Synaptic Plasticity in Mouse Models of Autism Spectrum Disorders

정의엽,Alexandra L. Bey,Yong-Hui Jiang 대한약리학회 2012 The Korean Journal of Physiology & Pharmacology Vol.16 No.6

Analysis of synaptic plasticity together with behavioral and molecular studies have become a popular approach to model autism spectrum disorders in order to gain insight into the pathosphysiological mechanisms and to find therapeutic targets. Abnormalities of specific types of synaptic plasticity have been revealed in numerous genetically modified mice that have molecular construct validity to human autism spectrum disorders. Constrained by the feasibility of technique, the common regions analyzed in most studies are hippocampus and visual cortex. The relevance of the synaptic defects in these regions to the behavioral abnormalities of autistic like behaviors is still a subject of debate. Because the exact regions or circuits responsible for the core features of autistic behaviors in humans are still poorly understood, investigation using region-specific conditional mutant mice may help to provide the insight into the neuroanatomical basis of autism in the future.

덴버코리아이엔씨(주)

정의엽 한국지반신소재학회 2018 한국토목섬유학회지 Vol.17 No.3

양파껍질을 이용한 우육포의 항산화 활성 및 품질 특성

정의엽,심기현,Jung, Eui Yoeb,Sim, Ki Hyeon 한국식품영양학회 2019 韓國食品營養學會誌 Vol.32 No.1

The objective of this study was to reduce the waste rate of onion peel, which has excellent functionalities, and to promote its industrial utilization. The methodology involved preparing beef jerkies using liquid seasonings with 0% (OPE0), 50% (OPE50) and 100% (OPE100) onion peel extract (OPE) of domestically produced onion, respectively; and assessing their antioxidant activities and quality characteristics. As the amount of added OPE increased, the contents of crude protein and crude ash increased, while those of crude fat decreased. As for color values, increase in the amount of added OPE led to increase in L value and b value, but decrease in a value. The measurement of mechanical texture showed that hardness and cohesiveness decreased as the amount of added OPE increased. TBARS (thiobarbituric acid reactive substance) content decreased as the amount of added OPE increased. And the amount of added OPE increased, all the antioxidant activity of beef jerky increased. Acceptability test showed the highest preference for OPE50 with regard to flavor, taste texture and overall acceptability. Quantitative descriptive analysis (QDA) showed that increase in the amount of added OPE led to increase in meat color, salty taste, sweet taste, meat flavor and chewiness and decrease in off-flavor. According to principal component analysis (PCA), OPE50 and OPE100 had high levels of the sensory attributes that increase preference-such as meat color, salty taste, sweet taste, meat flavor and chewiness. Based on such results, it was established that 50% is the optimal mixing ratio of OPE for preparing a beef jerky of high preference that also has excellent quality characteristics and antioxidant activity.

Recent Progress in GABAergic Excitation from Mature Brain

정의엽 대한약학회 2012 Archives of Pharmacal Research Vol.35 No.12

The excitatory effect of γ-Aminobutyric acid (GABA) has been recognized in very young animals and in seizure generation, but not so much in animals after weaning age or in adults. The existence of this phenomenon in mature brain is still controversial. In the course of debate, creative studies have identified and characterized the phenomenon in suprachiasmatic nucleus, cortex, hippocampus and basolateral amygdala, albeit mostly in single neurons. In neural circuit activity, presumed GABAergic excitation was observed in basolateral amygdala during the study of a neuropeptide, cholecystokinin. Though the functional meaning of this phenomenon in vivo remains to be uncovered, it may be implicated in epilepsy or anxiety in the adult brain.

Synaptic Plasticity in Angelman Syndrome

정의엽 한국발생생물학회 2012 발생과 생식 Vol.16 No.3

Angelman syndrome (AS) is a neurodevelopmental disorder characterized by intellectual disability and autism. The genetic cause is the absence of UBE3A, an E3 ubiquitin ligase, from the maternal chromosome which can arise from multiple origins. Recently discovered targets of Ube3a are important for activity dependent changes in synaptic transmission and spine morphology. Plasticity studies in an AS mouse model is important for basic plasticity research with regard to understanding protein homeostasis as well as the search for therapeutic targets for the patients. The progress on synaptic plasticity from this unique disorder is reviewed.

Comparison of the outcome of post-cardiac arrest care pre- and post-COVID-19 pandemic

정의엽 대한응급의학회 2022 대한응급의학회 학술대회초록집 Vol.2022 No.2

양파껍질을 이용한 우육포의 항산화 활성 및 품질 특성

정의엽,심기현 한국식품영양학회 2018 한국식품영양학회 학술대회논문집(학술심포지움) Vol.2018 No.12

가스터빈 블레이드 선단부의 충돌/유출 냉각 시스템 열응력 특성 연구

정의엽(Eui Yeop Jung),손호성(Ho-Seong Sohn),최석민(Seok Min Choi),김정주(JeongJu Kim),조형희(Hyung Hee Cho) 한국추진공학회 2018 한국추진공학회 학술대회논문집 Vol.2018 No.5

무릎 내측 구획 골관절염에서 초음파 유도하 경 반월상 연골 주사의 임상적 효과

정의엽(Eui Yub Jung),왕준호(Joon Ho Wang),이의섭(Eui-Sub Lee),이성산(Sung-Sahn Lee),소상연(Sang-Yeon So) 대한정형외과학회 2020 대한정형외과학회지 Vol.55 No.5

목적: 무릎 내측 구획 골관절염 환자에서 초음파 유도하 무릎 관절강내 경 반월상 연골 주사를 소개하고 그 임상적 결과를 분석하고자 하였다. 대상 및 방법: 2019년 3월부터 2019년 7월까지 3개월 이상 무릎 통증이 지속되었던 무릎 내측 구획 골관절염 환자 중 초음파 유도하 경 반월상 연골 주사를 시행한 36명의 환자에 대해서 후향적으로 분석하였다. 초음파 유도하 척추 바늘을 이용하여 무릎관절강내 내측 구획에 corticosteroid와 국소마취제를 주사하였다. 시술 전, 1주, 4주, 8주째 신체진찰을 하였고 numeric pain rating scale (NRS), Lequesne index, Western Ontario and McMaster Universities Osteoarthritis (WOMAC) 점수를 측정하였다. 시간에 따른 NRS, Lequesne index, WOMAC 점수를 분석하였으며 상당한 호전이 있었던 환자들의 비율을 분석하였다. 또한 내측 구획 골관절염의 단계에 따른 NRS, Lequesne index, 상당한 호전이 있었던 환자들의 비율을 분석하였다. 결과: 시술 전과 비교하여 1주, 4주, 8주째 NRS와 Lequesne index는 감소하였고 8주째까지 통증 감소 효과는 차이 없이 지속되었다. 상당한 호전이 있었던 환자들의 비율은 1주, 4주, 8주째 각각 50.0%, 47.2%, 52.8%였으며 8주째까지 통증 감소 효과는 차이 없이 지속되었다. 시술 전과 비교하여 1주, 4주, 8주째 WOMAC 점수는 감소하였고 8주째까지 차이 없이 감소가 지속되었다. 골관절염 1, 2단계 환자들에서 상당한 호전이 있었던 환자들의 비율이 골관절염 3, 4단계 환자들보다 1주, 4주, 8주째 유의하게 많았다(p<0.05). 결론: 무릎 내측 구획 골관절염 환자에서 초음파 유도하 무릎 관절강내 경 반월상 연골 주사는 평균 8주 이상의 통증 감소 및 기능개선 효과를 보였다. 특히 내측 구획 골관절염 1, 2단계 환자에서는 통증 감소 효과가 더 컸다. Purpose: The purpose of this study was to introduce the ultrasound-guided transmeniscal injection in medial compartment knee osteoarthritis and analyze the clinical outcomes. Materials and Methods: The electronic medical records of 36 patients with medial compartment knee osteoarthritis who were treated with an ultrasound-guided transmeniscal injection from March 2019 to July 2019 were accessed for this retrospective review. Using an ultrasound guided spinal needle, the patients received an intra-articular steroid injection at the medial compartment of the knee. A physical examination was conducted at the initial visit (pre-injection), and at one week, four weeks, and eight weeks after the injection. The numeric pain rating scale (NRS), Lequesne index, and Western Ontario and McMaster Universities Osteoarthritis (WOMAC) score were measured at each visit and analyzed over time. The percentage change of the patients who revealed substantial improvement was analyzed. The NRS, Lequesne index, and percentage of patients, who revealed substantial improvement over time classified by osteoarthritis grade, were analyzed. Results: The NRS and Lequesne index decreased at one week, four weeks, and eight weeks after the injection compared to the initial baseline, and the pain-relief effect continued without change until eight weeks. The percentage of patients who showed substantial improvement at one, four, and eight weeks was 50.0%, 47.2%, and 52.8%, respectively. The WOMAC scores decreased at one, four, and eight weeks compared to the initial baseline, and the decrease was continued without any difference until eight weeks. The percentage of patients with osteoarthritis stage 1 or 2 who revealed more than substantial improvement was significantly higher at one, four, and eight weeks than those with osteoarthritis stages 3 or 4 (p<0.05). Conclusion: In patients with medial compartment knee osteoarthritis, the pain reduction and functional improvement persisted for at least eight weeks after the ultrasound-guided transmeniscal injection at the medial compartment. In particular, patients with medial compartment osteoarthritis stage 1 or 2 showed more effective pain reduction.

전면 막냉각에서 냉각판의 열전도도에 따른 열전달 특성

정의엽(Eui Yeop Jung),정희윤(Heeyoon Chung),박세진(Sehjin Park),조형희(Hyung Hee Cho) 대한기계학회 2013 대한기계학회 춘추학술대회 Vol.2013 No.12

In the present study, total cooling effectiveness was obtained by experiment method on a full-coverage film cooling plate. To confirm the conduction effect of film cooling plate, we conducted three experimental cases. These cases used three different conductive materials, which were polycarbonate, Corian, and stainless steel. The test plates had same hole pattern in the three experiment cases. The hole diameter was 5 mm and the angle of film cooling hole was 35 degree. Spacing to hole diameter ratio (p/d) was 3 on the film cooled plate in both the streamwise and spanwise direction. The jet Reynolds number was controlled to 7,000. The detailed temperature distribution on the film cooled surface was measured using the infra-red thermographic technique. Total cooling effectiveness increased with thermal conductivity of film cooling plate. We demonstrated adiabatic film cooling effectiveness for using this research results.