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불균질 지반에 설치된 테이퍼 마찰말뚝의 자유진동 특성 분석
이준규,고준영,이광우,김동욱 한국지반신소재학회 2019 한국지반신소재학회 논문집 Vol.18 No.3
This paper presents a new analytical model for estimating the free vibration of tapered friction piles. The governing differential equation for the free vibration of statically axially-loaded piles embedded in non-homogeneous soil is derived. The equation is numerically integrated by the Runge-Kutta method, and then the eigenvalue of natural frequency is determined by the Regula-Falsi scheme. For a cylindrical non-tapered pile, the computed natural frequencies compare well with the available data from literature. Numerical examples are presented to investigate the effects of the tapering, the skin friction resistance, the end condition of the pile, the vertical compressive loading, and the soil non-homogeneity on the natural frequency and mode shape of tapered friction piles. 본 논문에서는 테이퍼 마찰말뚝의 자유진동을 평가할 수 있는 해석모델을 제안하였다. 불균질 지반에 설치된 정적 수직하중을받는 테이퍼 마찰말뚝의 자유진동을 지배하는 미분방정식을 유도하였다. 이 지배방정식을 Runge-Kutta 법을 이용하여 직접수치적분하였고, 미분방정식의 고유치인 고유진동수는 Regula-Falsi 법을 이용하여 산정하였다. 원통형 말뚝의 고유진동수계산값은 기존 문헌값과 잘 일치하였다. 수치예를 통해 말뚝의 변단면, 주면마찰력, 단부조건, 수직압축하중 및 지반의 불균질성이 고유진동수와 모드형상에 미치는 영향을 분석하였다.
이준규,Jung-Eun Kim,Bang Ju Park,Yoon-Jae Song 한국미생물학회 2020 The journal of microbiology Vol.58 No.1
We previously reported that human cytomegalovirus (HCMV) 86 kDa immediate-early 2 gene product (IE86) promotes proteasome-dependent degradation of STING. In the present study, we determined the specific residues of IE86 responsible for STING degradation using a STING-firefly luciferase fusion protein expression system for quantitative measurement of STING protein levels. IE86 amino acids (aa) 136–289 were sufficient to promote STING degradation and further induced down-regulation of 2 3 -cyclic GMP-AMP (cGAMP)-mediated IFN-β promoter activation. Interestingly, transactivation domains (TAD) of the IE86 protein located at the N- and C-termini were required for down-regulation of Toll/interleukin-1 receptor (TIR) domain-containing adaptor- inducing interferon β (IFN-β) (TRIF)-mediated IFN-β- and p65/RelA-induced NF-κB-dependent promoter activation while amino acids (aa) 136–289 had no significant effects. Our collective data suggest that the IE86 protein utilizes the aa 136–289 region to promote STING degradation and inhibit the cGAS-STING pathway.
이준규 한국상사법학회 2009 商事法硏究 Vol.28 No.2
This paper evaluates and suggests ways to improve the taxation on defacto merger in that the tax effect of de facto merger should be identical tothat of statutory merger in order to maintain tax neutrality and substanceover form as follows;First, the provisions for taxing a gain on merger should be abolishedsince the gain represents an unrealized increase in asset value and amerging corporation in a de facto merger is not taxed under the currentlaw. Second, special tax treatments for a certain reorganization should applyfor a de facto merger in case that the requirements similar to those in astatutory merger are met. A de facto merger which is made by transferringsubstantially all assets even though some assets are not transferred shouldbe treated as tax-free. Third, tax-favored merger for which statutory requirements are met shouldbe substituted with tax-free merger as in Internal Revenue Code of theUnited States of America in order for supporting and promoting businessreorganizations, since even in the merger which meets the requirements forspecial tax treatments, it can be possible to be taxed to the partiesinterested to the merger. Fourth, the taxation on an unfair merger, and succession of operatinglosses and tax reconciliation items should apply in a de facto merger as ina statutory merger. Finally, a merger with a completely controlled subsidiary should betax-free even though tax incentive requirements are not met, and aliquidating distribution made by completely controlled subsidiary shoud betreated tax-free as in a de facto merger.
소아에서 Methicillin-Resistant Staphylococcus Aureus(MRSA) 이루에 대한 치료분석
이준규,김승현,나애선,김창국,조용범 대한이비인후과학회 2003 대한이비인후과학회지 두경부외과학 Vol.46 No.1
Background and Objectives:Recently, incidence of community-acquired methicilin-resistant Staphylococcus aureus (MRSA) infection has been increasing. There are problems with children with MRSA otorrhea in visiting otolaryngology clinics, since higher. In this study, we used the conventional antibiotics orally and topically for the treatment of otorrhea by MRSA infection to compare the therapeutic effects of conventional antibiotics with the systemic vancomycin or teicoplanin. The author also tried to determine the timing of systemic vancomycin injection for the control of MRSA otorrhea. Materials and Method:Twenty-eight pediatric patients with MRSA otorrhea were treated with either conventional antibiotics (20 patients) topicaly and oraly or systemic vancomycin or teicoplanin injection (8 patients). The use of vancomycin or teicoplanin injection was indicated when otorrhea didnt stop despite of 3-4 weeks of conventional treatment and when refered from local clinics, and in case of chole-steatoma, when it came as a result of complication of midle ear disease. Results:The average therapeutic period for the con-ventionally treated group was 24.7 days. On the other hand, the average period was 12.3 days and 9.8 days for the systemic vancomycin and teicoplanin injection group, respectively. Conclusion:applied for the treatment of MRSA otorrhea in children, has advantages in relation to time and economy, although the average therapeutic period was longer than the treatment with systemic vancomycin or teicoplanin injection. The author suggests the usage of conventional antibiotics for 3 weks prior to the use of systemic vancomycin injection. (Korean J Otolaryngol 2003 ;46 :16-20)