향부자의 약리작용에 관한 연구

이향주(Hyang Joo Lee),양기숙(Ki Sook Yang),이덕행(Deuck Heng Lee),김태희(Tae Hee Kim) 한국생약학회 1985 생약학회지 Vol.16 No.1

향부자는 사초과에 속하는 다년초로서 이뇨, 통경, 소염, 진통제로 사용되어 왔으며 수치로서 동변초하여 이용되고 있다. 이에 연자등은 향부자와 동변초한 향부자의 약리작용을 비교 연구하였다. 진통실험에서 향부자의 메탄올 액기스와 동변초한 시료는 10g/㎏에서 각각 70.5%, 39.5%의 억제율이 인정되었다. 흰쥐를 이용한 이뇨실험에서는 두 시료가 모두투여후 2시간에서 유의한 뇨량과 전해질의 증가를 나타내었으며 후로세미드와 병용 투여에서는 투여후 1시간에서 유의한 뇨량의 감소가 인정되었다.

유전자 재조합 Erythropoietin (LB-00014) 의 일반약리작용

이은방(Eun Bang Lee),천선아(Seon Ah Cheon),이향주(Hyang Joo Lee),조성익(Sung Ig Cho),손지영(Jee Young Sohn) 한국응용약물학회 1996 Biomolecules & Therapeutics(구 응용약물학회지) Vol.4 No.2

General pharmacological properties of LB-00014, an erythropoietin which was produced by recombinant DNA technique in Biotech Research Institute, LG Chemical Ltd. were examined. The administration of LB-00014 (60, 600, 6000 IU/㎏, iv) in mice had no effect in general behavior and central nervous system, and no influences on normal body temperature, writhing syndromes induced by 0.7% acetic acid solution and chemoshock produced by strychnine and pentetrazole solution. LB-00014 (60, 600, 6000 IU/㎏, iv) given to anesthetized rabbits showed no effect on blood pressure of carotid artery and respiration rates, and it did not influence the responses produced by injection of acetylcholine or epinephrne. The administration of LB-00014 (601, 600, 6000 IU/㎏, iv) in rats had no effect on the plasma prothrombin time, activated partial thromboplastin time and hemolytic action. The platelet aggregation induced by collagen in human plasma was not influenced by LB-00014 (10, 100, 1000 IU/㎏, iv). It showed no direct effect at 100 and 1000IU/ml in isolated stomach fundus and uterus of rats and ileum of guinea-pig, and it also had no inhibition of contraction produced by acetylcholine, oxytocin, serotonin and histamine in the above-mentioned preparations. It did not influence gastric secretion, pH and acid output at 6000 IU/㎏, iv in rats, but showed a significant increase in intestinal propulsion of mice at 6000 IU/㎏, iv. Its administration (60, 600, 6000 IU/㎏, iv) caused no effect on urine and electrolyte excretion in rats. These results indicate that LB-00014 does not exsert any of serious pharmacological effects.

상품 컬러가 구매의도에 미치는 영향

황인석(In Suk Hwang),이향주(Hyang Joo Lee) 한국마케팅학회 2012 마케팅연구 Vol.27 No.1

본 연구는 상품 컬러가 구매의도에 미치는 영향을 컬러의 대표적 속성이라 할 수 있는 선호도 및 적합도 관점에서 실증 고찰하고 있다. 여기서 컬러 선호도란 말 그대로 특정 컬러를 선호하는 정도라고 할 수 있으며, 적합도는 컬러가 상품과 맞느냐, 맞지 않느냐 하는 개념이라 할 수 있다. 가설 검정을 위해 본 연구는 인쇄 광고를 사용하였으며 피험자로서 대학생 160명이 참가하였다. 연구 결과 선호도가 높은 컬러와 적합도가 높은 컬러는 각각 선호도가 낮은 컬러 및 적합도가 낮은 컬러보다 구매의도를 높이는 것으로 나타났다. 이러한 선호도의 영향은 구매 관여도가 낮은 상품에서 유의하게 나타났으며, 높은 상품에서 유의하게 나타나지 않았다. 반면 적합도의 영향은 구매 관여도가 낮은 상품에서 유의하게 나타나지 않았으며, 높은 상품에서 유의하게 나타났다. This study investigates effects of product color on purchase intention, specifically focusing on its preference and fit in print advertising. Color preference refers to the extent to which people like a color and color fit is defined as the extent to which a color evokes meanings(i.e. feelings, thoughts, images) that are fit, congruent, or in harmony with those evoked by a product. Based on the past studies, a total of four hypotheses are addressed in the study; High preferred color will show a greater positive effect than low preferred color on the purchase intention for an advertised product(H1), high fit color will show a greater positive effect than low fit color on the purchase intention for an advertised product(H2), the effect predicted by the H1 will be more evident in low purchase- involvement product condition(H3), and the effect predicted by the H2 will be more evident in high purchase-involvement product condition(H4). Especially, ELM(Elaboration Likelihood Model) was used for the formulation of the H3 and the H4. One hundred and sixty undergraduate students at the college of one of authors participated in the study. The sample aged between 20 and 26 with an average of 23.2 and was nearly 60 percent male. Pretests were conducted to select product categories for the manipulation of purchase-involvement and appropriate colors for each preference or fit condition. Each pretest used an independent sample. Based on the pretests, a digital camera and a USB were chosen for high or low purchase-involvement product condition respectively and black(high preferred and high fit condition), clean red-purple(high preferred and low fit condition), yellow green(low preferred and high fit condition), and dull yellow(low preferred and low fit condition) were selected to be used in the main experiment. Before the experiment, participants were told that the purpose of the study was to analyze consumers` responses to product advertising and that they would watch several ads. The ads consisted of one experimental and four nonexperimental ads which were made newly for the study. In order to control for primacy and recency effects, the experimental ad for the high- or low purchase-involvement product condition was placed third in the sequence of five ads. After watching each ad, participants answered the questionnaire items about the ad including their purchase intention for the advertised product. The purchase intention was measured using three items on a seven-point scale(α = .94). The items took the form ranging from ``definitely would not buy`` to ``definitely would buy``, ``improbably buy`` to ``probably buy``, ``definitely would not recommend the advertised product to my friends`` to ``definitely would recommend the advertised product to my friends``. The items were modified slightly from those used in the studies by Goldsmith and Lafferty(2000) and Till and Busler(2000). For further analysis, all multi- items were averaged. In the case of experimental ad, different from nonexperimental ads, manipulation- check measures were added into the questionnaire. Specifically, the purchase-involvement was measured by three seven-point scale items from Park and Young(1986) and Zaichkowsky`s(1985) studies("The purchase of an digital camera(or USB) is important to me," "I watch advertising for a digital camera(or USB) carefully," and "I spend a lot of time in purchasing a digital camera(or USB)") Each item was anchored by 1 = strongly disagree and 7 = strongly agree. The items exhibited high reliability(α = 96). The color preference and fit were measured using one and three items respectively on a seven-point scale. The former was developed by referring to MacInnis and Park(1991), anchored by 1 = not likable and 7 = likable while the latter was from Kellaris, Cox, and Cox(1993) and MacInnis and Park`s(1991) studies(fit, congruent, matched; 1 = strongly disagree, 7 = strongly agree). The reliability among the items for the fit was shown high(α =

재조합 부갑상선 홀몬의 일반약리작용

이은방(Eun Bang Lee),장혜옥(Hae Ock Chang),이향주(Hyang Joo Lee),천선아(Seon Ah Cheon) 한국응용약물학회 1998 Biomolecules & Therapeutics(구 응용약물학회지) Vol.6 No.2

General pharmacological properties of recombinant human parathyroid hormone (hPTH) were examined. The administration of hPTH (7, 35 and 175 IU/kg sc) in mice had no effects in general behavior and central nervous system, and no influences on normal body temperature, writhing syndromes induced by 0.7% acetic acid solution and chemoshock produced by strychnine and pentetrazol solution. hPTH (9 and 44 IU/kg, sc) given to anesthetized rabbits showed no effect on blood pressure of carotid artery and respiration, and it did not influence the responses produced by injection of acetylcholine or epinephrine. It showed no direct effect at 4.4 x 10^(-2) IU/ml in isolated stomach fundus and uterus of rats and ileum of guinea-pig, and it also showed no inhibition of contraction produced by acetylcholine, oxytocin, serotonin and histamine in the above-mentioned preparations. It did not influence intestinal propulsion at the doses of 7, 35 and 175 IU/kg sc in mice. This drug exhibited no effect on urinary excretion at the doses of 7 and 35 IU/kg sc in rats. However, at a dose of 175 IU/kg sc, it showed a decreased urination along with decreased excretion of potassium, sodium and chloride ion. These results indicate that hPTH does not exert any of serious pharmacological effects except the inhibition of urination at a highest dose used.

하안검내층 재건을 위한 비중격 점막연골 이식과 구개 점막이식과의 비교

이향주,이택종 大韓成形外科學會 1990 Archives of Plastic Surgery Vol.17 No.2

An eyelid is composed of three layers: an outer layer of skin, an inner layer of mucosa, and a semirigid tarsal plate interposed between them. Therefore, the reconstruction of an eyelid requires restoration of these elements. In reconstructing the lower eyelid the mucosa is replaced and additional support is necessary in order to overcome gravity and cicatrical contracture. We have experienced 8 cases of lower eyelid reconstruction since June,1984. In 6 cases lower eyelid cancer has been developed close to margin, 1 case was congenital syphilis and 1 case was post traumatic defect. The inner layer of lower eyelids was reconstructed with nasal septal mucochondral grafts in 4 cases and palatal mucosal grafts in 4 cases. For outer layer of lower eyelid we used various flaps; cheek rotation flaps in 5 cases, cheek rotation flap and temporal flap in 1 case, and orbicularis oculi myocutaneous flaps in 2 cases. We followed the patients comparing the palatal mucosal graft with the nasal septal mucochondral graft and concluded: 1. The nasal septal mucochondral graft apperaed to be more natural. 2. A tendency of the nasal septal mucochondral graft to curl towards the mucosa-covered side after thinning of the cartilage was an additional merit. 3. Both palatal mucosal graft and nasal septal mucochondral graft maintained stable margin of the lower eyelids. 4. Thick, mucoid secretion was troublesome in palatal graft group. Nevertheless, patients were tolerale in 2 or 3 months. 5. If the nasal septum was destroyed or deformed,palatal mucosa is advisible for inner layer of eyelid.

Scapular Osteocutaneous Free Flap 을 이용한 하악재건 3 예

윤근철,이택종,유장열,이향주 大韓成形外科學會 1989 Archives of Plastic Surgery Vol.16 No.3

Although there are many methods and donor sites in the mandibular reconstruction by microvascular tissue transfer, the iliac bone with deep circumflex iliac artery has been used most commonly. Meanwhile, Acland introduced scapular osteocutaneou free flap using the periosteal branch of circumflex scapular artery in 1985. In reconstructing 3 cases of mandibular composite defects, we adopted the scapular osteocutaneous free flap to avoid the handicaps of iliac bone free flap i.e bulkness, difficulties in mucosa-bone dissociated reconstruction etc.. After resonable period of follow-up, we reviewed the cases and methods of reconstruction and concluded that the scapular osteocutaneouos free flap hs following merits. 1. Technically easy especially in the large mucosal defect and in case the mucosal detet is not near to the bone defect. 2. Aesthetically good. 3. Structural stability is tolerable inspite of scapular bone osteotomies. And in one case we modified the procedure by elevating the bone with attached Teres major muscle belly to meet the need of soft tissue defect resulting from neck dissection.

Retinol Palmitate가 연골발생에 미치는 영향에 관한 형태학적 연구

이향주,김수일,이영호,김원식 충남대학교 의과대학 지역사회의학연구소 1993 충남의대잡지 Vol.20 No.1

Vitamin A, an isoprenoid which has cyclohexynyl ring chemically, is known to promote the growth and differentiation during development and regeneration, to maintain the state of health and to improve the vision, and is known to be essential in mucous secretion, reproduction and maintenance of epithelium. Recently, the anticarcinogenic and antimutagenic effects of vitamin A and the teratogenic effects were reported, however the mechanism of action of vitamin A was not confirmed thoroughly. In this experiment, the morphological changes after administration of retinol palmitate during the development of hindlimb and differentiation of chondrocytes were observed in the rat fetuses. SpragueDawley rats were used as an experimental animal. The rats were divided into 2 groups : control and vitamin A(retinol palmitate) treated group. In retinol palmitate treated group, 500mg/kg of retinol palmitate(Sigma Chemicals Co.) dissolved in corn oil(Sigma Chemicals Co.) was administered orally with gastric tube once at the day 8.5 of gestation. In the control group, corn oil of equal volume as in retinol palmitate treated group was administered. On the gestation day 12.5, 13.5, 14.5, 15.5 and 16.5, the rats were sacrificed under ether anesthesia, laparotomized and hysterectomized. Under stereoscope the pregnant sacs and the fetuses were observed, and the body weight of each fetus was measured. For the observation of external development of hindlimb, the embryos were stained with Nile blue sulfate, and compared the differences between 2 groups. The histological changes were observed light microscopically after routine processing, and H-E & alcian blue staining, and the ultrastructural changes of chondrocytes observed electron microscopically. The results were as follows ; 1. The survival rate of fetuses was lowered in the retinol palmitate treated group significantly except the day 12.5 of gestation. 2. In the retinol palmitate treated group, the development of hindlimb bud and aggregations of precarti lagenous mesenchymal cell were decreased significantly on the day 12.5 and 13.5 of gestation. 3. Cartilage matrix formation was found initially on the day 13.5 of gestation in control group and on the day 14.5 of gestation in retinol palmitate treated group. 4. Electron microscopic changes of chondrocytes after retinol palmitate administration were as the followings : mitochondrial and IR swelling, decreased filopodia, reduced intercellular space and cartilage matrix, abnormal aggregation of glycogen particles and increased intercellular junctions. According to the above results, it is considered that retinol palmitate has an inhibitory effect on the hindlimb developmnet by reducing the aggregations of precartilagenous mesenchymal cell and chondrocytic structural and metabolic changes.

생쥐 피부의 창상치유에 관한 형태학적 관찰

이향주,이영호,김홍선,김원식 충남대학교 의과대학 지역사회의학연구소 1989 충남의대잡지 Vol.16 No.1

The back skin of ICR mice were incised. The skin tissues were obtained from the incised wound on the 1st day, 1st weeks, and 2nd week after incision. And these tissue were fixed in 10% neutral buffered formalin and 2.5% glutaraldehyde solution. And, the formalin-fixed tissues were stained by PAS and alcian blue-safranin for the research of morphological changes of epidermis and the mast cells and granulation tissues of dermis. The tissues fixed in 2.5% glutaraldehyde solution were prepared for scanning electron micros-copy, and observed the crusts of scar surface. The results were as follows. 1. The collagen fibers in he granulation tissues at wound region were increased gradually, and became more dense than normal skin on the 2nd week after incision. 2. The newly-formed epidermis was thicker than that of normal skin at the 1st week, and increased in thickness to the 2nd week after incision gradually. 3. The mast cells were decreased in number than those of normal skin on the 1st day after incision, however, increased than those of normal skin on the 1st week after incision. On the 2nd week, the number of the mast cell were similar to those of normal skin. 4. Mixed mast cells containing both histamine and heparin appeared the granulation tissues on the 1st day and 1st week after incision. 5. In scanning electron microscopy, fibrin network on the scar began to appear on the 1st day, formed in a row on the 1st week. But fibrin network changed into irregular rough crusts on the 2nd week after incision.

흰쥐 횡격막 신경-근 표본에서 근 수축효과에 미치는 Tetraethylammonium 의 영향

이향주,이광수,김태요,송윤강,최봉규 대한마취과학회 1996 Korean Journal of Anesthesiology Vol.30 No.1

Background: Recently, the phannacologic and therapeutic significance of various types of potassium channels are being realized. Thus it was attempted to delineate the role of voltage-gated K-channels on the excitation-contraction coupling in skeletal muscle. Methads: The effects of tetraethylammonium, a well known K^+-channel blocker, on the electrically-evoked twitch response, train-of-four and tetanic stimulation, and the influence of various agents on the these effects were studied in the isolated rat hemi-diaphragm preparation. Results: Tetraethylammonium (1 & 3 mM) increased the electrically-evoked twitch response, but the large dose (10 mM) decreased the twitch response. And tetraethylammonium decreased the TOF- and tetanus-ratio in a dose-related fashion. d-Tubocurarine (1 uM) decreased the twitch response, and tetraethylammonium recovered the d-tubocurarine- induced-depression of twitch response. When the Ca^(++)(6 ×) and K^+ (2 ×) concentration of the medium were increased, the twitch response caud by tetraethylammonium were slightly inhibited than that observed in the normal solution, but the fade phenomenon was potentiated. The tetraethylammonium (10 mM)-induced depression of twitch response were reduced by reducing the stimulus frequency to 0.01 Hz and choline (400 μM) treatment. And N-ethylmaleimide inhibited the tetraethylammonium-induced increment of twitch response and also potentiated the tetraethylammonium-induced fade phenomenon. However, it is noteworth the 4-aminopy- ridine, another K^+-channel bloker, potentiated the electrically-evoked twitch response but did not affect the TOF-and tetanusratio. Conclusion: These result indicate that tetraethylammonium elicited two districtive types of response in the rat phrenic-hemidiaphragm preparation. The potentiating effects of twitch response is mediated by blocking delayed K^+-rectifier channel and decreasing effects of twitch response, TOF-and tetanus-ratio is may be due to decreased the acetylcholine release from presynaptic nerve terminal.

총수담관 결석을 동반한 담관 낭선암 1예

이향주,신용원,한호용,박신희,전하영,장석,권학중,신경철 대한소화기학회 1998 대한소화기학회지 Vol.31 No.5

Biliary cystadenomas and cystadenocarcinomas are rare tumors of biliary origin and constitute less than 5% of the total intrahepatic cysts of bile duct origin. They occur most commonly in middle age females. Clinical manifestations are non-specific, so these tumors are incidentally found during autopsy or surgery. The ultrasonogram, abdominal CT scan, angiography and aspiration cytology are valuable diagnostic methods. The typical sonographic appearance of these tumors is a large intrahepatic globular or ovoid thick-walled cystic mass which often contains multiple septations or papillary infoldings. The characteristic CT appearance of these tumors is similar to that of a low-density intrahepatic mass which may cantain mural nodule or internal septation. However, regardless of the diagnostic modalities, pre-operative diagnosis as well as intra-operative one is difficult. Since biliary cystadenocarcinomas are believed to arise from benign cystadenornas, complete surgical resections, if possible, is a warranted method to avoid malignant change of these tumor. We report one of biliary cystadenocarcinoma canfirmed by the operation with review of the literatures.