 No.1

This study was intended to find out the proper pattern of warming-up to improve performance, understanding the effects of four patterns(Non preparation; NP, Warm-up only(running); WP, warm-up and stretching; WS, stretching only; SP) of warming-up on isokinetic strength and comparing?analyzing performance ability according to the execution of WP and SP. Twelve male volunteers in university participated in the research for 4 days. After they conducted 4 patterns of warming-up, Isokinetic muscular function(knee 60°/sec, 180°/sec, ankle 60°/sec) was measured as follows. 1. Peak Torque in knee extensor showed high WS in 60°/sec and 180°/sec (F3,33=3.457, p=.028; F3,33=9.158, p=.000), and muscle fatigue displayed low WS (F3,33=4.200, p=.013). 2. Peak Torque in ankle plantar flexors presented high WS in 60°/sec (F3,33=3.191, p=.036), and there was no significant difference, although WP was high in ankle dorsi flexors. 3. Muscle fatigue was low in WS (F3,33=3.287, p=.033). According to the execution of WP, Peak Torque in knee extensor exhibited high WPY in 60°/sec (t=3.048, p=.011) and 180°/sec (t=3.208, p=.008). Peak Torque in ankle plantar flexors had high WPY (t=.391, p=.036) as well, but muscle fatigue of ankle dorsi flexors showed low WPY (t=2.614, p=.024). Therefore, it is effective to perform mixed warming-up with WP and SP for an event that requires consistent muscle strength.

사랑이 피는 뜨락

丁貞旭 대한사립학교장회(구 대한사립중고등학교장회) 1983 私學 Vol.24 No.-