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아벨리노각막이상증으로 진단된 한국인 환자의 각막병변의 분류 및 임상양상
정소향,김창염,김응권,So-Hyang Chung,Chang-Yeom Kim,Eung-Kweon Kim 대한안과학회 2005 대한안과학회지 Vol.46 No.6
Purpose: To classify Avellino corneal dystrophy (ACD) into 3 groups by slit lamp photography and to evaluate the inter-group differences. Methods: DNA analysis was performed in one member from each of 45 families who were clinically diagnosed as ACD. Corneal opacities were classified into mild (group I), moderate (group II), and severe (group III) based on slit lamp photograph. Results: Six patients were confirmed as homozygous ACD and ninety-two as heterozygous ACD. One homozygous patient was revealed to have a novel phenotype. The age increased with increasing severity, and the proportion of females in group III was significantly higher than that of the other two groups (p=0.001). The prevalence of laser in situ keratomileusis (LASIK) increased in group III (p=0.001), and the incidence of pterygium increased in group I compared with the other two groups (p=0.025). Conclusions: ACD was aggravated with age, while pterygium and LASIK altered the natural course of ACD.
정소향,김용민,이승재,김응권.So-Hyang Chung. M.D.. Yong-Min Kim. M.D.. Seung-Jae Lee. M.D.. Eung-Kweon Kim. M.D..Ph.D 대한안과학회 2005 대한안과학회지 Vol.46 No.12
Purpose: Vogt’s striae are defined as vertical stress lines that occur deep in the affected stroma of keratoconus. The purpose of this study was to report a case of horizontal Vogt’s striae in keratoconus. Methods: A 21-year-old male without history of trauma or contact lens wearing presented with decreased visual acuity in both eyes. He complained of chronic habitual eye rubbing due to ocular itching. The best corrected visual acuity of his right eye was 20/30 and was 20/40 in his left eye. A scissoring reflex was seen in both eyes upon retinoscopic examination. On slit lamp examination, multiple and fine parallel horizontal lines in the deep stroma and Descemet’s membrane were noted in his left eye. Corneal topography showed bilateral inferotemporal steepening with corneal thinning. The horizontal lines, which disappear after pressing the eyeball, are thought to be stress lines resembling Vogt’s striae. Results: To our knowledge, there have been no reports demonstrating horizontal stress lines resembling Vogt’s striae in keratoconus patients. Here, we report a case of horizontal Vogt’s striae in a keratoconus patient.
정소향,나경선,권형구,이현수,김수영,김은철,조양경,전은정,김현승,정성근,주천기,김만수 대한안과학회 2010 대한안과학회지 Vol.51 No.9
Purpose: To investigate levels of severity in dry eye syndrome according to Delphi panel classification. Methods: Three hundred and twenty-two eyes of 166 patients with dry eye syndrome that did not have coexisting lid margin disease or altered tear distribution and clearance were categorized into 1 of 4 levels of severity, according to the symptoms and signs in the Delphi panel classification. A symptom score was proposed depending on the frequency and impact on the quality of life. Degree of corneal staining using Lissamin green was categorized using the Oxford Scheme. In addition, measurement of the tear film break-up time (BUT) and Schirmer test were performed. Results: According to the levels of severity in the Delphi panel classification, 120 eyes (37.26%) were categorized as level 1, 166 eyes (51.55%) as level 2, 30 eyes (9.31%) as level 3, and 6 eyes (1.86%) as level 4. Negative correlations were observed between the levels of severity, BUT, and measurements of the Schirmer test (p<0.001). Conclusions: Of the 166 eyes with dry eye syndrome that did not have coexisting lid margin disease and altered tear distribution and clearance, 51.55% of eyes were classified as level 2, and 88.81% of eyes were classified as level 1 and level 2. J Korean Ophthalmol Soc 2010;51(9):1179-1183
IGF-1 Counteracts TGF-β-Mediated Enhancement of Fibronectin for in Vitro Human Lens Epithelial Cells
정소향,정선아,조영재,이준행,김응권 연세대학교의과대학 2007 Yonsei medical journal Vol.48 No.6
Purpose: To determine whether insulin-like growth factor (IGF-1) affects transforming growth factor (TGF-β)- mediated fibronectin accumulation in human lens epithelial cell line (HLE B-3) cells. Materials and Methods: HLE B-3 cells were incubated for 24 hours with TGF-β (10ng/ mL), IGF-1 (10ng/mL), or both. Expression of the fibronectin gene was determined using a real-time reverse transcriptase-polymerase chain reaction (RT-PCR). Fibronectin levels were examined using western blot analysis and immunofluorescence staining. Results: Expression of the fibronectin gene was not different between the TGF-β/IGF-1 treated group and the TGF-β treated group (p= 0.116). However, western blot analysis demonstrated decreased fibronectin levels in human lens epithelial cells treated with TGF-β and IGF-1 compared to those treated with TGF-β only (p<0.01). Immunofluorescence staining disclosed inhibition of TGF-β-induced fibronectin in the presence of IGF-1. Conclusion: This study suggests that IGF-1 counteracts TGF-β-mediated fibronectin accumulation in human lens epithelial cells.
동적 환경에서의 엣지 컴퓨팅을 위한 효율적 태스크 오프로딩 기법
정소향,장민희,김우영,이재호,이재민,김동성 한국통신학회 2022 韓國通信學會論文誌 Vol.47 No.12
본 논문은 두 가지 유형의 오프로딩 대상을 이용한 하이브리드 태스크 오프로딩 기법을 제안한다. 기지국 기반네트워크 구조에 UAV 기반 엣지 서버를 추가로 도입하여 데이터를 병렬처리 하여 태스크 오프로딩 성능을 향상하고자 한다. 이는 모바일 디바이스의 데드라인을 만족하기 위해 태스크를 가중치에 따라 분할하여 로컬, UAV 서버, 기지국 서버에서 처리하는 구조를 가진다. 본 논문에서는 공중/지상 경로에 따라 발생하는 총 실행 시간을계산하고 이를 문제 수식으로 정리하였다. 또한 문제 수식을 최소화하기 위해 디스커버리 프로세스와 가중치를 적용한 Greedy 알고리즘을 제안한다. 시뮬레이션 결과 제안한 기법을 사용했을 때 총 실행 시간이 29% 정도 향상된 것을 확인하였다.
양안 라식 수술 후에 발생한 단안의 급성 각막수종의 임상증례
정소향,조정우,김응권,So-Hyang Chung,Jung-Woo Cho,Eung-Kweon Kim,Ph,D 대한안과학회 2005 대한안과학회지 Vol.46 No.7
Purpose: To report a case of a patient who underwent penetrating keratoplasty due to acute hydrops six years after undergoing a bilateral LASIK procedure. Methods: A 19-year old male patient with -2.75 diopter myopia received a bilateral LASIK operation at a local clinic. Forty-seven months later, -2.00 cyl axis 130o astigmatism was induced in his left eye and additional surgery was performed to correct the LASIK-induced astigmatism. The patient was referred to our hospital 16 months after the secondary operation due to reduced visual acuity in his left eye. He was diagnosed with keratectasia and acute hydrops, and penetrating keratoplasty was performed. Results: The retrospective analysis of the corneal topography prior to the LASIK surgery revealed that the inferior minus superior(I-S) value was 1.25 in the right eye and 1.3 in the left eye. At the time of the first evaluation at out hospital, a slit lamp examination showed an approximate 8x7.5mm sized area filled with aqueous humor between the corneal flap and residual stroma, and Descemet`s membrane rupture was observed. Furthermore, the histopathological section of the patient`s cornea confirmed keratocytes with myxoid degeneration and edematous change. Conclusions: In young patient, particularly those with suspicious asymptomatic keratoconus, LASIK and further enhancement surgery afterwards should be considered and approached in a cautious and deliberate manner.