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철갑소이탄에 의한 전투시스템 내 적재포탄의 순간화재에 관한 전산해석
이승철(Lee, Seung-Cheol),전우철(Jeon, U-Cheol),이해평(Lee, Hae-Pyeong),이헌주(Lee, Heon-Ju) 한국화재소방학회 2013 한국화재소방학회 학술대회 논문집 Vol.2013 No.추계
본 연구에서는 철갑소이탄이 장갑을 관통한 후 전투시스템 내의 적재포탄(고폭탄 또는 추진제)에 피탄되었을 때 순간화재 발생확률에 대해 전산해석을 수행하였다. 장갑은 RHA 재질로 설정하였고, 장갑 두께를 5~30 mm까지 5 mm씩 증가시키며 전산해석을 실시하였다. 고폭탄은 COMPB, TNT, PBX가 사용되었으며 추진제는 ANB가 사용되었다. 본 해석은 Autodyn 프로그램을 사용하였으며, 순간화재 발생 여부를 해석하기 위해 Lee-Tarver ignition and growth model을 사용하였다. 해석 결과, 철갑소이탄이 고폭탄 TNT와 PBX에 피탄되었을 때, 순간화재 발생확률이 모두 100%를 나타내었으며, 고폭탄 COMPB의 경우, 0.8~0.08%로 나타났다. 추진제 ANB의 순간화재 발생확률은 3.8~3.6%로 나타났다.
간세포암에서 경동맥문맥조영중 전산화단층촬영 100예의 의의
이헌주(Heon Ju Lee),김홍진(Hong Jin Kim),장재천(Jae Chun Chang),박복환(Bok Hwan Park),조재호(Jae Ho Cho),한건수(Kon Soo Han),심민철(Min Cheol Shim),권굉보(Kyung Bo Kwun),김태년(Tae Nyon Kim),정문관(Mun Kwan Jung) 대한소화기학회 1993 대한소화기학회지 Vol.25 No.5
N/A We retrogradely analized the meannings of computed tomography during arterial portography (CTAP) compared with conventionally contrast enhanced computed tomography (conventional contrast CT) taken in 100 cases of hepatocellular carcinoma. We could find 57.8% additional borderline. lesions with CTAP in number of patients and 92.5% in numbers of masses. Portal vein invasion which was not demonstrated by conventional contrast CT could be detected by CTAP in 10 cases. In diagnosis of unilatral or bilateral lobe involvement for determinantion of treatment planning, CTAP could prevent 35.5% of mis-underdiagnosis of unilateral lobe involvement by demonstrating the nodule and/or portal vein invasion cf controlateral lobe. In conclusion, CTAP is very usefuI in detection of hidden borderline lesion, portal vein invasion, and recognition of portal venous flow nature in preserved portion of liver. Therefore CTAP is considered essential in pretreatment evaluation of hepatocellular carcinoma for determination of proper treatment principles.
이헌주 ( Heon Ju Lee ) 대한간학회 2010 Clinical and Molecular Hepatology(대한간학회지) Vol.16 No.2(S)
Unlike many western countries, the most common clinically important chronic progressive liver disease in Korea has been hepatitis B virus (HBV) related ones. But after HBV vaccination and very effective antiviral therapy with nucleos (t)ide analogues over 30 and 10 years respectively have made relative increase of the incidence and the importance of alcohlic liver disease (ALD) nowadays. The pathogenesis of ALD is very complex and obscure depending on the individual variability and susceptibility to alcoholic liver injury with environmental factors. Even lots of high quality pathphysiological research and bulky papers with genetics and molecular biologic process on ALD, no concentrated clear theory is yet. But in Korea, reports on clinical study and not to mention about basic research on ALD are scanty. Most of the knowledge including epidemiology adopting in clinical fields are based on the foreigners and there is no standarized Korean guidelines for ALD. An exact evalauation of the clincal importance and the issue of ALD in Korean society is essential to control the devastating alcoholics effectively and economically. The update world and Korean literature on ALD was referred for the more understanding of ALD present in Korea including necessity of Korean guideline for the clinician and also for the establishment of study subjects in ALD study group in KASL.
이헌주 ( Heon Ju Lee ),은종렬 ( Jong Ryul Eun ),장병익 ( Byung Ik Jang ),이정훈 ( Jung Hoon Lee ),이형우 ( Hyoung Woo Lee ),최준혁 ( Joon Hyuk Choi ),기창석 ( Chang Suk Ki ) 대한내과학회 2006 대한내과학회지 Vol.71 No.1
Glycogen storage disease type Ia is caused by a deficiency of glucose-6-phosphatase (G6PC), which leads to glycogen accumulation in many organs including liver. We could diagnose a case of glycogen storage disease type Ia with molecular genetic analysis. A 17-year-old man visited Yeungnam university hospital because of abdominal discomfort. Clinical features were characterized by short stature, hepatosplenomegaly, accompanying hypoglycemia, hypercholesterolemia, hyperuricemia. Liver needle biopsy disclosed compatible findings of glycogen storage disease. Molecular genetic analysis of the G6PC gene was performed by direct sequencing method. We identified two mutations within the exon 5 of the G6PC gene, 727G>T and 743G>A. We report this rare case with a review of the literature.(Korean J Med 71:91-96, 2006)
Anti - HBc 단독양성인 만성간질환 환자에서 중합효소 연쇄반응을 이용한 혈청 HBV DNA 의 검출 , anti - HBe 및 anti - HBc 역가
이헌주(Heon Ju Lee),서민호(Min Ho Suh) 대한내과학회 1994 대한내과학회지 Vol.46 No.4
N/A Objectives: The interpretation of isolated anti-HBc is very complex. One of the possibility is the role of a surrogate marker for low level HBV carriers, particularly in high titers of anti-HBc. Methods : Hepatitis B virus (HBV) DNA was tested in 43 objects that have antibody against hepatitis B core antigen (anti-HBc) as the isolated serological marker of HBV infection by the polymerase chain reaction (PCR). Anti-HBc titers were presented by Cut off point Counter Per Minute/Patient Count Per Minute (C/P ratios). HBV marks were tested by Abbott kits by radioimmunoassay. Results : HBV DNA was detected in 9 of 43 (20.9%) patients with liver disease. C/P ratios in 43 patients were higher (12.9±8.1) than that of normal control (4.6±0.7, p<0.005) but no difference was found between HRV DNA positive and negative group. Anti-HBe was positive in 4 of 9 HBV DNA positive objects. Conclusions : HBV DNA amplification by the PCR is the best method for the diagnosis of low level HBV carriers among isolated anti-HBc positive objects, Anti-HRc titers can not be the only way that detect low level HBV carriers any more. Anti-HBe should be checked in objects with isolated anti-HBc who are under the suspicion of low level HBV carriers. More cautions sould be payed on evaluation and management of isolated anti-HBc positive blood for the diagnosis and prevention of HBV infection by medical personell, expecially in blood bank.
혈청 anti - HCV 양성자의 역학 및 가족내 감염과 HBV 표지자에 관한 조사
이헌주(Heon Ju Lee),강호정(Ho Jung Kang),김기덕(Kee Duck Kim),박찬원(Chan Won Park),윤현대(Hyun Dae Yoon),전진종(Jin Chong Chun),최교원(Kyo Won Choi),최희진(Hee Jin Choi) 대한내과학회 1992 대한내과학회지 Vol.43 No.6
N/A Background: Transfusion is a well-known source of hepatitis C virus (HCV) infection but over half of the hepatitis C patients do not have any suspicious source of infection. Epidemiological survey and serological test for HBV marks were done among anti-HCV positive chronic liver disease patient and their family members. Method: 74 cases of anti-HCV postitive chronic liver disease patients were evaluated for the evident source of HCV infection and 188 of their family members were consulted for the infection of HCV. To compare the mode of HBV infection with HCV, serum HBsAg, anti-HBc and anti-HBs were checked in 43 of HBsAg positive chronic liver disease patients, 190 of their family members, 64 anti-HCV postive chronic liver disease patients and 239 of normal control persons. Results: 35cases (47.3%) of 74 anti-HCV positive chronic liver disease patients had no suspicious source of infection and only 16 cases (21.6%) had the history of past transfusion. No family members except 3 (one infant, one IV drug abuser and one wife) in 3 families among 74 families were anti-HCV positive. 29 of 43 (67. 4%) families of HBsAg positive chronic liver disease patients had at least one of HBsAg positive member. Characteristically, HBsAg was positive in almost all cases of offsprings born to mothers of HBsAg and HBeAg positive chronic liver disease. 2 of 64 (3.1%) serum anti-HCV positive patients had HBsAg in their sera. Anti-HBs positive cases were 11 of 64 (17.2%.) anti-HCV positive chronic liver disease patients and isolated anti-HBc positive cases were 40 of 64 (62.5%). On the other hand, in normal control, the positive rate of anti-HBs and isolated anti-HBc were 57,4% and 24.3%(> in each (p<0,005, in both). Conclusion: In Korea, vertical transmission was the main source of HBV infection but HCV disease might be horizontal and sporadic. No remarkable difference in HBV infection rate between anti-HCV positive chronic liver disease patients and control persons. Superinfection of HCV on person who already was exposed to HBV may occur but this assumption could be depend on accurate testings for HBV and HCV. Some derangement in immune system and reaction or interaction between HBV and HCV should be considered in anti- HCV positive patients but before, isolated serum anti- HBc positive sera of chronic liver disease patients should be examined by confirmatory tests. To reduce the number of HCV patients, defining the evident source of the sporadically infected HCV cases could be helpful.
이헌주(Heon Ju Lee),이현우(Hyun Woo Lee),윤봉영(Bong Young Yoon),김종명(Jong Myung Kim),김정회(Jung Hee Kim),곽철승(Chul Sung Kwak) 대한소화기학회 1989 대한소화기학회지 Vol.21 No.2
N/A Evaulation of serum bile acids has been used for prediction of abnormal serum liver profile in the world. But recently many reported that bile acids in a random sample of urine (URNBA), corrected for urine flow with creatinine, have high diagnostic value when compared with serum bile acid and routine serum liver tests. We analyzed URNBA as a predictor of liver abnormality in 27 subjects of various liver disease and 8 normal subjects and compared with the results of serum bile acids and routine serum liver profile. In the patients, the rates of abnormal elevation of URNBA and serum bile acid were 85.2% (23/27) and 74.1% (20/27), respectively. URNBA/creatinine in the random sample of urine revelaed the highest reliability that reflects the presence of liver disease. So we think that urine can be used to predict liver diasese with an accurary that equals or exceeds the serum bile acid and the routine liver tests.